Prognosis of Early-Stage Hepatocellular Carcinoma: The Clinical Implications of Substages of Barcelona Clinic Liver Cancer System Based on a Cohort of 1265 Patients.


:The prognostic implication of Barcelona Clinic Liver Cancer (BCLC) substages in Asian patients with hepatocellular carcinoma (HCC) is still obscure.The aim to this study is to compare the prognoses among HCC patients in different substages of the BCLC stage 0 and A.We enrolled 1265 treatment-naive HCC patients with BCLC stage 0 or A from 2007 to 2014. Factors in terms of prognoses were analyzed by multivariate analysis.There were 184, 446, 271, 92, and 272 patients in substage 0, A1, A2, A3, and A4, respectively. After a median follow-up period of 21.0 months, patients in stages 0 and A1 had comparable prognoses (P = 0.136). Both of them had significantly higher overall survival rates than those in stages A2-A4 (all P < 0.001). Multivariate analysis revealed that the factors associated with mortality were serum albumin ≤3.5 g/dL (hazard ratio [HR] 1.459), alpha-fetoprotein >20 ng/mL (HR 1.863), tumor size >3 cm (HR 1.542), BCLC stage A2-A4 (HR 1.488), and treatment modality. Surgical resection had the highest overall survival rate followed by radiofrequency ablation (RFA) (HR 1.598), transarterial chemoembolization (HR 2.224), and other treatments (HR 3.707). Verus patients receiving RFA, those who underwent resection had a higher overall survival rate and lower recurrence rate especially in BCLC stages A2-A4.The BCLC-staging system provided good prognostic stratification for early-stage HCC. Patients with a single tumor >2 cm but without portal hypertension or jaundice had similar prognosis to those in BCLC stage 0. Curative therapies-especially hepatic resection-are suggested in early-stage HCC.


Medicine (Baltimore)




Kao WY,Chao Y,Chang CC,Li CP,Su CW,Huo TI,Huang YH,Chang YJ,Lin HC,Wu JC




Has Abstract


2015-10-01 00:00:00
















  • Visual function evaluation for low vision patients with advanced glaucoma.

    abstract::This study aimed to compare various visual function parameters for evaluating the quality of life (QOL) of patients with advanced glaucoma with low vision.In total, 44 eyes of advanced glaucoma patients with low vision were included in this cross-sectional study. A moving pattern edge band program was used to assess e...


    pub_type: 杂志文章


    authors: Jeon SJ,Jung Y,Jung CS,Park HL,Park CK

    更新日期:2020-02-01 00:00:00

  • Correlation analysis and clinical significance of CA125, HE4, DDI, and FDP in type II epithelial ovarian cancer.

    abstract::Ovarian cancer is one of the common female malignant tumors. The early diagnosis and treatment of ovarian cancer has been a research hotspot. Therefore, we aimed to investigate the correlations between the levels of carbohydrate antigen 125 (CA125), human epididymis protein 4 (HE4), D-dimer (DDI), and fibrinogen degra...


    pub_type: 杂志文章


    authors: Qiao L,Chen X,Xi X,Chen X,Zhang P,Dong H,Wu X,Chen X

    更新日期:2020-12-04 00:00:00

  • The changing modes of human immunodeficiency virus transmission and spatial variations among women in a minority prefecture in southwest China: An exploratory study.

    abstract::Liangshan Yi Autonomous Prefecture in Southwest China has a high human immunodeficiency virus (HIV) prevalence rate. This study examined the changing modes of HIV transmission among women with new HIV infections and explored the spatial heterogeneities in the factors associated with heterosexual transmission in this m...


    pub_type: 杂志文章


    authors: Xiao C,Jike C,Liu D,Jia P,Xu X,Xiao L,Yu G,Nan L,Sun X,Ge J,Wang J,Wang K,Liao Q,Wang Q,Wenwen Z,Yang S

    更新日期:2020-02-01 00:00:00

  • Atypical case of posterior reversible encephalopathy syndrome related to late onset postpartum eclampsia: A case report.

