Primary pulmonary malignant fibrous histiocytoma: case report and literature review.

Abstract:

:Malignant fibrous histiocytoma (MFH) is an aggressive soft tissue sarcoma known to occur in various organs. Primary MFH arising in the lung is quite rare. Herein we report a case of a 61-year-old male with primary pulmonary MFH and explore the underlying molecular mechanisms by next-generation sequencing (NGS). Five gene mutations in TSC2, ARID1B, CDK8, KDM5C and CASP8 were detected, and the mTOR inhibitor might be an effective treatment for this patient. In addition, we reviewed the scientific literature of approximately 23 primary pulmonary MFH case reports since 1990 and summarized the clinical features and prognosis of this rare pulmonary malignant tumor.

journal_name

J Thorac Dis

authors

Li X,Liu R,Shi T,Dong S,Ren F,Yang F,Ren D,Fan H,Wei S,Chen G,Chen J,Xu S

doi

10.21037/jtd.2017.07.59

subject

Has Abstract

pub_date

2017-08-01 00:00:00

pages

E702-E708

issue

8

eissn

2072-1439

issn

2077-6624

pii

jtd-09-08-E702

journal_volume

9

pub_type

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