Does an imbalance in circulating vascular endothelial growth factors (VEGFs) cause atrial fibrillation in patients with valvular heart disease?

Abstract:

Background:The pathogenesis of atrial fibrillation (AF) remains unclear. Vascular endothelial growth factors (VEGFs) can stimulate fibrosis within the atrium and ventricle. We hypothesized that there is a relationship between the serum VEGFs/soluble vascular endothelial growth factor receptor (sVEGFRs) levels and AF in patients with valvular heart disease (VHD). This provides a new paradigm for studying AF. Methods:The plasma levels of VEGF-A, VEGF-C, sVEGFR-1 and sVEGFR-2 were detected by enzyme-linked immunosorbent assay (ELISA). A total of 100 people, consisting of AF patients (long-standing, persistent AF; n=49), sinus rhythm (SR) patients (n=31) and healthy controls (n=20), were included in this study. Results:The plasma levels of VEGF-A were significantly higher in AF patients compared to healthy control (P<0.05). The plasma levels of sVEGFR-1 were significantly higher in AF compared to SR (P<0.05). The plasma levels of sVEGFR-2 were significantly lower in AF patients compared to SR patients and healthy controls (both P<0.05). There was a significant and negative correlation between AF and the sVEGFR-2 levels in the groups (r=-0.432, P=0.000). Conclusions:An imbalance in VEGFs and sVEGFRs may contribute to AF by breaking the balance of angiogenesis and lymphangiogenesis. Additionally, sVEGFR-2 may be an important biomarker of AF.

journal_name

J Thorac Dis

authors

Wang K,Liu Y,Huang S,Li H,Hou J,Huang J,Chen J,Feng K,Liang M,Chen G,Wu Z

doi

10.21037/jtd.2019.11.32

subject

Has Abstract

pub_date

2019-12-01 00:00:00

pages

5509-5516

issue

12

eissn

2072-1439

issn

2077-6624

pii

jtd-11-12-5509

journal_volume

11

pub_type

杂志文章
  • Comparison of minimally invasive surgery for non-flail chest rib fractures: a prospective cohort study.

    abstract:Background:To evaluate therapeutic efficacy of minimally invasive and small incision surgery [minimally invasive surgery (MIS)] in patients with non-flail chest rib fractures through a prospective cohort study. Methods:This study included 98 patients with non-flail chest rib fractures (≥3 displaced fractures) and 66 p...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd-19-2586

    authors: Li Y,Gao E,Yang Y,Gao Z,He W,Zhao Y,Wu W,Zhao T,Guo X

    更新日期:2020-07-01 00:00:00

  • Arnold's nerve cough reflex: evidence for chronic cough as a sensory vagal neuropathy.

    abstract::Arnold's nerve ear-cough reflex is recognised to occur uncommonly in patients with chronic cough. In these patients, mechanical stimulation of the external auditory meatus can activate the auricular branch of the vagus nerve (Arnold's nerve) and evoke reflex cough. This is an example of hypersensitivity of vagal affer...

    journal_title:Journal of thoracic disease

    pub_type:

    doi:10.3978/j.issn.2072-1439.2014.04.22

    authors: Ryan NM,Gibson PG,Birring SS

    更新日期:2014-10-01 00:00:00

  • Right lung upper lobe carcinoma radical excision plus superior vena cava angioplasty.

    abstract::An elderly male patient was found to be with "nodule in upper lobe of right lung" during his health examination, although without any symptom. Chest CT at admission showed that the nodules were close to the superior vena cava, and CT reconstruction displayed an adipose space between the nodules and the superior vena c...

    journal_title:Journal of thoracic disease

    pub_type:

    doi:10.3978/j.issn.2072-1439.2013.11.22

    authors: Peng GL,Yin WQ,Zhang X,He JX

    更新日期:2013-12-01 00:00:00

  • Tracheal replacement.

    abstract::Non-malignant and malignant obstruction of the tracheal airway causes significant morbidity and mortality. With increased use of artificial airways, benign and iatrogenic complications are increasing. A tracheal stenosis that is less than 5 cm in length can be resected with end-to-end anastomosis. Longer tracheal lesi...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章,评审

    doi:10.3978/j.issn.2072-1439.2016.01.85

    authors: Delaere P,Van Raemdonck D

    更新日期:2016-03-01 00:00:00

  • Infrequent ERBB2 mutations in Chinese patients with non-small cell lung cancer.

