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Association between uterine leiomyoma and metabolic syndrome in parous premenopausal women: A case-control study.

Abstract：

:Previous studies have reported that uterine leiomyoma (UL) may share pathogenic features with obesity and hypertension, which are components of metabolic syndrome (MetS). We examined the association between UL and MetS in premenopausal parous women.This 1:1 case-control study was conducted on 615 asymptomatic women with UL and 615 women without UL that were matched for age, reproductive history, and hormonal use, who underwent a comprehensive health examination. UL was diagnosed by a gynecologist based on transvaginal ultrasonography findings. Blood pressure (BP), body composition, fasting plasma glucose, lipid profiles, insulin, and HOMA-IR were checked.Median age of the 1230 study subjects was 44 (40-47) years and 7% had MetS. Women with UL had significantly higher waist circumferences and body fat, BP, and low-density lipoprotein cholesterol (LDL-C) than women without UL. Although nonsignificant, the prevalence of MetS was higher in the UL group than in the non-UL group (9.3% vs 5.7%). In addition, the prevalence of UL increased as the number of abnormal metabolic components increased and was higher than in women without UL. Conditional logistic regression analysis, after adjustment for confounding factors, showed that hyperglycemia was significantly associated with an increased risk of UL (odds ratio = 1.45; 95% confidence interval, 1.10-1.89).Prevalence of abnormal metabolic component was higher in premenopausal women with UL than in normal controls, regardless of age or reproductive history. Furthermore, the study suggests that UL may share pathogenic features with the components of MetS and that women with UL be considered eligible for the early screening of metabolic abnormalities.

journal_name

Medicine (Baltimore)

journal_title

Medicine

authors

Tak YJ,Lee SY,Park SK,Kim YJ,Lee JG,Jeong DW,Kim SC,Kim IJ,Yi YH

doi

10.1097/MD.0000000000005325

subject

Has Abstract

pub_date

2016-11-01 00:00:00

pages

e5325

issue

46

eissn

0025-7974

issn

1536-5964

pii

00005792-201611150-00031

journal_volume

95

pub_type

杂志文章

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