Knockdown of KCNQ1OT1 attenuates cardiac hypertrophy through modulation of the miR-2054/AKT3 axis.

abstract：Background:For malignant pleural mesothelioma (MPM), the benefit of resection, as well as the optimal surgical technique, remain controversial. In efforts to better refine patient selection, this retrospective observational cohort study queried the National Cancer Database in an effort to quantify and evaluate predicto...

journal_title：Journal of thoracic disease

authors： Wright C,Verma V,Barsky AR,Haque W,Polamraju PV,Ludmir EB,Zaorsky NG,Lehrer EJ,Trifiletti DM,Grover S,Friedberg JS,Simone CB 2nd

更新日期：2020-11-01 00:00:00

abstract：INTRODUCTION:Mediastinal tuberculous lymphadenitis (MTL) is mostly seen in primary tuberculosis in children, uncommon observed in adults. It usually presents the toxic symptoms of tuberculosis but rarely with symptoms characteristic of esophageal compression, such as dysphagia. Such patients can easily be misdiagnosed ...

journal_title：Journal of thoracic disease

authors： Xiong L,Mao X,Li C,Liu Z,Zhang Z

更新日期：2013-10-01 00:00:00

abstract：:Rituximab, a monoclonal antibody against CD20+ antigen specific B cell, has been increasingly used in the treatment of non-Hodgkin's lymphoma and some other autoimmune diseases, such as systemic lupus erythematosus (SLE) and rheumatoid arthritis. It is noted that Rituximab could enhanced the efficacy of CHOP-based che...

journal_title：Journal of thoracic disease

authors： Jiang XQ,Fang L,Mei XD,Wang XJ,Bao MH

更新日期：2013-08-01 00:00:00

abstract：Background:It is recommended that dilated ascending aortas (≥45 mm) should be replaced at the time of aortic valve replacement (AVR) for bicuspid aortic valve (BAV). The risk of progressive sinus of Valsalva dilatation after AVR and ascending aorta replacement is less clear. Methods:We identified 156 patients (age 56....

journal_title：Journal of thoracic disease

authors： Wang Y,Lin Y,Yin K,Zhu K,Yang Z,Sun Y,Lai H,Wang C

更新日期：2017-09-01 00:00:00

abstract：Background:Although morphological abnormalities of the heart appear to be remarkable, most patients with tako-tsubo cardiomyopathy (TTC) remain clinically stable. We investigate real time changes in the left ventricular (LV) and right ventricular (RV) mechanics and function to explore the mechanism to preserve hemodyna...

journal_title：Journal of thoracic disease

authors： Lei J,Sun Z,Lyu L,Green RG,Scalzetti E,Feiglin D,Wang J,Liu K

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND:Recent evidence suggests that a histone deacetylase inhibitor, suberoylanilide hydroxamic acid (SAHA), has anti-fibrotic effect. However, the exact mechanism of its anti-fibrotic potential remains is unclear. In this study, we investigated the molecular mechanism of SAHA in attenuating pulmonary fibrosis by ...

journal_title：Journal of thoracic disease

authors： Rao SS,Zhang XY,Shi MJ,Xiao Y,Zhang YY,Wang YY,Zhang CZ,Shao SJ,Liu XM,Guo B

更新日期：2016-09-01 00:00:00

abstract：Background:The novel HeartMate 3 (Abbott, Chicago, IL, USA) left ventricular assist device (LVAD) was worldwide first implanted by Prof. Schmitto and his team in 2014 at the Hannover Medical School, Germany and received CE Mark approval in October, 2015 following completion of a clinical trial. Methods:Although HeartM...

journal_title：Journal of thoracic disease

authors： Schmitto JD,Krabatsch T,Damme L,Netuka I

更新日期：2018-06-01 00:00:00

abstract：:Tumors of trachea and bronchi are uncommon and can occur in the form of benign or low- and high-grade malignant tumors. Although tracheobronchial tumors (TBTs) represent only 0.6% of all pulmonary tumors, they are clinically significant. Delays in diagnosis of these tumors commonly occur because the signs and symptoms...

journal_title：Journal of thoracic disease

authors： Stevic R,Milenkovic B

更新日期：2016-11-01 00:00:00

abstract：:Sepsis is a medical emergency and life-threatening condition due to a dysregulated host response to infection, which is time-dependent and associated with unacceptably high mortality. Thus, when treating suspicious or confirmed cases of sepsis, clinicians must initiate broad-spectrum antimicrobials within the first ho...

journal_title：Journal of thoracic disease

authors： Martínez ML,Plata-Menchaca EP,Ruiz-Rodríguez JC,Ferrer R

更新日期：2020-03-01 00:00:00

abstract：:The stress response is a preserved evolutionary response that functions to enhance the survival of the species. In mammals, the stress response is characterized by activation of the HPA axis and sympathoadrenal system (SAS) as well as the increased synthesis and secretion of vitamin C. Cortisol, catecholamines, and vi...

