Abstract：
Background:To investigate the roles of gastrin-releasing peptide (ProGRP) in the diagnosis of small cell lung cancer (SCLC). Methods:We retrospectively analyzed data from 11,206 patients with clinical suspicion of lung cancer from January 1, 2015 to May 31, 2018. ProGRP and neuron-specific enolase (NSE) were detected in peripheral blood, and receiver operating characteristic curve (ROC) was used for analysis. Results:ROC indicated that the cutoff values of ProGRP and NSE were 66 ng/L and 18 µg/L respectively, and the diagnosis efficacy of ProGRP was greater than that of NSE (sensitivity: 86.5% vs. 78.8%; specificity: 96.5% vs. 86.3%, respectively) in the diagnosis of SCLC. Moreover, the median level of ProGRP in SCLC increased with the accompanying stages (P<0.001). Further analysis showed that diagnostic efficacy can be improved by using different cutoff values in different stages, but not stage I and II. The cut-off values of ProGRP in the diagnosis of SCLC in stage I-II, III and IV were 56, 71 and 99 ng/L respectively. In addition, the sensitivity (96.6% vs. 95.8% and 98.3% vs. 94.8%) and concordance rate (χ2 =1,526.9 and 988.7, both P<0.001) of detecting SCLC was improved by using different cutoff values compared with the only criteria of ProGRP being ≥66 ng/L in stage III and IV, but not stage I-II. Additionally in stage III and IV, the concordance rates of ProGRP ≥71 ng/L and ProGRP ≥99 ng/L were also higher than ProGRP ≥300 ng/L (both P<0.001), which was conventionally indicated for SCLC. Conclusions:ProGRP has significantly higher sensitivity and specificity than NSE in the diagnosis of SCLC. Furthermore, special thresholds for every stage may be more reasonable for the diagnosis of SCLC.
journal_name
J Thorac Disjournal_title
Journal of thoracic diseaseauthors
Dong A,Zhang J,Chen X,Ren X,Zhang Xdoi
10.21037/jtd.2019.04.29subject
Has Abstractpub_date
2019-04-01 00:00:00pages
1182-1189issue
4eissn
2072-1439issn
2077-6624pii
jtd-11-04-1182journal_volume
11pub_type
杂志文章abstract：BACKGROUND:The aim of this study was to reveal the short-term outcomes of video-assisted thoracoscopic surgery (VATS) segmentectomy without tracheal intubation compared with intubated general anesthesia with one-lung ventilation (OLV). METHODS:We performed a retrospective review of our institutional database of consec...
journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：10.21037/jtd.2016.02.50
更新日期：2016-03-01 00:00:00
abstract：:Myocardial ischemia is considered the cornerstone of the treatment of patients with coronary artery disease (CAD). Although the deleterious effects of myocardial infarction, the maximum expression of ischemia, have been extensively studied and described, the clinical effects of chronic, documented myocardial ischemia ...
journal_title：Journal of thoracic disease
pub_type： 杂志文章,评审
doi：10.21037/jtd.2019.02.85
更新日期：2019-03-01 00:00:00
abstract：:We report a case of video-assisted thoracoscopic surgery (VATS) tracheal resection and carinal reconstruction in a patient with tracheal tumor. The patient presented with adenoid cystic carcinoma (ACC) of the distal trachea, extending along the right main bronchus with carinal invasion. The reconstruction procedure wa...
journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：10.3978/j.issn.2072-1439.2016.01.45
更新日期：2016-01-01 00:00:00
abstract：:Central venous catheters (CVCs) have an important role in the management of critically ill patients. In contrast to the immediate complications after CVC insertion, the late complications were difficult to be noticed without high suspicion despite their life-threatening outcome. We report a rare but fatal delayed vasc...
journal_title：Journal of thoracic disease
pub_type：
doi：10.21037/jtd.2017.08.50
更新日期：2017-09-01 00:00:00
abstract：Background:To investigate the capability of radiomic analysis using T2-weighted (T2W) and spectral attenuated inversion-recovery T2-weighted (SPAIR T2W) magnetic resonance imaging (MRI) for predicting the therapeutic response of esophageal squamous cell carcinoma (ESCC) to chemoradiotherapy (CRT). Methods:Pretreatment...
journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：10.21037/jtd.2018.03.123
更新日期：2018-04-01 00:00:00
abstract：:In this study, we report the case of a 42-year-old female patient who was diagnosed with hemangioma in the pericardium connected to the main pulmonary artery. Chest CT revealed a hypodense, well-marginated, mass-like lesion, probably connected to the main pulmonary artery, and multiple heterogeneous attenuations were ...
journal_title：Journal of thoracic disease
pub_type：
doi：10.21037/jtd.2017.08.129
更新日期：2017-10-01 00:00:00
abstract：Background:Modern left ventricular assist devices (LVAD) have evolved to become standard of care in severe heart failure (HF) patients. Right HF (RHF) is a major complication responsible for early mortality. Several techniques for temporary right ventricular assist device (t-RVAD) have been described before, baring rel...
journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：10.21037/jtd.2018.11.121
更新日期：2019-04-01 00:00:00
abstract：Background:Continuous positive airway pressure (CPAP), the best available treatment for obstructive sleep apnea (OSA), requires long-term compliance to be effective. Behavioral interventions may be used to improve adherence to CPAP. We aimed to investigate whether positive or negative message framing impacts on CPAP co...
journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：10.21037/jtd.2017.07.110
更新日期：2018-01-01 00:00:00
abstract：Background:Although emphysema and small cell lung cancer (SCLC) are prevalent in smokers, no previous study has investigated the prognostic impact of computed tomography (CT)-determined emphysema in SCLC. This study was undertaken to analyze the prognostic value of emphysema scores as determined by baseline CT scans in...
journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：10.21037/jtd.2018.01.97
更新日期：2018-02-01 00:00:00
abstract：:Chronic dyspnoea, or breathlessness for more than four weeks duration, is a common symptom in adults presenting to primary and tertiary care. It often presents a diagnostic challenge due to the wide spectrum of underlying disease, which is multifactorial in approximately one third of cases. Challenges in diagnosis inc...
journal_title：Journal of thoracic disease
pub_type： 杂志文章,评审
doi：10.21037/jtd.2019.10.53
更新日期：2019-10-01 00:00:00
abstract：Background:Calcific aortic valve disease (CAVD) is the most common type of valvular heart disease in the elderly. This study is aimed to explore molecular mechanism of CAVD via bioinformatics analysis. Methods:The gene expression profiles of GSE51472 (including 5 normal aortic valve and 5 calcified aortic valve) and G...
journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：10.21037/jtd.2019.11.57
更新日期：2019-12-01 00:00:00
abstract：BACKGROUND:In patients with prior cardiac surgery requiring re-operative coronary and valve surgery, a hybrid approach of percutaneous coronary intervention followed by minimally invasive valve surgery (PCI + MIVS) may be an alternative to the standard median sternotomy coronary artery bypass and valve surgery (CABG + ...
journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：10.21037/jtd.2017.04.40
更新日期：2017-06-01 00:00:00
abstract：Background:The aim of this study is to evaluate the five-year outcomes after thoracic endovascular aortic repair (TEVAR) of symptomatic Stanford type B penetrating aortic ulcer (PAU) associated with intramural hematoma (IMH) in Chinese patients. Methods:From January 2009 to April 2013, 118 patients with typical severe...
journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：10.21037/jtd.2018.12.86
更新日期：2019-01-01 00:00:00
abstract：:Fatal hemoptysis is a serious complication of pulmonary tuberculosis, which can rarely be due to a bronchial aneurysm. Here, we present a case of fatal hemoptysis due to bronchial aneurysm occurred in a 59-year-old patient of Han ethnicity suffering from active pulmonary tuberculosis. Meanwhile, we perform a literatur...
journal_title：Journal of thoracic disease
pub_type：
doi：10.3978/j.issn.2072-1439.2014.04.07
更新日期：2014-06-01 00:00:00
abstract：Background:Multimorbidity is increasing common in Brazilian adults. Comorbid chronic lung disease, cardiovascular disease and diabetes are often inaccurately diagnosed or ineffectively treated. The Global Alliance against Chronic Respiratory Diseases (GARD) aims to strengthen health systems to prevent and control non-c...
journal_title：Journal of thoracic disease
pub_type： 杂志文章,评审
doi：10.21037/jtd.2018.07.34
更新日期：2018-07-01 00:00:00
abstract：BACKGROUND:Concurrent chemoradiotherapy (CRT) with 5-fluorouracil (5-FU) and cisplatin (CDDP) are often associated with significant incidence of toxic effects in elderly patients with esophageal cancer. This phase I trial was designed to determine the maximum tolerated dose (MTD) and dose-limiting toxicity (DLT) of S-1...
journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：10.21037/jtd.2016.02.70
更新日期：2016-03-01 00:00:00
abstract：Background:Many studies on fine-needle aspiration biopsy (FNAB) for undetermined pulmonary nodules reported that diagnostic accuracy tended to decline, whereas complication prevalence raised as the size of nodule decreased. Reconsideration on the effectiveness of FNAB would be appropriate considering the dramatic incre...
journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：10.21037/jtd.2019.02.58
更新日期：2019-03-01 00:00:00
abstract：:Professionals in the ICU, like nurses and doctors, are constantly working on quality improvement by developing protocols and monitoring the implementation with indicators. Protocols and quality indicators are usually based on evidence. Studies on quality improvement often measure the effect of protocols after implemen...
