Vitamin C: an essential "stress hormone" during sepsis.

Abstract:

:The stress response is a preserved evolutionary response that functions to enhance the survival of the species. In mammals, the stress response is characterized by activation of the HPA axis and sympathoadrenal system (SAS) as well as the increased synthesis and secretion of vitamin C. Cortisol, catecholamines, and vitamin C act synergistically to increase hemodynamic reserve, maintain immune function and protect the host against excessive oxidant injury. Humans (and anthropoid apes) have lost the ability to synthesize vitamin C and therefore have an impaired stress response. The inability to produce vitamin C has serious implications in septic humans. Treatment with vitamin C appears to restore the stress response and improve the survival of stressed humans.

journal_name

J Thorac Dis

authors

Marik PE

doi

10.21037/jtd.2019.12.64

subject

Has Abstract

pub_date

2020-02-01 00:00:00

pages

S84-S88

issue

Suppl 1

eissn

2072-1439

issn

2077-6624

pii

jtd-12-S1-S84

journal_volume

12

pub_type

杂志文章,评审
  • Prognostic significance of CT-determined emphysema in patients with small cell lung cancer.

    abstract:Background:Although emphysema and small cell lung cancer (SCLC) are prevalent in smokers, no previous study has investigated the prognostic impact of computed tomography (CT)-determined emphysema in SCLC. This study was undertaken to analyze the prognostic value of emphysema scores as determined by baseline CT scans in...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2018.01.97

    authors: Lee HY,Kim EY,Kim YS,Ahn HK,Kim YK

    更新日期:2018-02-01 00:00:00

  • Enhanced recovery after elective surgery for lung cancer patients: analysis of current pathways and perspectives.

    abstract::The concept of enhanced recovery after surgery (ERAS), initially introduced in the field of colorectal surgery, has been developed in order to optimize the postoperative course. In recent years the number of authors analyzing the role of ERAS in lung cancer surgery is increasing, highlighting several interventions wit...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章,评审

    doi:10.21037/jtd.2019.01.99

    authors: Comacchio GM,Monaci N,Verderi E,Schiavon M,Rea F

    更新日期:2019-03-01 00:00:00

  • Detection of plasma T790M mutation after the first generation EGFR-TKI resistance of non-small cell lung cancer in the real world.

    abstract:Background:The epidermal growth factor receptor (EGFR) gene has been identified as the driving gene of non-small cell lung cancer (NSCLC), and EGFR-tyrosine kinase inhibitor (TKI) has shown efficacy, but acquired resistance is inevitable. It has been confirmed that the secondary EGFR Thr790Met (T790M) mutation accounts...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2019.12.122

    authors: Li H,Wang J,Zhang G,Li Y,Lin L,Yang H,Zhou J,Zhang L,Lv D

    更新日期:2020-03-01 00:00:00

  • Double lung point in an 18-month-old child: a case report and literature review.

    abstract:OBJECTIVE:Double lung point is a rare sign of pneumothorax in clinical practice. In this report I presented an 18-month-old child who presented with bilateral pneumothorax. DATA SYNTHESIS AND CASE PRESENTATION:Ultrasonography examination revealed conventional lung point sign on the right and double lung point on the l...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.3978/j.issn.2072-1439.2015.01.14

    authors: Zhang Z

    更新日期:2015-03-01 00:00:00

  • The nationwide program of allergic disease prevention as an implementation of GARD guidelines in Poland.

    abstract:Background:In 2006, the Global Alliance against Chronic Respiratory Diseases (GARD) was established. The GARD strategy is based mainly on activities aimed at implementing preventive tasks at a local and global level. In Poland, the National Health Program (NHP) is the strategic document describing the tasks of governme...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2018.08.97

    authors: Raciborski F,Samoliński B,Krzych-Fałta E,Grąbczewska A,Furman F,Bieszczad M,Morkisz P,Witkowska P,Bousquet J,Gujski M

    更新日期:2018-09-01 00:00:00

  • A systematic review and meta-analysis of thoracoscopic versus thoracotomy sleeve lobectomy.

    abstract:Background:Operative safety and oncologic adequacy of thoracoscopic sleeve lobectomy remain controversial. As such, the purpose of this meta-analysis was to evaluate evidence comparing thoracoscopy and thoracotomy in sleeve lobectomy for centrally located non-small cell lung cancer (NSCLC). Methods:Electronic searches...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd-20-1855

    authors: Zhong Y,Wang Y,Hu X,Wang G,She Y,Deng J,Zhang L,Peng Q,Zhu Y,Jiang G,Yang M,Xie D,Chen C

    更新日期:2020-10-01 00:00:00

  • Image-guided thoracoscopic surgery with dye localization in a hybrid operating room.

