Prognosis of Early-Stage Hepatocellular Carcinoma: The Clinical Implications of Substages of Barcelona Clinic Liver Cancer System Based on a Cohort of 1265 Patients.


:The prognostic implication of Barcelona Clinic Liver Cancer (BCLC) substages in Asian patients with hepatocellular carcinoma (HCC) is still obscure.The aim to this study is to compare the prognoses among HCC patients in different substages of the BCLC stage 0 and A.We enrolled 1265 treatment-naive HCC patients with BCLC stage 0 or A from 2007 to 2014. Factors in terms of prognoses were analyzed by multivariate analysis.There were 184, 446, 271, 92, and 272 patients in substage 0, A1, A2, A3, and A4, respectively. After a median follow-up period of 21.0 months, patients in stages 0 and A1 had comparable prognoses (P = 0.136). Both of them had significantly higher overall survival rates than those in stages A2-A4 (all P < 0.001). Multivariate analysis revealed that the factors associated with mortality were serum albumin ≤3.5 g/dL (hazard ratio [HR] 1.459), alpha-fetoprotein >20 ng/mL (HR 1.863), tumor size >3 cm (HR 1.542), BCLC stage A2-A4 (HR 1.488), and treatment modality. Surgical resection had the highest overall survival rate followed by radiofrequency ablation (RFA) (HR 1.598), transarterial chemoembolization (HR 2.224), and other treatments (HR 3.707). Verus patients receiving RFA, those who underwent resection had a higher overall survival rate and lower recurrence rate especially in BCLC stages A2-A4.The BCLC-staging system provided good prognostic stratification for early-stage HCC. Patients with a single tumor >2 cm but without portal hypertension or jaundice had similar prognosis to those in BCLC stage 0. Curative therapies-especially hepatic resection-are suggested in early-stage HCC.


Medicine (Baltimore)




Kao WY,Chao Y,Chang CC,Li CP,Su CW,Huo TI,Huang YH,Chang YJ,Lin HC,Wu JC




Has Abstract


2015-10-01 00:00:00
















  • Anthropometric and Quality-of-Life Parameters in Acute Intermittent Porphyria Patients.

    abstract::The porphyrias are a group of rare metabolic disorders. The incidence and prevalence are low because the acute intermittent porphyria (AIP) is rare. Our aim was to assess the use of anthropometric and quality-of-life parameters in porphyric patients in order to identify predictor factors that might help in characteriz...


    pub_type: 杂志文章


    authors: Jiménez-Monreal AM,Murcia M,Gómez-Murcia V,Bibiloni MDM,Pons A,Tur JA,Martínez-Tomé M

    更新日期:2015-07-01 00:00:00

  • Gegen huangqin huanglian decoction for children rotavirus enteritis: A protocol for systematic review and meta-analysis.

    abstract:BACKGROUND:Rotavirus infection is the main cause of severe dehydration enteritis in children under 5 years old. It gives rise to malnutrition and even death in children even though there were rotavirus vaccines. However, there is no effective anti-virus drugs for rotavirus, supporting treatments are used in the clinics...


    pub_type: 杂志文章,meta分析


    authors: Wu Y,Tu X,Liang X,Chen J,Wan X,Zhang T,Jiang J,Zhong S

    更新日期:2020-12-04 00:00:00

  • Regulation of podocyte lesions in diabetic nephropathy via miR-34a in the Notch signaling pathway.

    abstract:BACKGROUND:The activation of the Notch signaling pathway has been shown to play an important role in diabetic nephropathy (DN) development. Besides, Notch-1 is a target gene in miR-34a. However, the regulation of the podocyte lesions involved in DN by miR-34a has not been identified. METHODS:This study utilized miR-34...


    pub_type: 杂志文章


    authors: Zhang X,Song S,Luo H

    更新日期:2016-11-01 00:00:00

  • Effect of Dexmedetomidine Alone for Intravenous Patient-Controlled Analgesia After Gynecological Laparoscopic Surgery: A Consort-Prospective, Randomized, Controlled Trial.

