Abstract：
Background:Tumor size of 8 cm or greater is a risk factor for recurrence after thymoma resection, but the role of induction therapy for large thymomas is not well defined. This study tested the hypothesis that induction therapy for thymomas 8 cm and larger improves survival. Methods:The use of induction therapy for patients treated with surgical resection for Masaoka stage I-III thymomas in the National Cancer Database between 2006-2013 was evaluated using logistic regression, Kaplan-Meier analysis, and Cox-proportional hazards methods. Results:Of the 1,849 patients who met inclusion criteria, 582 (31.5%) had tumors ≥8 cm. Five-year survival was worse in patients with tumors ≥8 cm compared to smaller tumors [84.6% (95% CI: 81.2-88.1%) vs. 89.4% (95% CI: 87.2-91.7%), P=0.003]. Induction therapy was used in 166 (9.0%) patients overall and was more likely in patients with tumors ≥8 cm [adjusted odds ratio (AOR) 3.257, P<0.001]. Induction therapy was not associated with improved survival in the subset of patients with tumors ≥8 cm in either univariate [80.9% (95% CI: 72.6-90.1%) vs. 85.4% (95% CI: 81.8-89.3%), P=0.27] or multivariable analysis [hazard ratio (HR) 1.54, P=0.10]. Increasing age (HR 1.56/decade, P<0.001) and Masaoka stage III (HR 1.76, P=0.04) were associated with worse survival in patients with tumors ≥8 cm. Conclusions:Survival after thymoma resection is worse for tumors 8 cm or larger compared to smaller tumors and is not improved by induction therapy. Size alone should not be a criterion for using induction therapy prior to thymoma resection.
journal_name
J Thorac Disjournal_title
Journal of thoracic diseaseauthors
Liou DZ,Ramakrishnan D,Lui NS,Shrager JB,Backhus LM,Berry MFdoi
10.21037/jtd.2020.02.63subject
Has Abstractpub_date
2020-04-01 00:00:00pages
1329-1341issue
4eissn
2072-1439issn
2077-6624pii
jtd-12-04-1329journal_volume
12pub_type
杂志文章abstract：:With accumulation of experiences in video-assisted thoracic surgery (VATS) lobectomy, complete VATS sleeve lobectomy (SL) has been carried out in more and more medical centers. We here presented a procedure of sleeve right upper lobectomy by complete VATS for a 62-year-old male patient with central squamous cell carci...
journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：10.21037/jtd.2018.03.112
更新日期：2018-07-01 00:00:00
abstract：Background:Thoracoscopic surgery (TS) has been used more commonly as a less invasive procedure for early-stage non-small cell lung cancer (NSCLC) than conventional thoracotomy (TH) in Japan. However, limited evidential data are available to compare the treatment efficacy of TS and TH. The purpose of this study was to r...
journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：10.21037/jtd.2019.07.02
更新日期：2019-07-01 00:00:00
abstract：Background:This study analyzes the outcomes of a one-stage hybrid procedure combining thoracic endovascular aortic repair (TEVAR) with extra-anatomic bypass in patients with distal aortic arch disease. Methods:This retrospective study collected 103 hybrid procedures combining TEVAR with extra-anatomic bypass (mean age...
journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：10.21037/jtd-20-2338
更新日期：2020-12-01 00:00:00
abstract：:Management of pulmonary nodules in terms of diagnosis and intraoperative localization can be challenging, especially in the minimal invasive video-assisted thoracoscopic surgery (VATS) approach, and may be even more difficult with single port VATS with limited access. The ability to localize small lesions intraoperati...
journal_title：Journal of thoracic disease
pub_type： 杂志文章,评审
doi：10.3978/j.issn.2072-1439.2016.02.27
更新日期：2016-03-01 00:00:00
abstract：BACKGROUND:Beta-2 adrenergic receptor (β2AR) downregulation is critical to asthma rescue therapy; however, tolerance, also known as β2AR or bronchodilator desensitization, mechanisms potentially resulting in life-threatening rescue treatment failure remain poorly understood. METHODS:Airway smooth muscle cells (ASMCs) ...
journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：10.3978/j.issn.2072-1439.2013.10.07
更新日期：2013-10-01 00:00:00
abstract：:With the improvement in thoracoscopic and laparoscopic surgery, thoracoscopic and laparoscopic esophagectomy (TLE), a minimally invasive approach, has attracted increasing attention as an alternative to open three-field esophagectomy. From June 2012 to October 2013, 90 patients underwent laparoscopic and thoracoscopic...
journal_title：Journal of thoracic disease
pub_type：
doi：10.3978/j.issn.2072-1439.2014.02.04
更新日期：2014-02-01 00:00:00
abstract：:The cornerstone of curative care for esophageal cancer is neoadjuvant chemoradiotherapy followed by esophagectomy with a radical lymphadenectomy. An esophagectomy is a major and complex surgical procedure and is often followed by postoperative morbidity, especially pulmonary complications. These complications may lead...
