Dabrafenib plus trametinib for compassionate use in metastatic melanoma: A STROBE-compliant retrospective observational postauthorization study.

abstract：:The prognostic implication of Barcelona Clinic Liver Cancer (BCLC) substages in Asian patients with hepatocellular carcinoma (HCC) is still obscure.The aim to this study is to compare the prognoses among HCC patients in different substages of the BCLC stage 0 and A.We enrolled 1265 treatment-naive HCC patients with BC...

journal_title：Medicine

authors： Kao WY,Chao Y,Chang CC,Li CP,Su CW,Huo TI,Huang YH,Chang YJ,Lin HC,Wu JC

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:Well-developed coronary collateral circulation usually results in fewer infarct size, improved cardiac function, and fewer mortality. Traditional coronary risk factors (diabetes, hypertension, and smoking) have some effects on coronary collateral circulation. However, the association between these risk facto...

journal_title：Medicine

authors： Xing Z,Pei J,Tang L,Hu X

更新日期：2018-04-01 00:00:00

abstract：RATIONALE:Repair of soft tissue defects on the dorsum of the hand with accompanying tendon defects is a challenging problem in clinical practice. PATIENT CONCERNS:Here, we describe the case of a 3-year-old boy with a 1-week old soft tissue injury with infection due to a soft tissue defect on the dorsum of his right ha...

journal_title：Medicine

authors： Tian H,Song D,Jin H,Liu Q,Zhao Y,Wang X,Qu W,Li R

更新日期：2020-08-21 00:00:00

abstract：:To investigate the age, gender, time, and etiology differences of traumatic lower limb fractures (TLLFs) in a population of children (≤18 years old), we retrospectively reviewed 936 children who had TLLFs and who came to our university-affiliated hospitals from 2001 to 2010. This study enrolled 657 males (70.2%) and 2...

journal_title：Medicine

authors： Liu H,Wang H,Shao B,Lu H,Zhang S,Ou L,Chen Y,Xiang L

更新日期：2019-09-01 00:00:00

abstract：:The purpose of this study is to compare the clinical features and treatment outcomes among patients with bacteremic urinary tract infection (UTI) caused by multidrug-resistant (MDR) and non-MDR Enterobacteriaceae and to identify whether MDR pathogens were independently associated with severe sepsis or septic shock at ...

journal_title：Medicine

authors： Lee YC,Hsiao CY,Hung MC,Hung SC,Wang HP,Huang YJ,Wang JT

更新日期：2016-05-01 00:00:00

abstract：:The aim of this study was to compare bone mineral densities (BMDs) and body composition between Southeast Asia college students and Chinese college students, in order to provide a certain reference enhancing college students' physical fitness.A total of 1694 Chinese college students (294 men and 1400 women, aged 18-22...

journal_title：Medicine

authors： Liu P,Ye Z,Lu J,Lu H,Guan L,Teng Z,Gao S,Li M

更新日期：2016-09-01 00:00:00

abstract：:Lymphoid follicles/aggregates in gastric biopsies have been traditionally linked to Helicobacter pylori gastritis, and less commonly to other inflammatory and neoplastic conditions. The frequency of such aggregates in normal stomachs has yet to be adequately evaluated. This is especially relevant when it comes to diag...

journal_title：Medicine

authors： Chakhachiro Z,Saroufim M,Safadi B,Attieh M,Assaf N,Shamseddine G,Tamim H,Boulos F

更新日期：2020-02-01 00:00:00

abstract：:The objective of this study was to evaluate the necessity of concurrent chemotherapy in T1-2N1 nasopharyngeal carcinoma (NPC) patients treated with intensity-modulated radiation therapy (IMRT). The retrospective analysis was conducted using the paired comparison method. We matched cases to controls using the greedy ma...

journal_title：Medicine

authors： Xu T,Shen C,Zhu G,Hu C

更新日期：2015-09-01 00:00:00

abstract：INTRODUCTION:Pyoderma gangrenosum (PG) is a neutrophilic dermatosis that may be associated with systemic diseases. The association of PG with lymphoid malignancies has rarely been reported. Extranodal natural killer/T-cell lymphoma (ENKTL) is a rare but aggressive entity with a poor prognosis. Here, we report the case ...

journal_title：Medicine

authors： Yang TH,Hu CH,Tsai HH

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:In order to increase treatment choices for patients with Parkinson disease (PD), we performed a retrospective assessment of adverse events associated with a novel once-daily extended-release (ER) formulation versus the standard immediate-release (IR) of the nonergolinic dopamine agonist, pramipexole. METHOD...

