An innovative panel to assess endothelial integrity of pedicled and skeletonized internal thoracic artery used as aortocoronary bypass graft: a randomized comparative histologic and immunohistochemical study.

Abstract:

Background:Optimal preservation of endothelial integrity of the vessels used as aortocoronary grafts is a crucial determinant of long-term clinical success of coronary artery bypass grafting (CABG). The purpose of this study was to evaluate an impact of two common techniques to harvest left internal thoracic artery (LITA) on endothelial integrity. Methods:One hundred twenty consecutive patients (84 males and 36 females) with a mean age of 64.9±8.8 years undergoing CABG were randomized to receive pedicled (group P; n=60) or skeletonized (group S; n=60) LITA grafts. During surgery LITA was harvested by the same experienced cardiac surgeon. The most peripheral surplus segments of LITA were obtained and then analysed histologically under light microscope. Additionally, endothelial expression of CD31, CD34, CD133 and nitric oxide synthase (eNOS) were evaluated by means of immunohistochemistry. Results:In both groups, no cases of major arterial wall damage such as disruption, dissection, thrombosis or subadventitial hematoma were noted on LITA cross sections. Immunohistochemical assessment of protein expression revealed no differences in endothelial expression of CD133, CD34 antigens (markers of regeneration potential) and eNOS (indicating preserved functional integrity) between studied groups. Contrary to them, endothelial immunoreactivity of CD31, a marker of the morphological integrity of the endothelium, was revealed to be stronger in group P. Conclusions:The skeletonized method of LITA harvesting may be associated with worse preservation of morphological integrity of endothelium but without compromising functional integrity and potential for tissue regeneration.

journal_name

J Thorac Dis

authors

Puslecki M,Buczkowski P,Nowicki M,Sujka-Kordowska P,Ligowski M,Misterski M,Stefaniak S,Dąbrowski M,Dabrowska A,Bocianski M,Szarpak L,Ruetzler K,Jemielity M,Perek B

doi

10.21037/jtd.2018.07.62

subject

Has Abstract

pub_date

2018-08-01 00:00:00

pages

4865-4873

issue

8

eissn

2072-1439

issn

2077-6624

pii

jtd-10-08-4865

journal_volume

10

pub_type

杂志文章
  • Thyroid cancer diagnosis in the era of precision imaging.

    abstract::Thyroid cancer affects 1.3% of the population with increasing rates of incidence over the last decade (approximately 2% per year). Although the overall prognosis is good in the differentiated subtypes, there has been a slow but steady increase in rate of deaths associated with thyroid cancer (approximately 0.7% per ye...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章,评审

    doi:10.21037/jtd.2019.08.37

    authors: Bonjoc KJ,Young H,Warner S,Gernon T,Maghami E,Chaudhry A

    更新日期:2020-09-01 00:00:00

  • Report on 153 sequential three-incision robotic-assisted pulmonary resections by a single surgeon: technical details and learning curve.

    abstract:Background:There are several techniques for robotic-assisted pulmonary resection, depending on the number and position of ports and utility incisions. We developed a technique for three-incision robotic-assisted pulmonary resection, and here we reported our initial results. Methods:Three-incision pulmonary resection w...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2019.12.116

    authors: Peng M,Wang X,Chen C,Tan S,Liu W,Yu F

    更新日期:2020-03-01 00:00:00

  • Right upper sleeve lobectomy by video-assisted thoracic surgery.

    abstract::With accumulation of experiences in video-assisted thoracic surgery (VATS) lobectomy, complete VATS sleeve lobectomy (SL) has been carried out in more and more medical centers. We here presented a procedure of sleeve right upper lobectomy by complete VATS for a 62-year-old male patient with central squamous cell carci...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2018.03.112

    authors: Guo J,Liu Y,Liang C

    更新日期:2018-07-01 00:00:00

  • Analysis of postoperative complications and risk factors in patients with permanent pacemaker implantation.