    abstract:RATIONALE:Eclampsia, an obstetric emergency frequently seen in pregnant or puerperal women, is a risk factor for posterior reversible encephalopathy syndrome (PRES). Most cases of eclampsia occur postpartum. We report a woman with PRES associated with eclampsia 10 weeks post-delivery, the latest onset ever reported. P...


    pub_type: 杂志文章


    authors: Masai K,Ueda Y,Naito H,Tsukahara K,Aokage T,Fujisaki N,Yamamoto H,Nakao A

    更新日期:2019-04-01 00:00:00

  • Influenza A with hemorrhagic shock and encephalopathy syndrome in an adult: A case report.

    abstract:INTRODUCTION:Hemorrhagic shock and encephalopathy syndrome (HSES) is a type of acute encephalopathy mainly seen in infants. It is a syndrome encompassing an onset of high fever, disturbance of consciousness, convulsion, and shock that rapidly progresses to watery diarrhea and liver and renal dysfunctions. It is extreme...


    pub_type: 杂志文章


    authors: Fukuda M,Yoshida T,Moroki M,Hirayu N,Nabeta M,Nakamura A,Uzu H,Takasu O

    更新日期:2019-04-01 00:00:00

  • Ear mold for congenital ear malformation: A randomized controlled trial.

    abstract:BACKGROUND:Congenital auricular deformities (CAD) are prevalent worldwide. The objective of this study is to investigate the effectiveness and safety of ear molding for children with CAD at their early days. METHODS:One hundred and nighty children (under 3 days) with CAD will be included in the study. Participants wil...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Zou K,Fan Y,Jiang L,Huang J,Miao Y,Yang C,Yang M,Zhao L

    更新日期:2020-07-24 00:00:00

  • An ovarian Leydig cell tumor of ultrasound negative in a postmenopausal woman with hirsutism and hyperandrogenism: A case report.

    abstract:RATIONALE:The incidence of severe hyperandrogenism associated with masculinity in women is very low. While rare and difficult to diagnose, androgen secreting tumors should be suspected in women with hyperandrogenism and hirsutism, especially in the postmenopausal population. Herein we present one case of ovarian Leydig...


    pub_type: 杂志文章


    authors: Chen M,Zhou W,Zhang Z,Zou Y,Li C

    更新日期:2018-03-01 00:00:00

  • A clinical prediction rule for acute bilirubin encephalopathy in neonates with extreme hyperbilirubinemia: A retrospective cohort study.

    abstract::To establish a clinical prediction rule for acute bilirubin encephalopathy (ABE) in term/near-term neonates with extreme hyperbilirubinemia.A retrospective cohort study was conducted between January 2015 and December 2018. Six hundred seventy-three out of 26,369 consecutive neonates with extreme hyperbilirubinemia wer...


    pub_type: 杂志文章


    authors: Zhang F,Chen L,Shang S,Jiang K

    更新日期:2020-02-01 00:00:00

  • Efficacy and safety of low dose aspirin and magnesium sulfate in the treatment of pregnancy induced hypertension: A protocol for systematic review and meta-analysis.

    abstract:BACKGROUND:Magnesium sulfate combined with low-dose aspirin can significantly reduce adverse reactions and effectively lower blood pressure in patients with pregnancy induced hypertension, but the overall efficacy and safety of the combination of drugs are not clear. The purpose of this study was to evaluate the effica...


    pub_type: 杂志文章


    authors: He G,Chen Y,Chen M,He G,Liu X

    更新日期:2020-11-13 00:00:00

  • Echocardiographic Diagnosis and Outcome of Pseudoaneurysm of the Mitral-Aortic Intervalvular Fibrosa: Results of a Single-Center Experience in Beijing.

    abstract::Pseudoaneurysm of the mitral-aortic intervalvular fibrosa (P-MAIVF) is a rare but potentially fatal entity. Early diagnosis and surgical treatment are particularly important to decrease risk of mortality. The purpose of this study was to explore the echocardiographic characteristics and outcome of P-MAIVF and to evalu...


    pub_type: 杂志文章


    authors: Han J,He Y,Gu X,Sun L,Zhao Y,Liu W,Zhang Y,Yang X,Li Y

    更新日期:2016-03-01 00:00:00

  • Factors associated with delayed diagnosis of infective endocarditis: A retrospective cohort study in a teaching hospital in Japan.

