Lung transplantation, ex-vivo reconditioning and regeneration: state of the art and perspectives.

abstract：Background:High levels of thymidylate synthase (TS) and dihydrofolate reductase (DHFR) expression in tumour tissues are an indicator of ineffective responses to pemetrexed-based chemotherapy in various tumours, including non-small cell lung cancer (NSCLC). However, tumour tissues are highly heterogeneous, so a single b...

journal_title：Journal of thoracic disease

authors： Li T,Huang JB,Lu JG,Li R,Wang Y,Shi XR,Shi MX,Zhang XD

更新日期：2020-12-01 00:00:00

abstract：:Natural history of acute Stanford type A aortic dissection (AAAD) implies the need of emergent surgical treatment in the vast majority of cases. Nevertheless, conservative treatment has been described to yield acceptable outcomes, when compared to surgery, in selected high risk cases of thrombosed false lumen. We repo...

journal_title：Journal of thoracic disease

authors： Piñón M,Acuña B,Lugo J,Pradas G

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:The aim of this study was to reveal the short-term outcomes of video-assisted thoracoscopic surgery (VATS) segmentectomy without tracheal intubation compared with intubated general anesthesia with one-lung ventilation (OLV). METHODS:We performed a retrospective review of our institutional database of consec...

journal_title：Journal of thoracic disease

authors： Guo Z,Yin W,Pan H,Zhang X,Xu X,Shao W,Chen H,He J

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:Recent evidence suggests that a histone deacetylase inhibitor, suberoylanilide hydroxamic acid (SAHA), has anti-fibrotic effect. However, the exact mechanism of its anti-fibrotic potential remains is unclear. In this study, we investigated the molecular mechanism of SAHA in attenuating pulmonary fibrosis by ...

journal_title：Journal of thoracic disease

authors： Rao SS,Zhang XY,Shi MJ,Xiao Y,Zhang YY,Wang YY,Zhang CZ,Shao SJ,Liu XM,Guo B

更新日期：2016-09-01 00:00:00

abstract：:Cardiopulmonary support is frequently required during lung transplantation. Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) has been recently shown to be an acceptable and, perhaps, safer alternative to cardiopulmonary bypass machine (CBM) for lung transplantation. However, therapeutic anticoagulation used...

journal_title：Journal of thoracic disease

authors： Bharat A,DeCamp MM

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND:Video-assisted thoracic surgery (VATS) emerged as a minimally invasive surgery for diseases in the field of thoracic surgery. We herein reviewed our experience on thoracoscopic lobectomy for early lung cancer and evaluated Health System use. METHODS:A cost-effectiveness study was performed comparing VATS vs...

journal_title：Journal of thoracic disease

authors： Mafé JJ,Planelles B,Asensio S,Cerezal J,Inda MD,Lacueva J,Esteban MD,Hernández L,Martín C,Baschwitz B,Peiró AM

更新日期：2017-08-01 00:00:00

abstract：:Prosthetic valve endocarditis (PVE) after transcatheter aortic valve implantation (TAVI) or surgical aortic valve replacement (SAVR) is a potential life threatening complication. Better understanding of the incidence, predictors, clinical presentation, diagnostic measures, complications and management of PVE may help ...

journal_title：Journal of thoracic disease

authors： Ahmad K,Klaaborg KE,Hjortdal V,Nørgaard BL,Terkelsen CJ,Jensen K,Christiansen EH,Terp KA,Andersen G,Hvitfeldt S,Andersen HR

更新日期：2016-10-01 00:00:00

abstract：:The Nuss procedure is a recently developed technique for correction of pectus excavatum. A 23-year-old female patient presented at our emergency department with clinical signs of cardiac tamponade, which required an emergency procedure. Sixteen months ago, she underwent the Nuss procedure with a single bar. Her preope...

journal_title：Journal of thoracic disease

authors： Baek JH,Lee YU,Jung TE,Lee DH,Lee JC

更新日期：2017-05-01 00:00:00

abstract：:Transcatheter aortic valve implantation (TAVI) has gained widespread acceptance as a treatment option for patients at high risk for conventional aortic valve replacement. The most commonly used access site for TAVI is the common femoral artery. Yet, in a significant number of patients the transfemoral access is not su...

journal_title：Journal of thoracic disease

authors： Schofer N,Deuschl F,Conradi L,Lubos E,Schirmer J,Reichenspurner H,Blankenberg S,Treede H,Schäfer U

更新日期：2015-09-01 00:00:00

abstract：Background:Sarcopenia is closely associated with surgical complications in patients with certain cancers. In this study we assessed the relationship between sarcopenia and postoperative complications in patients with oesophageal squamous cell carcinoma. Methods:We retrospectively analysed of patients who underwent tho...

