Idiopathic pulmonary fibrosis: a holistic approach to disease management in the antifibrotic age.

Abstract:

:Idiopathic pulmonary fibrosis (IPF) is the most common cause of interstitial lung disease (ILD) and carries a worse prognosis than many cancers. Until recently, there were no active treatment options available for patients with IPF, meaning palliation or lung transplantation in selected patients were the only options. The management of IPF has changed dramatically over the last decade with the advent of two antifibrotic agents; pirfenidone and nintedanib. These new agents have been shown to reduce decline in lung function and pirfenidone has been shown to reduce mortality. The changing landscape of IPF diagnosis and management present a number of issues that may be encountered including management of side effects related to antifibrotic therapy. This article aims to give an overview of the holistic approach to the management of patients with IPF, including antifibrotic management, symptom management and the invaluable role of the ILD specialist nurse.

journal_name

J Thorac Dis

authors

Shaw J,Marshall T,Morris H,Hayton C,Chaudhuri N

doi

10.21037/jtd.2017.10.111

subject

Has Abstract

pub_date

2017-11-01 00:00:00

pages

4700-4707

issue

11

eissn

2072-1439

issn

2077-6624

pii

jtd-09-11-4700

journal_volume

9

pub_type

杂志文章,评审
  • Severe gastroparesis causing postoperative respiratory complications in a heart-lung recipient.

    abstract::Heart-lung transplantation is reserved for selected patients who have end-stage cardiac and pulmonary disease. Gastroparesis, which is associated with aspiration, is commonly seen after transplantation. Here, we present a case in which gastric contents aspiration leads to Pseudomonas aeruginosa pulmonary infection, 11...

    journal_title:Journal of thoracic disease

    pub_type:

    doi:

    authors: Tao Y,Yan Z,Sha J,Zhu Z,Lei H

    更新日期:2010-06-01 00:00:00

  • An approach to antibiotic treatment in patients with sepsis.

    abstract::Sepsis is a medical emergency and life-threatening condition due to a dysregulated host response to infection, which is time-dependent and associated with unacceptably high mortality. Thus, when treating suspicious or confirmed cases of sepsis, clinicians must initiate broad-spectrum antimicrobials within the first ho...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章,评审

    doi:10.21037/jtd.2020.01.47

    authors: Martínez ML,Plata-Menchaca EP,Ruiz-Rodríguez JC,Ferrer R

    更新日期:2020-03-01 00:00:00

  • Clinical results of multimodality therapy for esophageal cancer with distant metastasis.

    abstract:Background:The purpose of this study is to evaluate outcomes in upfront local response and survival of patients with esophageal cancer and distant metastasis. Methods:This retrospective study included 34 patients (25 males) aged 42-92 years (median, 70 years) with a histological diagnosis of esophageal squamous cell c...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2018.03.45

    authors: Sakaguchi M,Maebayashi T,Aizawa T,Ishibashi N,Saito T

    更新日期:2018-03-01 00:00:00

  • Repositioning of migrated self-expanding metallic tracheobronchial stent: predictors of a successful maneuver and its impact on survival.

    abstract:Background:Endobronchial stents that are used to treat airway obstruction may migrate over time. These stents can be repositioned. However, not much has been reported about this technique. We retrospectively reviewed our experience with self-expanding metallic stents (SEMS) and attempted to determine-(I) factors relate...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd-20-608

    authors: Biswas A,Jantz MA,Fernandez-Bussy S,Flanagan M,Mehta HJ

    更新日期:2020-05-01 00:00:00

  • Sequencing postoperative radiotherapy and adjuvant chemotherapy in non-small cell lung cancer: unanswered questions on the not evidence-based approach.

    abstract::This editorial comments on the study by Lee et al. which reported on the use of postoperative radiotherapy (PORT) as first strategy after resection of stage IIIA-pN2 non-small cell lung cancer (NSCLC). After completion of PORT, 41% of patients received postoperative chemotherapy (POCT). The five-year overall survival ...

    journal_title:Journal of thoracic disease

    pub_type: 评论,杂志文章

    doi:10.21037/jtd.2016.05.76

    authors: Kepka L,Socha J,Rucinska M,Wasilewska-Tesluk E,Komosinska K

    更新日期:2016-07-01 00:00:00

  • Evaluating and assessing the prevalence of bedside ultrasound in emergency departments in China.

    abstract:Background:To survey the prevalence of bedside ultrasound assessment in emergency departments (EDs) in China. Methods:We designed an online survey for emergency physicians based in the China. The questionnaire included sixteen items querying common ED bedside ultrasound practices. Respondents were recruited via weblin...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2018.04.88

    authors: Shi D,Walline JH,Yu X,Xu J,Song PP,Zhu H

    更新日期:2018-05-01 00:00:00

  • Impact of postprocedural permanent pacemaker implantation on clinical outcomes after transcatheter aortic valve replacement: a systematic review and meta-analysis.