journal_title：Journal of thoracic disease
pub_type： 杂志文章,评审
doi：10.21037/jtd.2018.11.75
更新日期：2019-04-01 00:00:00
abstract：:Along with the progresses that have been made in techniques and instruments, uniportal video-assisted thoracoscopic surgery (VATS) became more and more popular. Here, we present the operation video of a 52-year-old female with early stage lung cancer in the right upper lobe (RUL), who underwent uniportal VATS right up...
journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：10.21037/jtd.2017.05.26
更新日期：2017-06-01 00:00:00
abstract：BACKGROUND:The use of uniportal video-assisted thoracoscopic surgery (VATS) has been increasing worldwide. Our main goal was to describe the evolution of uniportal surgery in the biggest private hospital in Latin America that is located in São Paulo, Brazil. METHODS:This descriptive and retrospective study included pa...
journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：10.21037/jtd.2016.10.79
更新日期：2017-04-01 00:00:00
abstract：:Glomus tumors (GTs) of the trachea are very rare neoplasms that usually arise from the distal portion of the respiratory tree. The origin of these tumors is modified smooth muscle cells of glomus bodies. In this study, we describe two cases of GT of the trachea, as well as the histologic features of these tumors and t...
journal_title：Journal of thoracic disease
pub_type：
doi：10.21037/jtd.2017.08.54
更新日期：2017-09-01 00:00:00
abstract：Background:Permanent pacemaker implantation (PPI) is widely used for the treatment of chronic arrhythmia. The aim of the present study was to investigate the incidence of postoperative complications and the risk factors in patients with PPI. Methods:The clinical data of 124 patients who underwent PPI in our hospital f...
journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：10.21037/jtd-20-2913
更新日期：2020-10-01 00:00:00
abstract：BACKGROUND:Presently, the clinical effect of radical video-assisted thoracic surgery (VATS) is equal to that of traditional open chest surgery and has received worldwide recognition of its advantages: less trauma and faster recovery. In the attempt to further the advancement of minimally invasive surgery the operative ...
journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：10.3978/j.issn.2072-1439.2015.12.51
更新日期：2015-12-01 00:00:00
abstract：:Although surgical fixation of rib fractures is increasingly being performed around the world, very little has been published on how to access the chest wall itself. Having performed over one hundred rib fixations in our institution in the past five years, our surgical technique has evolved as more has come to be under...
journal_title：Journal of thoracic disease
pub_type： 杂志文章,评审
doi：10.21037/jtd.2019.03.33
更新日期：2019-05-01 00:00:00
abstract：:Sensory information arising from the airways is processed in a distributed brain network that encodes for the discriminative and affective components of the resultant sensations. These higher brain networks in turn regulate descending motor control circuits that can both promote or suppress behavioural responses. Here...
journal_title：Journal of thoracic disease
pub_type： 杂志文章,评审
doi：10.21037/jtd.2017.08.119
更新日期：2017-10-01 00:00:00
abstract：:The medical management of bronchiectasis includes confirming the diagnosis of the disease, evaluating the patient for possible underlying etiologies and then properly assessing the patient for appropriate therapies. Patients with bronchiectasis are heterogeneous and a personalized approach to each patient is needed in...
journal_title：Journal of thoracic disease
pub_type： 杂志文章,评审
doi：10.21037/jtd.2018.09.39
更新日期：2018-10-01 00:00:00
abstract：:Chronic obstructive pulmonary disease (COPD) remains a common cause of morbidity and mortality worldwide. Patients with COPD and respiratory failure, whether acute or chronic have a poorer prognosis than patients without respiratory failure. Non-invasive ventilation (NIV) has been shown to be a useful tool in both the...
journal_title：Journal of thoracic disease
pub_type： 杂志文章,评审
doi：10.21037/jtd.2017.10.44
更新日期：2018-01-01 00:00:00
abstract：Background:Acute myocardial infarction (AMI) is an acute disease with high mortality and seriously threatens human health. The identification of new effective biological markers for AMI is a prerequisite for treatment. Most proteomic studies have focused on atherosclerotic plaques, vascular cells, monocytes and platele...
journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：10.21037/jtd.2019.08.100
更新日期：2019-09-01 00:00:00
abstract：Backgrounds:The aim of this study was to report our Institutional experience with extended sleeve lobectomy (ESL) in centrally located non-small cell lung cancer (NSCLC), focusing on technical details, post-operative results, recurrence and survival, to determine whether ESL can be accepted as a favorable alternative p...
journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：10.21037/jtd-20-1241
更新日期：2020-08-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Chronic obstructive pulmonary disease (COPD) represents an increasing healthcare concern as a leading cause of morbidity and mortality worldwide. Our objective was to predict the outcome of COPD patients associated with multiple organ dysfunction syndrome (MODS) by scoring models. METHODS:A re...
journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：10.3978/j.issn.2072-1439.2014.11.27
更新日期：2015-03-01 00:00:00
abstract：Background:Functional mitral valve regurgitation is a frequent consequence of left ventricular dysfunction in patients with severe heart failure and is associated with a poor prognosis. It is hypothesized that in this patient group the mitral valve repair, respectively replacement, improves hemodynamics and clinical sy...
journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：10.21037/jtd.2018.05.36
更新日期：2018-06-01 00:00:00
abstract：:The Nuss procedure is a recently developed technique for correction of pectus excavatum. A 23-year-old female patient presented at our emergency department with clinical signs of cardiac tamponade, which required an emergency procedure. Sixteen months ago, she underwent the Nuss procedure with a single bar. Her preope...
journal_title：Journal of thoracic disease
pub_type：
doi：10.21037/jtd.2017.04.11
更新日期：2017-05-01 00:00:00
abstract：:The severity of the clinical condition and co-morbidities of the patients for esophagectomy require a complex assessment and risk stratification before the operation, and most of the cases need complex management. We did a literature search and considered the data on risk stratification and complex management of patie...
journal_title：Journal of thoracic disease
pub_type： 杂志文章,评审
doi：10.21037/jtd.2018.12.11
更新日期：2019-04-01 00:00:00
abstract：:Novel targeted therapy for patients with non-small-cell lung cancer (NSCLC) and oncogenic mutations along with poor performance status (PS) sometimes evokes a "Lazarus" response. Moreover, for critically ill patients with NSCLC and respiratory failure requiring mechanical ventilation (MV) in the intensive care unit (I...
journal_title：Journal of thoracic disease
pub_type： 评论,杂志文章
doi：10.21037/jtd.2016.11.110
更新日期：2016-11-01 00:00:00
abstract：BACKGROUND:The aim of the present study was to identify specious radiologic and/or physiologic prognostic marker(s), which lead to optimize of the patient follow-up frequency. METHODS:Eighty consecutive patients with newly diagnosed pulmonary sarcoidosis. Patients underwent chest radiography, high-resolution computed ...
journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：10.21037/jtd.2017.01.17
更新日期：2017-01-01 00:00:00
abstract：BACKGROUND:Recurrence of pectus excavatum (PE) is not an uncommon problem after open repair using the Ravitch technique. The optimal approach for redo surgery is still under debate, especially in adults with less chest wall pliability. Aim of this study was to investigate the usefulness and efficacy of the minimally in...
journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：10.21037/jtd.2016.06.60
更新日期：2016-08-01 00:00:00
abstract：:Central venous catheters (CVCs) have an important role in the management of critically ill patients. In contrast to the immediate complications after CVC insertion, the late complications were difficult to be noticed without high suspicion despite their life-threatening outcome. We report a rare but fatal delayed vasc...
journal_title：Journal of thoracic disease
pub_type：
doi：10.21037/jtd.2017.08.50
更新日期：2017-09-01 00:00:00
abstract：Background:Fluid resuscitation is critical to perioperative maintenance of adequate preload and cardiac output after cardiac surgery. Liberal use of saline, however, is reportedly associated with an increased risk of acute kidney injury (AKI) in critically ill patients. This study examined the effects of high- versus l...
journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：10.21037/jtd.2018.10.113
更新日期：2018-12-01 00:00:00
abstract：Background:Whether lobe-specific lymph node dissection (L-SLND) could serve as an alternative to systematic lymph node dissection (SLND) in treating early-stage non-small cell lung cancer (NSCLC) remains unclear. Therefore, we conducted this comprehensive meta-analysis to compare the effect of L-SLND with that of SLND ...
journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：10.21037/jtd.2018.04.137
更新日期：2018-05-01 00:00:00
abstract：:Transesophageal echocardiography (TEE) was first used routinely in the operating rooms in the 1980s to facilitate surgical decision-making. Since then, TEE has evolved from the standard two-dimensional (2D) exam to include focused real-time three-dimensional (RT-3D) imaging both inside and outside the operating rooms....
journal_title：Journal of thoracic disease
pub_type： 杂志文章,评审
doi：10.21037/jtd.2017.03.123
更新日期：2017-04-01 00:00:00
abstract：Background:Various approaches and markers for marking the lungs prior to lung tumor resection have been reported. In clinical practice, the hook wire localization method is often used owing to the simplicity of the technique. However, although rare, this method is associated with air embolism, which can be lethal. Beca...
journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：10.21037/jtd.2020.01.06
更新日期：2020-03-01 00:00:00
