Impact of attenuated plaques on TIMI grade flow and clinical outcomes of coronary artery disease patients: a systematic review and meta analysis.

Abstract:

BACKGROUND:Plaques with a large necrotic core or lipid pool and thin-cap fibroatheroma manifest as attenuated plaques on intravascular ultrasound (IVUS). Their impact on TIMI grade flow and clinical outcomes remains undefined. We performed a systematic review and meta-analysis to summarize the association between attenuated plaque and distal embolization and clinical outcomes of coronary artery disease (CAD) from pooled data of published eligible cohort studies. METHODS:We searched the literature on TIMI grade flow and clinical outcomes on PubMed, Ovid, EMBASE, the Cochrane Library, CNKI and WanFang databases. Study heterogeneity and publication bias were estimated. RESULTS:A total of 3,833 patients were enrolled in nine studies. Five studies investigated TIMI grade flow and attenuated plaques. They revealed no difference in TIMI grade flow before percutaneous coronary intervention (PCI) between the attenuated and non-attenuated plaque group (RR =1.25; 95% CI: 0.65 to 2.41; P=0.50). After balloon dilation and stent implantation, the incidence of TIMI 0~2 grade flow in the attenuated plaque group was statistically significant higher than that of the non-attenuated plaque group (RR =4.73; 95% CI: 3.03 to 7.40; P<0.001). Five other studies investigated major cardiovascular events (MACEs) and attenuated plaques and found no difference in MACE rates within three years of follow up. CONCLUSIONS:Our study presents the evidence that plaque with ultrasound signal attenuation would induce slow/no reflow phenomenon and distal embolization during PCI, but this appearance has no impact on MACE rates within three years.

journal_name

J Thorac Dis

authors

Jia R,Nie X,Li H,Zhu H,Pu L,Li X,Han J,Yang D,Meng S,Jin Z

doi

10.21037/jtd.2016.02.51

subject

Has Abstract

pub_date

2016-03-01 00:00:00

pages

527-36

issue

3

eissn

2072-1439

issn

2077-6624

pii

jtd-08-03-527

journal_volume

8

pub_type

杂志文章
  • Circular RNA profiling identified as a biomarker for predicting the efficacy of Gefitinib therapy for non-small cell lung cancer.

    abstract:Background:Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) have become important treatment options for non-small cell lung cancer (NSCLC) patients with EGFR sensitive mutation. However, the detection of EGFR driver mutation is impeded by the lack of adequate tumor tissues, histopathological type...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2019.05.22

    authors: Liu YT,Han XH,Xing PY,Hu XS,Hao XZ,Wang Y,Li JL,Zhang ZS,Yang ZH,Shi YK

    更新日期:2019-05-01 00:00:00

  • Identification of key genes and pathways in calcific aortic valve disease by bioinformatics analysis.

    abstract:Background:Calcific aortic valve disease (CAVD) is the most common type of valvular heart disease in the elderly. This study is aimed to explore molecular mechanism of CAVD via bioinformatics analysis. Methods:The gene expression profiles of GSE51472 (including 5 normal aortic valve and 5 calcified aortic valve) and G...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2019.11.57

    authors: Zhang Y,Ma L

    更新日期:2019-12-01 00:00:00

  • Accumulation of periostin in acute exacerbation of familial idiopathic pulmonary fibrosis.

    abstract::Periostin, an extracellular matrix molecule, is associated with idiopathic pulmonary fibrosis (IPF). It is known that the frequency of familial IPF (FIPF) ranges from 0.5% to 2.2% among IPF cases. However, the relationship between periostin and FIPF has not been previously described. We report the first case of perios...

    journal_title:Journal of thoracic disease

    pub_type:

    doi:10.21037/jtd.2018.06.96

    authors: Murata K,Koga Y,Kasahara N,Hachisu Y,Nunomura S,Nakajima N,Yokoo H,Kaira K,Maeno T,Dobashi K,Izuhara K,Hisada T