    abstract::Gynecological laparoscopic surgery is minimally invasive compared with open surgical approaches, but postoperative pain is generally undermanaged. Pain management strategies related to the procedure-specific efficacy are needed. Many studies have shown that dexmedetomidine (DEX) has opioid-sparing properties. It is no...


    pub_type: 杂志文章,随机对照试验


    authors: Wang X,Liu W,Xu Z,Wang F,Zhang C,Wang B,Wang K,Yu J

    更新日期:2016-05-01 00:00:00

  • Atypical immunoglobulin light chain amyloidosis: Spontaneous vertebral compression fracture, liver involvement, and bone marrow involvement report of 3 cases and review of the literature.

    abstract:BACKGROUND:Primary immunoglobulin light chain amyloidosis (AL amyloidosis) is a plasma cell disorder which mainly affects heart, kidneys, liver, and peripheral nervous system. Cases of atypical AL amyloidosis presented as spontaneous vertebral compression fractures have been rarely reported, and data about the manageme...


    pub_type: 杂志文章,评审


    authors: Wu X,Feng J,Cao X,Zhang L,Zhou D,Li J

    更新日期:2016-09-01 00:00:00

  • New Deep Dermal ADM Incorporates Well in Case Series of Complex Breast Reconstruction Patients.

    abstract::Breast cancer patients with significant comorbidities present reconstructive challenges due to a predictably high complication rate. During expander-based breast reconstruction, human acellular dermal matrix (ADM) is often used to prevent pectoralis muscle retraction, facilitate early expansion, and improve cosmetic o...


    pub_type: 杂志文章


    authors: Wilson HB

    更新日期:2015-05-01 00:00:00

  • Whether statin use improves the survival of patients with glioblastoma?: A meta-analysis.

    abstract:BACKGROUND:Glioblastomas are malignant brain tumors associated with high mortality and poor prognosis. Evidence from preclinical studies suggests that statins have an antitumor role, but their effects on the survival of patients with glioblastoma remain controversial. This meta-analysis attempts to assess the associati...


    pub_type: 杂志文章,meta分析


    authors: Xie Y,Lu Q,Lenahan C,Yang S,Zhou D,Qi X

    更新日期:2020-02-01 00:00:00

  • Correction of labial tubercle defect in repaired bilateral cleft lips using bilateral vermilion musculomucosal sliding flaps: Case series.

    abstract:RATIONALE:Insignifificant, asymmetrical or lack of labial tubercle often occurs after cleft lip surgery due to improper treatment of vermilion tissue. Especially in the cases of bilateral cleft lip, because of short front lip and insuffificient vermilion tissue, the median vermilion depression often occurs after surger...


    pub_type: 杂志文章


    authors: Liang Y,Yang Y,Wu Y

    更新日期:2019-07-01 00:00:00

  • Orthostatic Hypotension and Mortality in Elderly Frail Patients: A Retrospective Cross-Sectional Study.

    abstract::Orthostatic hypotension (OH) is a common problem in the elderly age group, and some studies have reported an association between OH and increased mortality. We evaluated possible associations between OH and mortality in a retrospective study of frail elderly patients who came for a comprehensive geriatric assessment. ...


    pub_type: 杂志文章


    authors: Freud T,Punchik B,Press Y

    更新日期:2015-06-01 00:00:00

  • Nontraumatic avulsion of aortic valve commissure as a cause of acute aortic valve regurgitation: A case report.

    abstract:BACKGROUND:Avulsion of the aortic valve commissure as a cause of acute aortic valve regurgitation is mostly due to trauma, infective endocarditis, or ascending aortic dissection. Nontraumatic avulsion of the aortic valve commissure is very rare. We reviewed the literature and analyzed potential risk factors of nontraum...


    pub_type: 杂志文章


    authors: Chang RY,Chen CC,Hsu WP,Hsiao PC,Tsai HL,Hsiao PG,Wu JD,Guo HR

    更新日期:2016-10-01 00:00:00

  • Corrective osteotomy with retrograde Fassier-Duval nail in an osteogenesis imperfecta patient with bilateral genu valgum: A case report.

