Impact of cyclooxygenase-2 and prostaglandin-E2 expression on clinical outcome after pulmonary metastasectomy.


BACKGROUND:Pulmonary metastasectomy (PM) is a standard procedure in the treatment of stage IV colorectal cancer (CRC). In most centers the indication for PM is solely based on clinical factors without taking the tumor biology into account. This results in diverse outcomes ranging from long-term remission to early recurrence. Inflammation is considered a hallmark of cancer development and progression. On the other hand the accessibility of CRC cells to the immune system reflects the grade of tumor aggressiveness. We sought to investigate the impact of cyclooxygenase-2 (COX-2) and prostaglandin-E2 (PGE2) expression in pulmonary metastases on different outcome parameters following PM. METHODS:From 04/2009 to 11/2013 53 patients with complete PM for CRC were included in this single-center study. Tissue samples of resected pulmonary metastases and available corresponding primaries were collected and assessed by immunohistochemistry for COX-2 and PGE2 expression of the tumor tissue and the peritumoral stroma. Results were correlated with clinical outcome parameters. RESULTS:COX-2 and PGE2 were detected in nearly every pulmonary CRC metastasis. Staining intensities of pulmonary metastases correlated only weakly with intensities found in primary tumors. When dividing metastases in high expressing and low expressing tumors, a trend towards longer recurrence free survival and improved survival was found in tumors with strong COX-2 and PGE2 staining. CONCLUSIONS:In conclusion, this pilot study shows that COX-2 and PGE2 are uniformly overexpressed in pulmonary metastases from CRC. High expression of COX-2 and PGE2 seems to reflect a beneficial tumor biology with late tumor recurrence and prolonged overall survival after PM.


J Thorac Dis


Lang C,Hrdliczka E,Schweiger T,Glueck O,Lewik G,Schwarz S,Benazzo A,Lang G,Klepetko W,Hoetzenecker K




Has Abstract


2017-03-01 00:00:00














  • Perioperative change in neutrophil-to-lymphocyte ratio (NLR) is a prognostic factor in patients with completely resected primary pulmonary sarcomatoid carcinoma.

    abstract:Background:There has been controversy regarding prognostic factors for surgically resected primary pulmonary sarcomatoid carcinoma (PSC). Recently, several studies have shown that neutrophil-to-lymphocyte ratio (NLR) was a prognostic factor for various types of cancers from multiple organs. Therefore, we performed this...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章


    authors: Seong YW,Han SJ,Jung W,Jeon JH,Cho S,Jheon S,Kim K

    更新日期:2019-03-01 00:00:00

  • Understanding and managing in-stent restenosis: a review of clinical data, from pathogenesis to treatment.

    abstract::The lumen diameter reduction after percutaneous coronary intervention (PCI) is well known as "restenosis". This phenomenon is due to vessel remodeling/recoil in case of no-stent strategy or, in case of stent employ, "neointimal proliferation" that consists in an excessive tissue proliferation in the luminal surface of...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章,评审


    authors: Buccheri D,Piraino D,Andolina G,Cortese B

    更新日期:2016-10-01 00:00:00

  • Navigational transbronchial needle aspiration, percutaneous needle aspiration and its future.

    abstract::Peripheral lung nodule evaluation represents a clinical challenge. Given that many nodules will be incidentally found with lung cancer screening following the publication of the National Lung Screening Trial (NLST), the goal is to find an accurate, safe and minimally-invasive diagnostic modality to biopsy the concerni...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章,评审


    authors: Arias S,Yarmus L,Argento AC

    更新日期:2015-12-01 00:00:00

  • Patient safety in thoracic surgery and European Society of Thoracic Surgeons checklist.

    abstract::Improving patient safety seems to be a new interesting clinical subject but, in fact, it is no new. It has to do with one of the oldest ethical principles of our profession: curing and not harming. The important research that has been done in a short period of time has brought in new insight to this complex area that ...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章,评审


    authors: Novoa NM

    更新日期:2015-04-01 00:00:00

  • Air pollution, weather variations and primary spontaneous pneumothorax.

    abstract:BACKGROUND:Spontaneous pneumothoraces (SP) tend to occur in clusters which have been related to atmospheric pressure variations and thunderstorm insurgence. We examined the influence of standard meteorological parameter variations and concentrations of the major air pollutants on incidence of spontaneous pneumothorax (...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章


    authors: Bertolaccini L,Alemanno L,Rocco G,Cassardo C

    更新日期:2010-03-01 00:00:00

  • The anaesthetic consideration of tracheobronchial foreign body aspiration in children.