journal_title：Journal of thoracic disease

authors： Marik PE

更新日期：2020-02-01 00:00:00

abstract：Background:Trans-bronchoscope treatment for early stage small peripheral lung cancer, such as photodynamic therapy (PDT), has been investigated. However, despite the efficacy of PDT, light delivery issues limit its application. A method of administering mineral oil with a high refractive index (RI) was previously propo...

journal_title：Journal of thoracic disease

authors： Chang H,Liao KS,Hsieh YS

更新日期：2020-07-01 00:00:00

abstract：:The exact prevalence of pulmonary hypertension (PH) and cor pulmonale (CP) in chronic obstructive pulmonary disease (COPD) is unknown, and varies considerably from 20-91%. Usually, mean pulmonary artery pressure (mPAP) does not exceed 30 mmHg, and PH is not severe. However, PH and CP are important predictors of mortal...

journal_title：Journal of thoracic disease

authors： Opitz I,Ulrich S

更新日期：2018-08-01 00:00:00

abstract：Background:Tumor size of 8 cm or greater is a risk factor for recurrence after thymoma resection, but the role of induction therapy for large thymomas is not well defined. This study tested the hypothesis that induction therapy for thymomas 8 cm and larger improves survival. Methods:The use of induction therapy for pa...

journal_title：Journal of thoracic disease

authors： Liou DZ,Ramakrishnan D,Lui NS,Shrager JB,Backhus LM,Berry MF

更新日期：2020-04-01 00:00:00

abstract：Background:Bronchopleural fistula (BPF) remains a serious complication after surgery for lung cancer with bronchial resection. A free pericardial fat pad (FPFP) is applied in high-risk cases to reduce BPF frequency. BPF may occur 6 months after surgery. Thus, we evaluated the residual FPFP volume at 6 months after surg...

journal_title：Journal of thoracic disease

authors： Nagashima T,Ito H,Samejima J,Nemoto D,Eriguchi D,Nakayama H,Woo T,Masuda M

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND:A challenge for resection of thoracic inlet tumors lies in that high risk of injuring vital blood vessels and brachial plexus still exists during the resection. And the standard surgical approach for resection of thoracic inlet tumors has not yet been well established. METHODS:Small cervical incision-assist...

journal_title：Journal of thoracic disease

authors： Deng HY,Li ZH,Wang ZQ,Wang YC,Li G,Lin YD,Liu LX

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:Anastomotic leakage after cervical oesophagogastrostomy is a common and difficult problem. Mediastinal manifestation of anastomotic leakage may lead to mediastinitis with dramatic and potentially lethal outcome. Contamination of the mediastinum can be controlled by endoscopic placement of an expandable metal...

journal_title：Journal of thoracic disease

authors： Ponten JE,van der Horst S,Nieuwenhuijzen GA,Elenbaas TW,van Hillegersberg R,Luyer MD

更新日期：2013-04-01 00:00:00

abstract：Background:Robotic surgery is increasingly used to resect lung cancer. However costs are high. We compared costs and outcomes for robotic surgery, video-assisted thoracic surgery (VATS), and open surgery, to treat non-small cell lung cancer (NSCLC). Methods:We retrospectively assessed 103 consecutive patients given lo...

journal_title：Journal of thoracic disease

authors： Novellis P,Bottoni E,Voulaz E,Cariboni U,Testori A,Bertolaccini L,Giordano L,Dieci E,Granato L,Vanni E,Montorsi M,Alloisio M,Veronesi G

更新日期：2018-02-01 00:00:00

abstract：:Non-small-cell lung cancer (NSCLC) is a uniformly fatal disease and most patients will present with advanced stage. Treatment outcomes remain unsatisfactory, with low long-term survival rates. Standard treatment, such as palliative chemotherapy and radiotherapy, offers a median survival not exceeding 1 year. Hence, co...

journal_title：Journal of thoracic disease

authors： Méndez M,Custodio A,Provencio M

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:A clinical trial of extracorporeal membrane oxygenation (ECMO) as an alternative ventilator tool is being performed as a new indication for ECMO. The purpose of this study was to evaluate the feasibility of awake ECMO to increase the success rate of weaning patients from ECMO and ventilator care during treat...

journal_title：Journal of thoracic disease

authors： Yeo HJ,Cho WH,Kim D

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVE:To investigate diagnostic significance of percutaneous cavitary lavage (PCL) in differential diagnosis of benign and malignant pulmonary cavitary lesions. METHODS:An alternative diagnostic method called PCL was performed on 16 patients having peripherally located pulmonary cavitary lesions with thin walls wh...