journal_title：Medicine

authors： Shen Z,Kong D

更新日期：2018-08-01 00:00:00

abstract：:Endothelial dysfunction and chronic inflammatory process are prevalent in patients with end-stage renal disease (ESRD) on maintenance hemodialysis (HD). The aim of this study was to evaluate the acute and short-term effects of online hemodiafiltration (OL-HDF) versus conventional HD on endothelial function and inflamm...

journal_title：Medicine

authors： Jia P,Jin W,Teng J,Zhang H,Zou J,Liu Z,Shen B,Cao X,Ding X

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:A rigid video-stylet intubation device provides safe and accurate access to the trachea by enabling visualization of the airway structures during tracheal intubation. The primary purpose of this study was to examine the effects of glycopyrrolate premedication on tracheal intubation with a rigid video-stylet....

journal_title：Medicine

authors： Cho EA,Hwang SH,Lee SH,Ryu KH,Kim YH

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND:Chronic lymphocytic leukemia (CLL) is a rare hematological malignancy classified in the non-Hodgkin's lymphoma category. Ibrutinib, a first-in-class Bruton tyrosine kinase inhibitor has been approved for use in the treatment of CLL. This drug has shown beneficial effects including a higher overall response r...

journal_title：Medicine

authors： Zhou Y,Lu H,Yang M,Xu C

更新日期：2019-08-01 00:00:00

abstract：INTRODUCTION:Obesity represents a risk factor in case of major hepatectomy, because the future liver remnant (FLR) must be proportional with body weight. To avoid post-hepatectomy liver failure, and further increase the ratio between FLR and body weight, we performed a bariatric procedure in the first stage of the ALPP...

journal_title：Medicine

authors： Brusadin R,López-López V,de Angulo DR,López-Conesa A,Navarro-Barrios Á,Caballero-Planes A,Parrilla-Paricio P,Robles-Campos R

更新日期：2020-08-21 00:00:00

abstract：:To investigate the effect of multidisciplinary interventions on pain management in cancer inpatients.Four hundred thirty eight patients with cancer pain, who performed the multidisciplinary intervention were recruited. Before and after intervention, the Brief Pain Inventory (BPI) and the MD Anderson Symptom Inventory ...

journal_title：Medicine

authors： Yang B,Cui Z,Zhu X,Deng M,Pan Y,Li R,Guo M,Lu G,Zhang X,Guo L,Huang Y,Li F

更新日期：2020-11-25 00:00:00

abstract：BACKGROUND:This study is to summarize the status of knowledge, attitudes, implementation, facilitators, and barriers of evidence-based practice (EBP) in community nurses (CNs). EBP has been widely adopted but the knowledge, attitudes, and implementation of EBP among CNs, and the facilitators and barriers they perceived...

journal_title：Medicine

authors： Li S,Cao M,Zhu X

更新日期：2019-09-01 00:00:00

abstract：:This study aimed to compare the differences in radiological outcomes and complications between single- and multilevel anterior cervical discectomy and fusion (ACDF) by using a polyetheretherketone (PEEK) cage-plate fusion system.Fifty-seven patients who underwent ACDF via the PEEK cage-plate fusion system were enrolle...

journal_title：Medicine

authors： Lee HC,Chen CH,Wu CY,Guo JH,Chen YS

更新日期：2019-02-01 00:00:00

abstract：:This study aims to evaluate the clinical and radiographic treatment outcomes of comminuted Mason type II radial head fractures, which underwent open reduction and internal fixation (ORIF) using a new implant (mother-child screw, MCS).This study included 16 patients (7 male and 9 female patients; mean age: 40.9 years, ...

journal_title：Medicine

authors： Shi Y,Wang GF,Mei K,Zhang J,Yun CJ,Qian C,Sun JY

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND:Amyotrophic lateral sclerosis (ALS) is the most common form of motor neuron diseases. Until now, it lacks effective drugs for its treatment, and the median survival time of ALS is reported as only 20 to 48 months after the onset of symptoms. Acupuncture served as part of traditional Chinese therapy, has been...

journal_title：Medicine

authors： Liao Q,Li Z,Zeng H,Feng X,Huang W,Fu C,Liang X,Li T

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:Reversible splenial lesion syndrome (RESLES) is a newly recognized syndrome, and a reversible progress associated with transiently reduced diffusion lesion in the splenium of the corpus callosum (SCC) is the typical pathological finding. The routine clinical symptoms include mildly altered states of consciou...