    abstract::ERBB2 mutations have been reported to occur in a subset of patients with lung adenocarcinomas or lung squamous cell carcinomas for some ethnicities, but it is unclear for Chinese patients with lung squamous cell carcinomas up to now. We retrospectively evaluated the status of ERBB2 mutations in a large cross-sectional...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.3978/j.issn.2072-1439.2014.03.20

    authors: Feng S,Ling H,Guo H,Tong L,Hu G,Liao L,Lv X,Tan H,Wu Y

    更新日期:2014-05-01 00:00:00

  • Severe intraoperative complications during VATS Lobectomy compared with thoracotomy lobectomy for early stage non-small cell lung cancer.

    abstract:BACKGROUND:Video-assisted thoracic surgery (VATS) lobectomy has been proved to have shorter hospital stay, less perioperative complications and less pain compared with lobectomy by thoracotomy, but severe intraoperative complications during VATS lobectomy is rare reported. We compared intraoperative safety between VATS...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.3978/j.issn.2072-1439.2013.08.13

    authors: Liang C,Wen H,Guo Y,Shi B,Tian Y,Song Z,Liu D

    更新日期:2013-08-01 00:00:00

  • Clinical utility of robot-assisted transthoracic esophagectomy in advanced esophageal cancer after neoadjuvant chemoradiation therapy.

    abstract:Background:Although robot-assisted minimally-invasive esophagectomy (RAMIE) surgeries are expanding clinically, few studies have reported patients with locally-advanced esophageal cancer who underwent neoadjuvant chemoradiation therapy (nCRT). Methods:From 2013 to 2017, 219 patients with esophageal squamous cell carci...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2019.07.53

    authors: Yun JK,Lee IS,Gong CS,Kim BS,Kim HR,Kim DK,Park SI,Kim YH

    更新日期:2019-07-01 00:00:00

  • Video assistant thoracoscopic (VATS) lobectomy: right lower lobe.

    abstract::The 60-year-old female had a nodule in the right lower lobe of the lung, which was identified as a tumor by CT and PET-CT. Then the right lower lobectomy was performed. The posterior trocar placement, different from other surgery, is in the 5th intercostals space in the anterior latissimus dorsi, which can be built by...

    journal_title:Journal of thoracic disease

    pub_type:

    doi:10.3978/j.issn.2072-1439.2013.06.29

    authors: Zhao T,Chen H,Yang L,Jin H,Li Z,Zhang J

    更新日期:2013-08-01 00:00:00

  • Video-assisted thoracoscopic surgery tracheal resection and carinal reconstruction for tracheal adenoid cystic carcinoma.

    abstract::We report a case of video-assisted thoracoscopic surgery (VATS) tracheal resection and carinal reconstruction in a patient with tracheal tumor. The patient presented with adenoid cystic carcinoma (ACC) of the distal trachea, extending along the right main bronchus with carinal invasion. The reconstruction procedure wa...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.3978/j.issn.2072-1439.2016.01.45

    authors: He J,Wang W,Li J,Yin W,Xu X,Peng G,Chen Y,He P

    更新日期:2016-01-01 00:00:00

  • Factors associated with the prognosis and long-term survival of patients with metastatic lung adenocarcinoma: a retrospective analysis.

    abstract:Background:Outcome of patients with advanced non-small cell lung cancer (NSCLC) treated with platinum-based doublet chemotherapy is usually poor, with overall survival ranges from 8-13 months. However, the overall survival is improved to 21-28 months in the era of epidermal growth factor receptor (EGFR) tyrosine kinase...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2018.03.143

    authors: Huang CY,Chen BH,Chou WC,Yang CT,Chang JW

    更新日期:2018-04-01 00:00:00

  • Surgical treatment for recurrent spontaneous pneumothorax during twin pregnancy under video-assisted thoracoscopic surgery (VATS).