    abstract::Cases of tracheobronchial foreign body aspiration are frequently encountered emergency cases of childhood; and, delays in its recognition and treatment do result in serious morbidity and mortality. Diagnosis mainly relies on taking history which should indicate what the foreign body is, when it has been aspirated and ...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章,评审


    authors: Kendigelen P

    更新日期:2016-12-01 00:00:00

  • Patient preference for a maintenance inhaler in chronic obstructive pulmonary disease: a comparison of Breezhaler and Respimat.

    abstract:Background:Good compliance in chronic obstructive pulmonary disease (COPD) is of 'paramount importance' in reducing the occurrence of acute exacerbations, hospitalisation and mortality and in improving quality of life. However, a number of studies have confirmed that long-term compliance is low and often associated wit...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章


    authors: O'Hagan P,Dederichs J,Viswanad B,Gasser M,Walda S

    更新日期:2018-10-01 00:00:00

  • In the era of ultrasound technology, could conventional trans-bronchial needle aspiration still play a role in lung cancer mediastinal staging?

    abstract:BACKGROUND:To evaluate the feasibility of a combined strategy including conventional-trans-bronchial needle aspiration biopsy (C-TBNA) and endobronchial ultrasounds transbronchial needle aspiration (EBUS-TBNA) for sampling mediastinal adenopathies in patients with lung cancer in order to determinate whether in the era ...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章


    authors: Fiorelli A,Santoriello C,Di Natale D,Cascone R,Musella V,Mastromarino R,Serra N,Vicidomini G,Polverino M,Santini M

    更新日期:2017-05-01 00:00:00

  • Immunotherapy for extensive stage small cell lung cancer.

    abstract::Small cell lung cancer (SCLC) is an aggressive malignancy. Until recently the standard of care for newly diagnosed patients with extensive-stage disease was chemotherapy consisting of etoposide plus a platinum (EP). The median overall survival (OS) was only about 10 months with this systemic therapy. Immune checkpoint...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章,评审


    authors: Pacheco JM

    更新日期:2020-10-01 00:00:00

  • Difference of environment behind research and clinical practice between USA and Japan.

    abstract::Recent studies have demonstrated that there are differences among races in efficacy, tolerance and other outcomes in oncologic care. Some of these differences may be explained by different pharmacogenetics; however, social and environmental factors that can affect oncology practice are relatively underestimated. In th...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章,评审


    authors: Komiya T,Chaaya G,Deshotels L,Wang A

    更新日期:2020-07-01 00:00:00

  • Quantitation and predictors of short-term mortality following extrapleural pneumonectomy, pleurectomy/decortication, and nonoperative management for malignant pleural mesothelioma.

    abstract:Background:For malignant pleural mesothelioma (MPM), the benefit of resection, as well as the optimal surgical technique, remain controversial. In efforts to better refine patient selection, this retrospective observational cohort study queried the National Cancer Database in an effort to quantify and evaluate predicto...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章


    authors: Wright C,Verma V,Barsky AR,Haque W,Polamraju PV,Ludmir EB,Zaorsky NG,Lehrer EJ,Trifiletti DM,Grover S,Friedberg JS,Simone CB 2nd

    更新日期:2020-11-01 00:00:00

  • Metachronous lung cancer that presented as bilateral synchronous lung cancer.

    abstract::Every patient undergoing curative treatment for primary lung cancer is a candidate for metachronous lung cancer, with a reported risk of 5% per year. The majority of cases are stage I patients. Patients who undergo resection for lung cancer should be followed regularly. A metachronous lung cancer that develops as bila...

    journal_title:Journal of thoracic disease



    authors: Kocaturk CI,Cansever L,Kanmaz DZ,Bedirhan MA

    更新日期:2013-06-01 00:00:00

  • Severe intraoperative complications during VATS Lobectomy compared with thoracotomy lobectomy for early stage non-small cell lung cancer.

    abstract:BACKGROUND:Video-assisted thoracic surgery (VATS) lobectomy has been proved to have shorter hospital stay, less perioperative complications and less pain compared with lobectomy by thoracotomy, but severe intraoperative complications during VATS lobectomy is rare reported. We compared intraoperative safety between VATS...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章


    authors: Liang C,Wen H,Guo Y,Shi B,Tian Y,Song Z,Liu D

    更新日期:2013-08-01 00:00:00

  • Posterior mediastinal tuberculous lymphadenitis with dysphagia as the main symptom: a case report and literature review.