    abstract::Patients with infective endocarditis (IE), have high mortality and morbidity, however, its early diagnosis is difficult. Few studies have examined the delayed diagnosis of IE. We aimed to investigate the factors associated with the diagnostic delay of IE.A retrospective cohort study was conducted for consecutive patie...


    pub_type: 杂志文章


    authors: Nishiguchi S,Nishino K,Kitagawa I,Tokuda Y

    更新日期:2020-07-24 00:00:00

  • Short- and Long-Term Patient Outcomes From Combined Coronary Endarterectomy and Coronary Artery Bypass Grafting: A Meta-Analysis of 63,730 Patients (PRISMA).

    abstract::This meta-analysis aimed to compare the short- and long-term outcomes in patients undergoing combined coronary endarterectomy and coronary artery bypass grafting (CE + CABG) versus isolated CABG, and particularly to examine subgroup patients with high-risk profile and patients with diffuse disease in the left anterior...


    pub_type: 杂志文章,meta分析


    authors: Wang J,Gu C,Yu W,Gao M,Yu Y

    更新日期:2015-10-01 00:00:00

  • A 14-year literature survey on spine-related clinical research output by orthopedic surgeons from mainland China.

    abstract:BACKGROUND:In recent years, China is increasingly playing an active role in various fields of biomedical research. Many bibliometric studies have provided valuable insights to different fields of clinical studies. However, similar evaluation on spine surgery-related clinical research is still limited. We herein aimed t...


    pub_type: 杂志文章,meta分析,评审


    authors: Si G,Liu X,Xu N,Yu M,Liu X

    更新日期:2018-08-01 00:00:00

  • Study on the correlation between anti-ribosomal P protein antibody and systemic lupus erythematosus.

    abstract::The aims of this study were to compare diagnostic value of anti-ribosomal P protein antibody (anti-P), anti-Smith antibody (anti-Sm), anti-double-stranded DNA antibody (anti-dsDNA), anti-nucleosome antibody (ANuA), and anti-histone antibody (AHA) for systemic lupus erythematosus (SLE) as well as explore the correlatio...


    pub_type: 杂志文章


    authors: Wang Y,Luo P,Guo T,Zou L,Shi J,Chen P

    更新日期:2020-05-01 00:00:00

  • Association of high waist-to-height ratio with functional outcomes in patients with acute ischemic stroke: A report from the ACROSS-China study.

    abstract::The aim of our study was to investigate the relationship between the waist-to-height ratio (WHR) and all-cause mortality and functional outcomes after acute ischemic stroke in a prospective cohort study.A total of 2076 patients (36.66% females) with ischemic stroke were analyzed from ACROSS-China, which is a nationwid...


    pub_type: 杂志文章,多中心研究


    authors: Yu P,Pan Y,Zheng H,Wang X,Yan H,Tong X,Jing J,Zhang X,Guo L,Wang Y,investigators for the Survey on Abnormal Glucose Regulation in Patients With Acute Stroke Across China (ACROSS-China).

    更新日期:2017-03-01 00:00:00

  • Rituximab was used to treat recurrent IgG4-related hypophysitis with ophthalmopathy as the initial presentation: A case report and literature review.

    abstract:RATIONALE:Immunoglobulin G4 (IgG4)-related hypophysitis is a type of IgG4-related disease (IgG4-RD), which is characterized by plasma cells infiltration in the pituitary causing functional changes and (or) space-occupying effect in the pituitary. IgG4-related hypophysitis is sensitive to hormone therapy in most patient...


    pub_type: 杂志文章,评审


    authors: Gu WJ,Zhang Q,Zhu J,Li J,Wei SH,Mu YM

    更新日期:2017-06-01 00:00:00

  • Treatment for acute flares of gout: A protocol for systematic review.

    abstract:INTRODUCTION:The current evidence confirms the effectiveness and safety of several drug interventions in the treatment of acute flares of gout, however, the most preferred drugs are still unclear. We, therefore, seek to conduct a network meta-analysis that can systematically compare non-steroidal anti-inflammatory drug...


