Abstract：
:Lung cancer continues to be the leading cause of cancer death worldwide. Recently, immunotherapy for non-small cell lung cancer (NSCLC) has emerged as a powerful treatment option for advanced lung cancer. The relative success of programmed death 1 (PD-1) and/or programmed death ligand 1 (PD-L1) antibodies in metastatic disease have increased interest in expanding their use to earlier stage NSCLC. The complex and diverse nature of stage III disease also invites the incorporation of immunotherapy into treatment plans in both the neoadjuvant and consolidation settings. Currently available data of anti-PD-(L)1 therapies in stage III NSCLC are limited. However, interim results from two studies are encouraging: a phase II neoadjuvant nivolumab trial demonstrated early signals of efficacy, and the phase III PACIFIC trial of durvalumab recently showed significant improvement in progression-free survival (PFS). Preliminary results for the phase II DETERRED trial of durvalumab have also been reported. Many studies are testing anti-PD-(L)1 therapies in the neoadjuvant and consolidation settings for stage III NSCLC, and will be discussed. As these studies mature they may provide further treatment options in management of stage III NSCLC.
journal_name
J Thorac Disjournal_title
Journal of thoracic diseaseauthors
Yeh J,Marrone KA,Forde PMdoi
10.21037/jtd.2018.01.109subject
Has Abstractpub_date
2018-02-01 00:00:00pages
S451-S459issue
Suppl 3eissn
2072-1439issn
2077-6624pii
jtd-10-S3-S451journal_volume
10pub_type
杂志文章,评审abstract：BACKGROUND:To investigate the effect of percutaneous electrical stimulation on chemotherapy-induced bone marrow suppression in patients with lung cancer. METHODS:From December 2014 to August 2015, one hundred ninety-one non-small cell lung cancer patients with chemotherapy naive were randomly divided into control grou...
journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：10.21037/jtd.2017.03.12
更新日期：2017-03-01 00:00:00
abstract：:The last decade has seen significant advances in our understanding of lung cancer biology and management. Identification of key driver events in lung carcinogenesis has contributed to the development of targeted lung cancer therapies, heralding the era of personalised medicine for lung cancer. As a result, histologica...
journal_title：Journal of thoracic disease
pub_type： 杂志文章,评审
doi：10.3978/j.issn.2072-1439.2013.08.43
更新日期：2013-10-01 00:00:00
abstract：Background:Pulmonary metastasectomy (PM) has commonly been performed in patients with controlled metastatic sarcoma. We reviewed our single-institution experience with pulmonary resections for sarcoma to analyse clinical outcome and to identify prognostic factors associated with patient survival. Methods:All sarcoma p...
journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：10.21037/jtd.2019.08.10
更新日期：2019-08-01 00:00:00
abstract：BACKGROUND:Studies on diagnostic tests for exercise-induced bronchoconstriction (EIB) have centered around the asthmatic and elite athletic population. Traditionally, the exercise challenge test (ET) was recommended to assess EIB. We aimed to compare the performance of surrogate testing, mainly the hypertonic saline (H...
journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：10.21037/jtd.2017.02.70
更新日期：2017-03-01 00:00:00
abstract：BACKGROUND:The interleukin 28 receptor alpha (IL28RA) gene was indicated to be associated with apoptosis. However, it was not clear whether long non-coding RNA 260 (lncRNA 260)-specific siRNA targeting IL28RA gene could inhibit hypoxic reoxygenation (H/R) cardiomyocytes injury or not. To explore the mechanisms underlyi...
journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：10.21037/jtd.2017.07.07
更新日期：2017-08-01 00:00:00
abstract：:Ultrasound imaging has gained importance in pulmonary medicine over the last decades including conventional transcutaneous ultrasound (TUS), endoscopic ultrasound (EUS), and endobronchial ultrasound (EBUS). Mediastinal lymph node staging affects the management of patients with both operable and inoperable lung cancer ...
journal_title：Journal of thoracic disease
pub_type： 杂志文章,评审
doi：10.3978/j.issn.2072-1439.2015.09.40
更新日期：2015-09-01 00:00:00
abstract：BACKGROUND:The axillary vein is an easily accessible vessel that can be used for ultrasound-guided central vascular access and offers an alternative to the internal jugular and subclavian veins. The objective of this study was to identify which transducer orientation, longitudinal or transverse, is better for imaging t...
journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：10.21037/jtd.2017.03.137
更新日期：2017-04-01 00:00:00
abstract：Background:The pathogenesis of atrial fibrillation (AF) remains unclear. Vascular endothelial growth factors (VEGFs) can stimulate fibrosis within the atrium and ventricle. We hypothesized that there is a relationship between the serum VEGFs/soluble vascular endothelial growth factor receptor (sVEGFRs) levels and AF in...
journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：10.21037/jtd.2019.11.32
更新日期：2019-12-01 00:00:00
abstract：:Temporary mechanical circulatory support (MCS) refers to a group of devices generally used for less than 30 days to maintain adequate organ perfusion by compensating for a failure of the pumping mechanism of the heart. The increased availability and rapid adoption of new temporary MCS strategies necessitate physicians...
journal_title：Journal of thoracic disease
pub_type： 杂志文章,评审
doi：10.3978/j.issn.2072-1439.2015.09.14
更新日期：2015-12-01 00:00:00
abstract：:Management of pulmonary nodules in terms of diagnosis and intraoperative localization can be challenging, especially in the minimal invasive video-assisted thoracoscopic surgery (VATS) approach, and may be even more difficult with single port VATS with limited access. The ability to localize small lesions intraoperati...
journal_title：Journal of thoracic disease
pub_type： 杂志文章,评审
doi：10.3978/j.issn.2072-1439.2016.02.27
更新日期：2016-03-01 00:00:00
abstract：:This video demonstrated a performance of uniportal video-assisted thoracoscopic surgery (VATS) right upper lobectomy with systemic lymphadenectomy. The patient had a malignant mass in his right upper lobe. The operator took a posterior to anterior approach to dissection the right upper lobe, the adjacent structures we...
journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：10.21037/jtd.2016.05.01
更新日期：2016-08-01 00:00:00
abstract：:We reported the case of a 70-year-old man who was admitted to neurologic wards for recurrent syncope for 3 years. Unfortunately, just 2 hours after his admission, he suddenly collapsed and failed to return of spontaneous circulation (ROSC) after a 100-minute standard cardiopulmonary resuscitation (CPR). Fortunately, h...
journal_title：Journal of thoracic disease
pub_type：
doi：10.3978/j.issn.2072-1439.2014.12.23
更新日期：2014-12-01 00:00:00
abstract：BACKGROUND:According to the present evidences suggesting association between low testosterone level and prediction of reduced exercise capacity as well as poor clinical outcome in patients with heart failure, we sought to determine if testosterone replacement therapy (TRT) improves clinical and cardiovascular condition...
journal_title：Journal of thoracic disease
pub_type： 杂志文章,评审
doi：10.21037/jtd.2016.03.39
更新日期：2016-05-01 00:00:00
abstract：:Esophagectomy is a complex surgical procedure associated with high rates of mortality and morbidity, mainly dominated by pulmonary complications. Minimally invasive approaches have been developed in order to decrease postoperative morbidity, including totally minimally invasive esophagectomy (MIE) and hybrid esophagec...
journal_title：Journal of thoracic disease
pub_type： 杂志文章,评审
doi：10.21037/jtd.2018.12.92
更新日期：2019-04-01 00:00:00
abstract：Background:Spinal cord ischemia (SCI) is a recognized grave complication after thoracic endovascular aortic repair (TEVAR). The present study aimed to evaluate the incidence and investigate risk of SCI after TEVAR based on current prophylactic strategies designed against established risk factors. Methods:The study ret...
journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：10.21037/jtd.2018.10.99
更新日期：2018-11-01 00:00:00
abstract：Background:To survey the prevalence of bedside ultrasound assessment in emergency departments (EDs) in China. Methods:We designed an online survey for emergency physicians based in the China. The questionnaire included sixteen items querying common ED bedside ultrasound practices. Respondents were recruited via weblin...
journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：10.21037/jtd.2018.04.88
更新日期：2018-05-01 00:00:00
abstract：Background:Operative safety and oncologic adequacy of thoracoscopic sleeve lobectomy remain controversial. As such, the purpose of this meta-analysis was to evaluate evidence comparing thoracoscopy and thoracotomy in sleeve lobectomy for centrally located non-small cell lung cancer (NSCLC). Methods:Electronic searches...
journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：10.21037/jtd-20-1855
更新日期：2020-10-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Chronic obstructive pulmonary disease (COPD) represents an increasing healthcare concern as a leading cause of morbidity and mortality worldwide. Our objective was to predict the outcome of COPD patients associated with multiple organ dysfunction syndrome (MODS) by scoring models. METHODS:A re...
journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：10.3978/j.issn.2072-1439.2014.11.27
更新日期：2015-03-01 00:00:00
abstract：:The purpose of this article is to provide an overview of the epidemiology of COPD in India which is one of the most affected countries in the world and contributes significantly to the mortality and morbidity of this disease; to provide insights into the etiological determinants of COPD in India; comment on treatment ...
journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：10.3978/j.issn.2072-1439.2012.03.15
更新日期：2012-06-01 00:00:00
abstract：:Since its inception, minimally invasive surgery has made a dramatic impact on all branches of surgery. Video-assisted thoracic surgery (VATS) lobectomy for early-stage non-small cell lung cancer (NSCLC) was first described in the early 1990s and has since become popular in a number of tertiary referral centers. Propon...
journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：
更新日期：2009-12-01 00:00:00
abstract：Background:Postoperative air leaks are the most common complication after a pulmonary resection. There is no data in the literature comparing the traditional and digital chest drainage system after a robotic-assisted pulmonary lobectomy. Methods:This was a retrospective, correlational study. Medical records from 182 e...
journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：10.21037/jtd.2019.11.69
更新日期：2019-12-01 00:00:00
abstract：:Ultrasound imaging has gained importance in pulmonary medicine over the last decades including conventional transcutaneous ultrasound (TUS), endoscopic ultrasound (EUS), and endobronchial ultrasound (EBUS). Mediastinal lymph node (MLN) staging affects the management of patients with both operable and inoperable lung c...
journal_title：Journal of thoracic disease
pub_type： 杂志文章,评审
doi：10.3978/j.issn.2072-1439.2015.10.08
更新日期：2015-10-01 00:00:00
abstract：:Transbronchial lung biopsy with a cryoprobe, or cryobiopsy, is a promising new bronchoscopic biopsy technique capable of obtaining larger and better-preserved samples than previously possible using traditional biopsy forceps. Over two dozen case series and several small randomized trials are now available describing e...
journal_title：Journal of thoracic disease
pub_type： 杂志文章,评审
doi：10.21037/jtd.2017.06.96
更新日期：2017-07-01 00:00:00
abstract：OBJECTIVE:The purpose of this study was to detect the feasibility, safety, and effectiveness of mediastinoscopic esophagectomy for early esophageal cancer. METHODS:The clinical data of 194 patients who underwent mediastinoscopic esophagectomy for early esophageal cancer in our center from December 2005 to October 2014...
journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：10.3978/j.issn.2072-1439.2015.07.20
更新日期：2015-07-01 00:00:00
abstract：Background:Neoadjuvant radiochemotherapy (nRCT) followed by surgery has become the gold standard treatment in patients with locally advanced esophageal cancer. The pathological response is an important predictor in such patients. This work represents a single-center analysis investigating the impact of pathological com...
journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：10.21037/jtd.2018.06.85
更新日期：2018-07-01 00:00:00
abstract：:High grade lung neuroendocrine tumours are a heterogeneous subtype of pulmonary cancers including small cell lung cancer (SCLC) and large-cell neuroendocrine carcinoma (LCNEC). LCNEC represents approximately 2-3% of lung cancers, whereas SCLC represents 15-20% of lung cancers. Patients with SCLC and LCNEC have a poor ...
journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：10.21037/jtd.2017.01.60
更新日期：2017-11-01 00:00:00
abstract：BACKGROUND:Obstructive sleep apnoea (OSA) is the most common form of sleep-disordered breathing and a known risk factor for cardiovascular disease. We hypothesised that in patients with OSA the characteristics of nocturnal pulse rate (PR) are associated with changes in blood pressure and daytime sleepiness, following c...
journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：10.3978/j.issn.2072-1439.2014.05.09
更新日期：2014-06-01 00:00:00
abstract：:The failure of mitral valve repair procedures revealed in the outcomes of the recent randomized studies is suggesting the necessity for a better understanding of the biomechanical mechanisms underlying the failure of the surgical approaches. Use of biomechanical modelling and finite element analysis (FEA) in cardiovas...
journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：10.21037/jtd.2017.06.33
更新日期：2017-06-01 00:00:00
abstract：:A 69-year-old male patient with a history of melanoma and prostate cancer was found to have a 2.6 cm PET-avid, slowly enlarging, left upper lobe lung nodule that was suspicious for either metastasis or primary lung cancer. Due to the deep location of the nodule, a wedge resection was not recommended. A diagnostic and ...
journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：10.21037/jtd.2017.07.61
更新日期：2017-09-01 00:00:00
abstract：BACKGROUND:Flexion and compression forces to the trunk can cause severe instability of the vertebral column and the anterior chest wall, mostly associated with an unstable fracture of the sternum. In combination, the worst case would be a complete disruption of the trunk. Some authors consider the sternum-rib-complex t...
journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：10.21037/jtd.2017.03.37
更新日期：2017-04-01 00:00:00
