Impact of pathological complete response following neoadjuvant chemoradiotherapy in esophageal cancer.

Abstract:

Background:Neoadjuvant radiochemotherapy (nRCT) followed by surgery has become the gold standard treatment in patients with locally advanced esophageal cancer. The pathological response is an important predictor in such patients. This work represents a single-center analysis investigating the impact of pathological complete response (pCR) on treatment outcome. Methods:All patients treated with nRCT followed by surgery between January 2005 and December 2015 were reviewed. The patients were categorized into two groups according to the pathological response following nRCT: pCR group and non-pCR group. Results:Fifty-six patients with invasive cancer, 23 patients (41.1%) achieved pCR and 33 patients had non-pCR (58.9%) following nRCT. The average age was 62 years (±9.1), and most patients were males (83.9%). Histological types included squamous cell carcinoma (75%) and adenocarcinoma (25%). The total radiation dose was 45 Gy in 76.8% of the patients and 50.4 Gy in 23.2%. The median overall survival (OS) of the entire group was 3.5±1.2 years, and the 5-year OS rate was 38.2%, while the median disease-free survival (DFS) was 2.1±0.4 years and the 5-year DFS rate was 33.1%. The patients who achieved pCR had significantly higher 5-year OS and 5-year DFS rates: 47.2% and 48% compared to 27.3% and 21% for the non-pCR patients respectively (P=0.04, 0.03). The median time of local recurrence was 3.8±0.4 years in pCR group and 1.8±0.2 years in non-pCR group (P=0.01), while the median time of distant metastases in pCR group was 1.2±0.5 years and 1.1±0.2 years in non-pCR group (P=0.6). Conclusions:Complete pathological response predicts significantly higher rates of OS and DFS in patients with locally advanced esophageal cancer treated with nRCT followed by surgery.

journal_name

J Thorac Dis

authors

Soror T,Kho G,Zhao KL,Ismail M,Badakhshi H

doi

10.21037/jtd.2018.06.85

subject

Has Abstract

pub_date

2018-07-01 00:00:00

pages

4069-4076

issue

7

eissn

2072-1439

issn

2077-6624

pii

jtd-10-07-4069

journal_volume

10

pub_type

杂志文章
  • Robotic surgery, video-assisted thoracic surgery, and open surgery for early stage lung cancer: comparison of costs and outcomes at a single institute.

    abstract:Background:Robotic surgery is increasingly used to resect lung cancer. However costs are high. We compared costs and outcomes for robotic surgery, video-assisted thoracic surgery (VATS), and open surgery, to treat non-small cell lung cancer (NSCLC). Methods:We retrospectively assessed 103 consecutive patients given lo...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2018.01.123

    authors: Novellis P,Bottoni E,Voulaz E,Cariboni U,Testori A,Bertolaccini L,Giordano L,Dieci E,Granato L,Vanni E,Montorsi M,Alloisio M,Veronesi G

    更新日期:2018-02-01 00:00:00

  • Serum lactate dehydrogenase activity and its isoenzyme patterns in patients with pectus excavatum.

    abstract:Background:In previous study, we found elevated serum total lactate dehydrogenase (LDH) before correction of pectus excavatum and a decrease in total LDH after the deformity correction. In the present study, we analyzed total LDH activity and its isoenzyme patterns to investigate the causes of these laboratory findings...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2019.09.49

    authors: Jeong SC,Kim JJ,Kim YH,Kim IS,Han JW

    更新日期:2019-10-01 00:00:00

  • Lipid management for coronary heart disease patients: an appraisal of updated international guidelines applying Appraisal of Guidelines for Research and Evaluation II-clinical practice guideline appraisal for lipid management in coronary heart disease.

