Abstract:
:Atrial fibrillation (AF) is a complex disease that results from genetic and environmental factors and their interactions. In recent years, genome-wide association studies (GWAS) and family-based linkage analysis have found amounts of genetic variants associated with AF. Some of them lie in coding sequences and thus mediate the encoded proteins, some in non-coding regions and influence the expression of adjacent genes. These variants exert influence on the development of cardiovascular system and normal cardiac electrical activity in different levels, and eventually contribute to the occurrence of AF. Among these affected genes, as a crucial means of transcriptional regulation, several transcription factors play important roles in the pathogenesis of AF. In this review, we will focus on the potential role of PITX2, PRRX1, ZHFX3, TBX5, and NKX2.5 in AF.
journal_name
J Thorac Disjournal_title
Journal of thoracic diseaseauthors
Zhou M,Liao Y,Tu Xdoi
10.3978/j.issn.2072-1439.2015.01.21subject
Has Abstractpub_date
2015-02-01 00:00:00pages
152-8issue
2eissn
2072-1439issn
2077-6624pii
jtd-07-02-152journal_volume
7pub_type
杂志文章,评审abstract:Background:Monitoring of trends in the use of the intensive care unit (ICU) and the outcomes of ICU patients is essential for the assessment of the effective use of ICU. This study aims to investigate the incidence and outcome of critical care admissions in Taiwan from 1997 to 2013. Methods:Patients >18 years who had ...
journal_title:Journal of thoracic disease
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journal_title:Journal of thoracic disease
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journal_title:Journal of thoracic disease
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doi:10.21037/jtd.2018.01.10
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journal_title:Journal of thoracic disease
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journal_title:Journal of thoracic disease
pub_type: 杂志文章
doi:
更新日期:2010-03-01 00:00:00
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journal_title:Journal of thoracic disease
pub_type: 杂志文章,评审
doi:10.3978/j.issn.2072-1439.2013.12.05
更新日期:2014-04-01 00:00:00
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journal_title:Journal of thoracic disease
pub_type: 杂志文章
doi:10.21037/jtd.2019.09.52
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journal_title:Journal of thoracic disease
pub_type: 杂志文章
doi:10.21037/jtd.2020.03.04
更新日期:2020-04-01 00:00:00
abstract::Congenital pericardial defects are a rare anomaly, found during autopsy and cardiothoracic surgery. We describe a case of a 69-year-old female, with a right-sided congenital pericardial defect associated with a giant bronchogenic cyst (BC) found during surgery. The cyst was resected and the patient developed arrhythmi...
journal_title:Journal of thoracic disease
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doi:10.21037/jtd.2016.06.65
更新日期:2016-08-01 00:00:00
abstract:Background:Atherosclerosis in diabetic patients progresses fast. Evidence on how to choose target vessels of percutaneous coronary interventions (PCIs) in diabetic patients post-coronary artery bypass graft (post-CABG) is insufficient. Methods:One hundred and fifty-seven patients with diabetes and previous CABG, who u...
journal_title:Journal of thoracic disease
pub_type: 杂志文章
doi:10.21037/jtd.2019.10.33
更新日期:2019-11-01 00:00:00
abstract::Minimally invasive esophagectomy (MIE) is increasingly accepted in the treatment of locoregional or advanced esophageal cancer. Laparoscopic-thoracoscopic Ivor-Lewis esophagectomy has been proved to be effective in treating middle and distal esophageal cancer, however, intrathoracic esophagogastric anastomosis is tech...
journal_title:Journal of thoracic disease
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doi:10.3978/j.issn.2072-1439.2013.12.10
更新日期:2013-12-01 00:00:00
abstract::We describe herein a case of single-port thoracoscopic right main bronchial tumor sleeve resection and secondary carinal reconstruction. A 66-year-old male patient had a right main bronchial tumor longer than 12 months, who had been received endobronchial cryosurgery twice before. However, the tumor relapsed quickly. ...
journal_title:Journal of thoracic disease
pub_type: 杂志文章
doi:10.3978/j.issn.2072-1439.2015.10.51
更新日期:2015-10-01 00:00:00
abstract:Background:Robotic lobectomy is widely used for lung cancer treatment. So far, few studies have been performed to systematically analyze the learning curve. Our purpose is to define the learning curve to provide a training guideline of this technique. Methods:A total of 208 consecutive patients with primary lung cance...
journal_title:Journal of thoracic disease
pub_type: 杂志文章
doi:10.21037/jtd.2019.05.71
更新日期:2019-06-01 00:00:00
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journal_title:Journal of thoracic disease
pub_type: 杂志文章
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doi:10.21037/jtd.2017.02.70
更新日期:2017-03-01 00:00:00
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journal_title:Journal of thoracic disease
pub_type: 杂志文章,评审
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abstract:Background:To evaluate therapeutic efficacy of minimally invasive and small incision surgery [minimally invasive surgery (MIS)] in patients with non-flail chest rib fractures through a prospective cohort study. Methods:This study included 98 patients with non-flail chest rib fractures (≥3 displaced fractures) and 66 p...
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journal_title:Journal of thoracic disease
pub_type: 杂志文章
doi:10.3978/j.issn.2072-1439.2014.06.40
更新日期:2014-07-01 00:00:00
abstract::Natural history of acute Stanford type A aortic dissection (AAAD) implies the need of emergent surgical treatment in the vast majority of cases. Nevertheless, conservative treatment has been described to yield acceptable outcomes, when compared to surgery, in selected high risk cases of thrombosed false lumen. We repo...
journal_title:Journal of thoracic disease
pub_type: 社论
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journal_title:Journal of thoracic disease
pub_type: 杂志文章
doi:10.21037/jtd.2017.07.07
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journal_title:Journal of thoracic disease
pub_type: 杂志文章
doi:10.3978/j.issn.2072-1439.2015.07.10
更新日期:2015-07-01 00:00:00
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journal_title:Journal of thoracic disease
pub_type: 杂志文章
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