Night-shift work increases morbidity of breast cancer and all-cause mortality: a meta-analysis of 16 prospective cohort studies.


:Night-shift work (NSW) has previously been related to incidents of breast cancer and all-cause mortality, but many published studies have reported inconclusive results. The aim of the present study was to quantify a potential dose-effect relationship between NSW and morbidity of breast cancer, and to evaluate the association between NSW and risk of all-cause mortality. The outcomes included NSW, morbidity of breast cancer, cardiovascular mortality, cancer-related mortality, and all-cause mortality. Sixteen investigations were included, involving 2,020,641 participants, 10,004 incident breast cancer cases, 7185 cancer-related deaths, 4820 cardiovascular end points, and 2480 all-cause mortalities. The summary risk ratio (RR) of incident breast cancer for an increase of NSW was 1.057 [95% confidence interval (CI) 1.014-1.102; test for heterogeneity p = 0.358, I(2) = 9.2%]. The combined RR (95% CI) of breast cancer risk for NSW vs daytime work was: 1.029 (0.969-1.093) in the <5-year subgroup, 1.019 (1.001-1.038) for 5-year incremental risk, 1.025 (1.006-1.044) for 5- to 10-year exposure times, 1.074 (1.010-1.142) in the 10- to 20-year subgroup, and 1.088 (1.012-1.169) for >20-year exposure lengths. The overall RR was 1.089 (95% CI 1.016-1.166) in a fixed-effects model (test for heterogeneity p = 0.838, I(2) = 0%) comparing rotating NSW and day work. Night-shift work was associated with an increased risk of cardiovascular death (RR 1.027, 95% CI 1.001-1.053), and all-cause death 1.253 (95% CI 0.786-1.997). In summary, NSW increased the risk of breast cancer morbidity by: 1.9% for 5 years, 2.5% for 5-10 years, 7.4% for 10-20 years, and 8.8% for >20-years of NSW. Additionally, rotating NSW enhanced the morbidity of breast cancer by 8.9%. Moreover, NSW was associated with a 2.7% increase in cardiovascular death.


Sleep Med


Sleep medicine


Lin X,Chen W,Wei F,Ying M,Wei W,Xie X




Has Abstract


2015-11-01 00:00:00














  • Sleep disorder in alien hand syndrome.

    abstract::A 63-year-old right-handed woman developed an alien hand syndrome (AHS) after an acute infarction in the territory of the left anterior cerebral artery. The uncontrolled hand movements were present during the daytime and eventually disturbed sleep. Polysomnography revealed that these motor actions only appeared when t...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Ortega-Albás JJ,de Entrambasaguas M,Montoya FJ,Serrano AL,Geffner D

    更新日期:2003-05-01 00:00:00

  • Web- vs. telehealth-based delivery of cognitive behavioral therapy for insomnia: a randomized controlled trial.

    abstract:OBJECTIVES:The purpose of our study was to evaluate and compare two methods of service delivery (web-based and telehealth-based) for chronic insomnia with regard to patient preference, clinical effectiveness, and patient satisfaction. METHODS:Our study was a randomized controlled trial with manualized telehealth- and ...

    journal_title:Sleep medicine

    pub_type: 杂志文章,随机对照试验


    authors: Holmqvist M,Vincent N,Walsh K

    更新日期:2014-02-01 00:00:00

  • Predictors of long-term effectiveness to mandibular repositioning device treatment in obstructive sleep apnea patients after 1000 days.

    abstract:OBJECTIVE/BACKGROUND:In obstructive sleep apnea (OSA), long-term adherence to treatment is crucial. This prospective single-center study investigated factors associated with long-term adherence to mandibular repositioning device (MRD) therapy. PATIENTS/METHODS:All OSA patients who had MRD treatment initiated in the pr...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Attali V,Chaumereuil C,Arnulf I,Golmard JL,Tordjman F,Morin L,Goudot P,Similowski T,Collet JM

    更新日期:2016-01-01 00:00:00

  • Construct validity of the parent-child sleep interactions scale (PSIS): associations with parenting, family stress, and maternal and child psychopathology.