    abstract:Background:The incidence of conduction disturbances requiring permanent pacemaker (PPM) implantation following transcatheter aortic valve replacement (TAVR) have remained a common concern. The purpose of this study was to evaluate the impact of postprocedural PPM implantation following TAVR on clinical outcomes. Metho...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2019.12.02

    authors: Xi Z,Liu T,Liang J,Zhou YJ,Liu W

    更新日期:2019-12-01 00:00:00

  • McKeown or Ivor Lewis totally minimally invasive esophagectomy for cancer of the esophagus and gastroesophageal junction: systematic review and meta-analysis.

    abstract:BACKGROUND:Minimally invasive esophagectomy (MIE) has consistently been associated with improved perioperative outcome and similar oncological safety compared to open esophagectomy. However, it is currently unclear what type of MIE is preferred for patients with resectable esophageal cancer. METHODS:Literature was sea...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2017.03.173

    authors: van Workum F,Berkelmans GH,Klarenbeek BR,Nieuwenhuijzen GAP,Luyer MDP,Rosman C

    更新日期:2017-07-01 00:00:00

  • Correlation of cardiopulmonary exercise testing parameters with quality of life in stable COPD patients.

    abstract:BACKGROUND:The precise head to head relationships between Cardio-pulmonary exercise testing (CPET) parameters and patients' daily symptoms/activities and the disease social/emotional impact are less well defined. In this study, the correlation of COPD daily symptoms and quality of life [assessed by St. George's Respira...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2016.07.07

    authors: Mirdamadi M,Rahimi B,Safavi E,Abtahi H,Peiman S

    更新日期:2016-08-01 00:00:00

  • Albert-Lembert versus hybrid-layered suture in hand sewn end-to-end cervical esophagogastric anastomosis after esophageal squamous cell carcinoma resection.

    abstract:BACKGROUND:Hand sewn cervical esophagogastric anastomosis (CEGA) is regarded as preferred technique by surgeons after esophagectomy. However, considering the anastomotic leakage and stricture, the optimal technique for performing this anastomosis is still under debate. METHODS:Between November 2010 and September 2012,...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.3978/j.issn.2072-1439.2015.11.09

    authors: Feng F,Sun L,Xu G,Hong L,Yang J,Cai L,Li G,Guo M,Lian X,Zhang H

    更新日期:2015-11-01 00:00:00

  • Comparison of the single-lumen endotracheal tube and double-lumen endobronchial tube used in minimally invasive cardiac surgery for the fast track protocol.

    abstract:BACKGROUND:Minimally invasive cardiac surgery (MICS) has been more commonly performed due to the reduced amount of bleeding and transfusion and length of hospital stay. We investigated the feasibility of performing MICS using single-lumen endotracheal tube (SLT). METHODS:We conducted a retrospective review of clinical...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2016.03.13

    authors: Kim HY,Baek SH,Je HG,Kim TK,Kim HJ,Ahn JH,Park SJ

    更新日期:2016-05-01 00:00:00

  • Impact of cyclooxygenase-2 and prostaglandin-E2 expression on clinical outcome after pulmonary metastasectomy.

    abstract:BACKGROUND:Pulmonary metastasectomy (PM) is a standard procedure in the treatment of stage IV colorectal cancer (CRC). In most centers the indication for PM is solely based on clinical factors without taking the tumor biology into account. This results in diverse outcomes ranging from long-term remission to early recur...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2017.02.83

    authors: Lang C,Hrdliczka E,Schweiger T,Glueck O,Lewik G,Schwarz S,Benazzo A,Lang G,Klepetko W,Hoetzenecker K

    更新日期:2017-03-01 00:00:00

  • Revival of impaired lung perfusion after sleeve lobectomy.

    abstract::Sleeve resection, a mainstay for centrally-located lung cancer, is a challenging procedure when the preserved lung is impaired. We herein reported a 61-year-old male who underwent right upper sleeve lobectomy for squamous cell carcinoma located at the orifice of the upper bronchus. The tumor invaded the main bronchus....

    journal_title:Journal of thoracic disease

    pub_type:

    doi:10.21037/jtd.2016.02.17

    authors: Shibano T,Tsubochi H,Endo S,Yamamoto S,Maki M

    更新日期:2016-03-01 00:00:00

  • Observership in China-an opinion about current and future collaboration.

    abstract::China offers great opportunities for Europe in thoracic surgery training and research. Thoracic surgeons from Europe might profit from intense collaborations and on the other hand provide assist in academic structures, creating guidelines and patient follow-up strategies. With an observership award the AME Publishing ...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2016.09.27

    authors: Caviezel C

    更新日期:2016-09-01 00:00:00

  • Learning curve of uniportal video-assisted lobectomy: analysis of 15-month experience in a single center.