    abstract:INTRODUCTION:Mediastinal tuberculous lymphadenitis (MTL) is mostly seen in primary tuberculosis in children, uncommon observed in adults. It usually presents the toxic symptoms of tuberculosis but rarely with symptoms characteristic of esophageal compression, such as dysphagia. Such patients can easily be misdiagnosed ...

    journal_title:Journal of thoracic disease



    authors: Xiong L,Mao X,Li C,Liu Z,Zhang Z

    更新日期:2013-10-01 00:00:00

  • Small cervical incision facilitates minimally invasive resection of non-invasive thoracic inlet tumor.

    abstract:BACKGROUND:A challenge for resection of thoracic inlet tumors lies in that high risk of injuring vital blood vessels and brachial plexus still exists during the resection. And the standard surgical approach for resection of thoracic inlet tumors has not yet been well established. METHODS:Small cervical incision-assist...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章


    authors: Deng HY,Li ZH,Wang ZQ,Wang YC,Li G,Lin YD,Liu LX

    更新日期:2016-10-01 00:00:00

  • Giant bronchogenic cyst with pericardial defect: a case report & literature review in Japan.

    abstract::Congenital pericardial defects are a rare anomaly, found during autopsy and cardiothoracic surgery. We describe a case of a 69-year-old female, with a right-sided congenital pericardial defect associated with a giant bronchogenic cyst (BC) found during surgery. The cyst was resected and the patient developed arrhythmi...

    journal_title:Journal of thoracic disease



    authors: Kamata T,Yoshida S,Iwata T,Nakatani Y,Yoshino I

    更新日期:2016-08-01 00:00:00

  • Neutrophil/lymphocyte ratio is helpful for predicting weaning failure: a prospective, observational cohort study.

    abstract:Background:To assess the usefulness of the neutrophil/lymphocyte ratio (NLR), a marker of inflammation and/or stress, for predicting weaning failure in patients receiving invasive mechanical ventilation (IMV), compared to levels of leukocytes and C-reactive protein (CRP). Methods:This observational prospective cohort ...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章


    authors: Luo Z,Zheng Y,Yang L,Liu S,Zhu J,Zhao N,Pang B,Cao Z,Ma Y

    更新日期:2018-09-01 00:00:00

  • Tracheobronchial tumors.

    abstract::Tumors of trachea and bronchi are uncommon and can occur in the form of benign or low- and high-grade malignant tumors. Although tracheobronchial tumors (TBTs) represent only 0.6% of all pulmonary tumors, they are clinically significant. Delays in diagnosis of these tumors commonly occur because the signs and symptoms...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章,评审


    authors: Stevic R,Milenkovic B

    更新日期:2016-11-01 00:00:00

  • Lymph node involvement according to lung adenocarcinoma subtypes: lymph node involvement is influenced by lung adenocarcinoma subtypes.

    abstract:Backgrounds:Invasive adenocarcinoma subtypes are known to be associated with prognosis; however, the underlying reason remains unclear. To find out the reason, we investigated the possible influence of lymph node (LN) involvement by the constituent histologic subtypes in the tumor and clarified the different prognosis ...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章


    authors: Park JK,Kim JJ,Moon SW,Lee KY

    更新日期:2017-10-01 00:00:00

  • Use of efficient purse-string stapling technique for esophagogastric anastomosis in minimally invasive Ivor Lewis esophagectomy.

    abstract::Minimally invasive esophagectomy (MIE) is increasingly accepted in the treatment of locoregional or advanced esophageal cancer. Laparoscopic-thoracoscopic Ivor-Lewis esophagectomy has been proved to be effective in treating middle and distal esophageal cancer, however, intrathoracic esophagogastric anastomosis is tech...

    journal_title:Journal of thoracic disease



    authors: Shen G,Pan SB,Wu M,Zhang S,Xu XF,Chen G

    更新日期:2013-12-01 00:00:00

  • Interatrial block predicts atrial fibrillation in patients with carotid and coronary artery disease.

    abstract:Background:Interatrial block (IAB) has been previously shown to predict atrial fibrillation (AF) in cardiac populations. This study sought to evaluate the relationship between IAB and new-onset AF in a population of patients undergoing clinically indicated coronary angiography who received carotid ultrasonography. Met...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章


    authors: Alexander B,Baranchuk A,Haseeb S,van Rooy H,Kuchtaruk A,Hopman W,Çinier G,Hetu MF,Li TY,Johri AM

    更新日期:2018-07-01 00:00:00

  • The role of transcription factors in atrial fibrillation.