    pub_type: 杂志文章


    authors: Tang H,Xu G,Zheng Q,Cheng Y,Zheng H,Li J,Yin Z,Liang F,Chen J

    更新日期:2020-04-01 00:00:00

  • Effectiveness of continuous adductor canal block versus continuous femoral nerve block in patients with total knee arthroplasty: A PRISMA guided systematic review and meta-analysis.

    abstract:BACKGROUND:This study aimed to evaluate the effectiveness of continuous adductor canal block (CACB) versus continuous femoral nerve block (CFNB) in postoperative analgesia and early rehabilitation of patients with total knee arthroplasty (TKA). METHODS:The Cochrane Library, PubMed, and EMbase were systematically searc...


    pub_type: 杂志文章,meta分析


    authors: Zhang Z,Wang Y,Liu Y

    更新日期:2019-11-01 00:00:00

  • Sedative reduction method for children with intussusception.

    abstract::Intussusception is common emergency condition in children. Pneumatic or hydrostatic reduction (HR) is considered the first-choice management strategy in cases lacking indications for surgical intervention. Generally, sedatives are not used in children undergoing interventional radiology procedures. Surgical management...


    pub_type: 杂志文章


    authors: Doo JW,Kim SC

    更新日期:2020-01-01 00:00:00

  • Clinicopathological features, surgical treatments, and survival outcomes of patients with small bowel adenocarcinoma.

    abstract::To date, because of their rarity, the clinicopathological features and surgical outcomes of small bowel adenocarcinomas (SBAs) have been insufficiently explored. We evaluated the clinicopathological features and long-term outcomes of patients who underwent surgery for SBA.This retrospective study (from 1999 to 2016) e...


    pub_type: 杂志文章


    authors: Zhang S,Yuan W,Zhang J,Chen Y,Zheng C,Ma J,Jiang Q,Zhao Y,Xu Q,Wang C

    更新日期:2017-08-01 00:00:00

  • Large HDL Subfraction But Not HDL-C Is Closely Linked With Risk Factors, Coronary Severity and Outcomes in a Cohort of Nontreated Patients With Stable Coronary Artery Disease: A Prospective Observational Study.

    abstract::High-density lipoprotein (HDL) is highly heterogeneous in its size and composition. Till now, the link of HDL subfractions to coronary risk is less clear. We aimed to investigate the associations of HDL subfractions with traditional risk factors (RFs), coronary severity, and outcomes in a cohort of nontreated patients...


    pub_type: 杂志文章


    authors: Li JJ,Zhang Y,Li S,Cui CJ,Zhu CG,Guo YL,Wu NQ,Xu RX,Liu G,Dong Q,Sun J

    更新日期:2016-01-01 00:00:00

  • Modeling the effectiveness of nebulized terbutaline for decompensated chronic obstructive pulmonary disease patients in the emergency department.

    abstract::Short-acting β2-agonists (SABA) are widely used in the emergency department (ED) to treat patients with decompensated chronic obstructive pulmonary disease (COPD). We sought to model the effectiveness of nebulized SABA (terbutaline) on clinically relevant parameters associated with a reduction in work of breathing or ...


    pub_type: 杂志文章


    authors: Gueho F,Beaune S,Devillier P,Urien S,Faisy C

    更新日期:2016-08-01 00:00:00

  • Group A streptococcal bacteremia. A 10-year prospective study.

    abstract::In this paper we present a prospective evaluation of 100 patients with Group A Streptococcal (GAS) bacteremia evaluated in our hospital over a 10-year period. Sixty-two patients were intravenous drug users (IVDU); all but 1 of these had an obvious cutaneous portal of entry related to the injection of illicit drugs. Tw...


    pub_type: 杂志文章,评审


    authors: Bernaldo de Quirós JC,Moreno S,Cercenado E,Diaz D,Berenguer J,Miralles P,Catalán P,Bouza E

    更新日期:1997-07-01 00:00:00

  • Takotsubo cardiomyopathy caused by acute respiratory stress from extubation: A case report.

