Abstract:
Background:Methylenetetrahydrofolate reductase (MTHFR) is indispensable for the conversion of homocysteine (Hcy) to methionine. The single nucleotide polymorphism (SNP) of MTHFR gene (rs1801133, C667T) is correlated with decreased enzyme activity that eventually results in elevated plasma Hcy levels. Hyperhomocysteinemia has been confirmed to be involved in the pathogenesis of stroke, cerebral small vessel disease (CSVD), various metabolic disorders and so on. However, the relationship between the MTHFR gene polymorphisms, Hcy, and CSVD has not been investigated. In this study, the relationship between SNPs of MTHFR gene and CSVD was determined after adjusting for cardiovascular risk factors, and the potential mechanism based on Hcy levels was explored. Methods:A total of 163 consecutive CSVD patients were collected as the case group. In the corresponding period, 326 healthy people were selected as the control group, who were matched to these cases according to age (±2 years) and gender at a ratio of 2:1. SNPs of MTHFR rs1801133, rs1801131, rs2274976, rs4846048, rs4846049, rs13306561 and rs3737964, were genotyped with TaqMan Pre-Designed SNP Genotyping Assays. Plasma Hcy levels were detected using Hcy reagent through enzymatic cycling assay. Multivariate analysis was used to identify the SNPs associated with CSVD susceptibility. Plasma Hcy levels were compared between different genotypes. Results:The MTHFR rs1801133 TT and CT genotype had increased risk for CSVD, and the OR was higher in the TT genotype than in the CT genotype (2.307 vs 1.473). The plasma Hcy levels of different genotypes showed the tendency of the TT genotype > CT genotype > CC genotype (19.91 ± 8.73 pg/ml vs 17.04 ± 5.68 pg/ml vs 14.96 ± 4.85 pg/ml). Conclusions:The SNP of MTHFR rs1801133 was correlated with CSVD, and the TT and CT genotypes had increased risk for CSVD compared to the CC genotype. The potential mechanism was associated with elevated Hcy levels.
journal_name
PeerJjournal_title
PeerJauthors
Yuan H,Fu M,Yang X,Huang K,Ren Xdoi
10.7717/peerj.8627subject
Has Abstractpub_date
2020-02-20 00:00:00pages
e8627issn
2167-8359pii
8627journal_volume
8pub_type
杂志文章相关文献
PeerJ文献大全abstract::The Asian citrus psyllid (ACP), Diaphorina citri Kuwayama, is one of the most serious citrus pests worldwide due to its role as vector of huanglongbing or citrus greening disease. While some optimal plant species for ACP oviposition and development have been identified, little is known of the influence of host plants ...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.2663
更新日期:2016-11-03 00:00:00
abstract::Cellulosic waste represents a significant and underutilized carbon source for the biofuel industry. Owing to the recalcitrance of crystalline cellulose to enzymatic degradation, it is necessary to design economical methods of liberating the fermentable sugars required for bioethanol production. One route towards unloc...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.636
更新日期:2014-10-30 00:00:00
abstract:Background:Alcohol-related hepatocellular carcinoma (HCC) was reported to be diagnosed at a later stage, but the mechanism was unknown. This study aimed to identify special key genes (SKGs) during alcohol-related HCC development and progression. Methods:The mRNA data of 369 HCC patients and the clinical information we...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.6375
更新日期:2019-02-06 00:00:00
abstract::Gelatin hydrogel crosslinked by microbial transglutaminase (mTG) exhibits excellent performance in cell adhesion, proliferation, and differentiation. We examined the gelation time and gel strength of gelatin/mTG hydrogels in various proportions to investigate their physical properties and tested their degradation perf...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.2497
更新日期:2016-09-27 00:00:00
abstract::Long-term streamflow datasets inevitably include gaps, which must be filled to allow estimates of runoff and ultimately catchment water budgets. Uncertainty introduced by filling gaps in discharge records is rarely, if ever, reported. We characterized the uncertainty due to streamflow gaps in a reference watershed at ...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.9531
更新日期:2020-07-21 00:00:00
abstract::Pueraria lobata (willd.) Ohwi is a consumable selenium-enriched plant used for medicinal purposes. The molecular response to selenium (Se) stimuli in P. lobata is currently unknown. We used RNA-Seq to identify potential genes involved in selenite metabolism and analyzed their expression profiles. We obtained a total o...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.8768
更新日期:2020-03-24 00:00:00