journal_title：Journal of thoracic disease

authors： Belet U,Findik S,Ozmen Z,Atici AG,Akan H

更新日期：2013-08-01 00:00:00

abstract：:Liquid biopsy provides the opportunity of detecting and analyzing cancer in various body fluids. In peripheral blood, apart from circulating cell free DNA, circulating cancer cells and other tumor-associated compounds such as extracellular vesicles are also emerging candidates for detection. Compared to conventional t...

journal_title：Journal of thoracic disease

authors： Cheung AH,Chow C,To KF

更新日期：2018-06-01 00:00:00

abstract：Background:Pulmonary sequestration is a rare disease whose development begins in the embryonic stage. Surgery is the definitive treatment for eliminating respiratory symptoms and preventing complications. Reports of uniportal video-assisted thoracoscopic surgery (VATS) lobectomy and segmentectomy for pulmonary sequestr...

journal_title：Journal of thoracic disease

authors： Lin TH,Huang WL,Chang CC,Yen YT,Lai WW,Tseng YL,Chen YY

更新日期：2018-06-01 00:00:00

abstract：:Obstructive sleep apnea (OSA) is probably the most common respiratory disorder, with recent data from the United States and Europe suggesting that between 14% and 49% of middle-aged men have clinically significant OSA. The intimate relationship between OSA and obesity means that its prevalence will only increase as th...

journal_title：Journal of thoracic disease

authors： Garvey JF,Pengo MF,Drakatos P,Kent BD

更新日期：2015-05-01 00:00:00

abstract：Background:High levels of thymidylate synthase (TS) and dihydrofolate reductase (DHFR) expression in tumour tissues are an indicator of ineffective responses to pemetrexed-based chemotherapy in various tumours, including non-small cell lung cancer (NSCLC). However, tumour tissues are highly heterogeneous, so a single b...

journal_title：Journal of thoracic disease

authors： Li T,Huang JB,Lu JG,Li R,Wang Y,Shi XR,Shi MX,Zhang XD

更新日期：2020-12-01 00:00:00

abstract：Background:Hemoptysis can be a life-threatening condition that requires urgent treatment. Surgery still plays an important role in managing this critical situation, although previous reports have reported high postoperative morbidity and mortality rates. We report our experience with surgical resection for hemoptysis c...

journal_title：Journal of thoracic disease

authors： Yun JS,Song SY,Na KJ,Kim S,Jang KH,Jeong IS,Oh SG

更新日期：2018-06-01 00:00:00

abstract：Background:In patients with non-small cell lung cancer (NSCLC) the pathologic lymph node status N1 is a heterogeneous entity, and different forms of lymph node involvement may represent different prognoses. For methodological reasons, the 8th edition of the TNM staging system for NSCLC makes no official changes to the ...

journal_title：Journal of thoracic disease

authors： Griff S,Taber S,Bauer TT,Pfannschmidt J

更新日期：2019-08-01 00:00:00

abstract：OBJECTIVE:To investigate the relationship between respiratory viral load and lung lesion severity of patients with pandemic H1N1 2009 influenza A pneumonia. STUDY DESIGN:Cross-sectional observation study. METHODS:24 consecutive H1N1 influenza patients with viral pneumonia (13 males, 11 females, mean age: 17.5 years) ...

journal_title：Journal of thoracic disease

authors： Lu PX,Deng YY,Yang GL,Liu WL,Liu YX,Huang H,Wang YX

更新日期：2012-08-01 00:00:00

abstract：:Transcatheter aortic valve implantation is an important therapeutic option for patients with symptomatic, severe aortic stenosis at increased risk for open surgical aortic valve replacement. Although a number of alternative vascular access sites have been developed, transfemoral access is overwhelmingly the dominant a...

journal_title：Journal of thoracic disease

authors： Vora AN,Rao SV

更新日期：2018-11-01 00:00:00

abstract：Background:We describe a modified method to facilitate gastric mobilization in robotic esophagectomy. Furthermore, we performed a prospective comparative analysis of surgical outcomes between the conventional method and described technique. Methods:From April 1st, 2016 to December 31st, 2016, 59 consecutive patients w...

journal_title：Journal of thoracic disease

authors： Zheng Y,Zhao XW,Zhang HL,Wang ZH,Wang Y

更新日期：2017-12-01 00:00:00

abstract：Background:The incidence of conduction disturbances requiring permanent pacemaker (PPM) implantation following transcatheter aortic valve replacement (TAVR) have remained a common concern. The purpose of this study was to evaluate the impact of postprocedural PPM implantation following TAVR on clinical outcomes. Metho...

journal_title：Journal of thoracic disease

authors： Xi Z,Liu T,Liang J,Zhou YJ,Liu W

更新日期：2019-12-01 00:00:00