The technique of endoscopic airway tumor treatment.

Abstract:

:More than half of primary lung cancers are not resectable at diagnosis and 40% of deaths may be secondary to loco-regional disease. Many of these patients suffer from symptoms related to airways obstruction. Indications for therapeutic endoscopic treatment are palliation of dyspnea and other obstructive symptoms in advanced cancerous lesions and cure of early lung cancer. Bronchoscopic management is also indicated for all those patients suffering from benign or minimally invasive neoplasm who are not suitable for surgery due to their clinical conditions. Clinicians should select cases, evaluating tumor features (size, location) and patient characteristics (age, lung function impairment) to choose the most appropriate endoscopic technique. Laser therapy, electrocautery, cryotherapy and stenting are well-described techniques for the palliation of symptoms due to airway involvement and local treatment of endobronchial lesions. Newer technologies, with an established role in clinical practice, are endobronchial ultrasound (EBUS), autofluorescence bronchoscopy (AFB), and narrow band imaging (NBI). Other techniques, such as endobronchial intra-tumoral chemotherapy (EITC), EBUS-guided-transbronchial needle injection or bronchoscopy-guided radiofrequency ablation (RFA), are in development for the use within the airways. These endobronchial interventions are important adjuncts in the multimodality management of lung cancer and should become standard considerations in the management of patients with advanced lung cancer, benign or otherwise not approachable central airway lesions. We aimed at revising several endobronchial treatment modalities that can augment standard antitumor therapies for advanced lung cancer, including rigid and flexible bronchoscopy, laser therapy, endobronchial prosthesis, and photodynamic therapy (PDT).

journal_name

J Thorac Dis

authors

Scarlata S,Fuso L,Lucantoni G,Varone F,Magnini D,Antonelli Incalzi R,Galluccio G

doi

10.21037/jtd.2017.07.68

subject

Has Abstract

pub_date

2017-08-01 00:00:00

pages

2619-2639

issue

8

eissn

2072-1439

issn

2077-6624

pii

jtd-09-08-2619

journal_volume

9

pub_type

杂志文章,评审
  • Clinical feasibility and efficacy of video-assisted thoracic surgery (VATS) anatomical resection in patients with central lung cancer: a comparison with thoracotomy.

    abstract:BACKGROUND:The aim of this study is to evaluate the clinical feasibility and efficacy of video-assisted thoracoscopic surgery (VATS) anatomical pulmonary resection in patients with central lung cancer. METHODS:Between July 2004 and December 2011, 465 patients underwent anatomical pulmonary resection and systematic med...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.3978/j.issn.2072-1439.2015.10.32

    authors: Jung HS,Kim HR,Choi SH,Kim YH,Kim DK,Park SI

    更新日期:2015-10-01 00:00:00

  • Management of drug-resistant tuberculosis in special sub-populations including those with HIV co-infection, pregnancy, diabetes, organ-specific dysfunction, and in the critically ill.

    abstract::Tuberculosis remains a major problem globally, and is the leading cause of death from an infectious agent. Drug-resistant tuberculosis threatens to marginalise the substantial gains that have recently been made in the fight against tuberculosis. Drug-resistant TB has significant associated morbidity and a high mortali...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章,评审

    doi:10.21037/jtd.2018.05.11

    authors: Esmail A,Sabur NF,Okpechi I,Dheda K

    更新日期:2018-05-01 00:00:00

  • Video-assisted thoracic surgery and pneumothorax.

    abstract::Video-assisted thoracoscopic surgery (VATS) is a type of thoracic surgery performed using a small video camera that is introduced into the patient's chest via a scope. It is considered a minimally invasive technique where the surgeon is able to view the instruments that are being used along with the anatomy on which t...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章,评审

    doi:10.3978/j.issn.2072-1439.2015.01.35

    authors: Paliouras D,Barbetakis N,Lazaridis G,Baka S,Mpoukovinas I,Karavasilis V,Kioumis I,Pitsiou G,Papaiwannou A,Karavergou A,Lampaki S,Katsikogiannis N,Mpakas A,Tsakiridis K,Korantzis I,Fassiadis N,Zarogoulidis K,Zarogoulidis

    更新日期:2015-02-01 00:00:00

  • PTEN gene silencing contributes to airway remodeling and induces airway smooth muscle cell proliferation in mice with allergic asthma.

