Chemotherapy treatment in malignant pleural mesothelioma: a difficult history.

Abstract:

:Malignant pleural mesothelioma (MPM) is a rare neoplasm that typically arises from mesothelial surfaces of the pleural cavity. Despite treatment improvements, it carries a dismal prognosis. The majority of patients either have unresectable disease or are not candidates for surgery due to medical comorbidities or old age. For such patients, chemotherapy (CT) represents the gold-standard treatment. To date, combination CT with cisplatin plus pemetrexed represents the most widely used regimen in first-line setting for patients with unresectable MPM. Other first-line options are currently available, including the use of raltitrexed instead of pemetrexed combined with platinum. In this review, we discuss the role of CT in MPM mainly focusing on the results of the trials conducted in first-line setting.

journal_name

J Thorac Dis

authors

Cinausero M,Rihawi K,Sperandi F,Melotti B,Ardizzoni A

doi

10.21037/jtd.2017.10.19

subject

Has Abstract

pub_date

2018-01-01 00:00:00

pages

S304-S310

issue

Suppl 2

eissn

2072-1439

issn

2077-6624

pii

jtd-10-S2-S304

journal_volume

10

pub_type

杂志文章,评审
  • Long-term oncological outcome after thoracoscopic lobectomy for non-small cell lung cancer patients.

    abstract:Background:Thoracoscopic surgery (TS) has been used more commonly as a less invasive procedure for early-stage non-small cell lung cancer (NSCLC) than conventional thoracotomy (TH) in Japan. However, limited evidential data are available to compare the treatment efficacy of TS and TH. The purpose of this study was to r...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2019.07.02

    authors: Nakao M,Ichinose J,Matsuura Y,Nakagawa K,Okumura S,Mun M

    更新日期:2019-07-01 00:00:00

  • Short-term high-intensity rehabilitation in radically treated lung cancer: a three-armed randomized controlled trial.

    abstract:BACKGROUND:The feasibility and practicality of preoperative rehabilitation (PR) programs remains quite controversial in the treatment of lung cancer (LC). This study explored whether a short-term high-intensity rehabilitation program could improve postoperative outcomes compared to those achieved with conventional insp...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2017.06.15

    authors: Huang J,Lai Y,Zhou X,Li S,Su J,Yang M,Che G

    更新日期:2017-07-01 00:00:00

  • Prognostic factors for resection of isolated pulmonary metastases in breast cancer patients: a systematic review and meta-analysis.

    abstract:BACKGROUND:Lung is a common organ of metastases in patients with primary breast cancer. Pulmonary metastasis of primary breast cancer is usually considered as a systemic disease, however, the systemic approaches have achieved little progress in terms of prolonging survival time. In contrast, some studies revealed a pro...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.3978/j.issn.2072-1439.2015.08.10

    authors: Fan J,Chen D,Du H,Shen C,Che G

    更新日期:2015-08-01 00:00:00

  • Enhanced recovery after elective surgery for lung cancer patients: analysis of current pathways and perspectives.

    abstract::The concept of enhanced recovery after surgery (ERAS), initially introduced in the field of colorectal surgery, has been developed in order to optimize the postoperative course. In recent years the number of authors analyzing the role of ERAS in lung cancer surgery is increasing, highlighting several interventions wit...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章,评审

    doi:10.21037/jtd.2019.01.99

    authors: Comacchio GM,Monaci N,Verderi E,Schiavon M,Rea F

    更新日期:2019-03-01 00:00:00

  • Idiopathic pulmonary fibrosis: a holistic approach to disease management in the antifibrotic age.

    abstract::Idiopathic pulmonary fibrosis (IPF) is the most common cause of interstitial lung disease (ILD) and carries a worse prognosis than many cancers. Until recently, there were no active treatment options available for patients with IPF, meaning palliation or lung transplantation in selected patients were the only options....

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章,评审

    doi:10.21037/jtd.2017.10.111

    authors: Shaw J,Marshall T,Morris H,Hayton C,Chaudhuri N

    更新日期:2017-11-01 00:00:00

  • Revival of impaired lung perfusion after sleeve lobectomy.

    abstract::Sleeve resection, a mainstay for centrally-located lung cancer, is a challenging procedure when the preserved lung is impaired. We herein reported a 61-year-old male who underwent right upper sleeve lobectomy for squamous cell carcinoma located at the orifice of the upper bronchus. The tumor invaded the main bronchus....

    journal_title:Journal of thoracic disease

    pub_type:

    doi:10.21037/jtd.2016.02.17

    authors: Shibano T,Tsubochi H,Endo S,Yamamoto S,Maki M

    更新日期:2016-03-01 00:00:00

  • Mechanical interventricular dependency supports hemodynamics in tako-tsubo cardiomyopathy.