    abstract:BACKGROUND:The rate of detection of small pulmonary nodules (SPNs) has increased. Thoracoscopic resection following image-guided localization had been a reliable alternative in their treatment. We present our experience with image-guided dye localization using robotic C-arm computed tomography (CT) followed by immediat...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2016.09.55

    authors: Yang SM,Ko WC,Lin MW,Hsu HH,Chan CY,Wu IH,Chang YC,Chen JS

    更新日期:2016-10-01 00:00:00

  • Acute respiratory distress syndrome and pneumothorax.

    abstract::Acute respiratory distress syndrome (ARDS) can occur during the treatment of several diseases and in several interventional procedures as a complication. It is a difficult situation to handle and special care should be applied to the patients. Mechanical ventilation is used for these patients and several parameters ar...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章,评审

    doi:10.3978/j.issn.2072-1439.2014.08.34

    authors: Terzi E,Zarogoulidis K,Kougioumtzi I,Dryllis G,Kioumis I,Pitsiou G,Machairiotis N,Katsikogiannis N,Lampaki S,Papaiwannou A,Tsiouda T,Madesis A,Karaiskos T,Zaric B,Branislav P,Zarogoulidis P

    更新日期:2014-10-01 00:00:00

  • Latest development of liquid biopsy.

    abstract::Liquid biopsy provides the opportunity of detecting and analyzing cancer in various body fluids. In peripheral blood, apart from circulating cell free DNA, circulating cancer cells and other tumor-associated compounds such as extracellular vesicles are also emerging candidates for detection. Compared to conventional t...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章,评审

    doi:10.21037/jtd.2018.04.68

    authors: Cheung AH,Chow C,To KF

    更新日期:2018-06-01 00:00:00

  • Predictors of arterial desaturation during intubation: a nested case-control study of airway management-part I.

    abstract:Background:Arterial desaturations experienced during endotracheal intubation (ETI) may lead to poor outcomes. Thus, our primary aim was to identify predictors of arterial desaturation (pulse oximetry <90%) during the peri-intubation period and to assess outcomes of those who developed arterial hypoxemia. Methods:Adult...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2017.08.138

    authors: Smischney NJ,Seisa MO,Heise KJ,Wiegand RA,Busack KD,Loftsgard TO,Schroeder DR,Diedrich DA

    更新日期:2017-10-01 00:00:00

  • The diagnostic utility of endobronchial ultrasonography with a guide sheath and tomosynthesis images for ground glass opacity pulmonary lesions.

    abstract:BACKGROUND:With the widespread use of computed tomography (CT), the frequency of discovering ground glass opacity (GGO) pulmonary lesions has increased. There have been some reports on surgery or transthoracic needle aspiration (TTNA) for diagnostic sampling of GGOs but none on transbronchial biopsy (TBB). The purpose ...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.3978/j.issn.2072-1439.2013.11.30

    authors: Izumo T,Sasada S,Chavez C,Tsuchida T

    更新日期:2013-12-01 00:00:00

  • Experimental studies in the bronchial circulation. Which is the ideal animal model?

    abstract:BACKGROUND:The importance of the role of bronchial arteries is notable in modern days thoracic surgery. The significance of their anastomoses with adjusted structures has not yet been sufficiently rated, especially in cases of haemoptysis, heart-lung transplantations and treatment of aneurysms of the thoracic aorta. Th...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章,评审

    doi:10.3978/j.issn.2072-1439.2014.09.32

    authors: Kotoulas C,Panagiotou I,Tsipas P,Melachrinou M,Alexopoulos D,Dougenis D

    更新日期:2014-10-01 00:00:00

  • Use of laryngeal mask airway for non-endotracheal intubated anesthesia for patients with pectus excavatum undergoing thoracoscopic Nuss procedure.

    abstract:BACKGROUND:The aim of the present study was to determine the safety and feasibility of the use of laryngeal mask airway (LMA) for non-endotracheal intubated anesthesia for patients with pectus excavatum (PE) undergoing thoracoscopic Nuss procedure. METHODS:Between July 2015 and December 2015, 30 selected patients with...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2016.07.52

    authors: Du X,Mao S,Cui J,Ma J,Zhang G,Zheng Y,Zhou H,Xie L,Zhang D,Shi R,Chen G

    更新日期:2016-08-01 00:00:00

  • Uniportal video-assisted thoracoscopic surgery lobectomy and segmentectomy for pulmonary sequestration.

    abstract:Background:Pulmonary sequestration is a rare disease whose development begins in the embryonic stage. Surgery is the definitive treatment for eliminating respiratory symptoms and preventing complications. Reports of uniportal video-assisted thoracoscopic surgery (VATS) lobectomy and segmentectomy for pulmonary sequestr...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2018.05.151

    authors: Lin TH,Huang WL,Chang CC,Yen YT,Lai WW,Tseng YL,Chen YY

    更新日期:2018-06-01 00:00:00

  • Pleural dissemination of a mixed ground-glass opacity nodule treated as a nontuberculous mycobacterial infection for 6 years without growing remarkably.