    更新日期:2018-07-01 00:00:00

  • Role of electromagnetic navigational bronchoscopy in pulmonary nodule management.

    abstract::The incidence of pulmonary nodules and lung cancer is rising. Some of this increase in incidence is due to improved pick up by newer imaging modalities. However, the goal is to diagnose these lesion, many of which are located in the periphery, by safe and relatively non-invasive methods. This has led to the emergence ...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章,评审

    doi:10.21037/jtd.2016.02.73

    authors: Goud A,Dahagam C,Breen DP,Sarkar S

    更新日期:2016-07-01 00:00:00

  • Single-port video-assisted thoracoscopic surgery for a huge epiphrenic esophageal diverticulum.

    abstract::Epiphrenic esophageal diverticulum is uncommon disease, which is defined as the herniation of the mucosa and submucosa through the muscle layers of the esophageal wall in distal third of the esophagus. Traditionally, thoracotomy has been the preferred surgical approach. Recently, many surgeons have attempted minimally...

    journal_title:Journal of thoracic disease

    pub_type:

    doi:10.21037/jtd.2017.01.29

    authors: Kang DK

    更新日期:2017-01-01 00:00:00

  • Five-year outcomes after thoracic endovascular aortic repair of symptomatic type B penetrating aortic ulcer with intramural hematoma in Chinese patients.

    abstract:Background:The aim of this study is to evaluate the five-year outcomes after thoracic endovascular aortic repair (TEVAR) of symptomatic Stanford type B penetrating aortic ulcer (PAU) associated with intramural hematoma (IMH) in Chinese patients. Methods:From January 2009 to April 2013, 118 patients with typical severe...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2018.12.86

    authors: Liu J,Liu Y,Yang W,Gu J,Xue S

    更新日期:2019-01-01 00:00:00

  • Results of concomitant groin-free percutaneous temporary RVAD support using a centrifugal pump with a double-lumen jugular venous cannula in LVAD patients.

    abstract:Background:Modern left ventricular assist devices (LVAD) have evolved to become standard of care in severe heart failure (HF) patients. Right HF (RHF) is a major complication responsible for early mortality. Several techniques for temporary right ventricular assist device (t-RVAD) have been described before, baring rel...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2018.11.121

    authors: Schmack B,Farag M,Kremer J,Grossekettler L,Brcic A,Raake PW,Kreusser MM,Goldwasser R,Popov AF,Mansur A,Karck M,Ruhparwar A

    更新日期:2019-04-01 00:00:00

  • Update: non-invasive ventilation in chronic obstructive pulmonary disease.

    abstract::Chronic obstructive pulmonary disease (COPD) remains a common cause of morbidity and mortality worldwide. Patients with COPD and respiratory failure, whether acute or chronic have a poorer prognosis than patients without respiratory failure. Non-invasive ventilation (NIV) has been shown to be a useful tool in both the...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章,评审

    doi:10.21037/jtd.2017.10.44

    authors: Shah NM,D'Cruz RF,Murphy PB

    更新日期:2018-01-01 00:00:00

  • Tracheobronchial tumors.

    abstract::Tumors of trachea and bronchi are uncommon and can occur in the form of benign or low- and high-grade malignant tumors. Although tracheobronchial tumors (TBTs) represent only 0.6% of all pulmonary tumors, they are clinically significant. Delays in diagnosis of these tumors commonly occur because the signs and symptoms...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章,评审

    doi:10.21037/jtd.2016.11.24

    authors: Stevic R,Milenkovic B

    更新日期:2016-11-01 00:00:00

  • Comparison of outcomes following isolated repair of tricuspid versus bicuspid aortic valves.