    abstract:Background:Uniportal video-assisted thoracoscopic (U-VATS) lobectomy has been becoming the technique of choice in an increasing number of centers. The aim of our study was to review our experience, evaluating the learning curve of U-VATS for lung lobectomy and outcomes. Methods:The prospectively collected clinical dat...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2018.03.133

    authors: Nachira D,Meacci E,Porziella V,Vita ML,Congedo MT,Chiappetta M,Petracca Ciavarella L,Ismail M,Gualtieri E,Cesario A,Margaritora S

    更新日期:2018-11-01 00:00:00

  • COPD in India: Iceberg or volcano?

    abstract::The purpose of this article is to provide an overview of the epidemiology of COPD in India which is one of the most affected countries in the world and contributes significantly to the mortality and morbidity of this disease; to provide insights into the etiological determinants of COPD in India; comment on treatment ...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.3978/j.issn.2072-1439.2012.03.15

    authors: Bhome AB

    更新日期:2012-06-01 00:00:00

  • In the era of ultrasound technology, could conventional trans-bronchial needle aspiration still play a role in lung cancer mediastinal staging?

    abstract:BACKGROUND:To evaluate the feasibility of a combined strategy including conventional-trans-bronchial needle aspiration biopsy (C-TBNA) and endobronchial ultrasounds transbronchial needle aspiration (EBUS-TBNA) for sampling mediastinal adenopathies in patients with lung cancer in order to determinate whether in the era ...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2017.04.13

    authors: Fiorelli A,Santoriello C,Di Natale D,Cascone R,Musella V,Mastromarino R,Serra N,Vicidomini G,Polverino M,Santini M

    更新日期:2017-05-01 00:00:00

  • Dynamic expression of transformating growth factor-β1 and caveolin-1 in the lung of Bleomycin-induced interstitial lung disease.

    abstract:BACKGROUND:Interstitial lung disease (ILD) is a disease with high mortality worldwide. Unfortunately, its prognosis is still very poor. Therefore, developing the target molecular is very important for ILD diagnosis and treatment. Caveolin-1 (Cav-1) can regulate the formation of fibrosis by linking to the signaling path...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2017.07.01

    authors: Xing Y,Wang L,Wang H,Kong X,Zhan L

    更新日期:2017-08-01 00:00:00

  • Ultrasound-guided pleural cutting needle biopsy: accuracy and factors influencing diagnostic yield.

    abstract:Background:The aim of this study was to retrospectively investigate the diagnostic accuracy of ultrasound-guided pleural cutting needle biopsy (US-guided PCNB) and the potential factors influencing diagnostic yield. Methods:From July 2014 to June 2016, a total of 147 percutaneous US-guided PCNBs in 144 patients were r...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2018.05.94

    authors: Zhang Y,Tang J,Zhou X,Zhou D,Wang J,Tang Q

    更新日期:2018-06-01 00:00:00

  • Interatrial block predicts atrial fibrillation in patients with carotid and coronary artery disease.

    abstract:Background:Interatrial block (IAB) has been previously shown to predict atrial fibrillation (AF) in cardiac populations. This study sought to evaluate the relationship between IAB and new-onset AF in a population of patients undergoing clinically indicated coronary angiography who received carotid ultrasonography. Met...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2018.06.53

    authors: Alexander B,Baranchuk A,Haseeb S,van Rooy H,Kuchtaruk A,Hopman W,Çinier G,Hetu MF,Li TY,Johri AM

    更新日期:2018-07-01 00:00:00

  • Lung donor selection criteria.

    abstract::The criteria that define acceptable physiologic and social parameters for lung donation have remained constant since their empiric determination in the 1980s. These criteria include a donor age between 25-40, a arterial partial pressure of oxygen (PaO2)/FiO2 ratio greater than 350, no smoking history, a clear chest X-...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章,评审

    doi:10.3978/j.issn.2072-1439.2014.03.24

    authors: Chaney J,Suzuki Y,Cantu E 3rd,van Berkel V

    更新日期:2014-08-01 00:00:00

  • Identifying patients at higher risk of pneumonia after lung resection.

    abstract:BACKGROUND:Pneumonia is considered as one of the most common and serious complications after lung resection. The purpose of this study was to identify the risk factors associated with postoperative pneumonia (POP) after lung resection and to develop a scoring system to stratify patients with increased risk of POP. MET...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2017.04.42

    authors: Liu GW,Sui XZ,Wang SD,Zhao H,Wang J

    更新日期:2017-05-01 00:00:00

  • The diagnostic utility of endobronchial ultrasonography with a guide sheath and tomosynthesis images for ground glass opacity pulmonary lesions.