journal_title：Journal of thoracic disease
pub_type： 评论,社论
doi：10.21037/jtd.2017.03.48
更新日期：2017-03-01 00:00:00
abstract：BACKGROUND:Patient-initiated action plans are an important component of COPD self-management (SM) interventions. When integrated into SM interventions, these action plans have proven to be effective in reducing exacerbation severity, hospitalisations, and costs and in improving health status in patients with COPD witho...
journal_title：Journal of thoracic disease
pub_type： 杂志文章,评审
doi：10.3978/j.issn.2072-1439.2014.11.14
更新日期：2014-11-01 00:00:00
abstract：BACKGROUND:Although N-ERC/mesothelin (N-ERC) is an attractive diagnostic and treatment monitoring biomarker for malignant pleural mesothelioma (MPM), its clinical utility for predicting the prognosis has not yet been clarified. The aim of this study is to investigate whether the serum N-ERC level can accurately predict...
journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：10.3978/j.issn.2072-1439.2013.03.03
更新日期：2013-04-01 00:00:00
abstract：Background:Trans-subxiphoid thoracoscopic thymectomy is a promising procedure but technically demanding associated with ergonomic discomfort. In order to facilitate this complex procedure, the authors present a modified trans-subxiphoid thymectomy by the use of the Da Vinci robotic system. Methods:A 2-cm longitudinal ...
journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：10.21037/jtd.2018.03.07
更新日期：2018-03-01 00:00:00
abstract：:Non-small-cell lung cancer (NSCLC) is a uniformly fatal disease and most patients will present with advanced stage. Treatment outcomes remain unsatisfactory, with low long-term survival rates. Standard treatment, such as palliative chemotherapy and radiotherapy, offers a median survival not exceeding 1 year. Hence, co...
journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：10.3978/j.issn.2072-1439.2010.12.03
更新日期：2011-03-01 00:00:00
abstract：Background:Non-small cell lung cancer (NSCLC) harboring EGFR-sensitizing mutations has a distinct biology and heterogeneous clinical behavior. We evaluated the characteristics to progression such as clinical patterns of progression (dramatic, gradual, and local) with the prognosis of NSCLC patients treated with tyrosin...
journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：10.21037/jtd.2018.03.106
更新日期：2018-04-01 00:00:00
abstract：Background:Endoscopic thoracic sympathectomy (ETS) has not been widely adopted for treating craniofacial hyperhidrosis (CFH) due to its known postoperative complication, compensatory hyperhidrosis (CH). In this study, we evaluated whether the autonomic nerve analysis data via pre-ETS heart rate variability (HRV) test c...
journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：10.21037/jtd.2020.03.28
更新日期：2020-05-01 00:00:00
abstract：Background:Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) have become important treatment options for non-small cell lung cancer (NSCLC) patients with EGFR sensitive mutation. However, the detection of EGFR driver mutation is impeded by the lack of adequate tumor tissues, histopathological type...
journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：10.21037/jtd.2019.05.22
更新日期：2019-05-01 00:00:00
abstract：Background:In previous study, we found elevated serum total lactate dehydrogenase (LDH) before correction of pectus excavatum and a decrease in total LDH after the deformity correction. In the present study, we analyzed total LDH activity and its isoenzyme patterns to investigate the causes of these laboratory findings...
journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：10.21037/jtd.2019.09.49
更新日期：2019-10-01 00:00:00
abstract：:This video demonstrated a performance of uniportal video-assisted thoracoscopic surgery (VATS) right upper lobectomy with systemic lymphadenectomy. The patient had a malignant mass in his right upper lobe. The operator took a posterior to anterior approach to dissection the right upper lobe, the adjacent structures we...
journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：10.21037/jtd.2016.05.01
更新日期：2016-08-01 00:00:00
abstract：:During the last decades lung cancer is the leading cause of death worldwide for both sexes. Even though cigarette smoking has been proved to be the main causative factor, many other agents (e.g., occupational exposure to asbestos or heavy metals, indoor exposure to radon gas radiation, particulate air pollution) have ...
journal_title：Journal of thoracic disease
pub_type： 杂志文章,评审
doi：10.3978/j.issn.2072-1439.2014.03.06
更新日期：2014-03-01 00:00:00
abstract：:An 85-year-old woman was found to have a nodule in the left S6 of the lung on computed tomography (CT); the pathological diagnosis from the CT-guided biopsy was adenoid cystic carcinoma. We accordingly performed left lower lobectomy. Pathologically, the biphasic cell population showed admixtures in varying proportions...
journal_title：Journal of thoracic disease
pub_type：
doi：10.21037/jtd.2018.07.82
更新日期：2018-08-01 00:00:00
abstract：:Sensory information arising from the airways is processed in a distributed brain network that encodes for the discriminative and affective components of the resultant sensations. These higher brain networks in turn regulate descending motor control circuits that can both promote or suppress behavioural responses. Here...
journal_title：Journal of thoracic disease
pub_type： 杂志文章,评审
doi：10.21037/jtd.2017.08.119
更新日期：2017-10-01 00:00:00