    abstract:Background:Clinical practice guidelines (CPGs) provide many recommendations for hyperlipidemia management, but some of them are still debatable. Methods:We applied the six-domain Appraisal of Guidelines for Research and Evaluation II (AGREE II) instrument to evaluate the quality of guidelines with lipid management rec...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2019.07.71

    authors: Zhou H,Zhang S,Sun X,Yang D,Zhuang X,Guo Y,Hu X,Du Z,Zhang M,Liao X

    更新日期:2019-08-01 00:00:00

  • How well does pathologic stage predict survival for esophageal adenocarcinoma after neoadjuvant therapy?

    abstract:BACKGROUND:Cancer staging systems are designed to predict survival and stratify patients. The 7(th) edition of the American Joint Commission on Cancer (AJCC7) staging system for esophageal cancer was modeled using survival data on patients who underwent esophagectomy without induction or adjuvant therapy. In the United...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.3978/j.issn.2072-1439.2015.04.30

    authors: Kim JY,Nelson RA,Kim J,Raz D

    更新日期:2015-04-01 00:00:00

  • COPD in India: Iceberg or volcano?

    abstract::The purpose of this article is to provide an overview of the epidemiology of COPD in India which is one of the most affected countries in the world and contributes significantly to the mortality and morbidity of this disease; to provide insights into the etiological determinants of COPD in India; comment on treatment ...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.3978/j.issn.2072-1439.2012.03.15

    authors: Bhome AB

    更新日期:2012-06-01 00:00:00

  • The European Society of Thoracic Surgeons (ESTS) lung neuroendocrine tumors (NETs) database.

    abstract::Histological characteristics and clinical behaviour define lung neuroendocrine tumors (NETs), which are classified into four groups: typical (TC) and atypical carcinoids (AC), large-cell neuroendocrine carcinomas (LCNCs) and small-cell lung cancers (SCLCs). Historically, outcome and treatment of these rare neoplasms h...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章,评审

    doi:10.21037/jtd.2018.04.104

    authors: Filosso PL,Falcoz PE,Solidoro P,Pellicano D,Passani S,Guerrera F,Ruffini E,ESTS Lung Neuroendocrine Working-Group Participating Centers*.

    更新日期:2018-10-01 00:00:00

  • Occupational adverse effects and protective factors in bronchoscopy.

    abstract::The application of bronchoscopy has resolved a series of diagnostic and treatment challenges in pulmonary diseases. However, the occupational adverse effects experienced by healthcare workers in interventional pulmonology should receive increasing attention. Various aspects of adverse effects in bronchoscopy are often...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章,评审

    doi:10.21037/jtd.2019.03.73

    authors: Chen K,Bai C

    更新日期:2019-04-01 00:00:00

  • Nocturnal pulse rate and symptomatic response in patients with obstructive sleep apnoea treated with continuous positive airway pressure for one year.

    abstract:BACKGROUND:Obstructive sleep apnoea (OSA) is the most common form of sleep-disordered breathing and a known risk factor for cardiovascular disease. We hypothesised that in patients with OSA the characteristics of nocturnal pulse rate (PR) are associated with changes in blood pressure and daytime sleepiness, following c...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.3978/j.issn.2072-1439.2014.05.09

    authors: Pengo MF,Drakatos P,Kosky C,Williams A,Hart N,Rossi GP,Steier J

    更新日期:2014-06-01 00:00:00

  • Chemotherapy treatment in malignant pleural mesothelioma: a difficult history.

    abstract::Malignant pleural mesothelioma (MPM) is a rare neoplasm that typically arises from mesothelial surfaces of the pleural cavity. Despite treatment improvements, it carries a dismal prognosis. The majority of patients either have unresectable disease or are not candidates for surgery due to medical comorbidities or old a...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章,评审

    doi:10.21037/jtd.2017.10.19

    authors: Cinausero M,Rihawi K,Sperandi F,Melotti B,Ardizzoni A

    更新日期:2018-01-01 00:00:00

  • Difference of environment behind research and clinical practice between USA and Japan.