    abstract:Background:Allergic asthma is a complex genetic disorder that involves interactions between genetic and environmental factors. Usage of PTEN may be a good therapeutic strategy for the management of allergic inflammation. Thus, the present study aims to explore the effects of phosphatase and tensin homolog (PTEN) gene s...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2017.12.104

    authors: Wen X,Yan J,Han XR,Zheng GH,Tang R,Liu LF,Wu DM,Lu J,Zheng YL

    更新日期:2018-01-01 00:00:00

  • Nuss procedure for repair of pectus excavatum after failed Ravitch procedure in adults: indications and caveats.

    abstract:BACKGROUND:Recurrence of pectus excavatum (PE) is not an uncommon problem after open repair using the Ravitch technique. The optimal approach for redo surgery is still under debate, especially in adults with less chest wall pliability. Aim of this study was to investigate the usefulness and efficacy of the minimally in...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2016.06.60

    authors: Kocher GJ,Gstrein N,Jaroszewski DE,Ewais MM,Schmid RA

    更新日期:2016-08-01 00:00:00

  • Premitive neuro-ectodermal tumour of the lung.

    abstract::Primitive neuro-ectodermal tumour of the lung is an extremely rare occurrence and we hereby report a case of a neuro-ectodermal tumour of the lung which was proved by immuno-histochemical examination of the resected specimen, and he had a very aggressive pattern of behavior. ...

    journal_title:Journal of thoracic disease

    pub_type:

    doi:10.3978/j.issn.2072-1439.2011.07.02

    authors: Gaude GS,Patil P,Malur P,Annurshetru S

    更新日期:2015-12-01 00:00:00

  • Primary pulmonary malignant fibrous histiocytoma: case report and literature review.

    abstract::Malignant fibrous histiocytoma (MFH) is an aggressive soft tissue sarcoma known to occur in various organs. Primary MFH arising in the lung is quite rare. Herein we report a case of a 61-year-old male with primary pulmonary MFH and explore the underlying molecular mechanisms by next-generation sequencing (NGS). Five g...

    journal_title:Journal of thoracic disease

    pub_type:

    doi:10.21037/jtd.2017.07.59

    authors: Li X,Liu R,Shi T,Dong S,Ren F,Yang F,Ren D,Fan H,Wei S,Chen G,Chen J,Xu S

    更新日期:2017-08-01 00:00:00

  • A meta-analysis of video-assisted thoracoscopic decortication versus open thoracotomy decortication for patients with empyema.

    abstract:BACKGROUND:Thoracic pleural empyema is a collection of pus within a thoracic cavity. In stage 2 (fibrinopurulent) and stage 3 (organizational), decortication is the only choice. But there is no consensus on whether to choose video-assisted thoracoscopic decortication (VATD) or open thoracotomy decortication (OTD). We s...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2017.06.109

    authors: Pan H,He J,Shen J,Jiang L,Liang W,He J

    更新日期:2017-07-01 00:00:00

  • Temporary transection of innominate vein in surgery of midtracheal tumor.

    abstract::In this case, a patient presented with a large primary midtracheal tumor posterior to the innominate vein and brachiocephalic artery. The left innominate vein (LIV) was temporarily transected to attain proper access to the tumor. After complete removal of the tumor, the vessel was reanastomosed. The operation was unev...

    journal_title:Journal of thoracic disease

    pub_type:

    doi:10.3978/j.issn.2072-1439.2014.01.22

    authors: Ren F,Pu Q,Liu L

    更新日期:2014-02-01 00:00:00

  • Can muscle protein metabolism be specifically targeted by nutritional support and exercise training in chronic obstructive pulmonary disease?

    abstract::Chronic obstructive pulmonary disease (COPD) associates with several extra-pulmonary effects. Muscle dysfunction and wasting is one of the most prominent extra-pulmonary effects and contributes to exercise limitation and health related quality of life (HRQoL), morbidity as well as mortality. The loss of muscle mass is...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章,评审

    doi:10.21037/jtd.2018.05.81

    authors: Lakhdar R,Rabinovich RA

    更新日期:2018-05-01 00:00:00

  • Development of pulmonary Langerhans cell histiocytosis in a patient with established adenocarcinoma of the lung.

