Abstract：
BACKGROUND:Nightmares are a highly prevalent and distressing feature of post-traumatic stress disorder (PTSD). Previous studies have reached mixed conclusions regarding the effects of prazosin on nightmares, sleep quality, and overall PTSD symptoms in patients with PTSD. METHODS:MEDLINE, EMBASE, all EBM databases, PsycIFNO, and CINAHL were systematically searched from inception date to October 2018 for randomized clinical trials that included reporting of nightmares, sleep quality or overall PTSD symptoms. The analysis included data from eight trials involving 286 PTSD patients in the prazosin group and 289 PTSD patients in the placebo group. RESULTS:In our meta-analysis, prazosin resulted in a statistically significant improvement in nightmares (standardized mean difference (SMD) = -1.13, 95% confidence interval (CI) = -1.91 to -0.36), but was not more beneficial than placebo for overall PTSD symptoms (SMD = -0.45, 95% CI = -0.95 to 0.05) and sleep quality (SMD = -0.44, 95% CI = -1.44 to 0.55). In terms of acceptability, there was no significant difference between the prazosin group and the placebo group with respect to discontinuation for all causes (odds ratio (OR) = 1.00, 95% CI = 0.62-1.62). In conclusion, the use of prazosin was associated with an improvement of nightmare symptoms. CONCLUSION:Our findings indicate that additional studies are needed before considering downgrading the use of prazosin in the treatment of nightmares in patients with PTSD.
journal_name
Sleep Medjournal_title
Sleep medicineauthors
Zhang Y,Ren R,Sanford LD,Yang L,Ni Y,Zhou J,Zhang J,Wing YK,Shi J,Lu L,Tang Xdoi
10.1016/j.sleep.2019.06.010subject
Has Abstractpub_date
2020-03-01 00:00:00pages
225-231eissn
1389-9457issn
1878-5506pii
S1389-9457(19)30220-5journal_volume
67pub_type
杂志文章相关文献
SLEEP MEDICINE文献大全abstract：BACKGROUND:Habitually snoring children are at risk of manifesting disease-related problems even if their sleep studies are overall within normal limits. STUDY OBJECTIVES:To compare sleep spindle activity in children with primary snoring and healthy controls. METHODS:Sleep spindle activity including analysis of fast a...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2019.10.001
更新日期：2020-01-01 00:00:00
abstract：OBJECTIVE:Uremic restless legs syndrome (RLS) has been related to an enhanced mortality of hemodialysis (HD) patients. In the general population studies of this association have yielded inconsistent results. The aim of the present study was to re-evaluate the relationship of RLS and mortality in HD patients. METHODS:W...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2015.04.023
更新日期：2015-09-01 00:00:00
abstract：OBJECTIVE:To investigate cortical excitability in patients with obstructive sleep apnea syndrome (OSAS) during wakefulness. METHODS:The authors recruited 45 untreated severe OSAS (all males, mean age 47.2 years, mean apnea-hypopnea index=44.6h(-1)) patients and 44 age-matched healthy male volunteers (mean apnea-hypopn...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2010.02.015
更新日期：2010-10-01 00:00:00
abstract：BACKGROUND:Hypoxia plays an important role in the development of solid tumors. Intermittent hypoxia is the hallmark of sleep apnea (SA). We tested the hypothesis that SA may increase the risk of breast cancer in Taiwan by using a population-based data set. METHODS:Our study cohort consisted of women diagnosed with SA ...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2014.05.026
更新日期：2014-09-01 00:00:00
abstract：OBJECTIVE:To evaluate the association of sleep problems with weight and waist size gain during four years of follow-up. METHODS:We investigated 13,030 participants (35-74 years) of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil), a multicentric cohort conducted with civil servants from six academic inst...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2020.06.017
更新日期：2020-09-01 00:00:00
abstract：OBJECTIVE:Our objective was to explore the clinical characteristics of Parkinson's disease (PD) comorbidity with obstructive sleep apnea (OSA), explore the correlation between OSA and PD features and identify factors that are independent predictors of OSA in PD patients. METHODS:In sum, 239 PD patients were divided in...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2019.11.1251
更新日期：2020-03-01 00:00:00
abstract：BACKGROUND:Frequent nightmares show signs of hyperarousal in NREM sleep. Nevertheless, idiopathic nightmare disorder is considered a REM parasomnia, but the pathophysiology of REM sleep in relation to frequent nightmares is controversial. Cortical oscillatory activity in REM sleep is largely modulated by phasic and ton...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2020.07.014
更新日期：2020-11-01 00:00:00
abstract：OBJECTIVE:To assess the association between sleep duration and physical activity and dietary behaviors among adolescents in a representative sample. METHODS:The analysis was performed using data from the 2015 Ningbo Youth Risk Behavior Survey. Associations between physical activity and dietary behaviors and sleep dura...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2017.06.024
更新日期：2017-09-01 00:00:00
abstract：OBJECTIVE:To assess the impact of three hypopnea definitions on the severity classification of obstructive sleep apnea (OSA) and its association with cardiovascular mortality risk in women and elderly individuals. METHODS:We analyzed two Spanish clinical cohorts (1116 women and 939 elderly individuals) who were studie...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2016.05.020
