Combinational immunotherapy based on immune checkpoints inhibitors in small cell lung cancer: is this the beginning to reverse the refractory situation?

abstract：:Protocols for the management of air leaks are critical aspects in the postoperative course of patients following lung resections. Many investigations in the last decade are focusing on the chest tube modalities or preventative measures, however, little is known about the pathophysiology of air leak and the patient per...

journal_title：Journal of thoracic disease

authors： Pompili C,Miserocchi G

更新日期：2016-02-01 00:00:00

abstract：OBJECTIVE:Epidermal growth factor receptor (EGFR) mutation mostly occurred in lung adenocarcinoma, rarely in squamous cell carcinoma (SQCC). EGFR mutation rate in SQCC varied in previous reports, and the efficacy of EGFR tyrosine kinase inhibitors (TKIs) in SQCC harboring EGFR mutation has not yet been fully evaluated....

journal_title：Journal of thoracic disease

authors： Fang W,Zhang J,Liang W,Huang Y,Yan Y,Wu X,Hu Z,Ma Y,Zhao H,Zhao Y,Yang Y,Xue C,Zhang J,Zhang L

更新日期：2013-10-01 00:00:00

abstract：:Approximately 6% of women with breast cancer are diagnosed before the age of 40. Young age is an independent predictor of adverse outcome and most young breast cancer patients receive systemic treatment with chemotherapy, hormonal therapy or both. The loss or impairment of fertility is a potential side effect of antin...

journal_title：Journal of thoracic disease

authors： Lambertini M,Anserini P,Levaggi A,Poggio F,Del Mastro L

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND:There is increasing evidence that a considerable proportion of patients with diabetes remain undiagnosed and untreated, however, it is unclear whether this is associated with more severe coronary artery disease (CAD) and microvasculature changes compared with diagnosed patients. We assessed CAD extent and se...

journal_title：Journal of thoracic disease

authors： Phan K,Mitchell P,Liew G,Plant AJ,Wang SB,Xu J,Chiha J,Thiagalingam A,Burlutsky G,Gopinath B

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:Studies on diagnostic tests for exercise-induced bronchoconstriction (EIB) have centered around the asthmatic and elite athletic population. Traditionally, the exercise challenge test (ET) was recommended to assess EIB. We aimed to compare the performance of surrogate testing, mainly the hypertonic saline (H...

journal_title：Journal of thoracic disease

authors： Tan JHY,Chew WM,Lapperre TS,Tan GL,Loo CM,Koh MS

更新日期：2017-03-01 00:00:00

abstract：Background:The purpose of this study is to report the efficacy of the mono antiplatelet plus anticoagulation therapy for prevention of reocclusion in patients with atrial fibrillation (AF) undergoing endovascular treatment for lower extremity ischemia. Methods:From March 2014 to July 2016, 32 (21 males; range, 68-84 y...

journal_title：Journal of thoracic disease

authors： Yuan L,Chen C,Li Z,Zhu G,Bao J,Zhao Z,Lu Q,Jing Z

更新日期：2018-03-01 00:00:00

abstract：:Cardiopulmonary support is frequently required during lung transplantation. Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) has been recently shown to be an acceptable and, perhaps, safer alternative to cardiopulmonary bypass machine (CBM) for lung transplantation. However, therapeutic anticoagulation used...

journal_title：Journal of thoracic disease

authors： Bharat A,DeCamp MM

更新日期：2017-07-01 00:00:00

abstract：Background:To investigate the diagnostic performance of galactomannan (GM) detection in bronchoalveolar lavage fluid (BALF) corrected by urea dilution and modification of the AspICU clinical algorithm. Methods:GM detection in serum and BALF samples was performed in nonneutropenic patients on the day of clinically susp...

journal_title：Journal of thoracic disease

authors： Yu Y,Zhu C,Shen H,Liu C,Guo R,Gao Y,Wu W,Lu L

更新日期：2019-02-01 00:00:00

abstract：:Heart-lung transplantation is reserved for selected patients who have end-stage cardiac and pulmonary disease. Gastroparesis, which is associated with aspiration, is commonly seen after transplantation. Here, we present a case in which gastric contents aspiration leads to Pseudomonas aeruginosa pulmonary infection, 11...

journal_title：Journal of thoracic disease

authors： Tao Y,Yan Z,Sha J,Zhu Z,Lei H

更新日期：2010-06-01 00:00:00

abstract：Background:Obstructive sleep apnea (OSA) is an independent risk factor for hypertension. OSA-related hypertension is common and treatment of OSA can reduce blood pressure (BP). However, few studies have been conducted on this type of hypertension in the Chinese occupational population. Methods:We conducted a field inv...

journal_title：Journal of thoracic disease

authors： Pan M,Ou Q,Chen B,Hong Z,Liu H

更新日期：2019-10-01 00:00:00

abstract：Background:In 2006, the Global Alliance against Chronic Respiratory Diseases (GARD) was established. The GARD strategy is based mainly on activities aimed at implementing preventive tasks at a local and global level. In Poland, the National Health Program (NHP) is the strategic document describing the tasks of governme...