    abstract:Background:Although morphological abnormalities of the heart appear to be remarkable, most patients with tako-tsubo cardiomyopathy (TTC) remain clinically stable. We investigate real time changes in the left ventricular (LV) and right ventricular (RV) mechanics and function to explore the mechanism to preserve hemodyna...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2018.04.143

    authors: Lei J,Sun Z,Lyu L,Green RG,Scalzetti E,Feiglin D,Wang J,Liu K

    更新日期:2018-05-01 00:00:00

  • How to obtain adequate biopsy specımen in suspected thymic tumors.

    abstract::Pathologic diagnosis of thymic tumors (TTs) can be made by surgical or nonsurgical procedures. About 20% of TTs had been diagnosed by pretreatment biopsy methods while the rest had gone to surgery for diagnosis and treatment. However, in the last two decades there was an increase in pretreatment procedures for optimal...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章,评审

    doi:10.21037/jtd-2019-thym-14

    authors: Bilaçeroğlu S

    更新日期:2020-12-01 00:00:00

  • Detection, classification, and management of rejection after lung transplantation.

    abstract::Rejection is a major complication following lung transplantation. Acute cellular rejection, lymphocytic bronchiolitis, and antibody-mediated rejection (AMR) are all risk factors for the subsequent development of chronic lung allograft dysfunction (CLAD). Acute cellular rejection and lymphocytic bronchiolitis have well...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章,评审

    doi:10.21037/jtd.2019.03.83

    authors: Parulekar AD,Kao CC

    更新日期:2019-09-01 00:00:00

  • Role of electromagnetic navigational bronchoscopy in pulmonary nodule management.

    abstract::The incidence of pulmonary nodules and lung cancer is rising. Some of this increase in incidence is due to improved pick up by newer imaging modalities. However, the goal is to diagnose these lesion, many of which are located in the periphery, by safe and relatively non-invasive methods. This has led to the emergence ...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章,评审

    doi:10.21037/jtd.2016.02.73

    authors: Goud A,Dahagam C,Breen DP,Sarkar S

    更新日期:2016-07-01 00:00:00

  • Devising the guidelines: the techniques of uniportal video-assisted thoracic surgery-postoperative management and enhanced recovery after surgery.

    abstract::Kehlet first introduced the notion of enhanced recovery after surgery (ERAS). Moreover, in the last years, the fast-track programmes demonstrated a reduction of complications and the hospital length of stay in general surgery. ERAS involves a multidisciplinary to development the value of care introducing the evidence-...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章,评审

    doi:10.21037/jtd.2019.01.62

    authors: Bertolaccini L,Brunelli A

    更新日期:2019-09-01 00:00:00

  • Report on 153 sequential three-incision robotic-assisted pulmonary resections by a single surgeon: technical details and learning curve.

    abstract:Background:There are several techniques for robotic-assisted pulmonary resection, depending on the number and position of ports and utility incisions. We developed a technique for three-incision robotic-assisted pulmonary resection, and here we reported our initial results. Methods:Three-incision pulmonary resection w...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2019.12.116

    authors: Peng M,Wang X,Chen C,Tan S,Liu W,Yu F

    更新日期:2020-03-01 00:00:00

  • Comparison of the single-lumen endotracheal tube and double-lumen endobronchial tube used in minimally invasive cardiac surgery for the fast track protocol.

    abstract:BACKGROUND:Minimally invasive cardiac surgery (MICS) has been more commonly performed due to the reduced amount of bleeding and transfusion and length of hospital stay. We investigated the feasibility of performing MICS using single-lumen endotracheal tube (SLT). METHODS:We conducted a retrospective review of clinical...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2016.03.13

    authors: Kim HY,Baek SH,Je HG,Kim TK,Kim HJ,Ahn JH,Park SJ

    更新日期:2016-05-01 00:00:00

  • Influence of cannula positioning on brain injury during extracorporeal membrane oxygenation.

    abstract:Background:In veno-arterial extracorporeal membrane oxygenation (V-A ECMO), a patient is cannulated using either an atrio-aortic technique (central type ECMO; cECMO) or a femoro-femoral technique (peripheral type ECMO; pECMO). The direction of the pump flow at the aortic arch is anterograde from the ascending aorta in ...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2018.10.74

    authors: Jeong SC,Kim HJ,Shin YS,Han JW,Lim JY,Son HS

    更新日期:2018-11-01 00:00:00

  • Tracheal replacement.