    abstract::Spontaneous pneumothorax during pregnancy is a rare pathological condition. Few cases have been reported previously in the literature. There is no universal guideline for the management of this condition yet. We report a case of recurrent spontaneous pneumothorax during twin pregnancy in a 30-year-old woman. Surgical ...

    journal_title:Journal of thoracic disease

    pub_type:

    doi:10.3978/j.issn.2072-1439.2010.02.03.10

    authors: Hu R,Li H,Wang G

    更新日期:2010-09-01 00:00:00

  • Efficacy of epidermal growth factor receptor-tyrosine kinase inhibitors for Chinese patients with squamous cell carcinoma of lung harboring EGFR mutation.

    abstract:OBJECTIVE:Epidermal growth factor receptor (EGFR) mutation mostly occurred in lung adenocarcinoma, rarely in squamous cell carcinoma (SQCC). EGFR mutation rate in SQCC varied in previous reports, and the efficacy of EGFR tyrosine kinase inhibitors (TKIs) in SQCC harboring EGFR mutation has not yet been fully evaluated....

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.3978/j.issn.2072-1439.2013.09.15

    authors: Fang W,Zhang J,Liang W,Huang Y,Yan Y,Wu X,Hu Z,Ma Y,Zhao H,Zhao Y,Yang Y,Xue C,Zhang J,Zhang L

    更新日期:2013-10-01 00:00:00

  • On the complexity of scoring acute respiratory distress syndrome: do not forget hemodynamics!

    abstract::Acute respiratory distress syndrome (ARDS) remains associated with a poor outcome despite recent major therapeutic advances. Forecasting the outcome of patients suffering from such a syndrome is of a crucial interest and many scores have been proposed, all suffering from limits responsible for important discrepancies....

    journal_title:Journal of thoracic disease

    pub_type: 评论,杂志文章

    doi:10.21037/jtd.2016.07.54

    authors: Repessé X,Aubry A,Vieillard-Baron A

    更新日期:2016-08-01 00:00:00

  • Solitary fibrous tumor of the pleura: An analysis of forty patients.

    abstract:OBJECTIVE:To study the clinical characteristics, treatment and prognosis of patients with solitary fibrous tumor of the pleura (SFTP) in order to improve the diagnostic accuracy and treatment of SFTP. METHODS:A retrospective analysis of clinical and imaging features, serum biochemical changes, pathological characteris...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.3978/j.issn.2072-1439.2012.01.05

    authors: Chu X,Zhang L,Xue Z,Ren Z,Sun YE,Wang M,Liu M

    更新日期:2012-04-01 00:00:00

  • Impact of attenuated plaques on TIMI grade flow and clinical outcomes of coronary artery disease patients: a systematic review and meta analysis.

    abstract:BACKGROUND:Plaques with a large necrotic core or lipid pool and thin-cap fibroatheroma manifest as attenuated plaques on intravascular ultrasound (IVUS). Their impact on TIMI grade flow and clinical outcomes remains undefined. We performed a systematic review and meta-analysis to summarize the association between atten...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2016.02.51

    authors: Jia R,Nie X,Li H,Zhu H,Pu L,Li X,Han J,Yang D,Meng S,Jin Z

    更新日期:2016-03-01 00:00:00

  • Video-assisted thoracoscopic surgery segmentectomy by non-intubated or intubated anesthesia: a comparative analysis of short-term outcome.

    abstract:BACKGROUND:The aim of this study was to reveal the short-term outcomes of video-assisted thoracoscopic surgery (VATS) segmentectomy without tracheal intubation compared with intubated general anesthesia with one-lung ventilation (OLV). METHODS:We performed a retrospective review of our institutional database of consec...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2016.02.50

    authors: Guo Z,Yin W,Pan H,Zhang X,Xu X,Shao W,Chen H,He J

    更新日期:2016-03-01 00:00:00

  • Navigational transbronchial needle aspiration, percutaneous needle aspiration and its future.

    abstract::Peripheral lung nodule evaluation represents a clinical challenge. Given that many nodules will be incidentally found with lung cancer screening following the publication of the National Lung Screening Trial (NLST), the goal is to find an accurate, safe and minimally-invasive diagnostic modality to biopsy the concerni...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章,评审

    doi:10.3978/j.issn.2072-1439.2015.11.16

    authors: Arias S,Yarmus L,Argento AC

    更新日期:2015-12-01 00:00:00

  • Options for temporary mechanical circulatory support.