    abstract::Newly-appearing lung nodules on surveillance imaging in patients with pre-existing lung cancer can present a diagnostic dilemma when attempting to differentiate between metastatic disease, infection, and other inflammatory conditions. Here we report a case of an EGFR-/ALK-/BRAF+ metastatic adenocarcinoma patient who u...

    journal_title:Journal of thoracic disease

    pub_type:

    doi:10.21037/jtd.2017.11.12

    authors: Kalchiem-Dekel O,Paulk A,Kligerman SJ,Burke AP,Shah NG,Dixon RK

    更新日期:2017-12-01 00:00:00

  • Gabapentin versus baclofen for treatment of refractory gastroesophageal reflux-induced chronic cough.

    abstract::Refractory gastroesophageal reflux-induced chronic cough (GERC) is a special type of gastroesophageal reflux disease (GERD) with predominant cough resistant to pragmatic standard anti-reflux therapy including antisecretory agents alone or in combination with promotility agents but with a favorable response to intensif...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章,评审

    doi:10.21037/jtd-2020-icc-002

    authors: Zhang M,Zhu Y,Dong R,Qiu Z

    更新日期:2020-09-01 00:00:00

  • Detection of plasma T790M mutation after the first generation EGFR-TKI resistance of non-small cell lung cancer in the real world.

    abstract:Background:The epidermal growth factor receptor (EGFR) gene has been identified as the driving gene of non-small cell lung cancer (NSCLC), and EGFR-tyrosine kinase inhibitor (TKI) has shown efficacy, but acquired resistance is inevitable. It has been confirmed that the secondary EGFR Thr790Met (T790M) mutation accounts...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2019.12.122

    authors: Li H,Wang J,Zhang G,Li Y,Lin L,Yang H,Zhou J,Zhang L,Lv D

    更新日期:2020-03-01 00:00:00

  • Single-port thoracoscopic right main bronchial tumor sleeve resection and secondary carinal reconstruction.

    abstract::We describe herein a case of single-port thoracoscopic right main bronchial tumor sleeve resection and secondary carinal reconstruction. A 66-year-old male patient had a right main bronchial tumor longer than 12 months, who had been received endobronchial cryosurgery twice before. However, the tumor relapsed quickly. ...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.3978/j.issn.2072-1439.2015.10.51

    authors: Liang M,Chen C,Zheng W,Chen H,Wu W,Zhang S

    更新日期:2015-10-01 00:00:00

  • Preoperative predictors of lymph node metastasis in clinical T1 adenocarcinoma.

    abstract:Background:The subcategory "solid component of tumor" is a new criterion of tumor categories in the updated eighth edition of the TNM classification. Nevertheless, the predictors of lymph node metastasis among patients with clinical T1 adenocarcinoma, based on the TNM classification 8th edition, remain unclear. This st...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2020.03.74

    authors: Nakahashi K,Tsunooka N,Hirayama K,Matsuno M,Endo M,Akahira J,Taguri M

    更新日期:2020-05-01 00:00:00

  • A comparison of longitudinal and transverse approaches to ultrasound-guided axillary vein cannulation by experienced operators.

    abstract:BACKGROUND:The axillary vein is an easily accessible vessel that can be used for ultrasound-guided central vascular access and offers an alternative to the internal jugular and subclavian veins. The objective of this study was to identify which transducer orientation, longitudinal or transverse, is better for imaging t...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2017.03.137

    authors: He YZ,Zhong M,Wu W,Song JQ,Zhu DM

    更新日期:2017-04-01 00:00:00

  • Good neurological recovery after rescue thrombolysis of presumed pulmonary embolism despite prior 100 minutes CPR.

    abstract::We reported the case of a 70-year-old man who was admitted to neurologic wards for recurrent syncope for 3 years. Unfortunately, just 2 hours after his admission, he suddenly collapsed and failed to return of spontaneous circulation (ROSC) after a 100-minute standard cardiopulmonary resuscitation (CPR). Fortunately, h...

    journal_title:Journal of thoracic disease

    pub_type:

    doi:10.3978/j.issn.2072-1439.2014.12.23

    authors: Wu JP,Gu DY,Wang S,Zhang ZJ,Zhou JC,Zhang RF

    更新日期:2014-12-01 00:00:00

  • A study of weekly docetaxel and carboplatin as first-line chemotherapy for advanced non-small cell lung cancer.