    abstract:RATIONALE:The treatment of osteogenesis imperfecta (OI) requires a multidisciplinary approach to maximize function and reduce fracture incidence. The aim of this case report was to discuss an alternative surgical approach to stabilize a corrective osteotomy using the Fassier Duval (FD) system in an OI patient. PATIENT...


    pub_type: 杂志文章


    authors: Lin TY,Yang CY,Liu SC

    更新日期:2017-11-01 00:00:00

  • Sclerosing thymoma: A rare case report and brief review of literature.

    abstract:RATIONALE:Sclerosing thymoma is an extremely rare mediastinal neoplasm; it was recognized for the first time in 1994 and to date only 15 cases have been reported. PATIENT CONCERNS:The present study report a case of a 65-year-old man who was incidentally found to have an anterior mediastinal nodule, without clinical sy...


    pub_type: 杂志文章


    authors: Li X,Wang M,Sun D

    更新日期:2018-04-01 00:00:00

  • Direct reconstruction of chronic extensor digitorum longus tendon rupture using interposed scar tissue in the foot: A case report.

    abstract:RATIONALE:Primary repair of acute ligament injury is possible due to the proximity of the ends. In the case of chronic injury, however, primary repair is difficult because the ends of ruptured ligament will have receded, and tendon graft, transfer, or reconstruction is needed. Satisfactory clinical results have been re...


    pub_type: 杂志文章


    authors: Yeo ED,Han JK,Lee HS,Won SH,Jung KJ,Chang HJ,Cha JS,Ahn H,Lee DW,Kang JK,Kim WJ

    更新日期:2020-10-02 00:00:00

  • The effect of bone cement distribution on clinical efficacy after percutaneous kyphoplasty for osteoporotic vertebral compression fractures.

    abstract::To evaluate the influence of various distributions of bone cement on the clinical efficacy of percutaneous kyphoplasty (PKP) in treating osteoporotic vertebrae compression fractures.A total of 201 OVCF patients (30 males and 171 females) who received PKP treatment in our hospital were enrolled in this study. According...


    pub_type: 杂志文章


    authors: He S,Zhang Y,Lv N,Wang S,Wang Y,Wu S,He F,Chen A,Qian Z,Chen J

    更新日期:2019-12-01 00:00:00

  • An unruptured posterior communicating artery aneurysm ruptured during angiography: A case report.

    abstract:INTRODUCTION:Cerebrovascular imaging is the gold standard for diagnosis of intracranial aneurysms. Rupture of intracranial aneurysm is rare in cerebrovascular angiography, especially in unruptured intracranial aneurysm. PATIENT CONCERNS:A 74-year-old woman was admitted to the hospital for sudden onset of left eyelid p...


    pub_type: 杂志文章


    authors: Guo S,Wu X

    更新日期:2019-11-01 00:00:00

  • Successful treatment of isolated oral lichen planus on lower lip with traditional Chinese medicine and topical wet dressing: A case report.

    abstract:RATIONALE:Biopsy is very important for the diagnosis of oral lichen planus (OLP) on the lips. Traditional Chinese medicine (TCM) can be used to coordinate the whole body, soften and eliminate swellings and masses, and regulate the functions of qi and blood. Therefore, TCM could be an effective and safe treatment for OL...


    pub_type: 杂志文章


    authors: Yu F,Xu N,Zhao B,Ren X,Zhang F

    更新日期:2018-12-01 00:00:00

  • Do Recent Advances in Diagnostic and Therapeutic Procedures Negate the Benefit of Postmastectomy Radiotherapy in N1 Patients With a Low Risk of Locoregional Recurrence?

    abstract::Recent advances in breast cancer management might make the use of postmastectomy radiotherapy (PMRT) redundant in the treatment of pT1/T2N1 patients. We investigated the impact of PMRT on disease-free survival (DFS) in these patients who have a low risk of locoregional recurrence (LRR) after contemporary multidiscipli...


