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Decision-making at initial surgery for type A aortic dissection in patients with Marfan syndrome: proximal or extensive repair.

Abstract：

Background:Data on outcome of Stanford type A aortic dissection (TAAD) in Marfan syndrome (MFS) patients are limited. We investigated the full spectrum of reoperation and survival after initial surgery in MFS patients who suffered TAAD. Methods:Retrospective analysis of 85 consecutive MFS patients in one-single center during the past 15 years. Results:Overall, 85 MFS patients with TAAD underwent surgical repair [74% acute dissections; 80% DeBakey type I; 91% composite valved graft; 70% total arch replacement (TAR); 68% frozen elephant trunk (FET); 7% in-hospital mortality] at Changhai hospital affiliated to the Second Military Medical University over the past 15 years. Five (20.8%) patients in non-TAR group need aortic arch reintervention with resternotomy during follow-up, which is significantly higher than that in TAR group (P=0.001). Freedom from aortic arch reoperation in non-TAR group was all 78.7%±8.5% at 5, 10, and 15 years. No patient required aortic arch reoperation in TAR group (P=0.001). On the other hand, the FET was inserted into false lumen intentionally at initial surgery in 2 cases of chronic TAAD with narrowed true lumen. Scheduled thoracoabdominal aortic replacement was performed 6 months later. Both 2 patients are with well clinical outcomes. At last, we found that Debakey type and TAR at initial surgery were irrelevant to survival and reoperation for descending aorta. Conclusions:TAR combined with FET is recommended in MFS patients when the aortic arch is dissected or enlarged. The FET could be inserted into the false lumen intentionally in selective case for scheduled 2-staged descending aortic repair.

journal_name

J Thorac Dis

journal_title

Journal of thoracic disease

authors

Li N,Zhang Y,Gao Y,Bai Y,An Z,Zhang G,Han Q,Lu F,Li B,Han L,Xu Z

doi

10.21037/jtd.2019.12.21

subject

Has Abstract

pub_date

2019-12-01 00:00:00

pages

4951-4959

issue

12

eissn

2072-1439

issn

2077-6624

pii

jtd-11-12-4951

journal_volume

11

pub_type

杂志文章

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