    abstract:BACKGROUND:Weekly docetaxel demonstrated similar efficacy but better tolerability than standard triweekly docetaxel, and carboplatin was less nephrotoxic, neurotoxic and emetogenic than cisplatin. This study aimed to evaluate the efficacy and safety of weekly docetaxel with carboplatin as first-line chemotherapy for ad...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.3978/j.issn.2072-1439.2014.01.24

    authors: Jiang H,Zhang X,Chen J,Zhang L,Xiong J,Zhong L,Yu F,Qian J,Yu L,Wang X,Shi G,Deng J,Xu N

    更新日期:2014-02-01 00:00:00

  • Diagnostic value of ProGRP for small cell lung cancer in different stages.

    abstract:Background:To investigate the roles of gastrin-releasing peptide (ProGRP) in the diagnosis of small cell lung cancer (SCLC). Methods:We retrospectively analyzed data from 11,206 patients with clinical suspicion of lung cancer from January 1, 2015 to May 31, 2018. ProGRP and neuron-specific enolase (NSE) were detected ...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2019.04.29

    authors: Dong A,Zhang J,Chen X,Ren X,Zhang X

    更新日期:2019-04-01 00:00:00

  • Immunotherapy in the Asiatic population: any differences from Caucasian population?

    abstract::As "Immunotherapy age" is coming, immune checkpoint inhibitors (CPI) therapies have shown favorable clinical benefits and low toxicity profiles in patients with advanced non-small cell lung cancer (NSCLC). While it is a pity that there is a little clear clinical trials evidence about immunotherapy among Asian populati...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章,评审

    doi:10.21037/jtd.2018.05.106

    authors: Peng L,Wu YL

    更新日期:2018-05-01 00:00:00

  • Prosthetic valve endocarditis after transcatheter aortic valve implantation-diagnostic and surgical considerations.

    abstract::Prosthetic valve endocarditis (PVE) after transcatheter aortic valve implantation (TAVI) or surgical aortic valve replacement (SAVR) is a potential life threatening complication. Better understanding of the incidence, predictors, clinical presentation, diagnostic measures, complications and management of PVE may help ...

    journal_title:Journal of thoracic disease

    pub_type:

    doi:10.21037/jtd.2016.10.28

    authors: Ahmad K,Klaaborg KE,Hjortdal V,Nørgaard BL,Terkelsen CJ,Jensen K,Christiansen EH,Terp KA,Andersen G,Hvitfeldt S,Andersen HR

    更新日期:2016-10-01 00:00:00

  • How well does pathologic stage predict survival for esophageal adenocarcinoma after neoadjuvant therapy?

    abstract:BACKGROUND:Cancer staging systems are designed to predict survival and stratify patients. The 7(th) edition of the American Joint Commission on Cancer (AJCC7) staging system for esophageal cancer was modeled using survival data on patients who underwent esophagectomy without induction or adjuvant therapy. In the United...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.3978/j.issn.2072-1439.2015.04.30

    authors: Kim JY,Nelson RA,Kim J,Raz D

    更新日期:2015-04-01 00:00:00

  • Tumor heterogeneity on (18)F-FDG-PET/CT for response monitoring in non-small cell lung cancer treated with erlotinib.

    abstract::Response monitoring using fluorodeoxyglucose positron emission tomography acquired together with low dose computed tomography (FDG-PET/CT) textural features has potential in targeted treatment with erlotinib in non-small cell lung cancer (NSCLC) patients. Patients with substantial decrease of metabolic activity during...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2016.02.10

    authors: van Gool MH,Aukema TS,Sinaasappel M,Valdés Olmos RA,Klomp HM

    更新日期:2016-03-01 00:00:00

  • Macrolide antibiotics in the treatment of chronic rhinosinusitis: evidence from a meta-analysis.

    abstract:Background:The purpose of this study was to systematically assess the subjective and objective outcomes of macrolide therapy for chronic rhinosinusitis (CRS). Methods:PubMed, Embase and Cochrane databases were searched for clinical trials detailing the effects of macrolide therapy in patients with CRS and published up...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2018.10.41

    authors: Shen S,Lou H,Wang C,Zhang L

    更新日期:2018-10-01 00:00:00

  • Targeted therapy in lung cancer: IPASS and beyond, keeping abreast of the explosion of targeted therapies for lung cancer.

