Abstract:
:Primary neuroendocrine tumors (NETs) of the mediastinum are very rare. Prognosis is usually poor despite treatment options. We present the case of a primary atypical carcinoid tumor of the mediastinum successfully treated by multimodal approach. A 50-year-old man presented for asthenia, dyspnea, and substernal sense of weight for two weeks. A chest-CT scan revealed a tumor mass of 107×55×95 mm3 localized in the anterosuperior mediastinum compressing both brachiocephalic veins, the superior vena cava, the pericardium, and lungs. A FDG-PET demonstrated high FDG uptake only in the mediastinal mass; no metastases were seen. CT-guided needle biopsy revealed a NET; cells were immunoreactive for synaptophysin; Ki67 was 20%. After neoadjuvant chemotherapy, the chest CT-scan showed a significant reduction of the tumor. A surgical excision was proposed. The tumor was radically removed along with a partial resection of the vena cava and reconstruction with a bovine pericardium patch. The patient underwent 25 sessions of adjuvant radiotherapy. Microscopically the tumor showed clusters of medium-sized cells, eosinophilic cytoplasm with nuclear pleomorphism and small nucleoli, arranged in trabeculae, nests and lobules. No thymic tissue was found. Immunohistochemically the tumor cells were positive for CD117, synaptophysin, chromogranin, CD56, cytokeratin pool, epithelial membrane antigen (EMA), and negative for thyroid transcription factor-1 (TTF1), leukocyte common antigen (LCA), fibroblast-activation protein (FAP), prostate-specific antigen (PSA), P63, CD5 and CD99. Mitoses were found to be 8/10 HPF. The Ki67 was 10%. A diagnosis of primary NET of the mediastinum, intermediate grade (G2), atypical carcinoid according to WHO 2015, was formulated. Even in case of primary NE mediastinal tumor, a multimodal approach could lead to long-term survival.
journal_name
J Thorac Disjournal_title
Journal of thoracic diseaseauthors
Ventura L,Gnetti L,Silini EM,Rindi G,Carbognani P,Rusca M,Ampollini Ldoi
10.21037/jtd.2017.03.154subject
Has Abstractpub_date
2017-04-01 00:00:00pages
E367-E372issue
4eissn
2072-1439issn
2077-6624pii
jtd-09-04-E367journal_volume
9pub_type
abstract:BACKGROUND:Paired basic amino acid-cleaving enzyme 4 (PACE4) was shown to enhance tumor cells proliferation and invasive. This study provides the first investigation of PACE4 expression in non-small cell lung cancer (NSCLC) and the correlation with clinicopathologic features, prognostic indicators of 172 cases. METHOD...
journal_title:Journal of thoracic disease
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abstract::Immunotherapy agents in metastatic non-small cell lung cancer (NSCLC) can result in improved quality of life and survival when compared with platinum-based chemotherapy. Novel response patterns such as pseudoprogression and hyperprogression, however, have been described and pose a challenge to treating physicians. Pre...
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abstract::The application of bronchoscopy has resolved a series of diagnostic and treatment challenges in pulmonary diseases. However, the occupational adverse effects experienced by healthcare workers in interventional pulmonology should receive increasing attention. Various aspects of adverse effects in bronchoscopy are often...
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abstract:BACKGROUND:Influenza surveillance is carried out in Guangdong province, southern China. A better understanding of influenza seasonality and predominant Subtypes of influenza virus in Guangdong can help to improve evidence-based prevention and control strategies for influenza in the future. MATERIALS AND METHODS:THERE ...
journal_title:Journal of thoracic disease
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doi:10.3978/j.issn.2072-1439.2013.08.09
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abstract:Background:In 2013, the Centers for Disease Control and Prevention (CDC) issued the concept of the ventilator-associated events (VAEs) as a quality indicator (QI) in the intensive care unit (ICU). A number of studies have been conducted in the United States and other Western countries to evaluate its practicality. Howe...
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journal_title:Journal of thoracic disease
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journal_title:Journal of thoracic disease
pub_type: 杂志文章
doi:10.3978/j.issn.2072-1439.2011.10.02
更新日期:2012-02-01 00:00:00
abstract::The purpose of this article is to provide an overview of the epidemiology of COPD in India which is one of the most affected countries in the world and contributes significantly to the mortality and morbidity of this disease; to provide insights into the etiological determinants of COPD in India; comment on treatment ...
journal_title:Journal of thoracic disease
pub_type: 杂志文章
doi:10.3978/j.issn.2072-1439.2012.03.15
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pub_type: 杂志文章
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journal_title:Journal of thoracic disease
pub_type: 杂志文章
doi:10.21037/jtd-19-2586
更新日期:2020-07-01 00:00:00
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journal_title:Journal of thoracic disease
pub_type: 杂志文章,评审
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journal_title:Journal of thoracic disease
pub_type: 杂志文章
doi:10.21037/jtd.2020.02.20
更新日期:2020-05-01 00:00:00
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journal_title:Journal of thoracic disease
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doi:10.21037/jtd.2017.10.101
更新日期:2017-11-01 00:00:00
abstract:OBJECTIVE:To study the clinical characteristics, treatment and prognosis of patients with solitary fibrous tumor of the pleura (SFTP) in order to improve the diagnostic accuracy and treatment of SFTP. METHODS:A retrospective analysis of clinical and imaging features, serum biochemical changes, pathological characteris...
journal_title:Journal of thoracic disease
pub_type: 杂志文章
doi:10.3978/j.issn.2072-1439.2012.01.05
更新日期:2012-04-01 00:00:00
abstract::Sleeve resection, a mainstay for centrally-located lung cancer, is a challenging procedure when the preserved lung is impaired. We herein reported a 61-year-old male who underwent right upper sleeve lobectomy for squamous cell carcinoma located at the orifice of the upper bronchus. The tumor invaded the main bronchus....
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doi:10.21037/jtd.2016.02.17
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journal_title:Journal of thoracic disease
pub_type:
doi:10.3978/j.issn.2072-1439.2014.07.39
更新日期:2014-09-01 00:00:00
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journal_title:Journal of thoracic disease
pub_type:
doi:10.21037/jtd.2018.01.126
更新日期:2018-02-01 00:00:00
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journal_title:Journal of thoracic disease
pub_type: 杂志文章,评审
doi:10.21037/jtd.2018.04.104
更新日期:2018-10-01 00:00:00
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journal_title:Journal of thoracic disease
pub_type: 杂志文章,评审
doi:10.21037/jtd.2017.06.16
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journal_title:Journal of thoracic disease
pub_type: 杂志文章
doi:10.21037/jtd.2019.02.02
更新日期:2019-03-01 00:00:00
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journal_title:Journal of thoracic disease
pub_type: 杂志文章
doi:10.21037/jtd.2019.01.07
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journal_title:Journal of thoracic disease
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doi:10.3978/j.issn.2072-1439.2013.09.15
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更新日期:2016-12-01 00:00:00
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journal_title:Journal of thoracic disease
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doi:10.3978/j.issn.2072-1439.2015.04.03
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journal_title:Journal of thoracic disease
pub_type: 杂志文章
doi:10.21037/jtd.2016.05.15
更新日期:2016-07-01 00:00:00
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journal_title:Journal of thoracic disease
pub_type:
doi:10.3978/j.issn.2072-1439.2014.08.46
更新日期:2014-10-01 00:00:00
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journal_title:Journal of thoracic disease
pub_type: 杂志文章,评审
doi:10.21037/jtd.2020.02.54
更新日期:2020-06-01 00:00:00