abstract::Parrotfish are fundamental species in controlling algal phase-shifts and ensuring the resilience of coral reefs. Nevertheless, little is known on their ecological role in the south-western Atlantic Ocean. The present study analysed the ontogenetic foraging activity and feeding selectivity of the Brazilian endemic parr...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.2536
更新日期:2016-10-12 00:00:00
abstract::White-handed gibbons produce loud and acoustically complex songs when interacting with their neighbours or when encountering predators. In both contexts, songs are assembled from a small number of units although their composition differs in context-specific ways. Here, we investigated whether wild gibbons could infer ...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.9477
更新日期:2020-08-03 00:00:00
abstract::The adaptative bleaching hypothesis (ABH) states that, depending on the symbiotic flexibility of coral hosts (i.e., the ability of corals to "switch" or "shuffle" their algal symbionts), coral bleaching can lead to a change in the composition of their associated Symbiodinium community and, thus, contribute to the cora...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.2856
更新日期:2017-01-05 00:00:00
abstract:Context:Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease with unknown etiology. Objective:Human plasma is comprised of over 10 orders of magnitude concentration of proteins and tissue leakages. The changes in the abundance of these proteins have played an important role in various human ...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.4730
更新日期:2018-05-08 00:00:00
abstract:Background:Wearable activity trackers are regarded as a new opportunity to deliver health promotion interventions. Indeed, while the prediction of active behaviors is currently primarily relying on the processing of accelerometer sensor data, the emergence of smart clothes with multi-sensing capacities is offering new ...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.10170
更新日期:2020-10-28 00:00:00
abstract:Background:Sprint performance is an essential skill to target within soccer, which can be likely achieved with a variety of methods, including different on-field training options. One such method could be heavy resisted sprint training. However, the effects of such overload on sprint performance and the related kinetic...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.10507
更新日期:2020-12-15 00:00:00
abstract::Secondary cavity nesting (SCN) birds breed in holes that they do not excavate themselves. This is possible where there are large trees whose size and age permit the digging of holes by primary excavators and only rarely happens in forest plantations, where we expected a deficit of both breeding holes and SCN species. ...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.1806
更新日期:2016-03-15 00:00:00
abstract::Anemones of genus Exaiptasia are used as model organisms for the study of cnidarian-dinoflagellate (genus Symbiodinium) endosymbiosis. However, while most reef-building corals harbor Symbiodinium of clade C, Exaiptasia spp. anemones mainly harbor clade B Symbiodinium (ITS2 type B1) populations. In this study, we revea...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.2358
更新日期:2016-08-24 00:00:00
abstract:Background:"Quantile-dependent expressivity" occurs when the effect size of a genetic variant depends upon whether the phenotype (e.g. adiponectin) is high or low relative to its distribution. We have previously shown that the heritability (h2 ) of adiposity, lipoproteins, postprandial lipemia, pulmonary function, and ...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.10099
更新日期:2020-10-14 00:00:00
abstract::Closed cerebral hemorrhage (CCH) is a common symptom in traumatic brain injury (TBI) patients who suffer intracranial hemorrhage with the dura mater remaining intact. The diagnosis of CCH patients prior to hospitalization and in the early stage of the disease can help patients get earlier treatments that improve outco...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.6717
更新日期:2019-04-12 00:00:00
abstract:Background:DegS is a periplasmic serine protease that is considered to be the initiator of the σE stress response pathway, and this protein plays an important role in the regulation of the stress response in E. coli. However, knowledge of the biological function and global regulatory network of DegS in Vibrio cholerae ...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.7959
更新日期:2019-10-23 00:00:00
abstract:Background:Epidemiological surveillance of HIV infection in Japan involves two technical problems for directly applying a classical backcalculation method, i.e., (i) all AIDS cases are not counted over time and (ii) people diagnosed with HIV have received antiretroviral therapy, extending the incubation period. The pre...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.6275
更新日期:2019-01-15 00:00:00
