Wild-type transthyretin cardiac amyloidosis (ATTRwt-CA), previously known as senile cardiac amyloidosis: clinical presentation, diagnosis, management and emerging therapies.

Abstract:

:Cardiac amyloidosis is thought to be a rare group of diseases caused by extracellular deposition of misfolded proteins in the extracellular cardiac matrix resulting in heart failure with preserved ejection fraction (HFpEF). This review focuses on the similarities and differences between the pathophysiology, clinical presentation and diagnostic tests of wild-type transthyretin cardiac amyloidosis (ATTRwt-CA) compared to immunoglobulin light chain amyloidosis and hereditary cardiac amyloidosis. We address some obstacles to timely diagnosis and opportunities for management of the clinical symptoms as well as possibility of future novel disease modifying therapies.

journal_name

J Thorac Dis

authors

Halatchev IG,Zheng J,Ou J

doi

10.21037/jtd.2018.03.134

subject

Has Abstract

pub_date

2018-03-01 00:00:00

pages

2034-2045

issue

3

eissn

2072-1439

issn

2077-6624

pii

jtd-10-03-2034

journal_volume

10

pub_type

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