Combining targeted agents and hypo- and hyper-fractionated radiotherapy in NSCLC.

Abstract:

:Radical radiotherapy remains the cornerstone of treatment for patients with unresectable locally advanced non small cell lung cancer (NSCLC) either as single modality treatment for poor performance status patients or with sequential or concomitant chemotherapy for good performance status patients. Advances in understanding of tumour molecular biology, targeted drug development and experiences of novel agents in the advanced disease setting have brought targeted agents into the NSCLC clinic. In parallel experience using modified accelerated fractionation schedules in locally advanced disease have demonstrated improved outcomes compared to conventional fractionation in the single modality and sequential chemo-radiotherapy settings. Early studies of targeted agents combined with (chemo-) radiotherapy in locally advanced disease in different clinical settings are discussed below and important areas for future studies are high-lighted.

journal_name

J Thorac Dis

authors

McDonald F,Popat S

doi

10.3978/j.issn.2072-1439.2013.12.05

subject

Has Abstract

pub_date

2014-04-01 00:00:00

pages

356-68

issue

4

eissn

2072-1439

issn

2077-6624

pii

jtd-06-04-356

journal_volume

6

pub_type

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