Plasma proteomic analysis of systemic lupus erythematosus patients using liquid chromatography/tandem mass spectrometry with label-free quantification.

Abstract:

Context:Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease with unknown etiology. Objective:Human plasma is comprised of over 10 orders of magnitude concentration of proteins and tissue leakages. The changes in the abundance of these proteins have played an important role in various human diseases. Therefore, the research objective of this study is to identify the significantly altered expression levels of plasma proteins from SLE patients compared with healthy controls using proteomic analysis. The plasma proteome profiles of both SLE patients and controls were compared. Methods:A total of 19 active SLE patients and 12 healthy controls plasma samples were analyzed using high-resolution electrospray ionization liquid chromatography-tandem mass spectrometry (LC-ESI-MS/MS) followed by label-free quantification. Results:A total of 19 proteins showed a significant level of expression in the comparative LC-ESI-MS/MS triplicate analysis; among these, 14 proteins had >1.5- to three-fold up-regulation and five had <0.2- to 0.6-fold down-regulation. Gene ontology and DAVID (Database Annotation Visualization, and Integrated Discovery) functional enrichment analysis revealed that these proteins are involved in several important biological processes including acute phase inflammatory responses, complement activation, hemostasis, and immune system regulation. Conclusion:Our study identified a group of differentially expressed proteins in the plasma of SLE patients that are involved in the imbalance of the immune system and inflammatory responses. Therefore, these findings may have the potential to be used as prognostic/diagnostic markers for SLE disease assessment or disease monitoring.

journal_name

PeerJ

journal_title

PeerJ

authors

Madda R,Lin SC,Sun WH,Huang SL

doi

10.7717/peerj.4730

subject

Has Abstract

pub_date

2018-05-08 00:00:00

pages

e4730

issn

2167-8359

pii

4730

journal_volume

6

pub_type

杂志文章

相关文献

PeerJ文献大全
  • Integrative taxonomy of the genus Pseudostegana (Diptera, Drosophilidae) from China, with descriptions of eleven new species.

    abstract::The genus Pseudostegana (Okada, 1978) currently contains thirty-nine described species. A number of Pseudostegana were collected from the fieldwork in southwestern China from 2010 to 2017. Eleven new species were discovered and are described from southwestern China: Pseudostegana alpina Zhang & Chen, sp. nov.; Pseudos...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.5160

    authors: Lu J,Zhang Y,Chen H

    更新日期:2018-09-05 00:00:00

  • The PGI enzyme system and fitness response to temperature as a measure of environmental tolerance in an invasive species.

    abstract::In the field of invasion ecology, the determination of a species' environmental tolerance, is a key parameter in the prediction of its potential distribution, particularly in the context of global warming. In poikilothermic species such as insects, temperature is often considered the most important abiotic factor that...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.676

    authors: Lefort MC,Brown S,Boyer S,Worner S,Armstrong K

    更新日期:2014-11-25 00:00:00

  • Assessing distinct patterns of cognitive aging using tissue-specific brain age prediction based on diffusion tensor imaging and brain morphometry.

    abstract::Multimodal imaging enables sensitive measures of the architecture and integrity of the human brain, but the high-dimensional nature of advanced brain imaging features poses inherent challenges for the analyses and interpretations. Multivariate age prediction reduces the dimensionality to one biologically informative s...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.5908

    authors: Richard G,Kolskår K,Sanders AM,Kaufmann T,Petersen A,Doan NT,Monereo Sánchez J,Alnæs D,Ulrichsen KM,Dørum ES,Andreassen OA,Nordvik JE,Westlye LT

    更新日期:2018-11-30 00:00:00

  • A new tiny toad species of Amazophrynella (Anura: Bufonidae) from east of the Guiana Shield in Amazonia, Brazil.

    abstract::The combination of different approaches has successfully delimited new species within many Neotropical species complexes traditionally classified as a single nominal organism. Recent studies have shown that the Amazonian endemic genus Amazophrynella, currently composed of 12 small-sized species, could harbor several a...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.9887

    authors: Mângia S,Koroiva R,Santana DJ

    更新日期:2020-09-18 00:00:00

  • Students distracted by electronic devices perform at the same level as those who are focused on the lecture.

    abstract::Background. Little is known about the characteristics of internet distractions that students may engage in during lecture. The objective of this pilot study is to identify some of the internet-based distractions students engage in during in-person lectures. The findings will help identify what activities most commonly...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.572

    authors: Nalliah RP,Allareddy V

    更新日期:2014-09-16 00:00:00

  • Dinosaur origin of egg color: oviraptors laid blue-green eggs.

