Abstract：
Background:Although emphysema and small cell lung cancer (SCLC) are prevalent in smokers, no previous study has investigated the prognostic impact of computed tomography (CT)-determined emphysema in SCLC. This study was undertaken to analyze the prognostic value of emphysema scores as determined by baseline CT scans in patients with SCLC. Methods:The data of 149 consecutive patients with SCLC were analyzed. Emphysema severity was semi-quantitatively scored on baseline chest CT images using the Goddard scoring system (possible scores for individual patients ranged from 0 to 24). Data on clinical characteristics and survival were retrospectively collected. Survivals were estimated using the Kaplan-Meier method and compared using the log-rank test. A multivariable Cox proportional hazard model was used to identify prognostic factors. Results:Most of the 149 patients were male (85.2%) and current/ex-smokers (87.2%). The median CT emphysema score was 4 (range, 0 to 23). Univariable analysis, patients with a higher CT emphysema score (≥8) had significantly poorer overall survivals (OS) than those with lower scores (5.0 vs. 12.3 months, P<0.001). Multivariable analysis showed a higher CT emphysema score (treated as a continuous variable) was a significant independent prognostic factor of poor survival [hazard ratio (HR), 1.85; 95% confidence interval (CI), 1.14 to 3.00; P=0.012], along with extensive stage (HR, 2.27; 95% CI, 1.45-3.53; P<0.001), elevated lactate dehydrogenase (LDH) (HR, 1.52; 95% CI, 1.03-2.23; P=0.034), and supportive care only (HR, 6.46; 95% CI, 3.64-11.48; P<0.001). Conclusions:Emphysema severity, as determined by baseline CT, is significantly associated with poor prognosis in SCLC.
journal_name
J Thorac Disjournal_title
Journal of thoracic diseaseauthors
Lee HY,Kim EY,Kim YS,Ahn HK,Kim YKdoi
10.21037/jtd.2018.01.97subject
Has Abstractpub_date
2018-02-01 00:00:00pages
874-881issue
2eissn
2072-1439issn
2077-6624pii
jtd-10-02-874journal_volume
10pub_type
杂志文章abstract：Background:CirRNA Circ_0058063 has been proven as an oncogene in bladder cancer, while its involvement in esophageal squamous-cell carcinomas (ESCC) is unknown. This study aimed to investigate the role of Circ_0058063 in ESCC. Methods:Paired ESCC and non-tumor tissues were collected from ESCC patients and gene express...
journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：10.21037/jtd.2019.12.57
更新日期：2020-03-01 00:00:00
abstract：Background:Robotic surgery is increasingly used to resect lung cancer. However costs are high. We compared costs and outcomes for robotic surgery, video-assisted thoracic surgery (VATS), and open surgery, to treat non-small cell lung cancer (NSCLC). Methods:We retrospectively assessed 103 consecutive patients given lo...
journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：10.21037/jtd.2018.01.123
更新日期：2018-02-01 00:00:00
abstract：:The cornerstone of curative care for esophageal cancer is neoadjuvant chemoradiotherapy followed by esophagectomy with a radical lymphadenectomy. An esophagectomy is a major and complex surgical procedure and is often followed by postoperative morbidity, especially pulmonary complications. These complications may lead...
journal_title：Journal of thoracic disease
pub_type： 杂志文章,评审
doi：10.21037/jtd.2018.11.75
更新日期：2019-04-01 00:00:00
abstract：:In 2011, three authoritative academic communities, International Association for the Study of Lung Cancer, the American Thoracic Society, and the European Respiratory Society (IASLC/ATS/ERS), published a novel lung adenocarcinoma histologic classification. The major modifications of this classification include the abo...
journal_title：Journal of thoracic disease
pub_type： 杂志文章,评审
doi：10.3978/j.issn.2072-1439.2014.09.15
更新日期：2014-10-01 00:00:00
abstract：Background:Although morphological abnormalities of the heart appear to be remarkable, most patients with tako-tsubo cardiomyopathy (TTC) remain clinically stable. We investigate real time changes in the left ventricular (LV) and right ventricular (RV) mechanics and function to explore the mechanism to preserve hemodyna...
journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：10.21037/jtd.2018.04.143
更新日期：2018-05-01 00:00:00
abstract：:Presented is a rare case of a primary melanoma of the lung in an 89 year old male patient. Primary melanoma of the lung has been previously reported in the English literature in about 30 patients. Surgical resection either with lobectomy of pneumonectomy and a lymph node dissection has been shown to be the best chance...
journal_title：Journal of thoracic disease
pub_type：
doi：10.3978/j.issn.2072-1439.2011.04.02
更新日期：2011-09-01 00:00:00
abstract：BACKGROUND:Spontaneous pneumothoraces (SP) tend to occur in clusters which have been related to atmospheric pressure variations and thunderstorm insurgence. We examined the influence of standard meteorological parameter variations and concentrations of the major air pollutants on incidence of spontaneous pneumothorax (...
journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：
更新日期：2010-03-01 00:00:00
abstract：:Cardiopulmonary support is frequently required during lung transplantation. Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) has been recently shown to be an acceptable and, perhaps, safer alternative to cardiopulmonary bypass machine (CBM) for lung transplantation. However, therapeutic anticoagulation used...
journal_title：Journal of thoracic disease
pub_type：
doi：10.21037/jtd.2017.06.11
更新日期：2017-07-01 00:00:00
abstract：BACKGROUND:Children with infective endocarditis (IE) have to undergo valve replacement instead of valve repair in China due to severe valve damage. The present study is to review our experience on surgical treatment of children with IE in reference to the incidence, pathologic status, diagnosis, surgical strategies and...
journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：10.21037/jtd.2016.06.15
更新日期：2016-07-01 00:00:00
abstract：:During development, the mesoderm maintains a complex relationship with the developing endoderm giving rise to the mature lung. Pleural mesothelial cells (PMCs) derived from the mesoderm play a key role during the development of the lung. The pleural mesothelium differentiates to give rise to the endothelium and smooth...
journal_title：Journal of thoracic disease
pub_type： 杂志文章,评审
doi：10.3978/j.issn.2072-1439.2015.02.19
更新日期：2015-06-01 00:00:00
abstract：:Esophageal chondromatous hamartomas are very rare tumors, characterized by proliferating hyaline cartilage cells. We described the case of a 64-year-old woman, with a progressive foreign body sensation in the laryngopharynx caused by an intraluminal pedicled mass. Transcervical esophagectomy was performed and intraope...
journal_title：Journal of thoracic disease
pub_type：
doi：10.21037/jtd.2017.02.79
更新日期：2017-03-01 00:00:00
abstract：:As "Immunotherapy age" is coming, immune checkpoint inhibitors (CPI) therapies have shown favorable clinical benefits and low toxicity profiles in patients with advanced non-small cell lung cancer (NSCLC). While it is a pity that there is a little clear clinical trials evidence about immunotherapy among Asian populati...
journal_title：Journal of thoracic disease
pub_type： 杂志文章,评审
doi：10.21037/jtd.2018.05.106
更新日期：2018-05-01 00:00:00
abstract：Background:Atherosclerosis in diabetic patients progresses fast. Evidence on how to choose target vessels of percutaneous coronary interventions (PCIs) in diabetic patients post-coronary artery bypass graft (post-CABG) is insufficient. Methods:One hundred and fifty-seven patients with diabetes and previous CABG, who u...
journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：10.21037/jtd.2019.10.33
更新日期：2019-11-01 00:00:00
abstract：BACKGROUND:Discuss an appropriate strategy for treatment of invasive thymoma invading adjacent great vessels. METHODS:A retrospective study on 25 patients with invasive thymoma invading neighboring great vessels was performed. The corresponding data including clinical presentation, operation procedure, adjuvant radio-...
journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：10.21037/jtd.2017.03.03
更新日期：2017-03-01 00:00:00
abstract：:Carinal resection (CR) and sleeve pneumonectomy (SP) are one of the challenging issues in thoracic surgery and performed rarely. In spite of the knowledge of the technique, the incidence of postoperative complications is higher compared to standard resections. Adequate patient selection, improved anesthetic management...
journal_title：Journal of thoracic disease
pub_type： 杂志文章,评审
doi：10.21037/jtd.2016.08.47
更新日期：2016-11-01 00:00:00
abstract：:Chronic dyspnoea, or breathlessness for more than four weeks duration, is a common symptom in adults presenting to primary and tertiary care. It often presents a diagnostic challenge due to the wide spectrum of underlying disease, which is multifactorial in approximately one third of cases. Challenges in diagnosis inc...
journal_title：Journal of thoracic disease
pub_type： 杂志文章,评审
doi：10.21037/jtd.2019.10.53
更新日期：2019-10-01 00:00:00
abstract：Background:Pacing parameters may influence pacing lead life and pacemaker life. This study sought to determine whether different right atrial active-fixation lead implantation parameters are associated with chronic pacing performance. Methods:A retrospective observational study was conducted on all consecutive patient...
journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：10.21037/jtd.2019.04.04
更新日期：2019-04-01 00:00:00
abstract：Background:After lung transplantation (LT), between 2% and 25% of bronchial anastomoses develop complications requiring therapeutic intervention. The status of healing of both bronchial anastomoses and downhill airways are well described by the French consensual MDS standardized grading system (Macroscopic, Diameter, S...
journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：10.21037/jtd.2020.03.21
更新日期：2020-05-01 00:00:00
abstract：BACKGROUND:Studies on diagnostic tests for exercise-induced bronchoconstriction (EIB) have centered around the asthmatic and elite athletic population. Traditionally, the exercise challenge test (ET) was recommended to assess EIB. We aimed to compare the performance of surrogate testing, mainly the hypertonic saline (H...
journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：10.21037/jtd.2017.02.70
更新日期：2017-03-01 00:00:00
abstract：Background:A compression-ventilation (C:V) ratio of 30:2 is recommended for adult cardiopulmonary resuscitation (CPR) by the current American Heart Association (AHA) guidelines. However, continuous chest compression (CCC) is an alternative strategy for CPR that minimizes interruption especially when an advanced airway ...
journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：10.21037/jtd.2017.08.167
更新日期：2017-09-01 00:00:00
abstract：:Primitive neuro-ectodermal tumour of the lung is an extremely rare occurrence and we hereby report a case of a neuro-ectodermal tumour of the lung which was proved by immuno-histochemical examination of the resected specimen, and he had a very aggressive pattern of behavior. ...
journal_title：Journal of thoracic disease
pub_type：
doi：10.3978/j.issn.2072-1439.2011.07.02
更新日期：2015-12-01 00:00:00
abstract：Background:To evaluate the influence of tumor depth on preoperative computed tomography (CT) image, and resection margin length on local recurrence after pulmonary metastasectomy of colorectal cancer. Methods:Patients undergoing thoracoscopic pulmonary wedge resection for single pulmonary metastasis of colorectal canc...
journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：10.21037/jtd.2019.05.12
更新日期：2019-05-01 00:00:00
abstract：Background:Human rhinovirus (HRV) is one of the most common viral etiologies detected in community-acquired pneumonia (CAP) adult cases. However, few is known about the characteristics of HRV-associated CAP. To describe the clinical features of HRV-associated CAP in immunocompetent adults admitted to multiple medical c...
journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：10.21037/jtd.2017.10.107
更新日期：2017-11-01 00:00:00
abstract：Background:Pulmonary arterial compliance (PAC) was previously shown to be an important prognostic factor in pulmonary arterial hypertension (PAH), in addition to the conventional pulmonary vascular resistance (PVR). The product of PAC and PVR, the arterial time (RC) constant, expresses the logarithmic relationship betw...
journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：10.21037/jtd.2020.02.20
更新日期：2020-05-01 00:00:00
abstract：:Castleman's disease (CD) is an uncommon benign lymphoproliferative disorder that usually presents as a single or multiple mediastinal mass. In unicentric CD, constitutional symptoms are rare, but are curable with surgical resection. However, serious intraoperative bleeding often requires conversion to thoracotomy. We ...
journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：10.3978/j.issn.2072-1439.2015.07.10
更新日期：2015-07-01 00:00:00
abstract：Background:Endoscopic thoracic sympathectomy (ETS) has been considered as a definitive treatment for hyperhidrosis. However, despite its well-established success rate, surgical treatment for craniofacial hyperhidrosis (CFH) is rarely performed due to the possibility of fatal complications and compensatory sweating. The...
journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：10.21037/jtd.2018.05.190
更新日期：2018-06-01 00:00:00
abstract：Background:The primary objective of the study was to evaluate the health-related quality of life (HRQL) of patients with benign post-intubation tracheal stenosis considered as unfit for surgical treatment. Secondary objectives were: (I) to determine if clinical variables (gender, age, total treatment time, and type of ...
journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：10.21037/jtd.2018.07.80
更新日期：2018-08-01 00:00:00
abstract：INTRODUCTION:Mediastinal tuberculous lymphadenitis (MTL) is mostly seen in primary tuberculosis in children, uncommon observed in adults. It usually presents the toxic symptoms of tuberculosis but rarely with symptoms characteristic of esophageal compression, such as dysphagia. Such patients can easily be misdiagnosed ...
journal_title：Journal of thoracic disease
pub_type：
doi：10.3978/j.issn.2072-1439.2013.09.03
更新日期：2013-10-01 00:00:00
abstract：Background:To investigate the safety and effectiveness of a double semipurse string suture method for jejunum fixation in laparoscopic needle catheter jejunostomy in minimally invasive Ivor Lewis esophagectomy (MIILE). Methods:Two hundred and six esophageal cancer patients continuously receiving MIILE from March 2014 ...
journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：10.21037/jtd.2020.01.53
更新日期：2020-03-01 00:00:00
abstract：:Patients with locally advanced esophageal cancer are treated with definitive chemoradiation (dCXRT) for a number of reasons. Some patients are never referred to a surgeon for a con-versation about surgery, others decline surgery, and some are not candidates for surgery due to a sag in performance status secondary to t...
journal_title：Journal of thoracic disease
pub_type： 杂志文章,评审
doi：10.3978/j.issn.2072-1439.2014.03.29
更新日期：2014-05-01 00:00:00
