Night-shift work increases morbidity of breast cancer and all-cause mortality: a meta-analysis of 16 prospective cohort studies.


:Night-shift work (NSW) has previously been related to incidents of breast cancer and all-cause mortality, but many published studies have reported inconclusive results. The aim of the present study was to quantify a potential dose-effect relationship between NSW and morbidity of breast cancer, and to evaluate the association between NSW and risk of all-cause mortality. The outcomes included NSW, morbidity of breast cancer, cardiovascular mortality, cancer-related mortality, and all-cause mortality. Sixteen investigations were included, involving 2,020,641 participants, 10,004 incident breast cancer cases, 7185 cancer-related deaths, 4820 cardiovascular end points, and 2480 all-cause mortalities. The summary risk ratio (RR) of incident breast cancer for an increase of NSW was 1.057 [95% confidence interval (CI) 1.014-1.102; test for heterogeneity p = 0.358, I(2) = 9.2%]. The combined RR (95% CI) of breast cancer risk for NSW vs daytime work was: 1.029 (0.969-1.093) in the <5-year subgroup, 1.019 (1.001-1.038) for 5-year incremental risk, 1.025 (1.006-1.044) for 5- to 10-year exposure times, 1.074 (1.010-1.142) in the 10- to 20-year subgroup, and 1.088 (1.012-1.169) for >20-year exposure lengths. The overall RR was 1.089 (95% CI 1.016-1.166) in a fixed-effects model (test for heterogeneity p = 0.838, I(2) = 0%) comparing rotating NSW and day work. Night-shift work was associated with an increased risk of cardiovascular death (RR 1.027, 95% CI 1.001-1.053), and all-cause death 1.253 (95% CI 0.786-1.997). In summary, NSW increased the risk of breast cancer morbidity by: 1.9% for 5 years, 2.5% for 5-10 years, 7.4% for 10-20 years, and 8.8% for >20-years of NSW. Additionally, rotating NSW enhanced the morbidity of breast cancer by 8.9%. Moreover, NSW was associated with a 2.7% increase in cardiovascular death.


Sleep Med


Sleep medicine


Lin X,Chen W,Wei F,Ying M,Wei W,Xie X




Has Abstract


2015-11-01 00:00:00














  • The lullaby of the sun: the role of vitamin D in sleep disturbance.

    abstract::Vitamin D is a pro-hormone belonging to the category of the fat-soluble group of vitamins; it is obtained more from solar exposure and in smaller quantities through feeding. Although vitamin D has traditionally been shown to be involved in calcium homeostasis and bone health, recent studies have found a positive assoc...

    journal_title:Sleep medicine

    pub_type: 杂志文章,评审


    authors: Muscogiuri G,Barrea L,Scannapieco M,Di Somma C,Scacchi M,Aimaretti G,Savastano S,Colao A,Marzullo P

    更新日期:2019-02-01 00:00:00

  • Rem sleep brady-arrhythmias: an indication to pacemaker implantation?

    abstract:OBJECTIVES:Important adjustments in the autonomic nervous system occur during sleep. Bradycardia, due to increased vagal tone, and hypotension, caused by reduction of sympathetic activity, may occur during non rapid eye movement (REM) sleep (NREM). Increased sympathetic activity, causing increased heart rate, is conver...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Serafini A,Dolso P,Gigli GL,Fratticci L,Cancelli I,Facchin D,Gigli M,Valente M

    更新日期:2012-06-01 00:00:00

  • Diagnostic accuracy of the standard and alternative periodic leg movement during sleep indices for restless legs syndrome.

    abstract:OBJECTIVE:To evaluate the diagnostic accuracy of the standard periodic leg movement during sleep (PLMS) index, a recently introduced alternative one, and the periodicity index (PI) for restless legs syndrome (RLS). SUBJECTS AND METHODS:A total of 107 patients with RLS were retrospectively identified and included (47 m...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Ferri R,Rundo F,Zucconi M,Manconi M,Aricò D,Bruni O,Ferini-Strambi L,Fulda S