    abstract::Recent studies have demonstrated that there are differences among races in efficacy, tolerance and other outcomes in oncologic care. Some of these differences may be explained by different pharmacogenetics; however, social and environmental factors that can affect oncology practice are relatively underestimated. In th...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章,评审

    doi:10.21037/jtd.2019.07.70

    authors: Komiya T,Chaaya G,Deshotels L,Wang A

    更新日期:2020-07-01 00:00:00

  • Impact of metformin on survival outcome of esophageal squamous cell carcinomas patients undergoing surgical resection: a multicenter retrospective study.

    abstract:Background:Diabetes mellitus is a recognized risk factor for esophageal squamous cell carcinomas (ESCC), and metformin is a recognized protective factor for some gastrointestinal tumors. But knowledge is limited regarding the effect of metformin on survival outcome of ESCC patients with type 2 diabetes mellitus (T2DM)....

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2019.12.98

    authors: He HH,Fu JH,Hao ZX,Wu HF,Zhong Q,Wang F,Liu HH,Gu XS,Wang B,Huang HD,Li ZY,He JX

    更新日期:2020-03-01 00:00:00

  • Use of laryngeal mask airway for non-endotracheal intubated anesthesia for patients with pectus excavatum undergoing thoracoscopic Nuss procedure.

    abstract:BACKGROUND:The aim of the present study was to determine the safety and feasibility of the use of laryngeal mask airway (LMA) for non-endotracheal intubated anesthesia for patients with pectus excavatum (PE) undergoing thoracoscopic Nuss procedure. METHODS:Between July 2015 and December 2015, 30 selected patients with...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2016.07.52

    authors: Du X,Mao S,Cui J,Ma J,Zhang G,Zheng Y,Zhou H,Xie L,Zhang D,Shi R,Chen G

    更新日期:2016-08-01 00:00:00

  • Risk factors for obstructive sleep apnea-related hypertension in police officers in Southern China.

    abstract:Background:Obstructive sleep apnea (OSA) is an independent risk factor for hypertension. OSA-related hypertension is common and treatment of OSA can reduce blood pressure (BP). However, few studies have been conducted on this type of hypertension in the Chinese occupational population. Methods:We conducted a field inv...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2019.09.83

    authors: Pan M,Ou Q,Chen B,Hong Z,Liu H

    更新日期:2019-10-01 00:00:00

  • Results of the introduction of a minimally invasive esophagectomy program in a tertiary referral center.

    abstract:BACKGROUND:Esophagectomy is accompanied by a high postoperative complication rate. Minimally invasive esophageal surgery appears to be a promising technique that might be associated with a lower pulmonary morbidity rate. The objective of this study was to describe the implementation of minimally invasive esophageal sur...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.3978/j.issn.2072-1439.2012.09.05

    authors: Blom RL,Klinkenbijl JH,Hollmann MW,Bergman JJ,Cuesta MA,Bemelman WA,Busch OR,van Berge Henegouwen MI

    更新日期:2012-10-01 00:00:00

  • Interstitial lung disease: the diagnostic role of bronchoscopy.

    abstract::Interstitial lung diseases (ILDs) form one of the most fascinating fields in pulmonary medicine. They also pose one of the greatest challenges for accurate diagnosis and proper treatment. Even within the recommended and warranted multidisciplinary approach, differentiating between one disease and another may lead to f...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章,评审

    doi:10.21037/jtd.2017.06.39

    authors: Kebbe J,Abdo T

    更新日期:2017-09-01 00:00:00

  • Erratum to rhinovirus is associated with severe adult community-acquired pneumonia in China.

    abstract::[This corrects the article DOI: 10.21037/jtd.2017.10.107.]. ...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章,已发布勘误

    doi:10.21037/jtd.2018.11.11

    authors: Wang K,Xi W,Yang D,Zheng Y,Zhang Y,Chen Y,Yan C,Tian G,An S,Li X,An F,Du J,Hu K,Cao J,Ren L,Huang F,Gao Z

    更新日期:2018-12-01 00:00:00

  • Macrolide antibiotics in the treatment of chronic rhinosinusitis: evidence from a meta-analysis.