    abstract:Background:Permanent pacemaker implantation (PPI) is widely used for the treatment of chronic arrhythmia. The aim of the present study was to investigate the incidence of postoperative complications and the risk factors in patients with PPI. Methods:The clinical data of 124 patients who underwent PPI in our hospital f...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd-20-2913

    authors: Jing S,Hu S,Ma S

    更新日期:2020-10-01 00:00:00

  • Evaluating and assessing the prevalence of bedside ultrasound in emergency departments in China.

    abstract:Background:To survey the prevalence of bedside ultrasound assessment in emergency departments (EDs) in China. Methods:We designed an online survey for emergency physicians based in the China. The questionnaire included sixteen items querying common ED bedside ultrasound practices. Respondents were recruited via weblin...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2018.04.88

    authors: Shi D,Walline JH,Yu X,Xu J,Song PP,Zhu H

    更新日期:2018-05-01 00:00:00

  • Nursing for the complete VATS lobectomy performed with non-tracheal intubation.

    abstract::Video-assisted thoracoscopic surgery (VATS) has without doubt been the most important advance in thoracic surgery. The general anesthesia before the tracheal intubation for VATS was often accompanied with tracheal mucosa and lung injuries, which were typically manifested as painful throat, nausea, vomiting, and other ...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.3978/j.issn.2072-1439.2014.06.35

    authors: Wang L,Wang Y,Lin S,Yin P,Xu Y

    更新日期:2014-07-01 00:00:00

  • Implications of pneumonitis after chemoradiation and durvalumab for locally advanced non-small cell lung cancer.

    abstract:Background:Consolidation durvalumab improved overall survival (OS) in locally advanced non-small cell lung cancer (LA-NSCLC) treated with chemoradiotherapy (CRT) in the PACIFIC trial; however, pneumonitis was increased with durvalumab. We sought to examine real-world outcomes with the PACIFIC paradigm, especially facto...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd-20-1792

    authors: Hassanzadeh C,Sita T,Savoor R,Samson PP,Bradley J,Gentile M,Roach M,Mohindra N,Waqar S,Kruser TJ,Robinson C

    更新日期:2020-11-01 00:00:00

  • Infrequent ERBB2 mutations in Chinese patients with non-small cell lung cancer.

    abstract::ERBB2 mutations have been reported to occur in a subset of patients with lung adenocarcinomas or lung squamous cell carcinomas for some ethnicities, but it is unclear for Chinese patients with lung squamous cell carcinomas up to now. We retrospectively evaluated the status of ERBB2 mutations in a large cross-sectional...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.3978/j.issn.2072-1439.2014.03.20

    authors: Feng S,Ling H,Guo H,Tong L,Hu G,Liao L,Lv X,Tan H,Wu Y

    更新日期:2014-05-01 00:00:00

  • Non-intercostal access for video-assisted thoracic surgery-analysis of technical advantages and disadvantages.

    abstract:Background:Video-assisted thoracoscopic surgery (VATS) lobectomy has become an accepted method for the treatment of early-stage non-small-cell lung cancer (NSCLC). The standard VATS approach is an intercostal one which is often followed by postoperative pain due to injury of the intercostal nerve. The non-intercostal t...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2018.09.139

    authors: Zieliński M,Gwozdz P,Wilkojc M,Kosinski S,Fryzlewicz E,Nabialek T,Pankowski J,Kwiatkowski R

    更新日期:2018-11-01 00:00:00

  • Erroneous diagnosis of small cell lung cancer based on small biopsies with far-reaching consequences: case report of a typical carcinoid tumor.

    abstract::Although neuroendocrine tumors (NETs) of the lung are frequently discussed together, carcinoids are very different from high-grade small cell lung carcinoma (SCLC). SCLC is found in heavy-smoking, older patients, whereas smoking is not strongly associated with carcinoid tumors. We present the case of a 46-year-old nev...

    journal_title:Journal of thoracic disease

    pub_type:

    doi:10.21037/jtd.2017.02.35

    authors: Kyritsis I,Krebs B,Kampe S,Theegarten D,Aigner C,Welter S

    更新日期:2017-02-01 00:00:00

  • Rapid detection of Streptococcus pneumoniae by real-time fluorescence loop-mediated isothermal amplification.