journal_title：Journal of thoracic disease

authors： Raciborski F,Samoliński B,Krzych-Fałta E,Grąbczewska A,Furman F,Bieszczad M,Morkisz P,Witkowska P,Bousquet J,Gujski M

更新日期：2018-09-01 00:00:00

abstract：:The bidirectional interaction between sleep-disordered breathing (SDB) and stroke has been the subject of many studies. On the one hand, different forms of SDB, and especially obstructive sleep apnea, increase the risk of stroke either directly or indirectly by influencing other known cardiovascular risk factors such ...

journal_title：Journal of thoracic disease

authors： Alexiev F,Brill AK,Ott SR,Duss S,Schmidt M,Bassetti CL

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND:Influenza surveillance is carried out in Guangdong province, southern China. A better understanding of influenza seasonality and predominant Subtypes of influenza virus in Guangdong can help to improve evidence-based prevention and control strategies for influenza in the future. MATERIALS AND METHODS:THERE ...

journal_title：Journal of thoracic disease

authors： Lin J,Kang M,Zhong H,Zhang X,Yang F,Ni H,Huang P,Hong T,Ke C,He J

更新日期：2013-08-01 00:00:00

abstract：:Thyroid cancer affects 1.3% of the population with increasing rates of incidence over the last decade (approximately 2% per year). Although the overall prognosis is good in the differentiated subtypes, there has been a slow but steady increase in rate of deaths associated with thyroid cancer (approximately 0.7% per ye...

journal_title：Journal of thoracic disease

authors： Bonjoc KJ,Young H,Warner S,Gernon T,Maghami E,Chaudhry A

更新日期：2020-09-01 00:00:00

abstract：INTRODUCTION:Mediastinal tuberculous lymphadenitis (MTL) is mostly seen in primary tuberculosis in children, uncommon observed in adults. It usually presents the toxic symptoms of tuberculosis but rarely with symptoms characteristic of esophageal compression, such as dysphagia. Such patients can easily be misdiagnosed ...

journal_title：Journal of thoracic disease

authors： Xiong L,Mao X,Li C,Liu Z,Zhang Z

更新日期：2013-10-01 00:00:00

abstract：:The application of bronchoscopy has resolved a series of diagnostic and treatment challenges in pulmonary diseases. However, the occupational adverse effects experienced by healthcare workers in interventional pulmonology should receive increasing attention. Various aspects of adverse effects in bronchoscopy are often...

journal_title：Journal of thoracic disease

authors： Chen K,Bai C

更新日期：2019-04-01 00:00:00

abstract：:In functionally fit patients with localized disease surgical resection remains the treatment of choice. There is also good evidence to support the use of chemotherapy in stages II-III. However, whether to use neoadjuvant or adjuvant therapy has been the topic of much debate. With its strong evidence base, adjuvant che...

journal_title：Journal of thoracic disease

authors： McElnay P,Lim E

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND:For patients diagnosed with locally advanced esophageal cancer, neoadjuvant therapy followed by surgery is the most common approach. However, randomized trials resulted in inconsistent conclusions. We conducted this retrospective study to evaluate the influence of neoadjuvant therapy on postoperative events ...

journal_title：Journal of thoracic disease

authors： Lin D,Ma L,Ye T,Pan Y,Shao L,Song Z,Jiang S,Chen H,Xiang J

更新日期：2017-02-01 00:00:00

abstract：:Transbronchial lung biopsy with a cryoprobe, or cryobiopsy, is a promising new bronchoscopic biopsy technique capable of obtaining larger and better-preserved samples than previously possible using traditional biopsy forceps. Over two dozen case series and several small randomized trials are now available describing e...

journal_title：Journal of thoracic disease

authors： Lentz RJ,Argento AC,Colby TV,Rickman OB,Maldonado F

更新日期：2017-07-01 00:00:00

abstract：:Obstructive sleep apnoea (OSA) is a global health problem of increasing prevalence. Effective treatments are available with continuous positive airway pressure (CPAP) therapy and mandibular advancement devices (MAD). However, there is limited long-term adherence to therapy, as CPAP and MAD require permanent usage to a...

journal_title：Journal of thoracic disease

authors： He B,Al-Sherif M,Nido M,Tas R,Beach M,Schwarz EI,Cheng M,Ishak A,Lee K,Shah N,Kent B,Eze-John P,Ratneswaran C,Rafferty G,Williams AJ,Hart N,Luo Y,Moxham J,Pengo M,Steier J

更新日期：2019-05-01 00:00:00

abstract：Background:Retrospective compared the results of root reconstruction and root replacement for acute type A aortic dissection (ATAAD) patients and observed the rate of aortic insufficiency (AI) and aortic root dilation in the midterm follow-up period. Methods:From 2008-2016, 427 ATAAD patients received surgical therapy...