    更新日期:2016-06-01 00:00:00

  • A convenient expiratory positive airway pressure nasal device for the treatment of sleep apnea in patients non-adherent with continuous positive airway pressure.

    abstract:BACKGROUND:While continuous positive airway pressure (CPAP) effectively treats obstructive sleep apnea (OSA), adherence to CPAP is suboptimal. The short-term efficacy of and adherence with a convenient expiratory positive airway pressure (EPAP) nasal device was evaluated in OSA patients non-adherent with CPAP. METHODS...

    journal_title:Sleep medicine

    pub_type: 临床试验,杂志文章


    authors: Walsh JK,Griffin KS,Forst EH,Ahmed HH,Eisenstein RD,Curry DT,Hall-Porter JM,Schweitzer PK

    更新日期:2011-02-01 00:00:00

  • Simple interventions improve re-attendance when treating the sleep apnoea syndrome.

    abstract:BACKGROUND AND PURPOSE:Interventions to improve treatment outcomes in sleep apnoea-hypopnoea syndrome (SAHS) have had mixed success. Most have concentrated on following the use of a continuous positive airway pressure (CPAP) machines; poorer users may not return for machine readings, so any compliance study must take i...

    journal_title:Sleep medicine

    pub_type: 杂志文章,随机对照试验


    authors: Lewis KE,Bartle IE,Watkins AJ,Seale L,Ebden P

    更新日期:2006-04-01 00:00:00

  • Do reports of sleep disturbance relate to coronary and aortic calcification in healthy middle-aged women?: Study of women's health across the nation.

    abstract:BACKGROUND:Poor sleep may be associated with the cardiovascular disease (CVD) morbidity and mortality. It is less clear if poor sleep is associated with subclinical CVD. We evaluated cross-sectional associations between self-reported sleep disturbance and duration and calcification in the coronary arteries (CAC) and ao...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Matthews KA,Everson-Rose SA,Kravitz HM,Lee L,Janssen I,Sutton-Tyrrell K

    更新日期:2013-03-01 00:00:00

  • Effects of after-midnight intake of zolpidem and temazepam on driving ability in women with non-organic insomnia.

    abstract:BACKGROUND:Occasionally, insomniac patients may take a sleeping pill after midnight. This may have consequences on their ability to drive a car and result in an increased risk of car accidents. METHODS:This double-blind, randomized, placebo-controlled, three-treatment three-period cross-over study investigated the eff...

    journal_title:Sleep medicine

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Partinen M,Hirvonen K,Hublin C,Halavaara M,Hiltunen H

    更新日期:2003-11-01 00:00:00

  • Ultradian rhythms of alternating cerebral hemispheric EEG dominance are coupled to rapid eye movement and non-rapid eye movement stage 4 sleep in humans.

    abstract::Objective: To replicate the left minus right (L-R) hemisphere EEG power shifts coupled to rapid eye movement (REM) and non-rapid eye movement (NREM) sleep observed in 1972 by Goldstein (Physiol Behav (1972) 811), and to characterize the L-R EEG power spectra for total EEG, delta, theta, alpha and beta bands.Background...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Shannahoff-Khalsa DS,Gillin JC,Yates FE,Schlosser A,Zawadzki EM

    更新日期:2001-07-01 00:00:00

  • Sleep problems and their association with weight and waist gain - The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).

    abstract:OBJECTIVE:To evaluate the association of sleep problems with weight and waist size gain during four years of follow-up. METHODS:We investigated 13,030 participants (35-74 years) of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil), a multicentric cohort conducted with civil servants from six academic inst...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Camargo TR,Luft VC,Duncan BB,Nunes MAA,Chor D,Griep RH,da Fonseca MJM,Barreto SM,de Matos SMA,Schmidt MI

    更新日期:2020-09-01 00:00:00

  • Self-reported sleep quality is associated with gut microbiome composition in young, healthy individuals: a pilot study.

    abstract:OBJECTIVES:The microbiota-gut-brain axis is an intricate communication network that is emerging as a key modulator of psychological and physiological wellbeing. Recent pioneering work in the field has suggested a possible link between gut microbiome composition with sleep, an evolutionarily conserved behavior demonstra...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Grosicki GJ,Riemann BL,Flatt AA,Valentino T,Lustgarten MS