    abstract::Temporary mechanical circulatory support (MCS) refers to a group of devices generally used for less than 30 days to maintain adequate organ perfusion by compensating for a failure of the pumping mechanism of the heart. The increased availability and rapid adoption of new temporary MCS strategies necessitate physicians...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章,评审

    doi:10.3978/j.issn.2072-1439.2015.09.14

    authors: Saffarzadeh A,Bonde P

    更新日期:2015-12-01 00:00:00

  • Incidence and risk factors of iatrogenic pneumothorax after thoracentesis in emergency department settings.

    abstract:Background:There is a lack of data regarding the incidence and associated factors of pneumothorax following thoracentesis conducted in emergency department (ED) settings. The present study aims to determine the incidence of pneumothorax following thoracentesis in ED settings and evaluate the association of specific dem...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2017.08.127

    authors: Cho HY,Ko BS,Choi HJ,Koh CY,Sohn CH,Seo DW,Lee YS,Lee JH,Oh BJ,Lim KS,Kim WY

    更新日期:2017-10-01 00:00:00

  • Root reconstruction for proximal repair in acute type A aortic dissection.

    abstract:Background:Retrospective compared the results of root reconstruction and root replacement for acute type A aortic dissection (ATAAD) patients and observed the rate of aortic insufficiency (AI) and aortic root dilation in the midterm follow-up period. Methods:From 2008-2016, 427 ATAAD patients received surgical therapy...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2019.10.62

    authors: Xue Y,Zhou Q,Pan J,Cao H,Fan F,Zhu X,Chong H,Wang D

    更新日期:2019-11-01 00:00:00

  • Metachronous lung cancer that presented as bilateral synchronous lung cancer.

    abstract::Every patient undergoing curative treatment for primary lung cancer is a candidate for metachronous lung cancer, with a reported risk of 5% per year. The majority of cases are stage I patients. Patients who undergo resection for lung cancer should be followed regularly. A metachronous lung cancer that develops as bila...

    journal_title:Journal of thoracic disease

    pub_type:

    doi:10.3978/j.issn.2072-1439.2013.04.16

    authors: Kocaturk CI,Cansever L,Kanmaz DZ,Bedirhan MA

    更新日期:2013-06-01 00:00:00

  • Levels of 1,25(OH)2D3 for patients with pulmonary tuberculosis and correlations of 1,25(OH)2D3 with the clinical features of TB.

    abstract:BACKGROUND:To determine the 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] concentrations to patients with tuberculosis (TB) and whether it influenced the patient's clinical features. METHODS:For the first part, a total of 153 healthy adults and 74 patients with pulmonary TB (PTB) were enrolled. Serum concentrations of 1,25(O...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.3978/j.issn.2072-1439.2014.05.12

    authors: Gao WW,Wang Y,Zhang XR,Yin CY,Hu CM,Tian M,Wang HW,Zhang X

    更新日期:2014-06-01 00:00:00

  • Thoracoscopic segmentectomy with simple routine bronchoscopic inflation for intersegmental plane identification: short and mid-term outcomes compared with lobectomy.

    abstract:Background:The technical concepts of thoracoscopic segmentectomy are still evolving. In this study we present a simple bronchoscopy-based intersegmental demarcation technique with short- and mid-term outcomes compared between thoracoscopic segmentectomy and lobectomy. Methods:All 105 consecutive patients with lung can...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd-20-656

    authors: Helminen O,Valo J,Andersen H,Lautamäki A,Räsänen J,Sihvo E

    更新日期:2020-06-01 00:00:00

  • Initial experience with a 3D printed model for preoperative simulation of the Nuss procedure for pectus excavatum.

    abstract::The incidence of pectus excavatum has been estimated to be between 0.1% and 0.8% though a large autopsy series reports. After publication of the Nuss procedure for pectus excavatum, it became widely accepted. However, there are still some complications, such as over-correction and recurrence. To reduce differences in ...