    abstract::Advances in the treatment of non-small cell lung cancer (NSCLC) over the last decade have predominantly involved the development of therapies directed at molecular targets such as mutations in the epidermal growth factor receptor (EGFR) or rearrangements in the anaplastic lymphoma kinase (ALK) gene. Other targets have...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章,评审

    doi:10.3978/j.issn.2072-1439.2013.08.52

    authors: Savas P,Hughes B,Solomon B

    更新日期:2013-10-01 00:00:00

  • Extended sleeve-lobectomy for centrally located locally advanced non-small cell lung cancer is a feasible approach to avoid pneumonectomy.

    abstract:Backgrounds:The aim of this study was to report our Institutional experience with extended sleeve lobectomy (ESL) in centrally located non-small cell lung cancer (NSCLC), focusing on technical details, post-operative results, recurrence and survival, to determine whether ESL can be accepted as a favorable alternative p...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd-20-1241

    authors: Voltolini L,Gonfiotti A,Viggiano D,Borgianni S,Farronato A,Bongiolatti S

    更新日期:2020-08-01 00:00:00

  • Preoperative evaluation for lung cancer resection.

    abstract::During the last decades lung cancer is the leading cause of death worldwide for both sexes. Even though cigarette smoking has been proved to be the main causative factor, many other agents (e.g., occupational exposure to asbestos or heavy metals, indoor exposure to radon gas radiation, particulate air pollution) have ...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章,评审

    doi:10.3978/j.issn.2072-1439.2014.03.06

    authors: Spyratos D,Zarogoulidis P,Porpodis K,Angelis N,Papaiwannou A,Kioumis I,Pitsiou G,Pataka A,Tsakiridis K,Mpakas A,Arikas S,Katsikogiannis N,Kougioumtzi I,Tsiouda T,Machairiotis N,Siminelakis S,Argyriou M,Kotsakou M,Kess

    更新日期:2014-03-01 00:00:00

  • Efficacy of epidermal growth factor receptor-tyrosine kinase inhibitors for Chinese patients with squamous cell carcinoma of lung harboring EGFR mutation.

    abstract:OBJECTIVE:Epidermal growth factor receptor (EGFR) mutation mostly occurred in lung adenocarcinoma, rarely in squamous cell carcinoma (SQCC). EGFR mutation rate in SQCC varied in previous reports, and the efficacy of EGFR tyrosine kinase inhibitors (TKIs) in SQCC harboring EGFR mutation has not yet been fully evaluated....

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.3978/j.issn.2072-1439.2013.09.15

    authors: Fang W,Zhang J,Liang W,Huang Y,Yan Y,Wu X,Hu Z,Ma Y,Zhao H,Zhao Y,Yang Y,Xue C,Zhang J,Zhang L

    更新日期:2013-10-01 00:00:00

  • Perioperative outcome of lung cancer surgery in women: results from a Spanish nationwide prospective cohort study.

    abstract:Background:To assess possible differences in the perioperative profile between men and women in lung cancer surgery. Methods:A prospective cohort multicenter study was design, in which consecutive patients undergoing curative intent surgery for lung cancer in 24 Thoracic Services throughout Spain were included. Clinic...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2019.03.30

    authors: Fibla JJ,Molins L,Quero F,Izquierdo JM,Sánchez D,Hernández J,Bayarri C,Boada M,Guirao Á,Cueto A

    更新日期:2019-04-01 00:00:00

  • Pleural dissemination of a mixed ground-glass opacity nodule treated as a nontuberculous mycobacterial infection for 6 years without growing remarkably.

    abstract::Pulmonary ground-glass opacity (GGO) nodules, which do not grow remarkably, are often observed without treatment. Lung tumors coexisting with inflammation and infection are difficult to diagnose. In this paper, we describe a very rare case of a pulmonary mixed GGO nodule with pleural dissemination. In 67-year-old fema...

    journal_title:Journal of thoracic disease

    pub_type:

    doi:10.3978/j.issn.2072-1439.2015.09.32

    authors: Shinohara S,Kuroda K,Shimokawa H,Kuwata T,Takenaka M,Chikaishi Y,Oka S,Hirai A,Imanishi N,Uramoto H,Tanaka F

    更新日期:2015-09-01 00:00:00