    abstract:RATIONAL:Takotsubo cardiomyopathy (TCM) is a transient systolic dysfunction of the left ventricular apex without stenosis of coronary arteries and is induced by various psychological and physical factors. TCM sometimes causes lethal complications such as arrhythmia, thrombogenesis, and even cardiac rupture, and thus it...


    pub_type: 杂志文章


    authors: Taniguchi K,Takashima S,Iida R,Ota K,Nitta M,Sakane K,Fujisaka T,Ishizaka N,Umegaki O,Uchiyama K,Takasu A

    更新日期:2017-12-01 00:00:00

  • The diagnostic performance of serum LIM homeobox transcription factor 1 alpha in patients with gastric cancer.

    abstract::The study was conducted to investigate the diagnostic performance of serum LIM homeobox transcription factor 1 alpha (LMX1A) in patients with gastric cancer (GC).The serum level of LMX1A in GC, benign, and healthy groups was measured using quantitative real time PCR (qRT-PCR) and compared with the student t test. The ...


    pub_type: 杂志文章


    authors: Li D,Li C

    更新日期:2019-05-01 00:00:00

  • Development of indicators for assessing rational drug use to treat community-acquired pneumonia in children in hospitals and clinics: A modified Delphi study.

    abstract::Community-acquired pneumonia (CAP) is a common infectious disease in children. Rational drug use (RDU) is an important approach to reducing the disease burden and mortality rate of CAP in children. There are no monitoring indicators for assessing RDU in children. This study aimed to develop a set of indicators to asse...


    pub_type: 杂志文章


    authors: Li W,Zeng L,Li J,Huang L,Gui G,Song J,Chen L,Jiang L,Zhang L

    更新日期:2017-12-01 00:00:00

  • Usefulness of AFP, AFP-L3, and PIVKA-II, and their combinations in diagnosing hepatocellular carcinoma.

    abstract::Alpha-fetoprotein (AFP), Lens culinaris-agglutinin-reactive fraction of AFP (AFP-L3), and protein induced by vitamin K absence or antagonist-II (PIVKA-II) are widely used as tumor markers for the diagnosis of hepatocellular carcinoma (HCC). This study compared the diagnostic values of AFP, AFP-L3, and PIVKA-II individ...


    pub_type: 杂志文章


    authors: Park SJ,Jang JY,Jeong SW,Cho YK,Lee SH,Kim SG,Cha SW,Kim YS,Cho YD,Kim HS,Kim BS,Park S,Bang HI

    更新日期:2017-03-01 00:00:00

  • The degree of intubation difficulties and the frequency of complications in obese patients at the Hospital Emergency Department and the Intensive Care Unit: Case-control study.

    abstract::The intubation difficulties in obese patients are not a new problem. They may result from an accumulation of fat in the oral cavity and cheeks. A thick tongue is also a significant factor. The literature reports that some tests to determine the intubation difficulties in obese people may be unreliable. The observed pr...


    pub_type: 杂志文章


    authors: Cierniak M,Sobczak R,Timler D,Wieczorek A,Borkowski B,Gaszyński T

    更新日期:2016-12-01 00:00:00

  • Lead poisoning in a 16-year-old girl: a case report and a review of the literature (CARE compliant).

    abstract:BACKGROUND:Lead is a toxic element of the environment which leads to major complications once it enters the blood stream, affecting multiple organs and systems of the body. METHODS:We present the case of a 16-year-old girl, diagnosed with lead poisoning after occupational exposure due to the fact that the girl was act...


    pub_type: 杂志文章,评审


    authors: Mărginean CO,Meliţ LE,Moldovan H,Lupu VV,Mărginean MO

    更新日期:2016-09-01 00:00:00

  • Breast Cancer Subtype is Associated With Axillary Lymph Node Metastasis: A Retrospective Cohort Study.

    abstract::The purpose of this study was to assess whether breast cancer subtype (BCS) as determined by estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 can predict the axillary lymph node metastasis in breast cancer. Patients who received breast conserving surgery or mastectomy and axillary...


    pub_type: 杂志文章,多中心研究


    authors: He ZY,Wu SG,Yang Q,Sun JY,Li FY,Lin Q,Lin HX

    更新日期:2015-12-01 00:00:00