Intraocular infiltration of Philadelphia chromosome-positive acute lymphoblastic leukemia diagnosed by polymerase chain reaction from the aqueous humor: A case report.

Abstract:

RATIONALE:Intraocular manifestation of hematopoietic tumors is rare and often difficult to distinguish from inflammation. We report a patient with acute lymphoblastic leukemia (ALL) who developed intraocular infiltration during the remission period. PATIENT CONCERNS:A 40-year-old man presented with hypopyon in his right eye. Three months later, extensive subretinal infiltration and the elevation of intraocular pressure were observed. Fourteen months prior to this, he had been diagnosed with Philadelphia chromosome-positive ALL, and had received chemotherapy and bone marrow transplantation that resulted in complete remission. DIAGNOSIS:The breakpoint cluster region-Ableson (BCR/ABL) chimera was detected by polymerase chain reaction (PCR) analysis in the patient's aqueous humor. Additionally, a high expression of WT1 (Wilms tumor gene) mRNA in the aqueous humor was discovered. A bone marrow examination yielded a high expression of BCR/ABL fusion gene, and it was determined the patient had experienced a relapse of ALL. INTERVENTIONS:The dasatinib was administered orally to the patient. OUTCOMES:The intraocular infiltration disappeared, and intraocular pressure was normalized. LESSONS:Intraocular infiltration in leukemia patients may be an indication of relapse regardless of systemic conditions. Analyzing mRNA expression of BCR/ABL and WT1 of ocular fluid in patients with hypopyon is beneficial in diagnosing topical relapses in leukemia.

journal_name

Medicine (Baltimore)

journal_title

Medicine

authors

Hiraoka M,Ohguro H,Ikeda H,Furuya D,Takahashi S

doi

10.1097/MD.0000000000018872

subject

Has Abstract

pub_date

2020-01-01 00:00:00

pages

e18872

issue

4

eissn

0025-7974

issn

1536-5964

pii

00005792-202001240-00049

journal_volume

99

pub_type

杂志文章

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