    abstract:Background:The purpose of this study was to systematically assess the subjective and objective outcomes of macrolide therapy for chronic rhinosinusitis (CRS). Methods:PubMed, Embase and Cochrane databases were searched for clinical trials detailing the effects of macrolide therapy in patients with CRS and published up...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2018.10.41

    authors: Shen S,Lou H,Wang C,Zhang L

    更新日期:2018-10-01 00:00:00

  • Enhanced recovery pathways in thoracic surgery from Italian VATS Group: preoperative optimisation.

    abstract::Preoperative patient optimisation is a key point of enhanced recovery after thoracic surgery pathways. This could be particularly advantageous when considering video-assisted thoracic surgery (VATS) lobectomy, because reduced trauma related to minimally invasive techniques is one of the main factors favouring improved...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章,评审

    doi:10.21037/jtd.2017.12.82

    authors: D'Andrilli A,Massullo D,Rendina EA

    更新日期:2018-03-01 00:00:00

  • Surgery for hemoptysis in patients with benign lung disease.

    abstract:Background:Hemoptysis can be a life-threatening condition that requires urgent treatment. Surgery still plays an important role in managing this critical situation, although previous reports have reported high postoperative morbidity and mortality rates. We report our experience with surgical resection for hemoptysis c...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2018.05.122

    authors: Yun JS,Song SY,Na KJ,Kim S,Jang KH,Jeong IS,Oh SG

    更新日期:2018-06-01 00:00:00

  • Severe gastroparesis causing postoperative respiratory complications in a heart-lung recipient.

    abstract::Heart-lung transplantation is reserved for selected patients who have end-stage cardiac and pulmonary disease. Gastroparesis, which is associated with aspiration, is commonly seen after transplantation. Here, we present a case in which gastric contents aspiration leads to Pseudomonas aeruginosa pulmonary infection, 11...

    journal_title:Journal of thoracic disease

    pub_type:

    doi:

    authors: Tao Y,Yan Z,Sha J,Zhu Z,Lei H

    更新日期:2010-06-01 00:00:00

  • Mitral valve repair for ischemic mitral regurgitation: lessons from the Cardiothoracic Surgical Trials Network randomized study.

    abstract::Approximately 30% to 50% of patients will develop ischemic mitral regurgitation (MR) after a myocardial infarction, which is a result of progressive left ventricular remodeling and dysfunction of the subvalvular apparatus, and portends a poor long-term prognosis. Surgical treatment is centered on mitral valve repair u...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.3978/j.issn.2072-1439.2016.01.27

    authors: Mihos CG,Santana O

    更新日期:2016-01-01 00:00:00

  • Aberrant epithelial remodeling with impairment of cilia architecture in non-cystic fibrosis bronchiectasis.

    abstract:Background:Aberrant epithelial remodeling and/or abnormalities in mucociliary apparatus in airway epithelium contribute to infection and inflammation. It is uncertain if these changes occur in both large and small airways in non-cystic fibrosis bronchiectasis (non-CF bronchiectasis). In this study, we aim to investigat...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2018.02.13

    authors: Chen ZG,Li YY,Wang ZN,Li M,Lim HF,Zhou YQ,Cai LM,Li YT,Yang LF,Zhang TT,Wang DY

    更新日期:2018-03-01 00:00:00

  • Interatrial block predicts atrial fibrillation in patients with carotid and coronary artery disease.

    abstract:Background:Interatrial block (IAB) has been previously shown to predict atrial fibrillation (AF) in cardiac populations. This study sought to evaluate the relationship between IAB and new-onset AF in a population of patients undergoing clinically indicated coronary angiography who received carotid ultrasonography. Met...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2018.06.53

    authors: Alexander B,Baranchuk A,Haseeb S,van Rooy H,Kuchtaruk A,Hopman W,Çinier G,Hetu MF,Li TY,Johri AM

    更新日期:2018-07-01 00:00:00

  • Uniportal video-assisted thoracic surgery right upper lobectomy with systemic lymphadenectomy.