journal_title：Journal of thoracic disease

authors： Xu J,Zheng B,Zhang S,Zeng T,Chen H,Zheng W,Chen C

更新日期：2019-06-01 00:00:00

abstract：:Peripheral lung nodule evaluation represents a clinical challenge. Given that many nodules will be incidentally found with lung cancer screening following the publication of the National Lung Screening Trial (NLST), the goal is to find an accurate, safe and minimally-invasive diagnostic modality to biopsy the concerni...

journal_title：Journal of thoracic disease

authors： Arias S,Yarmus L,Argento AC

更新日期：2015-12-01 00:00:00

abstract：:While ionizing radiotherapy (RT) can provide durable local control, the relative radiosensitivity of surrounding organs such as the lungs and heart and the distributed nature of the pleura limit the ability to safely deliver RT for patients with malignant pleural mesothelioma (MPM). Recent advances in the technologica...

journal_title：Journal of thoracic disease

authors： Cramer G,Simone CB 2nd,Busch TM,Cengel KA

更新日期：2018-08-01 00:00:00

abstract：:Primitive neuro-ectodermal tumour of the lung is an extremely rare occurrence and we hereby report a case of a neuro-ectodermal tumour of the lung which was proved by immuno-histochemical examination of the resected specimen, and he had a very aggressive pattern of behavior. ...

journal_title：Journal of thoracic disease

authors： Gaude GS,Patil P,Malur P,Annurshetru S

更新日期：2015-12-01 00:00:00

abstract：Background:Complete resection is the mainstay of treatment for thymoma, but few studies have investigated the extent of resection on normal thymus. Extended thymectomy is considered the treatment of choice for myasthenic patients with thymoma, while the optimal therapy for non-myasthenic patients is still a matter of d...

journal_title：Journal of thoracic disease

authors： Tassi V,Ceccarelli S,Zannori C,Gili A,Daddi N,Bellezza G,Ascani S,Liberati AM,Puma F

更新日期：2017-10-01 00:00:00

abstract：Background:Pleural effusions are common complications of various diseases. Patients with malignant pleural effusion (MPE) usually face poor prognosis and short life expectancy. Discriminating between MPE and benign pleural effusion remains to be difficult. The aim of our current study was to evaluate whether CD206+CD14...

journal_title：Journal of thoracic disease

authors： Pei XB,Wu XZ,Yi FS,Zhai K,Shi HZ

更新日期：2019-07-01 00:00:00

abstract：:Pathologic diagnosis of thymic tumors (TTs) can be made by surgical or nonsurgical procedures. About 20% of TTs had been diagnosed by pretreatment biopsy methods while the rest had gone to surgery for diagnosis and treatment. However, in the last two decades there was an increase in pretreatment procedures for optimal...

journal_title：Journal of thoracic disease

authors： Bilaçeroğlu S

更新日期：2020-12-01 00:00:00

abstract：:Three-dimensional printing (3Dp) has a broad array of medical applications and has been applied extensively in congenital heart disease given the variety and complexity of lesions encountered. 3Dps are unique when compared to other imaging modalities in that they are theoretically equally interpretable by radiologists...

journal_title：Journal of thoracic disease

authors： Hermsen JL,Roldan-Alzate A,Anagnostopoulos PV

更新日期：2020-03-01 00:00:00

abstract：Background:To assess the usefulness of the neutrophil/lymphocyte ratio (NLR), a marker of inflammation and/or stress, for predicting weaning failure in patients receiving invasive mechanical ventilation (IMV), compared to levels of leukocytes and C-reactive protein (CRP). Methods:This observational prospective cohort ...

journal_title：Journal of thoracic disease

authors： Luo Z,Zheng Y,Yang L,Liu S,Zhu J,Zhao N,Pang B,Cao Z,Ma Y

更新日期：2018-09-01 00:00:00

abstract：Background:Surgery plays an important role in the management of complex thoracic infections (CTIs). We aimed to describe the contemporary surgical outcomes of CTIs. Methods:The 2014-2017 National Surgical Quality Improvement Program (NSQIP) database was queried for patients with the following procedures: bilobectomy, ...

journal_title：Journal of thoracic disease

authors： Bostock IC,Sheikh F,Millington TM,Finley DJ,Phillips JD

更新日期：2018-09-01 00:00:00

abstract：Background:There are several techniques for robotic-assisted pulmonary resection, depending on the number and position of ports and utility incisions. We developed a technique for three-incision robotic-assisted pulmonary resection, and here we reported our initial results. Methods:Three-incision pulmonary resection w...

journal_title：Journal of thoracic disease

authors： Peng M,Wang X,Chen C,Tan S,Liu W,Yu F

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:Weekly docetaxel demonstrated similar efficacy but better tolerability than standard triweekly docetaxel, and carboplatin was less nephrotoxic, neurotoxic and emetogenic than cisplatin. This study aimed to evaluate the efficacy and safety of weekly docetaxel with carboplatin as first-line chemotherapy for ad...