    abstract:BACKGROUND AND AIM OF STUDY:A significant human pathogenic bacterium, Streptococcus pneumoniae was recognized as a major cause of pneumonia, and is the subject of many humoral immunity studies. Diagnosis is generally made based on clinical suspicion along with a positive culture from a sample from virtually any place i...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.3978/j.issn.2072-1439.2014.07.29

    authors: Xia Y,Guo XG,Zhou S

    更新日期:2014-09-01 00:00:00

  • Influence of cannula positioning on brain injury during extracorporeal membrane oxygenation.

    abstract:Background:In veno-arterial extracorporeal membrane oxygenation (V-A ECMO), a patient is cannulated using either an atrio-aortic technique (central type ECMO; cECMO) or a femoro-femoral technique (peripheral type ECMO; pECMO). The direction of the pump flow at the aortic arch is anterograde from the ascending aorta in ...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2018.10.74

    authors: Jeong SC,Kim HJ,Shin YS,Han JW,Lim JY,Son HS

    更新日期:2018-11-01 00:00:00

  • Tracheobronchial tuberculosis: a clinical review.

    abstract::Endobronchial tuberculosis (EBTB) is defined as tuberculous infection of the tracheobronchial tree. The exact pathogenesis is unclear, and it has a heterogenous clinical course. Its diagnosis requires the clinician to have a high index of suspicion based on clinical symptoms and radiological features. Computed tomogra...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章,评审

    doi:10.21037/jtd.2017.01.49

    authors: Siow WT,Lee P

    更新日期:2017-01-01 00:00:00

  • The nationwide program of allergic disease prevention as an implementation of GARD guidelines in Poland.

    abstract:Background:In 2006, the Global Alliance against Chronic Respiratory Diseases (GARD) was established. The GARD strategy is based mainly on activities aimed at implementing preventive tasks at a local and global level. In Poland, the National Health Program (NHP) is the strategic document describing the tasks of governme...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2018.08.97

    authors: Raciborski F,Samoliński B,Krzych-Fałta E,Grąbczewska A,Furman F,Bieszczad M,Morkisz P,Witkowska P,Bousquet J,Gujski M

    更新日期:2018-09-01 00:00:00

  • Anomalous origin of the left coronary artery from the pulmonary artery diagnosed during transcatheter treatment of severe pulmonary branch stenoses: a potentially life-threatening situation.

    abstract::We report an 8-year-old female undergoing interventional catheterization for treatment of pulmonary artery stenoses, atrial septal defect and patent ductus arteriosus. Anomalous left coronary artery arising from the pulmonary artery was diagnosed during the procedure. We highlight the importance of recognizing this ra...

    journal_title:Journal of thoracic disease

    pub_type:

    doi:10.21037/jtd.2018.05.20

    authors: Robinson L,Baruteau AE,Fraisse A

    更新日期:2018-05-01 00:00:00

  • Ultrasound techniques in the evaluation of the mediastinum, part 2: mediastinal lymph node anatomy and diagnostic reach of ultrasound techniques, clinical work up of neoplastic and inflammatory mediastinal lymphadenopathy using ultrasound techniques and h

    abstract::Ultrasound imaging has gained importance in pulmonary medicine over the last decades including conventional transcutaneous ultrasound (TUS), endoscopic ultrasound (EUS), and endobronchial ultrasound (EBUS). Mediastinal lymph node (MLN) staging affects the management of patients with both operable and inoperable lung c...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章,评审

    doi:10.3978/j.issn.2072-1439.2015.10.08

    authors: Jenssen C,Annema JT,Clementsen P,Cui XW,Borst MM,Dietrich CF

    更新日期:2015-10-01 00:00:00

  • Options for temporary mechanical circulatory support.

    abstract::Temporary mechanical circulatory support (MCS) refers to a group of devices generally used for less than 30 days to maintain adequate organ perfusion by compensating for a failure of the pumping mechanism of the heart. The increased availability and rapid adoption of new temporary MCS strategies necessitate physicians...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章,评审

    doi:10.3978/j.issn.2072-1439.2015.09.14

    authors: Saffarzadeh A,Bonde P

    更新日期:2015-12-01 00:00:00

  • Risk factors for obstructive sleep apnea-related hypertension in police officers in Southern China.