    abstract::Atrial fibrillation (AF) is a complex disease that results from genetic and environmental factors and their interactions. In recent years, genome-wide association studies (GWAS) and family-based linkage analysis have found amounts of genetic variants associated with AF. Some of them lie in coding sequences and thus me...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章,评审


    authors: Zhou M,Liao Y,Tu X

    更新日期:2015-02-01 00:00:00

  • Bronchoscopic lung volume reduction: recent updates.

    abstract::Emphysema causes significant morbidity and mortality, incurring both financial and psychosocial costs. Alternatives to medical therapy and surgical lung volume reduction surgery (LVRS) have increased interest in bronchoscopic techniques. Bronchoscopic lung volume reduction (BLVR) is still in its infancy and additional...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章,评审


    authors: Ramaswamy A,Puchalski J

    更新日期:2018-04-01 00:00:00

  • Short-term high-intensity rehabilitation in radically treated lung cancer: a three-armed randomized controlled trial.

    abstract:BACKGROUND:The feasibility and practicality of preoperative rehabilitation (PR) programs remains quite controversial in the treatment of lung cancer (LC). This study explored whether a short-term high-intensity rehabilitation program could improve postoperative outcomes compared to those achieved with conventional insp...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章


    authors: Huang J,Lai Y,Zhou X,Li S,Su J,Yang M,Che G

    更新日期:2017-07-01 00:00:00

  • Management of clinical T2N0 esophageal cancer: a review.

    abstract::While management of locally advanced esophageal cancer has mostly involved multimodality therapy, management of clinical T2N0 patients has been more controversial, primarily as a result of inaccurate clinical staging with existing modalities. This review article examines current literature on this topic and provides r...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章,评审


    authors: Vining P,Birdas TJ

    更新日期:2019-08-01 00:00:00

  • Nonintubated uniportal thoracoscopic surgery for resection of lung lesions.

    abstract:BACKGROUND:Sporadic case reports have shown that wedge resection and lobectomy can be performed via nonintubated video-assisted thoracoscopic surgery (VATS) with a single incision. We report the feasibility and safety of nonintubated uniportal VATS for resection of various lung lesions. METHODS:From January 2014 to Ju...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章


    authors: Hung WT,Hsu HH,Hung MH,Hsieh PY,Cheng YJ,Chen JS

    更新日期:2016-03-01 00:00:00

  • Effects of preoperative sarcopenia on postoperative complications of minimally invasive oesophagectomy for oesophageal squamous cell carcinoma.

    abstract:Background:Sarcopenia is closely associated with surgical complications in patients with certain cancers. In this study we assessed the relationship between sarcopenia and postoperative complications in patients with oesophageal squamous cell carcinoma. Methods:We retrospectively analysed of patients who underwent tho...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章


    authors: Xu J,Zheng B,Zhang S,Zeng T,Chen H,Zheng W,Chen C

    更新日期:2019-06-01 00:00:00

  • Erroneous diagnosis of small cell lung cancer based on small biopsies with far-reaching consequences: case report of a typical carcinoid tumor.

    abstract::Although neuroendocrine tumors (NETs) of the lung are frequently discussed together, carcinoids are very different from high-grade small cell lung carcinoma (SCLC). SCLC is found in heavy-smoking, older patients, whereas smoking is not strongly associated with carcinoid tumors. We present the case of a 46-year-old nev...

    journal_title:Journal of thoracic disease



    authors: Kyritsis I,Krebs B,Kampe S,Theegarten D,Aigner C,Welter S

    更新日期:2017-02-01 00:00:00

  • Sudden hypotension occurring after 4 days of left-sided central catheter placement.

    abstract::Central venous catheters (CVCs) have an important role in the management of critically ill patients. In contrast to the immediate complications after CVC insertion, the late complications were difficult to be noticed without high suspicion despite their life-threatening outcome. We report a rare but fatal delayed vasc...

    journal_title:Journal of thoracic disease



    authors: Kim YJ,Kim WY

    更新日期:2017-09-01 00:00:00

  • Effect of high- versus low-volume saline administration on acute kidney injury after cardiac surgery.

    abstract:Background:Fluid resuscitation is critical to perioperative maintenance of adequate preload and cardiac output after cardiac surgery. Liberal use of saline, however, is reportedly associated with an increased risk of acute kidney injury (AKI) in critically ill patients. This study examined the effects of high- versus l...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章


    authors: Lim JY,Kang PJ,Jung SH,Choo SJ,Chung CH,Lee JW,Kim JB

    更新日期:2018-12-01 00:00:00