    abstract::Non-malignant and malignant obstruction of the tracheal airway causes significant morbidity and mortality. With increased use of artificial airways, benign and iatrogenic complications are increasing. A tracheal stenosis that is less than 5 cm in length can be resected with end-to-end anastomosis. Longer tracheal lesi...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章,评审

    doi:10.3978/j.issn.2072-1439.2016.01.85

    authors: Delaere P,Van Raemdonck D

    更新日期:2016-03-01 00:00:00

  • Atypical histiocytosis in the lung.

    abstract:OBJECTIVE:To report a rare case of atypical histiocytic tumor of the lung with a review of literature. METHODS:The clinical materials were noted. Literature related to this condition from the past 50 years was reviewed from the group of histiocytic tumors. RESULTS AND CONCLUSIONS:Clinical manifestations were non-spec...

    journal_title:Journal of thoracic disease

    pub_type:

    doi:10.3978/j.issn.2072-1439.2013.07.26

    authors: Li H,Cao W,Li H,Zhang R,Zhou Y,Xu J,Garfield DH

    更新日期:2013-08-01 00:00:00

  • New molecular targeted therapies for advanced non-small-cell lung cancer.

    abstract::Non-small-cell lung cancer (NSCLC) is a uniformly fatal disease and most patients will present with advanced stage. Treatment outcomes remain unsatisfactory, with low long-term survival rates. Standard treatment, such as palliative chemotherapy and radiotherapy, offers a median survival not exceeding 1 year. Hence, co...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.3978/j.issn.2072-1439.2010.12.03

    authors: Méndez M,Custodio A,Provencio M

    更新日期:2011-03-01 00:00:00

  • Veno-arterial extracorporeal membrane oxygenation without therapeutic anticoagulation for intra-operative cardiopulmonary support during lung transplantation.

    abstract::Cardiopulmonary support is frequently required during lung transplantation. Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) has been recently shown to be an acceptable and, perhaps, safer alternative to cardiopulmonary bypass machine (CBM) for lung transplantation. However, therapeutic anticoagulation used...

    journal_title:Journal of thoracic disease

    pub_type:

    doi:10.21037/jtd.2017.06.11

    authors: Bharat A,DeCamp MM

    更新日期:2017-07-01 00:00:00

  • Development of a self-treatment approach for patients with COPD and comorbidities: an ongoing learning process.

    abstract:BACKGROUND:Patient-initiated action plans are an important component of COPD self-management (SM) interventions. When integrated into SM interventions, these action plans have proven to be effective in reducing exacerbation severity, hospitalisations, and costs and in improving health status in patients with COPD witho...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章,评审

    doi:10.3978/j.issn.2072-1439.2014.11.14

    authors: Effing TW,Lenferink A,Buckman J,Spicer D,Cafarella PA,Burt MG,Bassett KL,van Ommeren C,Anesbury S,van der Valk PD,Frith PA,van der Palen J

    更新日期:2014-11-01 00:00:00

  • Total endoscopic repair of atrial septal defect under on-pump beating heart.

    abstract:Background:We previously reported the techniques for total endoscopic atrial septal defect (ASD) repair on hearts arrested with cardioplegia through three small incisions in the chest wall without aid of a surgical robotic system. The optimal results motivated us to use total thoracoscopic technology for ASD on perfuse...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2018.10.89

    authors: Tang Y,Wu Y,Zhu J,Liu X,Zhou J,Huang H,Li M,Dai Y,Han X

    更新日期:2018-12-01 00:00:00

  • Lobectomy versus sublobar resection in patients with non-small cell lung cancer: a systematic review.

    abstract::Surgery is the gold standard treatment of lung cancer. The minimally invasive technique does not only concern access to the chest but also the limits of parenchymal resection. The study debates on the safety and oncological adequacy of sublobar resections in bronchogenic carcinoma patients. A systematic analysis of th...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章,评审

    doi:10.21037/jtd.2020.02.54

    authors: Divisi D,De Vico A,Zaccagna G,Crisci R

    更新日期:2020-06-01 00:00:00

  • Uniportal video-assisted thoracoscopic sleeve lobectomy and other complex resections.

    abstract::Thanks to the recent improvements in thoracoscopy, a great deal of complex lung resections can be performed without performing thoracotomies. During the last years, experience gained through video-assisted thoracoscopic techniques, enhancement of the surgical instruments and improvement of high definition cameras have...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.3978/j.issn.2072-1439.2014.09.17

    authors: Gonzalez-Rivas D,Fieira E,Delgado M,de la Torre M,Mendez L,Fernandez R

    更新日期:2014-10-01 00:00:00

  • Lymph node involvement according to lung adenocarcinoma subtypes: lymph node involvement is influenced by lung adenocarcinoma subtypes.