    abstract:Background:Obstructive sleep apnea (OSA) is an independent risk factor for hypertension. OSA-related hypertension is common and treatment of OSA can reduce blood pressure (BP). However, few studies have been conducted on this type of hypertension in the Chinese occupational population. Methods:We conducted a field inv...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2019.09.83

    authors: Pan M,Ou Q,Chen B,Hong Z,Liu H

    更新日期:2019-10-01 00:00:00

  • Serum lactate dehydrogenase activity and its isoenzyme patterns in patients with pectus excavatum.

    abstract:Background:In previous study, we found elevated serum total lactate dehydrogenase (LDH) before correction of pectus excavatum and a decrease in total LDH after the deformity correction. In the present study, we analyzed total LDH activity and its isoenzyme patterns to investigate the causes of these laboratory findings...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2019.09.49

    authors: Jeong SC,Kim JJ,Kim YH,Kim IS,Han JW

    更新日期:2019-10-01 00:00:00

  • Video-assisted thoracoscopic surgery segmentectomy by non-intubated or intubated anesthesia: a comparative analysis of short-term outcome.

    abstract:BACKGROUND:The aim of this study was to reveal the short-term outcomes of video-assisted thoracoscopic surgery (VATS) segmentectomy without tracheal intubation compared with intubated general anesthesia with one-lung ventilation (OLV). METHODS:We performed a retrospective review of our institutional database of consec...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2016.02.50

    authors: Guo Z,Yin W,Pan H,Zhang X,Xu X,Shao W,Chen H,He J

    更新日期:2016-03-01 00:00:00

  • Robotic lung segmentectomy for malignant and benign lesions.

    abstract:OBJECTIVE:Surgical use of robots has evolved over the last 10 years. However, the academic experience with robotic lung segmentectomy remains limited. We aimed to analyze our lung segmentectomy experience with robot-assisted thoracoscopic surgery. METHODS:Prospectively recorded clinical data of 21 patients who underwe...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.3978/j.issn.2072-1439.2014.06.40

    authors: Toker A,Ayalp K,Uyumaz E,Kaba E,Demirhan O,Erus S

    更新日期:2014-07-01 00:00:00

  • A phase I dose escalation study of S-1 with concurrent radiotherapy in elderly patients with esophageal cancer.

    abstract:BACKGROUND:Concurrent chemoradiotherapy (CRT) with 5-fluorouracil (5-FU) and cisplatin (CDDP) are often associated with significant incidence of toxic effects in elderly patients with esophageal cancer. This phase I trial was designed to determine the maximum tolerated dose (MTD) and dose-limiting toxicity (DLT) of S-1...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2016.02.70

    authors: Ji Y,Qiu G,Sheng L,Sun X,Zheng Y,Chen M,Du X

    更新日期:2016-03-01 00:00:00

  • Prosthetic valve endocarditis after transcatheter aortic valve implantation-diagnostic and surgical considerations.

    abstract::Prosthetic valve endocarditis (PVE) after transcatheter aortic valve implantation (TAVI) or surgical aortic valve replacement (SAVR) is a potential life threatening complication. Better understanding of the incidence, predictors, clinical presentation, diagnostic measures, complications and management of PVE may help ...

    journal_title:Journal of thoracic disease

    pub_type:

    doi:10.21037/jtd.2016.10.28

    authors: Ahmad K,Klaaborg KE,Hjortdal V,Nørgaard BL,Terkelsen CJ,Jensen K,Christiansen EH,Terp KA,Andersen G,Hvitfeldt S,Andersen HR

    更新日期:2016-10-01 00:00:00

  • Predictors of arterial desaturation during intubation: a nested case-control study of airway management-part I.