    pub_type: 杂志文章


    authors: Chang JS,Lee J,Kim KH,Sohn JH,Kim SI,Park BW,Chung HC,Keum KC,Suh CO,Kim YB

    更新日期:2015-08-01 00:00:00

  • The association between rs2476601 polymorphism in PTPN22 gene and risk of alopecia areata: A meta-analysis of case-control studies.

    abstract:BACKGROUND:The single nucleotide polymorphism (SNP) rs2476601 of the protein tyrosine phosphatase, nonreceptor type 22 (PTPN22) gene has been presented to implicate in the pathogenesis of alopecia areata (AA) in a few association investigations with limited sample size and inconsistent conclusions. METHODS:The aim of ...


    pub_type: 杂志文章,meta分析


    authors: Lei ZX,Chen WJ,Liang JQ,Wang YJ,Jin L,Xu C,Kang XJ

    更新日期:2019-05-01 00:00:00

  • Impact of supraglottic device with assist ventilation under general anesthesia combined with nerve block in uniportal video-assisted thoracoscopic surgery.

    abstract:BACKGROUND:With the improvement of anesthesia and surgical techniques, supraglottic device with assist ventilation under general anesthesia (GA) combined with nerve block is gradually applied to video-assisted thoracoscopic surgery. However, the safety of assist ventilation has not been fully confirmed, and a large num...


    pub_type: 杂志文章,随机对照试验


    authors: Xiang X,Zhou H,Wu Y,Fang J,Lian Y

    更新日期:2020-03-01 00:00:00

  • Delayed bilateral facet dislocation at L4-5: A case report.

    abstract:RATIONALE:Traumatic bilateral facet dislocation in the lumbar (L) spine has rarely been reported. All reported cases were presented with acute facet dislocation. However, we present the first case of delayed bilateral facet dislocation at L4-5. PATIENT CONCERNS:A 34-year-old woman presented with back pain after a head...


    pub_type: 杂志文章


    authors: Park HY,Ha KY,Kim YH,Kim SI,Min HK,Oh IS,Seo JY,Chang DG,Alhazmi MA,Cho JH

    更新日期:2018-09-01 00:00:00

  • Risk factors analysis of nosocomial pneumonia in elderly patients with acute cerebral infraction.

    abstract::To investigate the risk factors of nosocomial pneumonia (NP) in elderly patients with acute cerebral infarction (ACI).In this study, 324 aged 70 years and over patients with ACI who were admitted to the inpatient department of TianJin First Hospital (China) from January 2012 to February 2018 were retrospectively analy...


    pub_type: 杂志文章


    authors: NanZhu Y,Xin L,Xianghua Y,Jun C,Min L

    更新日期:2019-03-01 00:00:00

  • Treatment of lateral epicondylitis with acupuncture and glucocorticoid: A retrospective cohort study.

    abstract::Lateral epicondylitis (LE) is a common musculoskeletal disorder for which an effective treatment strategy remains unknown. The goal of this study is to examine whether acupuncture is more effective than injection of glucocorticoid in adults with LE.Adults with LE received either acupuncture or injection of glucocortic...


    pub_type: 杂志文章


    authors: Peng Z,Zhang M,Li Y,Feng Z

    更新日期:2020-02-01 00:00:00

  • Characterization of ocular biometrics and aqueous humor dynamics in primary angle closure suspects.

    abstract::Detailed characterizations of ocular biometrics and parameters of aqueous humor dynamics are lacking in primary angle closure suspect (PACS) patients. This study aims to characterize these parameters and compare them with age-matched healthy volunteers.Elderly healthy volunteers (60.6 ± 7.2 years of age, mean ± SD, n ...


    pub_type: 杂志文章


    authors: Guo L,Deng Y,Fang L,Liu C,Guo T

    更新日期:2017-02-01 00:00:00

  • Assessment of the periodontal health status in patients undergoing orthodontic treatment with fixed appliances and Invisalign system: A meta-analysis.