    abstract::Protoporphyrin (PP) and biliverdin (BV) give rise to the enormous diversity in avian egg coloration. Egg color serves several ecological purposes, including post-mating signaling and camouflage. Egg camouflage represents a major character of open-nesting birds which accomplish protection of their unhatched offspring a...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.3706

    authors: Wiemann J,Yang TR,Sander PN,Schneider M,Engeser M,Kath-Schorr S,Müller CE,Sander PM

    更新日期:2017-08-29 00:00:00

  • L1 and L2 reading skills in Dutch adolescents with a familial risk of dyslexia.

    abstract:BACKGROUND:The present study investigated differences in reading and spelling outcomes in Dutch and English as a second language (ESL) in adolescents with a high familial risk of dyslexia, of whom some have developed dyslexia (HRDys) while others have not (HRnonDys), in comparison to a low familial risk control group w...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.3895

    authors: van Setten ERH,Tops W,Hakvoort BE,van der Leij A,Maurits NM,Maassen BAM

    更新日期:2017-10-16 00:00:00

  • Historical reconstruction of climatic and elevation preferences and the evolution of cloud forest-adapted tree ferns in Mesoamerica.

    abstract:BACKGROUND:Cloud forests, characterized by a persistent, frequent or seasonal low-level cloud cover and fragmented distribution, are one of the most threatened habitats, especially in the Neotropics. Tree ferns are among the most conspicuous elements in these forests, and ferns are restricted to regions in which minimu...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.2696

    authors: Sosa V,Ornelas JF,Ramírez-Barahona S,Gándara E

    更新日期:2016-11-16 00:00:00

  • Identification and prognostic value of DLGAP5 in endometrial cancer.

    abstract:Background:Endometrial cancer poses a serious threat to women's health worldwide, and its pathogenesis, although actively explored, is not fully understood. DLGAP5 is a recently identified cell cycle-regulation gene not reported in endometrial cancer. This study was aiming to analyze the role of DLGAP5 in tumorigenesis...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.10433

    authors: Zheng R,Shi Z,Li W,Yu J,Wang Y,Zhou Q

    更新日期:2020-11-27 00:00:00

  • Estimating food resource availability in arid environments with Sentinel 2 satellite imagery.

    abstract:Background:In arid environments, plant primary productivity is generally low and highly variable both spatially and temporally. Resources are not evenly distributed in space and time (e.g., soil nutrients, water), and depend on global (El Niño/ Southern Oscillation) and local climate parameters. The launch of the Senti...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.9209

    authors: Funghi C,Heim RHJ,Schuett W,Griffith SC,Oldeland J

    更新日期:2020-05-26 00:00:00

  • Potential antidiabetic effect of ethanolic and aqueous-ethanolic extracts of Ricinus communis leaves on streptozotocin-induced diabetes in rats.

    abstract::Recently, herbal drugs and their bioactive compounds have gained popularity in the management of diabetes mellitus (DM), which has become an epidemic disease all over the world and is especially prevalent in the Kingdom of Saudi Arabia (KSA). This study aimed to investigate the antidiabetic effect of ethanolic and aqu...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.6441

    authors: Gad-Elkareem MAM,Abdelgadir EH,Badawy OM,Kadri A

    更新日期:2019-02-18 00:00:00

  • Sexual dimorphism in the Arachnid orders.

    abstract::Sexual differences in size and shape are common across the animal kingdom. The study of sexual dimorphism (SD) can provide insight into the sexual- and natural-selection pressures experienced by males and females in different species. Arachnids are diverse, comprising over 100,000 species, and exhibit some of the more...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.5751

    authors: McLean CJ,Garwood RJ,Brassey CA

    更新日期:2018-11-06 00:00:00

  • Metaproteomics of saliva identifies human protein markers specific for individuals with periodontitis and dental caries compared to orally healthy controls.

    abstract:BACKGROUND:The composition of the salivary microbiota has been reported to differentiate between patients with periodontitis, dental caries and orally healthy individuals. To identify characteristics of diseased and healthy saliva we thus wanted to compare saliva metaproteomes from patients with periodontitis and denta...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.2433

    authors: Belstrøm D,Jersie-Christensen RR,Lyon D,Damgaard C,Jensen LJ,Holmstrup P,Olsen JV

    更新日期:2016-09-14 00:00:00

  • Effects of disputes and easement violations on the cost-effectiveness of land conservation.