    更新日期:2020-09-01 00:00:00

  • Antidepressant action of melatonin in the treatment of Delayed Sleep Phase Syndrome.

    abstract:BACKGROUND:Depression is a common problem in patients with Delayed Sleep Phase Syndrome (DSPS). This study used a randomized, double-blind, crossover, placebo-controlled approach to test the hypothesis that exogenous melatonin (5mg) can attenuate depressive symptomatology in DSPS patients. METHODS:Twenty patients with...

    journal_title:Sleep medicine

    pub_type: 杂志文章,随机对照试验


    authors: Rahman SA,Kayumov L,Shapiro CM

    更新日期:2010-02-01 00:00:00

  • Abnormal night sleep duration and poor sleep quality are independently and combinedly associated with elevated depressive symptoms in Chinese rural adults: Henan Rural Cohort.

    abstract:OBJECTIVE:To assess the independent and combined effects of night sleep duration and sleep quality on depressive symptoms. METHODS:A total of 28,202 participants (11,236 males and 16,966 females) aged 18-79 years from the Henan Rural Cohort were included in this study. Night sleep duration and sleep quality were defin...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Jiang J,Li Y,Mao Z,Wang F,Huo W,Liu R,Zhang H,Tian Z,Liu X,Zhang X,Tu R,Qian X,Liu X,Luo Z,Bie R,Wang C

    更新日期:2020-06-01 00:00:00

  • Secondary ''incidental'' REM sleep behavior disorder: do we ever think of it?

    abstract::Most secondary forms of REM sleep behavior disorder are associated with neurodegenerative diseases belonging to the α-synucleinopathies or with narcolepsy. However, RBD may also occur in subacute- or acute-onset conditions involving the central nervous system, irrespective of subjects' age and sex, and with or without...

    journal_title:Sleep medicine

    pub_type: 杂志文章,评审


    authors: Manni R,Ratti PL,Terzaghi M

    更新日期:2011-12-01 00:00:00

  • Longer habitual afternoon napping is associated with a higher risk for impaired fasting plasma glucose and diabetes mellitus in older adults: results from the Dongfeng-Tongji cohort of retired workers.

    abstract:OBJECTIVES:Afternoon napping is a common habit in China. We used data obtained from the Dongfeng-Tongji cohort to examine if duration of habitual afternoon napping was associated with risks for impaired fasting plasma glucose (IFG) and diabetes mellitus (DM) in a Chinese elderly population. METHODS:A total of 27,009 p...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Fang W,Li Z,Wu L,Cao Z,Liang Y,Yang H,Wang Y,Wu T

    更新日期:2013-10-01 00:00:00

  • Comparison of Epworth Sleepiness Scale scores by patients with obstructive sleep apnea and their bed partners.

    abstract:OBJECTIVES:In some patients with obstructive sleep apnea (OSA), Epworth Sleepiness Scale scores (ESS) do not reflect the severity of disease. In many cases, bed partners (BPs) report more severe hypersomnia on the part of the patient than the patient him/herself. The purpose of this study was to assess the agreement be...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Walter TJ,Foldvary N,Mascha E,Dinner D,Golish J

    更新日期:2002-01-01 00:00:00

  • Timing of light exposure and activity in adults with delayed sleep-wake phase disorder.

    abstract:OBJECTIVE:To characterize the patterns of light exposure and physical activity level and assess their relationship with sleep quality and depressive symptoms in adults with delayed sleep-wake phase disorder (DSWPD). METHODS:42 DSWPD (22 female, mean age 34.5 y) and 26 (±4 years) age-and-sex-matched controls (12 female...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Joo EY,Abbott SM,Reid KJ,Wu D,Kang J,Wilson J,Zee PC

    更新日期:2017-04-01 00:00:00

  • Sensitivity and specificity of Frontal Assessment Battery in newly diagnosed and untreated obstructive sleep apnea patients.