    abstract:Background:Aortic valve repair (AV-repair) is an alternative treatment option for patients with aortic regurgitation (AR), but durability is still reason for concern, especially for bicuspid aortic valves (BAV). We retrospectively evaluated mid-term results after AV-repair in patients with BAV or tricuspid aortic valve...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd-19-4193

    authors: Prinzing A,Boehm J,Erlebach M,Sideris K,Lange R,Krane M

    更新日期:2020-07-01 00:00:00

  • Clinicopathological characteristics and prognosis of non-lepidic invasive adenocarcinoma presenting as ground glass opacity nodule.

    abstract:BACKGROUND:Ground glass opacity (GGO) generally associated with the lepidic component of lung adenocarcinoma. However, in some cases, GGO nodules have been associated with invasive adenocarcinomas, where a lepidic component is minimal or absent. The purpose of this study is to evaluate the clinicopathological character...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2016.08.46

    authors: Moon Y,Sung SW,Lee KY,Park JK

    更新日期:2016-09-01 00:00:00

  • Adiponectin protects rat heart from left ventricular remodeling induced by chronic intermittent hypoxia via inhibition of TGF-β/smad2/3 pathway.

    abstract:OBJECTIVE:Obstructive sleep apnea syndrome (OSAS) is associated with many cardiovascular disorders. Chronic intermittent hypoxia (CIH) is the primary player in OSAS of the many associated factors. This study was in order to investigate the effects of the Adiponectin (Ad) on left ventricular remodeling induced by CIH. ...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.3978/j.issn.2072-1439.2014.07.44

    authors: Ding WX,Dong YB,Ding N,Zhang XF,Zhang SJ,Zhang XL,Liu JN,Lu G

    更新日期:2014-09-01 00:00:00

  • Technical difficulties and extending the indications for VATS lobectomy.

    abstract:BACKGROUND:Data on advantages of video-assisted thoracoscopic surgery (VATS) lobectomies has been accumulated during the last 10 years then number of thoracoscopic anatomic pulmonary resections rapidly increased. But still there is no agreement about limitations of the method. The most popular "technical contraindicati...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.3978/j.issn.2072-1439.2014.10.11

    authors: Pischik VG

    更新日期:2014-10-01 00:00:00

  • Outcomes of minimally invasive sleeve resection.

    abstract:Background:Sleeve resection allows for preservation of lung parenchyma and improved long-term outcomes when compared with pneumonectomy. Little is known about minimally invasive sleeve resection, especially indications, feasibility, technical aspects, complications, and outcomes. We reviewed our institutional experienc...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2018.10.97

    authors: Caso R,Watson TJ,Khaitan PG,Marshall MB

    更新日期:2018-12-01 00:00:00

  • Combining current of injury and P-wave sensing optimized right atrial active-fixation leads implantation.

    abstract:Background:Pacing parameters may influence pacing lead life and pacemaker life. This study sought to determine whether different right atrial active-fixation lead implantation parameters are associated with chronic pacing performance. Methods:A retrospective observational study was conducted on all consecutive patient...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2019.04.04

    authors: Chen MR,Zhang FL,Wang WW,Chen XH,Chen JH,Chen LL

    更新日期:2019-04-01 00:00:00

  • The role of red blood cell distribution width in mortality and cardiovascular risk among patients with coronary artery diseases: a systematic review and meta-analysis.

    abstract:BACKGROUND:Red cell distribution width (RDW) might be a novel biomarker that reflects multiple physiological impairments related to atherosclerosis and coronary artery diseases (CAD). We conducted this systematic review and meta-analysis to evaluate the association of RDW between all-cause mortality and fatal/non-fatal...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.3978/j.issn.2072-1439.2014.09.10

    authors: Su C,Liao LZ,Song Y,Xu ZW,Mei WY

    更新日期:2014-10-01 00:00:00

  • Erratum to transcatheter valve-in-valve implantation versus reoperative conventional aortic valve replacement: a systematic review.

    abstract::[This corrects the article on p. E83 in vol. 8, PMID: 26904259.]. ...

    journal_title:Journal of thoracic disease

    pub_type: 已发布勘误

    doi:10.21037/jtd.2016.09.33

    authors:

    更新日期:2016-09-01 00:00:00

  • Combining targeted agents and hypo- and hyper-fractionated radiotherapy in NSCLC.

    abstract::Radical radiotherapy remains the cornerstone of treatment for patients with unresectable locally advanced non small cell lung cancer (NSCLC) either as single modality treatment for poor performance status patients or with sequential or concomitant chemotherapy for good performance status patients. Advances in understa...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章,评审

    doi:10.3978/j.issn.2072-1439.2013.12.05

    authors: McDonald F,Popat S

    更新日期:2014-04-01 00:00:00

  • Unusual cardiac paraganglioma mimicking an atypical carcinoid tumor of the lung.

    abstract::We present a case of unusual cardiac paraganglioma (PG) initially misdiagnosed as atypical carcinoid tumor of the lung and discuss key clinical and pathologic characteristics that guide surgical management of these rare chromaffin cell tumors. A 64-year-old female with persistent cough and back pain was found to have ...

    journal_title:Journal of thoracic disease

    pub_type:

    doi:10.21037/jtd.2017.11.132

    authors: Spencer D,Evans M,Wang B,Delrosario JL,Cheng T,Milliken J

    更新日期:2018-01-01 00:00:00

  • Implications of pneumonitis after chemoradiation and durvalumab for locally advanced non-small cell lung cancer.

    abstract:Background:Consolidation durvalumab improved overall survival (OS) in locally advanced non-small cell lung cancer (LA-NSCLC) treated with chemoradiotherapy (CRT) in the PACIFIC trial; however, pneumonitis was increased with durvalumab. We sought to examine real-world outcomes with the PACIFIC paradigm, especially facto...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd-20-1792

    authors: Hassanzadeh C,Sita T,Savoor R,Samson PP,Bradley J,Gentile M,Roach M,Mohindra N,Waqar S,Kruser TJ,Robinson C

    更新日期:2020-11-01 00:00:00

  • Impact of pathological complete response following neoadjuvant chemoradiotherapy in esophageal cancer.

    abstract:Background:Neoadjuvant radiochemotherapy (nRCT) followed by surgery has become the gold standard treatment in patients with locally advanced esophageal cancer. The pathological response is an important predictor in such patients. This work represents a single-center analysis investigating the impact of pathological com...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2018.06.85

    authors: Soror T,Kho G,Zhao KL,Ismail M,Badakhshi H

    更新日期:2018-07-01 00:00:00

  • Clinical feasibility and efficacy of video-assisted thoracic surgery (VATS) anatomical resection in patients with central lung cancer: a comparison with thoracotomy.

    abstract:BACKGROUND:The aim of this study is to evaluate the clinical feasibility and efficacy of video-assisted thoracoscopic surgery (VATS) anatomical pulmonary resection in patients with central lung cancer. METHODS:Between July 2004 and December 2011, 465 patients underwent anatomical pulmonary resection and systematic med...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.3978/j.issn.2072-1439.2015.10.32

    authors: Jung HS,Kim HR,Choi SH,Kim YH,Kim DK,Park SI

    更新日期:2015-10-01 00:00:00

  • Efficacy and safety of high-dose budesonide/formoterol in patients with bronchiolitis obliterans syndrome after allogeneic hematopoietic stem cell transplant.

    abstract:Background:Bronchiolitis obliterans syndrome (BOS) is a rare, progressive and irreversible airway disease associated with significant mortality after allogeneic hematopoietic stem-cell transplantation (HSCT). In this study, we investigated the therapeutic effect of high-dose budesonide/formoterol (320/9 µg bid) in pati...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd-19-3475

    authors: Kim KH,Lee J,Kim HJ,Lee S,Kim YJ,Lee JH,Rhee CK

    更新日期:2020-08-01 00:00:00

  • Dynamic expression of transformating growth factor-β1 and caveolin-1 in the lung of Bleomycin-induced interstitial lung disease.