    abstract::Conservation initiatives to protect and restore valued species communities in human-dominated landscapes face challenges linked to their potential costs. Conservation easements on private land may represent a cost-effective alternative to land purchase, but long-term costs to monitor and enforce easements, or defend l...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.1185

    authors: Schuster R,Arcese P

    更新日期:2015-08-13 00:00:00

  • Effects of preservation duration at 4 °C on the quality of RNA in rabbit blood specimens.

    abstract::A prolonged preservation duration of blood specimens at 4 °C may occur due to the distance from collection points to storage facilities in many biobanks, especially for multicenter studies. This could lead to RNA degradation, affecting downstream analyses. However, effects of preservation durations at 4 °C on RNA qual...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.8940

    authors: Song J,Zhou J

    更新日期:2020-04-10 00:00:00

  • Asymmetrical dispersal and putative isolation-by-distance of an intertidal blenniid across the Atlantic-Mediterranean divide.

    abstract::Transition zones are of high evolutionary interest because unique patterns of spatial variation are often retained. Here, we investigated the phylogeography of the peacock blenny, Salaria pavo, a small marine intertidal fish that inhabits rocky habitats of the Mediterranean and the adjacent Atlantic Ocean. We screened...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.3195

    authors: Castilho R,Cunha RL,Faria C,Velasco EM,Robalo JI

    更新日期:2017-04-27 00:00:00

  • Molecular phylogenetics, seed morphometrics, chromosome number evolution and systematics of European Elatine L. (Elatinaceae) species.

    abstract::The genus Elatine contains ca 25 species, all of which are small, herbaceous annuals distributed in ephemeral waters on both hemispheres. However, due to a high degree of morphological variability (as a consequence of their amphibious life-style), the taxonomy of this genus remains controversial. Thus, to fill this ga...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.2800

    authors: Sramkó G,Molnár V A,Tóth JP,Laczkó L,Kalinka A,Horváth O,Skuza L,Lukács BA,Popiela A

    更新日期:2016-12-21 00:00:00

  • Evaluation of granular anaerobic ammonium oxidation process for the disposal of pre-treated swine manure.

    abstract::With rising environmental concerns on potable water safety and eutrophication, increased media attention and tighter environmental regulations, managing animal waste in an environmentally responsible and economically feasible way can be a challenge. In this study, the possibility of using granular anammox process for ...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.336

    authors: Ni SQ,Yang N

    更新日期:2014-04-08 00:00:00

  • The mitochondrial genome of Paragonimus westermani (Kerbert, 1878), the Indian isolate of the lung fluke representative of the family Paragonimidae (Trematoda).

    abstract::Among helminth parasites, Paragonimus (zoonotic lung fluke) gains considerable importance from veterinary and medical points of view because of its diversified effect on its host. Nearly fifty species of Paragonimus have been described across the globe. It is estimated that more than 20 million people are infected wor...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.484

    authors: Biswal DK,Chatterjee A,Bhattacharya A,Tandon V

    更新日期:2014-08-12 00:00:00

  • The ΦBT1 large serine recombinase catalyzes DNA integration at pseudo-attB sites in the genus Nocardia.

    abstract::Plasmid vectors based on bacteriophage integrases are important tools in molecular microbiology for the introduction of foreign DNA, especially into bacterial species where other systems for genetic manipulation are limited. Site specific integrases catalyze recombination between phage and bacterial attachment sites (...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.4784

    authors: Herisse M,Porter JL,Guerillot R,Tomita T,Goncalves Da Silva A,Seemann T,Howden BP,Stinear TP,Pidot SJ

    更新日期:2018-05-04 00:00:00

  • A comparative in-silico analysis of autophagy proteins in ciliates.

    abstract::Autophagy serves as a turnover mechanism for the recycling of redundant and/or damaged macromolecules present in eukaryotic cells to re-use them under starvation conditions via a double-membrane structure known as autophagosome. A set of eukaryotic genes called autophagy-related genes (ATGs) orchestrate this highly el...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.2878

    authors: Aslan E,Küçükoğlu N,Arslanyolu M

    更新日期:2017-01-17 00:00:00

  • Genome survey sequencing of the Caribbean spiny lobster Panulirus argus: Genome size, nuclear rRNA operon, repetitive elements, and microsatellite discovery.