    abstract:BACKGROUND:At present, many scholars have studied the periodontal health status of patients undergoing orthodontic treatment with fixed appliances and invisalign. However, those results are inconsistent. Therefore, we conducted this meta-analysis, and then provide reference for clinical treatment. METHODS:Most databas...


    pub_type: 杂志文章,meta分析


    authors: Lu H,Tang H,Zhou T,Kang N

    更新日期:2018-03-01 00:00:00

  • TNM Staging of Colorectal Cancer Should be Reconsidered According to Weighting of the T Stage: Verification Based on a 25-Year Follow-Up.

    abstract::The gradient monotonicity of existing tumor, node, metastases staging systems for colorectal cancer is unsatisfactory. Our proposed T-plus staging system strengthens weighting of the T stage. In this study, applicability of the T-plus staging system was verified with data of a Chinese colorectal cancer center.Records ...


    pub_type: 杂志文章


    authors: Li J,Yi CH,Hu YT,Li JS,Yuan Y,Zhang SZ,Zheng S,Ding KF

    更新日期:2016-02-01 00:00:00

  • Association of Migraine and Sleep-Related Breathing Disorder: A Population-Based Cohort Study.

    abstract::In this nationwide population-based cohort study, we aimed to evaluate the effects of sleep-related breathing disorders (SBD) on migraine development.Patients ages 20 years or more and diagnosed with SBD between 2000 and 2009 were evaluated as the SBD cohort (n = 3411), and compared with comparison cohort (n = 13,644)...


    pub_type: 杂志文章


    authors: Harnod T,Wang YC,Kao CH

    更新日期:2015-09-01 00:00:00

  • Obesity and metabolic syndrome in children in Brazil: The challenge of lifestyle change.

    abstract::The purpose of this observational study was to examine the prevalence of obesity in children of 6 to 8 years of age from primary public schools over a period of 6 years and the associated environmental and metabolic health risk factors.This was a cohort observational study to investigate the prevalence of obesity in c...


    pub_type: 杂志文章


    authors: Sentalin PBR,Pinheiro AO,Oliveira RR,Zângaro RA,Campos LA,Baltatu OC

    更新日期:2019-05-01 00:00:00

  • Preventing Staphylococcus aureus bacteremia and sepsis in patients with Staphylococcus aureus colonization of intravascular catheters: a retrospective multicenter study and meta-analysis.

    abstract::Two previous studies in tertiary care hospitals identified Staphylococcus aureus colonization of intravascular (IV) catheters as a strong predictor of subsequent S. aureus bacteremia (SAB), even in the absence of clinical signs of systemic infection. Bacteremia was effectively prevented by timely antibiotic therapy. W...


    pub_type: 杂志文章,meta分析,多中心研究,评审


    authors: Hetem DJ,de Ruiter SC,Buiting AGM,Kluytmans JAJW,Thijsen SF,Vlaminckx BJM,Wintermans RGF,Bonten MJM,Ekkelenkamp MB

    更新日期:2011-07-01 00:00:00

  • Acellular dermal matrix combined with oxidized regenerated cellulose for partial breast reconstruction: Two case reports.

    abstract:RATIONALE:Filling materials for partial defect of the breast have rarely been developed because of safety and durability. PATIENT CONCERNS:Two female patients (ages, 53 and 50 years) with breast cancer underwent partial mastectomy with sentinel lymph node biopsy. DIAGNOSIS:Core needle biopsy revealed an invasive duct...


    pub_type: 杂志文章


    authors: Lee J,Yang JD,Lee JW,Li J,Jung JH,Kim WW,Park CS,Lee JS,Park HY

    更新日期:2020-07-31 00:00:00

  • Bilateral stellate ganglion block for migraine: A case report.

    abstract:RATIONALE:Migraine is a recurrent, disabling neurovascular headache disorder. The patient's quality of life can be severely impaired by migraine attacks. Stellate ganglion block (SGB) can be used to relieve pain in the head, neck, and upper extremities. In the present cases, we performed SGB in 2 patients with migraine...


    pub_type: 杂志文章


    authors: Moon S,Lee J,Jeon Y

    更新日期:2020-05-01 00:00:00