abstract:Background:Kinorhynchs are marine, microscopic invertebrates inhabiting the seafloors. Their segmented trunk equipped with spines and processes has inspired scientists to give them the common name "mud dragons." Even though kinorhynchs have been known since the 19th century, less than 300 species are known to science, ...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.5653
更新日期:2018-09-28 00:00:00
abstract::Background. Quotations and references are an indispensable element of scientific communication. They should support what authors claim or provide important background information for readers. Studies indicate, however, that quotations not serving their purpose-quotation errors-may be prevalent. Methods. We carried out...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.1364
更新日期:2015-10-27 00:00:00
abstract::Garden Warblers Sylvia borin were studied during autumn stopover in Crete before crossing the barrier of the Mediterranean Sea and the Sahara Desert. Birds followed with transmitters show extensive stopover periods, which were longer in first-year birds, 16 days, compared with adult birds, 14 days. The distribution of...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.319
更新日期:2014-03-25 00:00:00
abstract::Rhizoctonia solani causes the disease peanut sheath blight, involving symptoms of maceration and necrosis of infected tissue, mainly caused by cell-wall-degrading enzymes (CWDEs). This study investigated the production of CWDEs including polygalacturonase (PG), polymethyl-galacturonase (PMG), cellulase (Cx) and β-gluc...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.5580
更新日期:2018-09-05 00:00:00
abstract::In this paper, we propose a method for automatically detecting the times during which game players exhibit specific behavior, such as when players commonly show excitement, concentration, immersion, and surprise. The proposed method detects such outlying behavior based on the game players' characteristics. These chara...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.1502
更新日期:2015-12-10 00:00:00
abstract::Weevils (Coleoptera: Curculionoidea) represent one of the most diverse groups of organisms on Earth; interactions with their host plants have been recognized to play a central role in their remarkable diversity, yet the exact mechanisms and factors still remain poorly understood. Using phylogenetic comparative analyse...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.6625
更新日期:2019-03-20 00:00:00
abstract::Partible paternity refers to the conception belief that children can have multiple fathers ("co-fathers") and is common to indigenous cultures of lowland South America. The nature of social relationships observed between co-fathers reveals information about the reproductive strategies underlying partible paternity. He...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.899
更新日期:2015-04-14 00:00:00
abstract::Ischemia postconditioning (IPo) is a promising strategy in reducing myocardial ischemia reperfusion (I/R) injury (MIRI), but its specific molecular mechanism is incompletely understood. Langendorff-perfused isolated rat hearts were subjected to global I/R and received IPo in the absence or presence of the mitochondria...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.1706
更新日期:2016-02-16 00:00:00
abstract::Osteogenic cells form mineralized matrices in vitro, as well as in vivo. The formation and shape of the mineralized matrices are highly regulated by the cells. In vitro formation of mineralized matrices by osteogenic cells can be a model for in vivo osteogenesis. In this study, using a three-dimensional (3D) collagen ...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.7889
更新日期:2019-10-23 00:00:00
abstract::A cervical vertebra of the large, pelagic pterodactyloid pterosaur Pteranodon sp. from the Late Cretaceous Niobrara Formation of Kansas, USA is significant for its association with a tooth from the large lamniform shark, Cretoxyrhina mantelli. Though the tooth does not pierce the vertebral periosteum, the intimate ass...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.6031
更新日期:2018-12-14 00:00:00
abstract::Nephila clavata L Koch, known as the Joro spider and native to East Asia (Japan, China, Korea, and Taiwan), is newly reported from North America. Specimens from several locations in northeast Georgia were collected from around residential properties in Barrow, Jackson, and Madison counties in late October and early No...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.763
更新日期:2015-02-05 00:00:00
abstract::This study aimed to investigate the effects of Clostridium butyricum as a dietary probiotic supplement in fishmeal based diet on growth, gut microbiota and immune performance of marron (Cherax cainii). Marron were randomly distributed into two different treatment groups, control and probiotic fed group. After 42 days ...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.7553
更新日期:2019-08-27 00:00:00