    abstract:Background:Panulirus argus is an ecologically relevant species in shallow water hard-bottom environments and coral reefs and target of the most lucrative fishery in the greater Caribbean region. Methods:This study reports, for the first time, the genome size and nuclear repetitive elements, including the 45S ribosomal...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.10554

    authors: Baeza JA

    更新日期:2020-12-17 00:00:00

  • Changes in sprint performance and sagittal plane kinematics after heavy resisted sprint training in professional soccer players.

    abstract:Background:Sprint performance is an essential skill to target within soccer, which can be likely achieved with a variety of methods, including different on-field training options. One such method could be heavy resisted sprint training. However, the effects of such overload on sprint performance and the related kinetic...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.10507

    authors: Lahti J,Huuhka T,Romero V,Bezodis I,Morin JB,Häkkinen K

    更新日期:2020-12-15 00:00:00

  • Effects of stream grazers with different functional traits on the spatial heterogeneity of periphyton mats.

    abstract:Background:Grazing activity on periphytic mats determines mat structure and spatial heterogeneity. Spatial complexity in stream periphyton is highly divergent and may depend on the functional traits of the different primary consumers species (i.e., grazers) such as mouthpart morphology, feeding behavior, and feeding ac...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.6747

    authors: Katano I,Doi H

    更新日期:2019-06-05 00:00:00

  • Serum metabolite profiling of a 4-Nitroquinoline-1-oxide-induced experimental oral carcinogenesis model using gas chromatography-mass spectrometry.

    abstract:Background:Oral cancer progresses from hyperplastic epithelial lesions through dysplasia to invasive carcinoma. The critical needs in oral cancer treatment are expanding our knowledge of malignant tumour progression and the development of useful approaches to prevent dysplastic lesions. This study was designed to gain ...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.10619

    authors: Ge S,Zhou H,Zhou Z,Liu L,Lou J

    更新日期:2021-01-04 00:00:00

  • Evaluation of the effective dose of amygdalin for the improvement of antioxidant gene expression and suppression of oxidative damage in mice.

    abstract:Background:Little is known regarding the toxic and therapeutic doses of amygdalin. Treatment regimens and schedules can vary between humans and animal models, and there have been reports of cyanide toxicity due to amygdalin use. Objective:The aim of this study was to evaluate the effect of different doses of amygdalin...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.9232

    authors: Albogami S,Hassan A,Ahmed N,Alnefaie A,Alattas A,Alquthami L,Alharbi A

    更新日期:2020-05-21 00:00:00

  • Parents know best: transgenerational predator recognition through parental effects.

    abstract::In highly biodiverse systems, such as coral reefs, prey species are faced with predatory threats from numerous species. Recognition of predators can be innate, or learned, and can help increase the chance of survival. Research suggests that parental exposure to increased predatory threats can affect the development, b...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.9340

    authors: Atherton JA,McCormick MI

    更新日期:2020-06-18 00:00:00

  • Comparing the catch composition, profitability and discard survival from different trammel net designs targeting common spiny lobster (Palinurus elephas) in a Mediterranean fishery.

    abstract::In the Balearic Islands, different trammel net designs have been adopted to promote fisheries sustainability and reduce discards. Here, we compare the catch performance of three trammel net designs targeting the spiny lobster Palinurus elephas in terms of biomass, species composition and revenue from commercial catche...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.4707

    authors: Catanese G,Hinz H,Gil MDM,Palmer M,Breen M,Mira A,Pastor E,Grau A,Campos-Candela A,Koleva E,Grau AM,Morales-Nin B

    更新日期:2018-05-17 00:00:00

  • -Complete plastid genome sequences of two species of the Neotropical genus Brunellia (Brunelliaceae).

    abstract::Here we present the first two complete plastid genomes for Brunelliaceae, a Neotropical family with a single genus, Brunellia. We surveyed the entire plastid genome in order to find variable cpDNA regions for further phylogenetic analyses across the family. We sampled morphologically different species, B. antioquensis...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.8392

    authors: Valencia-D J,Murillo-A J,Orozco CI,Parra-O C,Neubig KM

    更新日期:2020-01-28 00:00:00

  • Longevity extension of worker honey bees (Apis mellifera) by royal jelly: optimal dose and active ingredient.

    abstract::In the Western honey bee, Apis mellifera, queens and workers have different longevity although they share the same genome. Queens consume royal jelly (RJ) as the main food throughout their life, including as adults, but workers only eat worker jelly when they are larvae less than 3 days old. In order to explore the ef...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.3118

    authors: Yang W,Tian Y,Han M,Miao X

    更新日期:2017-03-28 00:00:00