journal_title：Medicine

authors： Dong K,Zhang Q,Ding J,Ren L,Zhang Z,Wu L,Feng W,Song H

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND AND RATIONALE:Uncertainty persists over the optimal management of blood pressure (BP) in the early phase of acute ischemic stroke (AIS). This study aims to determine the safety and effects of intensive BP lowering on cerebral blood flow (CBF) and functional in AIS patients treated with intravenous thrombolys...

journal_title：Medicine

authors： Sharma VK,Tan BYQ,Sim MY,Kulkarni A,Seow PA,Hong CS,Du Z,Wong LYH,Chen J,Chee EYH,Ng BSM,Low Y,Ngiam NJH,Yeo LLL,Teoh HL,Paliwal PR,Rathakrishnan R,Sinha AK,Chan BPL,Butcher K,Anderson CS

更新日期：2018-10-01 00:00:00

abstract：:Revision total hip arthroplasty (THA) may cause intra- and postoperative massive bleeding. This prospective observational study evaluated if the maximum clot firmness of FIBTEM (MCFFIB) could act as a predictor of perioperative massive bleeding in revision THA.Fifty-eight adult patients undergoing revision THA were in...

journal_title：Medicine

authors： Shin HJ,Min BH,Na HS

更新日期：2018-06-01 00:00:00

abstract：INTRODUCTION:Several intensive-care units (ICUs) in Wuhan are nonstandard wards that were repurposed from general wards. Considering the shortage of medical resources and the need to prevent nosocomic infection, the respiratory-treatment strategy in these nonstandard ICUs is different from those in general wards and st...

journal_title：Medicine

authors： Lu X,Xu S

更新日期：2020-05-22 00:00:00

abstract：:The Helicobacter species in the gut microbiota comprise Helicobacter pylori (H pylori) and enterohepatic Helicobacter species (EHS), which can colonize the intestinal mucosa. However, it is unclear whether EHS are associated with inflammatory bowel disease (IBD). Therefore, we conducted this meta-analysis to examine t...

journal_title：Medicine

authors： Yu Q,Zhang S,Li L,Xiong L,Chao K,Zhong B,Li Y,Wang H,Chen M

更新日期：2015-11-01 00:00:00

abstract：:Purpose of this study was to evaluate the outcomes of patients underwent hemiarthroplasty for proximal femoral fracture converted to total hip arthroplasty (THA).A total of 138 patients from October 2009 till October 2014 had conversion of their failed hemiarthroplasties following a proximal femoral fracture to total ...

journal_title：Medicine

authors： Taheriazam A,Saeidinia A

更新日期：2017-10-01 00:00:00

abstract：:To determine the association between mammographic density (MD) and the risk of breast cancer (BC) in Chinese women and to investigate the role of fertility risk factors in regulating the relationship between MD and BC.We used Quantra software and the BI-RADS classification to assess MD in 466 patients and 932 controls...

journal_title：Medicine

authors： Wang JM,Zhao HG,Liu TT,Wang FY

更新日期：2020-11-13 00:00:00

abstract：:We have reviewed the alveolar hemorrhage (AH) syndromes, defined as immune or idiopathic disorders associated with diffuse microvascular hemorrhage into the acinar portion of the lung. The disorders that are most often associated with AH include antibasement membrane antibodies (ABMA) disease, idiopathic pulmonary hem...

journal_title：Medicine

authors： Leatherman JW,Davies SF,Hoidal JR

更新日期：1984-11-01 00:00:00

abstract：:The enterococci, members of the group D streptococci and the predominant aerobic streptococci of the gastrointestinal and female genital tracts, have long been recognized as significant pathogens in infective endocarditis. Over the past 2 decades, enterococci have become increasingly important nosocomial pathogens, re...

journal_title：Medicine

authors： Maki DG,Agger WA

更新日期：1988-07-01 00:00:00

abstract：:The purpose of this observational study was to examine the prevalence of obesity in children of 6 to 8 years of age from primary public schools over a period of 6 years and the associated environmental and metabolic health risk factors.This was a cohort observational study to investigate the prevalence of obesity in c...

journal_title：Medicine

authors： Sentalin PBR,Pinheiro AO,Oliveira RR,Zângaro RA,Campos LA,Baltatu OC

更新日期：2019-05-01 00:00:00

abstract：:A few decades ago, antibiotic prophylaxis for patients with acute variceal bleeding was reported beneficial. However, endoscopic and systemic therapy for variceal bleeding has dramatically improved since then, so the necessity of prophylactic antibiotics can be questioned. In this study, we reevaluated the efficacy of...

journal_title：Medicine

authors： Ueno M,Kayahara T,Sunami T,Takayama H,Takabatake H,Morimoto Y,Yamamoto H,Mizuno M

更新日期：2020-05-01 00:00:00