    abstract:BACKGROUND:Executive dysfunction (ED) is often observed in subjects diagnosed with obstructive sleep apnea (OSA), but their assessment requires facilities that are not always available. We aim to evaluate the extent to which Frontal Assessment Battery (FAB) discriminates ED in newly diagnosed, untreated, and without-co...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Ladera V,Sargento P,Perea V,Faria M,Garcia R

    更新日期:2018-02-01 00:00:00

  • Familial aggregation of narcolepsy.

    abstract:OBJECTIVES:To determine the familial aggregation of narcolepsy from perspectives of clinical symptomatology, polysomnographic data, and human leukocyte antigen (HLA) typing. METHODS:This was a Family study at the University-affiliated hospital. The participants were narcolepsy probands and their first degree relatives...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Wing YK,Chen L,Lam SP,Li AM,Tang NL,Ng MH,Cheng SH,Ho CK,Mok V,Leung HW,Lau A,Chan MH,Chan HS,Chan PS

    更新日期:2011-12-01 00:00:00

  • Normative values of polysomnographic parameters in childhood and adolescence: quantitative sleep parameters.

    abstract:OBJECTIVE:To provide normative values for sleep macroarchitecture of healthy children aged 1-18 years using the AASM sleep scoring criteria, assessing the effects of gender, age, and Tanner pubertal stage. METHODS:One-night polysomnography was performed at subjects' habitual bedtimes in 16 laboratories on 209 healthy ...

    journal_title:Sleep medicine

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Scholle S,Beyer U,Bernhard M,Eichholz S,Erler T,Graness P,Goldmann-Schnalke B,Heisch K,Kirchhoff F,Klementz K,Koch G,Kramer A,Schmidtlein C,Schneider B,Walther B,Wiater A,Scholle HC

    更新日期:2011-06-01 00:00:00

  • Machine learning sleep duration classification in Preschoolers using waist-worn ActiGraphs.

    abstract:OBJECTIVE:To create a sleep duration classification technique for waist-worn ActiGraph accelerometers in preschool-aged children. METHODS:Children wore ActiGraph wGT3X-BT accelerometers on their right hip for 7 days (24 h/day). Ground truth nap, sleep, and wake were estimated through visual inspection of accelerometer...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Kuzik N,Spence JC,Carson V

    更新日期:2021-01-08 00:00:00

  • Feasibility of electronic sleep disorder screening in healthcare workers of a large healthcare system.

    abstract:STUDY OBJECTIVES:Many healthcare workers live with sleep disorders and may be unaware of their condition. We aimed to ascertain sleep disorder symptoms including high-risk obstructive sleep apnea (hrOSA), significant insomnia, and excessive daytime sleepiness (EDS) by work shift in a sample of healthcare workers. We ai...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Pascoe M,Alberts J,Wang L,Bruton M,Rogen B,Rehm SJ,McHugh L,Katzan I,Foldvary-Schaefer N

    更新日期:2020-09-01 00:00:00

  • Sleep architecture and attenuated heart rate response to arousal from sleep in patients with autonomic failure.

    abstract:OBJECTIVE:To determine if patients with autonomic failure have increased sleep disturbances and if multiple system atrophy (MSA) and pure autonomic failure (PAF) patients have frequent arousals from sleep associated with an attenuated heart rate (HR) response compared to healthy volunteers. METHODS:With informed conse...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Freilich S,Goff EA,Malaweera AS,Twigg GL,Simonds AK,Mathias CJ,Morrell MJ

    更新日期:2010-01-01 00:00:00

  • Prediction of normal values for central apnea-hypopnea index at different ages and altitudes above sea level in healthy children.

    abstract:BACKGROUND:There is a critical need for studies aimed to help clinicians to establish the normal/expected central apnea-hypopnea index (CAHI) at altitudes above sea level and ages other than those reported in the current available studies. The aim of the present study was to develop predictive models useful for determi...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Restrepo-Gualteros SM,Villamil-Osorio M,Rodriguez-Martinez CE

    更新日期:2020-12-31 00:00:00

  • A 2-week efficacy and safety study of gaboxadol and zolpidem using electronic diaries in primary insomnia outpatients.