    journal_title:Journal of thoracic disease

    pub_type:

    doi:10.21037/jtd.2018.01.126

    authors: Matsuo N,Matsumoto K,Taura Y,Sakakibara Y,Taniguchi D,Takagi K,Yamane Y,Obatake M,Yamasaki N,Nagayasu T

    更新日期:2018-02-01 00:00:00

  • Type 2 diabetes is associated with failure of non-operative treatment for sternoclavicular joint infection.

    abstract:Background:A standardized treatment algorithm for sternoclavicular joint infection management is lacking in the literature. While major risk factors for sternoclavicular joint infection, including immunosuppression, rheumatoid arthritis, type 2 diabetes, indwelling catheters, and intravenous drug use have been identifi...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd-20-1897

    authors: Reddy SB,Mizelle J,Sterbling HM,Lin B,Litle VR,Suzuki K

    更新日期:2020-10-01 00:00:00

  • The technique of endoscopic airway tumor treatment.

    abstract::More than half of primary lung cancers are not resectable at diagnosis and 40% of deaths may be secondary to loco-regional disease. Many of these patients suffer from symptoms related to airways obstruction. Indications for therapeutic endoscopic treatment are palliation of dyspnea and other obstructive symptoms in ad...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章,评审

    doi:10.21037/jtd.2017.07.68

    authors: Scarlata S,Fuso L,Lucantoni G,Varone F,Magnini D,Antonelli Incalzi R,Galluccio G

    更新日期:2017-08-01 00:00:00

  • Reducing pulmonary complications after esophagectomy for cancer.

    abstract::The cornerstone of curative care for esophageal cancer is neoadjuvant chemoradiotherapy followed by esophagectomy with a radical lymphadenectomy. An esophagectomy is a major and complex surgical procedure and is often followed by postoperative morbidity, especially pulmonary complications. These complications may lead...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章,评审

    doi:10.21037/jtd.2018.11.75

    authors: Seesing MFJ,Kingma BF,Weijs TJ,Ruurda JP,van Hillegersberg R

    更新日期:2019-04-01 00:00:00

  • Prognostic analysis of the bronchoplastic and broncho-arterioplastic lobectomy of non-small cell lung cancers-10-year experiences of 161 patients.

    abstract:BACKGROUND:Bronchoplastic and broncho-arterioplastic lobectomy is technically demanding. Present study performed a prognostic analysis of lobectomy patient based on 10-year data in a high-volume center. METHODS:Overall, 161 non-small cell lung cancer (NSCLC) cases underwent bronchoplastic and broncho-arterioplastic lo...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.3978/j.issn.2072-1439.2015.12.59

    authors: Zhao LL,Zhou FY,Dai CY,Ren YJ,Jiang GN,Fei K,Chen C

    更新日期:2015-12-01 00:00:00

  • Bivalirudin versus heparin in percutaneous coronary intervention-a systematic review and meta-analysis of randomized trials stratified by adjunctive glycoprotein IIb/IIIa strategy.

    abstract:Background:Bivalirudin has been shown to be associated with less major bleeding than heparin in patients undergoing percutaneous coronary intervention (PCI); but the confounding effect of concomitant glycoprotein IIb/IIIa inhibitors (GPI) limits meaningful comparison. We performed a systematic review and meta-analysis ...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2018.05.76

    authors: Anantha-Narayanan M,Anugula D,Gujjula NR,Reddy YNV,Baskaran J,Kaushik M,Alla VM,Raveendran G

    更新日期:2018-06-01 00:00:00

  • An innovative panel to assess endothelial integrity of pedicled and skeletonized internal thoracic artery used as aortocoronary bypass graft: a randomized comparative histologic and immunohistochemical study.

    abstract:Background:Optimal preservation of endothelial integrity of the vessels used as aortocoronary grafts is a crucial determinant of long-term clinical success of coronary artery bypass grafting (CABG). The purpose of this study was to evaluate an impact of two common techniques to harvest left internal thoracic artery (LI...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2018.07.62

    authors: Puslecki M,Buczkowski P,Nowicki M,Sujka-Kordowska P,Ligowski M,Misterski M,Stefaniak S,Dąbrowski M,Dabrowska A,Bocianski M,Szarpak L,Ruetzler K,Jemielity M,Perek B

    更新日期:2018-08-01 00:00:00