    abstract::This video demonstrated a performance of uniportal video-assisted thoracoscopic surgery (VATS) right upper lobectomy with systemic lymphadenectomy. The patient had a malignant mass in his right upper lobe. The operator took a posterior to anterior approach to dissection the right upper lobe, the adjacent structures we...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2016.05.01

    authors: Han DP,Xiang J,Li HC,Hang JB

    更新日期:2016-08-01 00:00:00

  • Lung transplantation, ex-vivo reconditioning and regeneration: state of the art and perspectives.

    abstract::Lung transplantation is the only therapeutic option for end-stage pulmonary failure. Nevertheless, the shortage of donor pool available for transplantation does not allow to satisfy the requests, thus the mortality on the waiting list remains high. One of the tools to overcome the donor pool shortage is the use of ex-...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章,评审

    doi:10.21037/jtd.2018.04.151

    authors: Rosso L,Zanella A,Righi I,Barilani M,Lazzari L,Scotti E,Gori F,Mendogni P

    更新日期:2018-07-01 00:00:00

  • Devising the guidelines: the techniques of uniportal video-assisted thoracic surgery-postoperative management and enhanced recovery after surgery.

    abstract::Kehlet first introduced the notion of enhanced recovery after surgery (ERAS). Moreover, in the last years, the fast-track programmes demonstrated a reduction of complications and the hospital length of stay in general surgery. ERAS involves a multidisciplinary to development the value of care introducing the evidence-...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章,评审

    doi:10.21037/jtd.2019.01.62

    authors: Bertolaccini L,Brunelli A

    更新日期:2019-09-01 00:00:00

  • Aorta-atria-septum combined incision for aortic valve re-replacement.

    abstract::This case report illustrates a patient who underwent supra-annular mechanical aortic valve replacement then suffered from prosthesis dysfunction, increasing pressure gradient with aortic valve. She was successfully underwent aortic valve re-replacement, sub-annular pannus removing and aortic annulus enlargement proced...

    journal_title:Journal of thoracic disease

    pub_type:

    doi:10.21037/jtd.2018.04.48

    authors: Xu Y,Ye X,Li Z,Zhao Q

    更新日期:2018-04-01 00:00:00

  • Transcatheter aortic valve implantation for patients with lung cancer and aortic valve stenosis.

    abstract::Many patients who require lung resection have cardiovascular and cerebrovascular comorbidities. It has been recommended that surgical aortic valve replacement (SAVR) should precede lung resection in patients with severe aortic valve stenosis (AS). However, by first undergoing transcatheter aortic valve implantation (T...

    journal_title:Journal of thoracic disease

    pub_type:

    doi:10.21037/jtd.2018.04.83

    authors: Sakai T,Yahagi K,Miura S,Hoshino T,Yokota T,Tanabe K,Ikeda S

    更新日期:2018-05-01 00:00:00

  • Navigational transbronchial needle aspiration, percutaneous needle aspiration and its future.

    abstract::Peripheral lung nodule evaluation represents a clinical challenge. Given that many nodules will be incidentally found with lung cancer screening following the publication of the National Lung Screening Trial (NLST), the goal is to find an accurate, safe and minimally-invasive diagnostic modality to biopsy the concerni...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章,评审

    doi:10.3978/j.issn.2072-1439.2015.11.16

    authors: Arias S,Yarmus L,Argento AC

    更新日期:2015-12-01 00:00:00

  • Clinical features of pulmonary mucormycosis in patients with different immune status.

    abstract:Background:Pulmonary mucormycosis (PM) is a relatively rare but often fatal and rapidly progressive disease. Most studies of PM are case reports or case series with limited numbers of patients, and focus on immunocompromised patients. We investigated the clinical manifestations, imaging features, treatment, and outcome...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2019.12.53

    authors: Peng M,Meng H,Sun Y,Xiao Y,Zhang H,Lv K,Cai B

    更新日期:2019-12-01 00:00:00