    abstract:Backgrounds:Invasive adenocarcinoma subtypes are known to be associated with prognosis; however, the underlying reason remains unclear. To find out the reason, we investigated the possible influence of lymph node (LN) involvement by the constituent histologic subtypes in the tumor and clarified the different prognosis ...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2017.08.132

    authors: Park JK,Kim JJ,Moon SW,Lee KY

    更新日期:2017-10-01 00:00:00

  • Robotic lung segmentectomy for malignant and benign lesions.

    abstract:OBJECTIVE:Surgical use of robots has evolved over the last 10 years. However, the academic experience with robotic lung segmentectomy remains limited. We aimed to analyze our lung segmentectomy experience with robot-assisted thoracoscopic surgery. METHODS:Prospectively recorded clinical data of 21 patients who underwe...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.3978/j.issn.2072-1439.2014.06.40

    authors: Toker A,Ayalp K,Uyumaz E,Kaba E,Demirhan O,Erus S

    更新日期:2014-07-01 00:00:00

  • Erratum to rhinovirus is associated with severe adult community-acquired pneumonia in China.

    abstract::[This corrects the article DOI: 10.21037/jtd.2017.10.107.]. ...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章,已发布勘误

    doi:10.21037/jtd.2018.11.11

    authors: Wang K,Xi W,Yang D,Zheng Y,Zhang Y,Chen Y,Yan C,Tian G,An S,Li X,An F,Du J,Hu K,Cao J,Ren L,Huang F,Gao Z

    更新日期:2018-12-01 00:00:00

  • Three common exposures of the chest wall for rib fixation: anatomical considerations.

    abstract::Although surgical fixation of rib fractures is increasingly being performed around the world, very little has been published on how to access the chest wall itself. Having performed over one hundred rib fixations in our institution in the past five years, our surgical technique has evolved as more has come to be under...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章,评审

    doi:10.21037/jtd.2019.03.33

    authors: Greiffenstein P,Tran MQ,Campeau L

    更新日期:2019-05-01 00:00:00

  • Tubeless video-assisted thoracoscopic surgery (VATS) under non-intubated, intravenous anesthesia with spontaneous ventilation and no placement of chest tube postoperatively.

    abstract:BACKGROUND:To assess the feasibility and safety of tubeless video-assisted thoracoscopic surgery (VATS) under non-intubated, intravenous anesthesia with spontaneous ventilation and no placement of a chest tube postoperatively compared with VATS under intubated anesthesia with single-lung mechanical ventilation. METHOD...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2016.08.02

    authors: Cui F,Liu J,Li S,Yin W,Xin X,Shao W,He J

    更新日期:2016-08-01 00:00:00

  • Should primary tumor be resected for non-small cell lung cancer with malignant pleural disease unexpectedly found during operation?-a systemic review and meta-analysis.

    abstract:BACKGROUND:Non-small cell lung cancer (NSCLC) with malignant pleural disease (MPD) was considered to be contraindication for surgery, but sometimes MPD was unexpectedly found intraoperatively. There was no consensus on the role of surgical intervention on the primary tumor in patients with MPD. The object of this resea...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2016.10.19

    authors: Xu Y,Chen N,Wang Z,Zhang Y,Mei J,Liu C,Liu L

    更新日期:2016-10-01 00:00:00

  • Wild-type transthyretin cardiac amyloidosis (ATTRwt-CA), previously known as senile cardiac amyloidosis: clinical presentation, diagnosis, management and emerging therapies.

    abstract::Cardiac amyloidosis is thought to be a rare group of diseases caused by extracellular deposition of misfolded proteins in the extracellular cardiac matrix resulting in heart failure with preserved ejection fraction (HFpEF). This review focuses on the similarities and differences between the pathophysiology, clinical p...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章,评审

    doi:10.21037/jtd.2018.03.134

    authors: Halatchev IG,Zheng J,Ou J

    更新日期:2018-03-01 00:00:00

  • Relationship between radiologic patterns, pulmonary function values and bronchoalveolar lavage fluid cells in newly diagnosed sarcoidosis.

    abstract:BACKGROUND:The aim of the present study was to identify specious radiologic and/or physiologic prognostic marker(s), which lead to optimize of the patient follow-up frequency. METHODS:Eighty consecutive patients with newly diagnosed pulmonary sarcoidosis. Patients underwent chest radiography, high-resolution computed ...

    journal_title:Journal of thoracic disease

    pub_type: 杂志文章

    doi:10.21037/jtd.2017.01.17

    authors: Aleksonienė R,Zeleckienė I,Matačiūnas M,Puronaitė R,Jurgauskienė L,Malickaitė R,Strumilienė E,Gruslys V,Zablockis R,Danila E

    更新日期:2017-01-01 00:00:00