更新日期：2016-01-01 00:00:00
abstract：BACKGROUND AND PURPOSE:To document and provide a micro analysis of the relationship between insomnia and health problems, health-care use, absenteeism, productivity and accidents. PARTICIPANTS AND METHODS:A population-based sample of 953 French-speaking adults from Québec, Canada. Participants were categorized as havi...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2008.04.005
更新日期：2009-04-01 00:00:00
abstract：:Objective: This study examines specific hypotheses that both sleep loss and behavioral changes occurring with the time shifts for Daylight Savings Time (DST) significantly effect the number of fatal traffic accidents in the United States of America.Background: It has been reported that there is a significant increase ...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/s1389-9457(00)00032-0
更新日期：2001-01-01 00:00:00
abstract：:Vitamin D is a pro-hormone belonging to the category of the fat-soluble group of vitamins; it is obtained more from solar exposure and in smaller quantities through feeding. Although vitamin D has traditionally been shown to be involved in calcium homeostasis and bone health, recent studies have found a positive assoc...
journal_title：Sleep medicine
pub_type： 杂志文章,评审
doi：10.1016/j.sleep.2018.10.033
更新日期：2019-02-01 00:00:00
abstract：BACKGROUND:Noise in the vicinity of airports is a public health issue. Exposure to aircraft noise has been shown to have adverse effects on health and particularly on sleep. Many studies support the hypothesis that noise at night can affect subjective sleep quality. Fewer studies, however, have performed objective meas...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2018.10.013
更新日期：2019-02-01 00:00:00
abstract：OBJECTIVE:Functional connectivity (FC) changes can occur prior to structural changes. This study aimed to evaluate data-driven whole-brain FC associated with isolated rapid eye movement sleep behavior disorder (iRBD) using multivariate pattern analysis (MVPA). METHODS:This was a cross-sectional study of 50 polysomnogr...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2020.12.038
更新日期：2021-01-02 00:00:00
abstract：BACKGROUND AND PURPOSE:Studies examining the impact of daytime preoccupations with sleep are rare. The aim of the present study was to determine whether daytime preoccupations mediate the relationship between anxiety and attributions for poor sleep within older adults. METHOD:A cross-sectional study examined the media...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2006.08.011
更新日期：2007-04-01 00:00:00
abstract：BACKGROUND:Sleep-disordered breathing (SDB) is often co-morbid with conductive hearing loss in early childhood due to a shared aetiology of adenotonsillar hypertrophy. Hearing loss is independently associated with impairment of executive function and behavioural difficulties. We hypothesised that these impairments in c...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2017.02.008
更新日期：2017-06-01 00:00:00
abstract：OBJECTIVE:To examine the associations between sleep hygiene and sleep patterns in children ages newborn to 10 years. The relationships between key features of good sleep hygiene in childhood and recognizable outcomes have not been studied in large, nationally representative samples. PARTICIPANTS AND METHODS:A national...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2008.07.016
更新日期：2009-08-01 00:00:00
abstract：STUDY OBJECTIVES:The objective of this study was to investigate whether nightmare (NM) sufferers exhibit an abnormal network of emotional semantic associations as measured by a recently developed, rapid eye movement (REM) sleep-sensitive, associational breadth (AB) task. DESIGN:NM sufferers were compared to healthy co...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2015.11.013
更新日期：2016-04-01 00:00:00
abstract：:Sleep-related eating disorder (SRED) is characterized by nocturnal partial arousals associated with compulsive consumption of food and altered levels of consciousness. Reports of an increased incidence of SRED in relatives of affected individuals suggest a genetic predisposition. We report a woman with SRED whose frat...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/s1389-9457(02)00137-5
更新日期：2002-11-01 00:00:00
abstract：OBJECTIVES:Sleep-disordered breathing (SDB) is very common in acute stroke patients and has been related to poor outcome. However, there is a lack of data about the association between SDB and stroke in developing countries. The study aims to characterize the frequency and severity of SDB in Brazilian patients during t...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2015.11.008
更新日期：2016-03-01 00:00:00
abstract：BACKGROUND:Relatively few epidemiologic studies have focused on narcolepsy, a disabling sleep disorder with a strong association with HLA-DQB1 *0602. METHODS:We sought to estimate the prevalence of narcolepsy using multiple overlapping techniques to identify residents of King County, WA who were 18 years or older with...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2008.05.009
更新日期：2009-04-01 00:00:00
abstract：:Children and adolescents with autistic spectrum disorders (ASD) suffer from sleep problems, particularly insomnia, at a higher rate than typically developing children, ranging from 40% to 80%. Sleep problems in ASD might occur as a result of complex interactions between biological, psychological, social/environmental,...
