Abstract:
BACKGROUND:Bronchoplastic and broncho-arterioplastic lobectomy is technically demanding. Present study performed a prognostic analysis of lobectomy patient based on 10-year data in a high-volume center. METHODS:Overall, 161 non-small cell lung cancer (NSCLC) cases underwent bronchoplastic and broncho-arterioplastic lobectomy between January 2004 and November 2013. Follow-up information was obtained for 88.8% patients. Prognostic analysis was performed with the Cox proportional hazards model. RESULTS:There were 133 bronchoplastic and 28 broncho-arterioplastic procedures. In detail, 97 sleeve and 64 wedge broncho-resection and reconstructions were conducted; pulmonary artery sleeve reconstructions were performed in 26 cases and tangential resection in 135 cases. 90-day post-operative mortality was 3.1% (5/161), and 24.8% (40/161) patients had post-operative complications. 5-year overall survival was 53.4% and 5-year disease-free survival (DFS) was 48.2% for the entire case series; these survival rates were 67.7% and 55.7% for stage I (n=31), 64.4% and 58.9% for stage II (n=62), and 36.9% and 31.9% for stage III disease, respectively. Univariate analysis revealed that age >65 and higher grade of pN were associated with worse overall survival while right side tumor, non-squamous histology type, and higher grade of pT and pN were associated with worse DFS. Multivariate analysis revealed that pN is the only independent factor of worse outcome. CONCLUSIONS:Bronchoplastic and broncho-arterioplastic lobectomy are safe procedures for indicated NSCLC patients associated with a low rate of post-operative complications but favorable long-term survival. Recognition of prognostic factors helps improve outcomes for these patients.
journal_name
J Thorac Disjournal_title
Journal of thoracic diseaseauthors
Zhao LL,Zhou FY,Dai CY,Ren YJ,Jiang GN,Fei K,Chen Cdoi
10.3978/j.issn.2072-1439.2015.12.59subject
Has Abstractpub_date
2015-12-01 00:00:00pages
2288-99issue
12eissn
2072-1439issn
2077-6624pii
jtd-07-12-2288journal_volume
7pub_type
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journal_title:Journal of thoracic disease
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journal_title:Journal of thoracic disease
pub_type: 杂志文章,评审
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journal_title:Journal of thoracic disease
pub_type: 杂志文章,评审
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journal_title:Journal of thoracic disease
pub_type: 杂志文章
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更新日期:2016-08-01 00:00:00
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journal_title:Journal of thoracic disease
pub_type: 杂志文章
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更新日期:2019-03-01 00:00:00
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journal_title:Journal of thoracic disease
pub_type: 杂志文章
doi:10.3978/j.issn.2072-1439.2014.12.15
更新日期:2014-12-01 00:00:00
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journal_title:Journal of thoracic disease
pub_type: 杂志文章,评审
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更新日期:2019-10-01 00:00:00
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journal_title:Journal of thoracic disease
pub_type: 杂志文章,评审
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更新日期:2020-09-01 00:00:00
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更新日期:2019-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2018-12-01 00:00:00
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journal_title:Journal of thoracic disease
pub_type: 杂志文章,评审
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更新日期:2019-05-01 00:00:00
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journal_title:Journal of thoracic disease
pub_type: 杂志文章,评审
doi:10.3978/j.issn.2072-1439.2015.01.21
更新日期:2015-02-01 00:00:00
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journal_title:Journal of thoracic disease
pub_type: 杂志文章
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journal_title:Journal of thoracic disease
pub_type: 杂志文章,评审
doi:10.21037/jtd.2016.02.73
更新日期:2016-07-01 00:00:00
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journal_title:Journal of thoracic disease
pub_type: 杂志文章
doi:10.21037/jtd.2019.07.71
更新日期:2019-08-01 00:00:00
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journal_title:Journal of thoracic disease
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journal_title:Journal of thoracic disease
pub_type: 杂志文章
doi:10.3978/j.issn.2072-1439.2014.07.29
更新日期:2014-09-01 00:00:00
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journal_title:Journal of thoracic disease
pub_type: 杂志文章,评审
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更新日期:2020-06-01 00:00:00
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pub_type: 杂志文章
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更新日期:2019-12-01 00:00:00