    abstract:BACKGROUND:Interstitial lung disease (ILD) is a disease with high mortality worldwide. Unfortunately, its prognosis is still very poor. Therefore, developing the target molecular is very important for ILD diagnosis and treatment. Caveolin-1 (Cav-1) can regulate the formation of fibrosis by linking to the signaling path...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2017.07.01

    authors: Xing Y,Wang L,Wang H,Kong X,Zhan L

    更新日期:2017-08-01 00:00:00

  • Uniportal video-assisted thoracoscopic right upper lobectomy and systemic mediastinal lymph nodes dissection.

    abstract::Along with the progresses that have been made in techniques and instruments, uniportal video-assisted thoracoscopic surgery (VATS) became more and more popular. Here, we present the operation video of a 52-year-old female with early stage lung cancer in the right upper lobe (RUL), who underwent uniportal VATS right up...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2017.05.26

    authors: He J,Ma D,Li S

    更新日期:2017-06-01 00:00:00

  • Image-guided thoracoscopic surgery with dye localization in a hybrid operating room.

    abstract:BACKGROUND:The rate of detection of small pulmonary nodules (SPNs) has increased. Thoracoscopic resection following image-guided localization had been a reliable alternative in their treatment. We present our experience with image-guided dye localization using robotic C-arm computed tomography (CT) followed by immediat...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2016.09.55

    authors: Yang SM,Ko WC,Lin MW,Hsu HH,Chan CY,Wu IH,Chang YC,Chen JS

    更新日期:2016-10-01 00:00:00

  • Bronchoscopic light delivery method for peripheral lung cancer photodynamic therapy.

    abstract:Background:Trans-bronchoscope treatment for early stage small peripheral lung cancer, such as photodynamic therapy (PDT), has been investigated. However, despite the efficacy of PDT, light delivery issues limit its application. A method of administering mineral oil with a high refractive index (RI) was previously propo...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd-19-3887

    authors: Chang H,Liao KS,Hsieh YS

    更新日期:2020-07-01 00:00:00

  • EphA2 chimeric antigen receptor-modified T cells for the immunotherapy of esophageal squamous cell carcinoma.

    abstract:Background:It is urgent to explore an effective potential therapeutic strategy for ESCC. In recent years, cell-based cancer immunotherapy has become a potentially close for carcinoma therapy. Chimeric antigen receptor (CAR) T cell technology is a kind of adoptive cell therapy technique which has been developed rapidly....

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2018.04.91

    authors: Shi H,Yu F,Mao Y,Ju Q,Wu Y,Bai W,Wang P,Xu R,Jiang M,Shi J

    更新日期:2018-05-01 00:00:00

  • Urinothorax: a systematic review.

    abstract:BACKGROUND:The characteristics of patients with urinothorax (UT) are poorly defined. METHODS:A systematic review was performed searching for studies reporting clinical findings, pleural fluid (PF) characteristics, and the most effective treatment of UT. Case descriptions and retrospective studies were included. RESUL...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2017.04.22

    authors: Toubes ME,Lama A,Ferreiro L,Golpe A,Álvarez-Dobaño JM,González-Barcala FJ,San José E,Rodríguez-Núñez N,Rábade C,Lourido T,Valdés L

    更新日期:2017-05-01 00:00:00

  • PET/CT evaluation of response to chemotherapy in non-small cell lung cancer: PET response criteria in solid tumors (PERCIST) versus response evaluation criteria in solid tumors (RECIST).

    abstract:BACKGROUND:(18)F-FDG PET/CT is increasingly used in evaluation of treatment response for patients with non-small cell lung cancer (NSCLC). There is a need for an accurate criterion to evaluate the effect and predict the prognosis. The aim of this study is to evaluate therapeutic response in NSCLC with comparing PET res...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.3978/j.issn.2072-1439.2014.05.10

    authors: Ding Q,Cheng X,Yang L,Zhang Q,Chen J,Li T,Shi H

    更新日期:2014-06-01 00:00:00