    abstract::Pulmonary ground-glass opacity (GGO) nodules, which do not grow remarkably, are often observed without treatment. Lung tumors coexisting with inflammation and infection are difficult to diagnose. In this paper, we describe a very rare case of a pulmonary mixed GGO nodule with pleural dissemination. In 67-year-old fema...

    journal_title:Journal of thoracic disease

    pub_type:

    doi:10.3978/j.issn.2072-1439.2015.09.32

    authors: Shinohara S,Kuroda K,Shimokawa H,Kuwata T,Takenaka M,Chikaishi Y,Oka S,Hirai A,Imanishi N,Uramoto H,Tanaka F

    更新日期:2015-09-01 00:00:00

  • Uniportal video-assisted thoracoscopic sleeve lobectomy and other complex resections.

    abstract::Thanks to the recent improvements in thoracoscopy, a great deal of complex lung resections can be performed without performing thoracotomies. During the last years, experience gained through video-assisted thoracoscopic techniques, enhancement of the surgical instruments and improvement of high definition cameras have...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.3978/j.issn.2072-1439.2014.09.17

    authors: Gonzalez-Rivas D,Fieira E,Delgado M,de la Torre M,Mendez L,Fernandez R

    更新日期:2014-10-01 00:00:00

  • Prognostic significance of the pattern of pathological N1 lymph node metastases for non-small cell lung cancer.

    abstract:Background:In patients with non-small cell lung cancer (NSCLC) the pathologic lymph node status N1 is a heterogeneous entity, and different forms of lymph node involvement may represent different prognoses. For methodological reasons, the 8th edition of the TNM staging system for NSCLC makes no official changes to the ...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2019.07.73

    authors: Griff S,Taber S,Bauer TT,Pfannschmidt J

    更新日期:2019-08-01 00:00:00

  • Enhanced recovery pathways in thoracic surgery from Italian VATS Group: preoperative optimisation.

    abstract::Preoperative patient optimisation is a key point of enhanced recovery after thoracic surgery pathways. This could be particularly advantageous when considering video-assisted thoracic surgery (VATS) lobectomy, because reduced trauma related to minimally invasive techniques is one of the main factors favouring improved...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章,评审

    doi:10.21037/jtd.2017.12.82

    authors: D'Andrilli A,Massullo D,Rendina EA

    更新日期:2018-03-01 00:00:00

  • Nm23-H1 was involved in regulation of KAI1 expression in high-metastatic lung cancer cells L9981.

    abstract:BACKGROUND:The tetraspanin KAI1/CD82 was identified as a tumor metastasis suppressor that down-regulated in malignant progression of lung cancer. However, the underlying mechanism of anti-metastasis role of KAI1 in lung cancer is hardly known. In this paper, we sought to study the function and regulatory mechanism of K...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2016.04.59

    authors: You J,Chang R,Liu B,Zu L,Zhou Q

    更新日期:2016-06-01 00:00:00

  • Association between blood eosinophils with exacerbation and patient-reported outcomes in chronic obstructive pulmonary disease patients in an endemic area for parasitic infections: a prospective study.

    abstract:Background:Eosinophilic chronic obstructive pulmonary disease (COPD) patients have eosinophilic airway inflammation. No prospective study has reported blood eosinophil counts in an endemic area for parasitic infection. The primary objective was to compare exacerbation rates. The secondary objectives were patient-report...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd-19-4101

    authors: Juthong S,Kaenmuang P

    更新日期:2020-09-01 00:00:00

  • Bronchial aneurysm secondary to tuberculosis presenting with fatal hemoptysis: a case report and review of the literature.

    abstract::Fatal hemoptysis is a serious complication of pulmonary tuberculosis, which can rarely be due to a bronchial aneurysm. Here, we present a case of fatal hemoptysis due to bronchial aneurysm occurred in a 59-year-old patient of Han ethnicity suffering from active pulmonary tuberculosis. Meanwhile, we perform a literatur...

    journal_title:Journal of thoracic disease

    pub_type:

    doi:10.3978/j.issn.2072-1439.2014.04.07

    authors: Cheng YS,Lu ZW

    更新日期:2014-06-01 00:00:00

  • To avoid compensatory hyperhidrosis after sympathetic surgery for craniofacial hyperhidrosis.

    abstract:Background:Endoscopic thoracic sympathectomy (ETS) has not been widely adopted for treating craniofacial hyperhidrosis (CFH) due to its known postoperative complication, compensatory hyperhidrosis (CH). In this study, we evaluated whether the autonomic nerve analysis data via pre-ETS heart rate variability (HRV) test c...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2020.03.28

    authors: Moon DH,Kang DY,Lee HS,Lee JW,Lee YJ,Lee S

    更新日期:2020-05-01 00:00:00

  • Learning curve of uniportal video-assisted lobectomy: analysis of 15-month experience in a single center.