    abstract:BACKGROUND:With the widespread use of computed tomography (CT), the frequency of discovering ground glass opacity (GGO) pulmonary lesions has increased. There have been some reports on surgery or transthoracic needle aspiration (TTNA) for diagnostic sampling of GGOs but none on transbronchial biopsy (TBB). The purpose ...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.3978/j.issn.2072-1439.2013.11.30

    authors: Izumo T,Sasada S,Chavez C,Tsuchida T

    更新日期:2013-12-01 00:00:00

  • Bronchoscopic lung volume reduction: recent updates.

    abstract::Emphysema causes significant morbidity and mortality, incurring both financial and psychosocial costs. Alternatives to medical therapy and surgical lung volume reduction surgery (LVRS) have increased interest in bronchoscopic techniques. Bronchoscopic lung volume reduction (BLVR) is still in its infancy and additional...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章,评审

    doi:10.21037/jtd.2018.02.72

    authors: Ramaswamy A,Puchalski J

    更新日期:2018-04-01 00:00:00

  • Aortic and mitral valve surgery for infective endocarditis with reconstruction of the intervalvular fibrous body: an analysis of clinical outcomes.

    abstract:Background:Reconstruction of the aorto-mitral curtain (AMC) for invasive double-valve infective endocarditis (IE) is a rare and challenging procedure. This study presents the short- and mid-term results of reconstruction of AMC in a single center. Methods:From 2016 to 2019, 14 patients with invasive double-valve under...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2020.03.04

    authors: Jiang X,Liu J,Khan F,Tang R,Zhang Y,Gu T

    更新日期:2020-04-01 00:00:00

  • Patient safety in thoracic surgery and European Society of Thoracic Surgeons checklist.

    abstract::Improving patient safety seems to be a new interesting clinical subject but, in fact, it is no new. It has to do with one of the oldest ethical principles of our profession: curing and not harming. The important research that has been done in a short period of time has brought in new insight to this complex area that ...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章,评审

    doi:10.3978/j.issn.2072-1439.2015.03.13

    authors: Novoa NM

    更新日期:2015-04-01 00:00:00

  • Primary atypical carcinoid tumor of the mediastinum: a very rare finding.

    abstract::Primary neuroendocrine tumors (NETs) of the mediastinum are very rare. Prognosis is usually poor despite treatment options. We present the case of a primary atypical carcinoid tumor of the mediastinum successfully treated by multimodal approach. A 50-year-old man presented for asthenia, dyspnea, and substernal sense o...

    journal_title:Journal of thoracic disease

    pub_type:

    doi:10.21037/jtd.2017.03.154

    authors: Ventura L,Gnetti L,Silini EM,Rindi G,Carbognani P,Rusca M,Ampollini L

    更新日期:2017-04-01 00:00:00

  • One-stage hybrid procedure for distal aortic arch disease: mid-term experience at a single center.

    abstract:Background:This study analyzes the outcomes of a one-stage hybrid procedure combining thoracic endovascular aortic repair (TEVAR) with extra-anatomic bypass in patients with distal aortic arch disease. Methods:This retrospective study collected 103 hybrid procedures combining TEVAR with extra-anatomic bypass (mean age...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd-20-2338

    authors: Chen SW,Zhong YL,Qiao ZY,Li CN,Ge YP,Qi RD,Hu HO,Sun LZ,Zhu JM

    更新日期:2020-12-01 00:00:00

  • Neoadjuvant and consolidation immuno-oncology therapy in stage III non-small cell lung cancer.

    abstract::Lung cancer continues to be the leading cause of cancer death worldwide. Recently, immunotherapy for non-small cell lung cancer (NSCLC) has emerged as a powerful treatment option for advanced lung cancer. The relative success of programmed death 1 (PD-1) and/or programmed death ligand 1 (PD-L1) antibodies in metastati...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章,评审

    doi:10.21037/jtd.2018.01.109

    authors: Yeh J,Marrone KA,Forde PM

    更新日期:2018-02-01 00:00:00

  • Ultrasound techniques in the evaluation of the mediastinum, part 2: mediastinal lymph node anatomy and diagnostic reach of ultrasound techniques, clinical work up of neoplastic and inflammatory mediastinal lymphadenopathy using ultrasound techniques and h

    abstract::Ultrasound imaging has gained importance in pulmonary medicine over the last decades including conventional transcutaneous ultrasound (TUS), endoscopic ultrasound (EUS), and endobronchial ultrasound (EBUS). Mediastinal lymph node (MLN) staging affects the management of patients with both operable and inoperable lung c...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章,评审

    doi:10.3978/j.issn.2072-1439.2015.10.08

    authors: Jenssen C,Annema JT,Clementsen P,Cui XW,Borst MM,Dietrich CF

    更新日期:2015-10-01 00:00:00