journal_title：Journal of thoracic disease

authors： Jiang H,Zhang X,Chen J,Zhang L,Xiong J,Zhong L,Yu F,Qian J,Yu L,Wang X,Shi G,Deng J,Xu N

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:Bronchoplastic and broncho-arterioplastic lobectomy is technically demanding. Present study performed a prognostic analysis of lobectomy patient based on 10-year data in a high-volume center. METHODS:Overall, 161 non-small cell lung cancer (NSCLC) cases underwent bronchoplastic and broncho-arterioplastic lo...

journal_title：Journal of thoracic disease

authors： Zhao LL,Zhou FY,Dai CY,Ren YJ,Jiang GN,Fei K,Chen C

更新日期：2015-12-01 00:00:00

abstract：:Small cell lung cancer (SCLC), a particular neuroendocrine tumor, occupies 13% of lung cancers, with the highest mortality among cancers. Immune checkpoints inhibitors (ICIs) based on programmed cell death protein-1 (PD-1)/programmed cell death one ligand (PD-L1) inhibitors and cytotoxic T-lymphocyte-associated protei...

journal_title：Journal of thoracic disease

authors： Guo H,He Y,Chen P,Wang L,Li W,Chen B,Liu Y,Wang H,Zhao S,Zhou C

更新日期：2020-10-01 00:00:00

abstract：Background:To review our experience of transmanubrial osteomuscular sparing approach (TMA) for resection of various lesions involving the thoracic inlet and to prove the feasibility and safety of the approach. Methods:Retrospective review of 58 consecutive cases, from April 2007 to January 2016, with surgical resectio...

journal_title：Journal of thoracic disease

authors： Pan X,Gu C,Wang R,Zhao H,Yang J,Shi J

更新日期：2017-09-01 00:00:00

abstract：:Veno-venous extracorporeal membrane oxygenation (VV-ECMO) has been traditionally delivered with two independent cannulae at different venous insertion sites. The bicaval dual lumen cannula has gained popularity as a cannula for simultaneous venous drainage and reinfusion of blood via the internal jugular vein (IJV). I...

journal_title：Journal of thoracic disease

authors： Ngai CW,Ng PY,Sin WC

更新日期：2018-03-01 00:00:00

abstract：Background:After lung transplantation (LT), between 2% and 25% of bronchial anastomoses develop complications requiring therapeutic intervention. The status of healing of both bronchial anastomoses and downhill airways are well described by the French consensual MDS standardized grading system (Macroscopic, Diameter, S...

journal_title：Journal of thoracic disease

authors： Patoir A,Luchez A,Tiffet O,Vercherin P,Grima R,Tronc F,Philit F,Mornex JF,Vergnon JM,Maury JM

更新日期：2020-05-01 00:00:00

abstract：:Acute respiratory distress syndrome (ARDS) can occur during the treatment of several diseases and in several interventional procedures as a complication. It is a difficult situation to handle and special care should be applied to the patients. Mechanical ventilation is used for these patients and several parameters ar...

journal_title：Journal of thoracic disease

authors： Terzi E,Zarogoulidis K,Kougioumtzi I,Dryllis G,Kioumis I,Pitsiou G,Machairiotis N,Katsikogiannis N,Lampaki S,Papaiwannou A,Tsiouda T,Madesis A,Karaiskos T,Zaric B,Branislav P,Zarogoulidis P

更新日期：2014-10-01 00:00:00

abstract：:The last decade has seen significant advances in our understanding of lung cancer biology and management. Identification of key driver events in lung carcinogenesis has contributed to the development of targeted lung cancer therapies, heralding the era of personalised medicine for lung cancer. As a result, histologica...

journal_title：Journal of thoracic disease

authors： Davidson MR,Gazdar AF,Clarke BE

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:Concurrent chemoradiotherapy (CRT) with 5-fluorouracil (5-FU) and cisplatin (CDDP) are often associated with significant incidence of toxic effects in elderly patients with esophageal cancer. This phase I trial was designed to determine the maximum tolerated dose (MTD) and dose-limiting toxicity (DLT) of S-1...

journal_title：Journal of thoracic disease

authors： Ji Y,Qiu G,Sheng L,Sun X,Zheng Y,Chen M,Du X

更新日期：2016-03-01 00:00:00

abstract：:This review provides an update on the current role of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) and mediastinoscopy (Med) in assessment of patients with non-small cell lung cancer (NSCLC). Invasive mediastinal lymph node (LN) staging is the major application for both of these techniq...

journal_title：Journal of thoracic disease

authors： Czarnecka-Kujawa K,Yasufuku K

更新日期：2017-03-01 00:00:00