    abstract:Background:Uniportal video-assisted thoracoscopic (U-VATS) lobectomy has been becoming the technique of choice in an increasing number of centers. The aim of our study was to review our experience, evaluating the learning curve of U-VATS for lung lobectomy and outcomes. Methods:The prospectively collected clinical dat...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2018.03.133

    authors: Nachira D,Meacci E,Porziella V,Vita ML,Congedo MT,Chiappetta M,Petracca Ciavarella L,Ismail M,Gualtieri E,Cesario A,Margaritora S

    更新日期:2018-11-01 00:00:00

  • Combined lipiodol marking and video-assisted thoracoscopic surgery in a hybrid operating room.

    abstract:Background:The development of diagnostic technology has led to detection of an increasing number of small pulmonary nodules (SPNs), which can be difficult to locate intraoperatively. Here, we report our experience performing single-stage lipiodol localization and surgical resection in a hybrid operating room (OR). Met...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2018.05.28

    authors: Fumimoto S,Sato K,Koyama M,Yamamoto K,Narumi Y,Hanaoka N,Katsumata T

    更新日期:2018-05-01 00:00:00

  • Resection of the sidewall of superior vena cava using video-assisted thoracic surgery mechanical suture technique.

    abstract::Lung cancer invading the superior vena cava (SVC) is a locally advanced condition, for which poor prognosis is expected with conservative treatment alone. Surgical resection of the lesion can rapidly relieve the symptoms and significantly improve survival for some patients. Replacement, repair and partial resection of...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2016.01.55

    authors: Xu X,Qiu Y,Pan H,Mo L,Chen H,He J

    更新日期:2016-03-01 00:00:00

  • Premitive neuro-ectodermal tumour of the lung.

    abstract::Primitive neuro-ectodermal tumour of the lung is an extremely rare occurrence and we hereby report a case of a neuro-ectodermal tumour of the lung which was proved by immuno-histochemical examination of the resected specimen, and he had a very aggressive pattern of behavior. ...

    journal_title:Journal of thoracic disease

    pub_type:

    doi:10.3978/j.issn.2072-1439.2011.07.02

    authors: Gaude GS,Patil P,Malur P,Annurshetru S

    更新日期:2015-12-01 00:00:00

  • Cone beam CT imaging for bronchoscopy: a technical review.

    abstract::Cone beam computed tomography (CBCT) is a well-established imaging modality with numerous proven applications across multiple clinical disciplines. More recently, CBCT has emerged as an important imaging tool for bronchoscopists, primarily used during transbronchial biopsy of peripheral pulmonary lesions (PPLS). For t...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章,评审

    doi:10.21037/jtd-20-2382

    authors: Setser R,Chintalapani G,Bhadra K,Casal RF

    更新日期:2020-12-01 00:00:00

  • Uniportal video-assisted thoracoscopic surgery left upper lobe trisegmentectomy using flexible tip 3D video scope.

    abstract::A 69-year-old male patient with a history of melanoma and prostate cancer was found to have a 2.6 cm PET-avid, slowly enlarging, left upper lobe lung nodule that was suspicious for either metastasis or primary lung cancer. Due to the deep location of the nodule, a wedge resection was not recommended. A diagnostic and ...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2017.07.61

    authors: Thomas M

    更新日期:2017-09-01 00:00:00

  • Robotic lung segmentectomy for malignant and benign lesions.

    abstract:OBJECTIVE:Surgical use of robots has evolved over the last 10 years. However, the academic experience with robotic lung segmentectomy remains limited. We aimed to analyze our lung segmentectomy experience with robot-assisted thoracoscopic surgery. METHODS:Prospectively recorded clinical data of 21 patients who underwe...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.3978/j.issn.2072-1439.2014.06.40

    authors: Toker A,Ayalp K,Uyumaz E,Kaba E,Demirhan O,Erus S

    更新日期:2014-07-01 00:00:00

  • Anomalous right coronary artery origin with interarterial pathway-importance of morphological origin assessment and the role of percutaneous interventionism.

    abstract::Anomalies in coronary arteries (CA) are an important issue in cardiology and cardiovascular surgery. Specifically the anomalous origin of the right coronary artery (RCA) is of special importance because it is the most frequent anomaly. Clinical practice guidelines recommend the revascularization treatment in cases of ...

    journal_title:Journal of thoracic disease

    pub_type:

    doi:10.21037/jtd.2017.05.15

    authors: García Iglesias D,Martínez Fernández L,Martín Fernández M,García Suárez L,García Pérez L,Calvo Blanco J,Cigarrán Sexto H,Del Valle Fernández R,Morís de la Tassa C

    更新日期:2017-05-01 00:00:00