    abstract:Background:Arterial desaturations experienced during endotracheal intubation (ETI) may lead to poor outcomes. Thus, our primary aim was to identify predictors of arterial desaturation (pulse oximetry <90%) during the peri-intubation period and to assess outcomes of those who developed arterial hypoxemia. Methods:Adult...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2017.08.138

    authors: Smischney NJ,Seisa MO,Heise KJ,Wiegand RA,Busack KD,Loftsgard TO,Schroeder DR,Diedrich DA

    更新日期:2017-10-01 00:00:00

  • Immunotherapy for extensive stage small cell lung cancer.

    abstract::Small cell lung cancer (SCLC) is an aggressive malignancy. Until recently the standard of care for newly diagnosed patients with extensive-stage disease was chemotherapy consisting of etoposide plus a platinum (EP). The median overall survival (OS) was only about 10 months with this systemic therapy. Immune checkpoint...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章,评审

    doi:10.21037/jtd.2020.01.37

    authors: Pacheco JM

    更新日期:2020-10-01 00:00:00

  • Hybrid theatre and alternative localization techniques in conventional and single-port video-assisted thoracoscopic surgery.

    abstract::Management of pulmonary nodules in terms of diagnosis and intraoperative localization can be challenging, especially in the minimal invasive video-assisted thoracoscopic surgery (VATS) approach, and may be even more difficult with single port VATS with limited access. The ability to localize small lesions intraoperati...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章,评审

    doi:10.3978/j.issn.2072-1439.2016.02.27

    authors: Zhao ZR,Lau RW,Ng CS

    更新日期:2016-03-01 00:00:00

  • Long-term outcomes of multiple and single arterial off-pump coronary artery bypass grafting.

    abstract:Background:To compare the clinical outcomes between multiple arterial (MA) and single arterial (SA) off-pump coronary artery bypass grafting (OPCAB) when applied to left main coronary disease or three-vessel disease. Methods:A total of 537 patients with left main coronary disease or three-vessel disease underwent MA O...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2019.01.101

    authors: Zhu P,Chen A,Wang Z,Ye X,Zhou M,Liu J,Zhao Q

    更新日期:2019-03-01 00:00:00

  • Clinical utility of robot-assisted transthoracic esophagectomy in advanced esophageal cancer after neoadjuvant chemoradiation therapy.

    abstract:Background:Although robot-assisted minimally-invasive esophagectomy (RAMIE) surgeries are expanding clinically, few studies have reported patients with locally-advanced esophageal cancer who underwent neoadjuvant chemoradiation therapy (nCRT). Methods:From 2013 to 2017, 219 patients with esophageal squamous cell carci...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2019.07.53

    authors: Yun JK,Lee IS,Gong CS,Kim BS,Kim HR,Kim DK,Park SI,Kim YH

    更新日期:2019-07-01 00:00:00

  • Clinical feasibility and efficacy of video-assisted thoracic surgery (VATS) anatomical resection in patients with central lung cancer: a comparison with thoracotomy.

    abstract:BACKGROUND:The aim of this study is to evaluate the clinical feasibility and efficacy of video-assisted thoracoscopic surgery (VATS) anatomical pulmonary resection in patients with central lung cancer. METHODS:Between July 2004 and December 2011, 465 patients underwent anatomical pulmonary resection and systematic med...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.3978/j.issn.2072-1439.2015.10.32

    authors: Jung HS,Kim HR,Choi SH,Kim YH,Kim DK,Park SI

    更新日期:2015-10-01 00:00:00

  • Bronchial aneurysm secondary to tuberculosis presenting with fatal hemoptysis: a case report and review of the literature.

    abstract::Fatal hemoptysis is a serious complication of pulmonary tuberculosis, which can rarely be due to a bronchial aneurysm. Here, we present a case of fatal hemoptysis due to bronchial aneurysm occurred in a 59-year-old patient of Han ethnicity suffering from active pulmonary tuberculosis. Meanwhile, we perform a literatur...

    journal_title:Journal of thoracic disease

    pub_type:

    doi:10.3978/j.issn.2072-1439.2014.04.07

    authors: Cheng YS,Lu ZW

    更新日期:2014-06-01 00:00:00