    abstract:OBJECTIVES:To evaluate the efficacy and safety profile of gaboxadol, a selective extrasynaptic GABA(A) agonist (SEGA) previously in development for the treatment of insomnia. METHODS:This was a randomised, double-blind, placebo-controlled, parallel-group, 2-week, Phase III study of gaboxadol 5, 10 and 15mg in outpatie...

    journal_title:Sleep medicine

    pub_type: 杂志文章,随机对照试验


    authors: Hajak G,Hedner J,Eglin M,Loft H,Stórustovu SI,Lütolf S,Lundahl J,Gaboxadol Study 99775 Group.

    更新日期:2009-08-01 00:00:00

  • The neurophysiology of the alternating leg muscle activation (ALMA) during sleep: study of one patient before and after treatment with pramipexole.

    abstract:BACKGROUND AND PURPOSES:To report the neurophysiological features of a patient with alternating leg muscle activation (ALMA) during sleep, a quickly alternating pattern of anterior tibialis activation which might represent transient facilitation of a spinal central pattern generator for locomotion, perhaps due to the s...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Cosentino FI,Iero I,Lanuzza B,Tripodi M,Ferri R

    更新日期:2006-01-01 00:00:00

  • Subclinical rhythmic electrographic discharge of adults (SREDA) in REM sleep.

    abstract::We describe the first reported case of subclinical rhythmic electrographic discharge of adults (SREDA) during rapid eye movement (REM) sleep. This 48-year-old man, with a history of witnessed apneic spells, was sent for a baseline polysomnogram. Besides demonstrating obstructive sleep apnea, his study showed the occur...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Fleming WE,Avidan A,Malow BA

    更新日期:2004-01-01 00:00:00

  • Sawtooth wave density analysis during REM sleep in temporal lobe epilepsy patients.

    abstract:BACKGROUND AND PURPOSE:This study analyzes sawtooth waves (STW), a characteristic feature of rapid eye movement (REM) sleep, in temporal lobe epilepsy patients in order to test the hypothesis of STW dysfunction in this population. METHODS:Polysomnographic records from 16 patients with temporal lobe epilepsy and 11 con...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Vega-Bermudez F,Szczepanski S,Malow B,Sato S

    更新日期:2005-07-01 00:00:00

  • Sleep duration as a risk factor for the development of type 2 diabetes or impaired glucose tolerance: analyses of the Quebec Family Study.

    abstract:OBJECTIVE:To examine the long-term relationship between sleep duration and type 2 diabetes or impaired glucose tolerance (IGT). METHODS:Body composition measurements and self-reported sleep duration were determined in a longitudinal sample of 276 individuals aged 21 to 64 years followed for a mean of 6 years. Risk fac...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Chaput JP,Després JP,Bouchard C,Astrup A,Tremblay A

    更新日期:2009-09-01 00:00:00

  • Capturing PLMS and their variability in children with sickle cell disease: does ankle activity monitoring measure up to polysomnography?

    abstract:OBJECTIVES:To test agreement and define differences in periodic limb movements in sleep (PLMS) measured by polysomnography and an ankle activity monitor, and to describe PLMS variability across nights, feasibility of home monitoring, and correlates of PLMS in children with sickle cell disease (SCD). METHODS:Twenty chi...

    journal_title:Sleep medicine

    pub_type: 临床试验,杂志文章


    authors: Rogers VE,Gallagher PR,Marcus CL,Ohene-Frempong K,Traylor JT,Mason TB

    更新日期:2012-09-01 00:00:00

  • Psychophysiological insomnia: combined effects of pharmacotherapy and relaxation-based treatments.

    abstract::Objective: To compare treatment outcomes associated with combined pharmacologic and non-pharmacologic treatments for psychophysiological insomnia.Background: Treatments for insomnia have included a variety of pharmacotherapy and cognitive-behavioral interventions, although few studies have investigated the combined ef...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Rosen RC,Lewin DS,Goldberg L,Woolfolk RL

    更新日期:2000-10-01 00:00:00