journal_title：Journal of thoracic disease

authors： Xue Y,Zhou Q,Pan J,Cao H,Fan F,Zhu X,Chong H,Wang D

更新日期：2019-11-01 00:00:00

abstract：Background:Previous retrospective study suggested that acute lung injury (ALI) is frequent (78.49%) in patients undergoing aortic dissection surgery, and accompanied by a number of untoward consequences, and even induces death. Methods:This prospective single-center cross-sectional study, registered in the ClinicalTri...

journal_title：Journal of thoracic disease

authors： Pan X,Lu J,Cheng W,Yang Y,Zhu J,Jin M

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND:Recurrence of pectus excavatum (PE) is not an uncommon problem after open repair using the Ravitch technique. The optimal approach for redo surgery is still under debate, especially in adults with less chest wall pliability. Aim of this study was to investigate the usefulness and efficacy of the minimally in...

journal_title：Journal of thoracic disease

authors： Kocher GJ,Gstrein N,Jaroszewski DE,Ewais MM,Schmid RA

更新日期：2016-08-01 00:00:00

abstract：:During the last decades lung cancer is the leading cause of death worldwide for both sexes. Even though cigarette smoking has been proved to be the main causative factor, many other agents (e.g., occupational exposure to asbestos or heavy metals, indoor exposure to radon gas radiation, particulate air pollution) have ...

journal_title：Journal of thoracic disease

authors： Spyratos D,Zarogoulidis P,Porpodis K,Angelis N,Papaiwannou A,Kioumis I,Pitsiou G,Pataka A,Tsakiridis K,Mpakas A,Arikas S,Katsikogiannis N,Kougioumtzi I,Tsiouda T,Machairiotis N,Siminelakis S,Argyriou M,Kotsakou M,Kess

更新日期：2014-03-01 00:00:00

abstract：:The 60-year-old female had a nodule in the right lower lobe of the lung, which was identified as a tumor by CT and PET-CT. Then the right lower lobectomy was performed. The posterior trocar placement, different from other surgery, is in the 5th intercostals space in the anterior latissimus dorsi, which can be built by...

journal_title：Journal of thoracic disease

authors： Zhao T,Chen H,Yang L,Jin H,Li Z,Zhang J

更新日期：2013-08-01 00:00:00

abstract：Background:Clinical practice guidelines (CPGs) provide many recommendations for hyperlipidemia management, but some of them are still debatable. Methods:We applied the six-domain Appraisal of Guidelines for Research and Evaluation II (AGREE II) instrument to evaluate the quality of guidelines with lipid management rec...

journal_title：Journal of thoracic disease

authors： Zhou H,Zhang S,Sun X,Yang D,Zhuang X,Guo Y,Hu X,Du Z,Zhang M,Liao X

更新日期：2019-08-01 00:00:00

abstract：Background:Recent studies incorporating dose escalated radiation identified heart dose as a predictor of cardiac toxicity in unresectable lung cancer patients. Whether conventionally dosed radiation impacts cardiac events remains unclear. Methods:Stage III lung cancer patients undergoing definitive chemoradiation to 6...

journal_title：Journal of thoracic disease

authors： Ni L,Koshy M,Connell P,Pitroda S,Golden DW,Al-Hallaq H,Hubert G,Kauffman G,McCall A,Malik R

更新日期：2019-06-01 00:00:00

abstract：Background:The detection rate of ground-glass opacity (GGO) in young patients has increased year by year with the increasingly widespread use of high-resolution computed tomography (HRCT) and the increased resolution of HRCT imaging. However, no scholars have reported the clinical characteristics and prognosis of GGO i...

journal_title：Journal of thoracic disease

authors： Wang J,Ma H,Ni CJ,He JK,Ma HT,Ge JF

更新日期：2019-02-01 00:00:00

abstract：:The new drugs delamanid and bedaquiline are increasingly used to treat multidrug-resistant (MDR-) and extensively drug-resistant tuberculosis (XDR-TB). As evidence is lacking, the World Health Organization recommends their use under specific conditions in adults, delamanid only being recommended in children ≥6 years o...

journal_title：Journal of thoracic disease

authors： D'Ambrosio L,Centis R,Tiberi S,Tadolini M,Dalcolmo M,Rendon A,Esposito S,Migliori GB

更新日期：2017-07-01 00:00:00

abstract：:In the last few years, the treatment of patients with non-small cell lung cancer (NSCLC) has impressively benefitted from immunotherapy, in particular from the inhibition of immune checkpoints such as programmed cell death-1 (PD-1) and programmed cell death ligand-1 (PD-L1). However, despite the significant survival b...

journal_title：Journal of thoracic disease

authors： Berland L,Heeke S,Humbert O,Macocco A,Long-Mira E,Lassalle S,Lespinet-Fabre V,Lalvée S,Bordone O,Cohen C,Leroy S,Hofman V,Hofman P,Ilié M

更新日期：2019-01-01 00:00:00