journal_title：Sleep medicine
pub_type： 杂志文章,评审
doi：10.1016/j.sleep.2010.01.010
更新日期：2010-08-01 00:00:00
abstract：OBJECTIVES/BACKGROUND:Because both REM sleep behavior disorder (RBD) and Obstructive Sleep Apnea (OSA) can present with similar symptoms, it is important to understand the influence of OSA in the clinical manifestations of RBD and whether RBD modulates OSA severity. Our objectives were to compare: 1. the intensity of n...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2017.05.012
更新日期：2017-09-01 00:00:00
abstract：BACKGROUND:Sleep disorder prevalence exhibited a six-fold relative increase from 2000 to 2010 in the United States. Sleep problems could increase the risk of stroke, cardiovascular disease, diabetes and cancer. Objective short sleep duration is associated with increased mortality. Obesity, smoking and sex differences c...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2020.07.032
更新日期：2020-10-01 00:00:00
abstract：OBJECTIVE:The aim of the present study was to investigate the impact of sleep on osteoporosis. METHODS:The study used a baseline examination of the Hiroshima Sleep and Healthcare study, which was a cross-sectional and cohort study that addressed the association of sleep habits with lifestyle-related diseases. A total ...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2016.06.029
更新日期：2016-09-01 00:00:00
abstract：OBJECTIVE/BACKGROUND:In obstructive sleep apnea (OSA), long-term adherence to treatment is crucial. This prospective single-center study investigated factors associated with long-term adherence to mandibular repositioning device (MRD) therapy. PATIENTS/METHODS:All OSA patients who had MRD treatment initiated in the pr...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2016.10.004
更新日期：2016-01-01 00:00:00
abstract：OBJECTIVE:To examine the effect of nasal bilevel positive airway pressure (BiPAP) treatment for concurrent sleep-related breathing disorders (SRBDs) and attention-deficit hyperactivity disorder (ADHD) on electrophysiological measures of spontaneous brain activity and auditory stimulus processing. METHODS:Nineteen chil...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/s1389-9457(01)00121-6
更新日期：2001-09-01 00:00:00
abstract：OBJECTIVES:Although sleep disorders have been reported to affect more than half of adults with attention-deficit/hyperactivity disorder (ADHD), the association between sleep and ADHD is poorly understood. The aims of our study were to investigate sleep-related variables in adults with ADHD and to assess if any differen...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2013.03.003
更新日期：2013-07-01 00:00:00
abstract：:Night-shift work (NSW) has previously been related to incidents of breast cancer and all-cause mortality, but many published studies have reported inconclusive results. The aim of the present study was to quantify a potential dose-effect relationship between NSW and morbidity of breast cancer, and to evaluate the asso...
journal_title：Sleep medicine
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.sleep.2015.02.543
更新日期：2015-11-01 00:00:00
abstract：:Lingual thyroid has been reported to cause obstructive sleep apnea (OSA) only once in the literature. We present a case of a 49-year-old nonobese female with a 2-year history of progressive snoring, apneas, snort arousals, and daytime somnolence associated with the sensation of an 'enlarging tongue'. She was found to ...
journal_title：Sleep medicine
pub_type： 杂志文章,评审
doi：10.1016/j.sleep.2004.06.005
更新日期：2004-11-01 00:00:00