    abstract:STUDY OBJECTIVES:Using a multi-method design, this study examined the construct validity of the Parent-Child Sleep Interactions Scale (PSIS; Alfano et al., 2013), which measures sleep-related parenting behaviors and interactions that contribute to preschoolers' sleep problems. METHODS:Participants included a community...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Smith VC,Leppert KA,Alfano CA,Dougherty LR

    更新日期:2014-08-01 00:00:00

  • Randomized trial of pramipexole for patients with restless legs syndrome (RLS) and RLS-related impairment of mood.

    abstract:OBJECTIVES:Patients with restless legs syndrome (RLS) have an elevated prevalence of mood disorders compared with the general population. We investigated the change of RLS-related mood impairment during treatment of RLS with pramipexole, a dopamine D(3)/D(2) agonist. METHODS:Adults with moderate to very severe RLS wer...

    journal_title:Sleep medicine

    pub_type: 杂志文章,随机对照试验


    authors: Montagna P,Hornyak M,Ulfberg J,Hong SB,Koester J,Crespi G,Albrecht S

    更新日期:2011-01-01 00:00:00

  • Excessive fragmentary myoclonus in Machado-Joseph disease.

    abstract:OBJECTIVE:Machado-Joseph disease (MJD) is a neurodegenerative disease which usually presents several clinical findings including cerebellar ataxia and other extracerebellar features, such as Parkinsonism, dystonia, peripheral neuropathy, and lower motor neuron disease. Some data have demonstrated a high frequency of sl...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: dos Santos DF,Pedroso JL,Braga-Neto P,Silva GM,de Carvalho LB,Prado LB,Barsottini OG,do Prado GF

    更新日期:2014-03-01 00:00:00

  • Emergence of restless legs syndrome after subthalamic stimulation in Parkinson's disease: a dopaminergic overstimulation?

    abstract:OBJECTIVE:Studies investigating the effects of subthalamic deep-brain stimulation (DBS-STN) on restless legs syndrome (RLS) in Parkinson's disease (PD) are limited and report conflicting results, with some describing the emergence of RLS after DBS-STN, while others report postoperative improvement of this disorder. Sev...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Marques A,Fantini ML,Morand D,Pereira B,Derost P,Ulla M,Debilly B,Lemaire JJ,Durif F

    更新日期:2015-05-01 00:00:00

  • Are the Insomnia Severity Index and Pittsburgh Sleep Quality Index valid outcome measures for Cognitive Behavioral Therapy for Insomnia? Inquiry from the perspective of response shifts and longitudinal measurement invariance in their Chinese versions.

    abstract:OBJECTIVE:The purpose of this study was to examine whether the Insomnia Severity Index (ISI) and Pittsburgh Sleep Quality Index (PSQI) are valid outcome measures for Cognitive Behavioral Therapy for Insomnia (CBT-I). Specifically, we tested whether the factorial parameters of the ISI and the PSQI could remain invariant...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Chen PY,Jan YW,Yang CM

    更新日期:2017-07-01 00:00:00

  • Sleep-related eating disorder in fraternal twins.

    abstract::Sleep-related eating disorder (SRED) is characterized by nocturnal partial arousals associated with compulsive consumption of food and altered levels of consciousness. Reports of an increased incidence of SRED in relatives of affected individuals suggest a genetic predisposition. We report a woman with SRED whose frat...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: De Ocampo J,Foldvary N,Dinner DS,Golish J

    更新日期:2002-11-01 00:00:00

  • Sleep-stage transitions during polysomnographic recordings as diagnostic features of type 1 narcolepsy.

    abstract:OBJECTIVE:Type 1 narcolepsy/hypocretin deficiency is characterized by excessive daytime sleepiness, sleep fragmentation, and cataplexy. Short rapid eye movement (REM) latency (≤15 min) during nocturnal polysomnography (PSG) or during naps of the multiple sleep latency test (MSLT) defines a sleep-onset REM sleep period ...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Christensen JA,Carrillo O,Leary EB,Peppard PE,Young T,Sorensen HB,Jennum P,Mignot E

    更新日期:2015-12-01 00:00:00

  • Increased severity of sleep-disordered breathing is associated with insomnia and excessive somnolence in primary school children.

    abstract:OBJECTIVE:The aim of the study was to investigate the prevalence of difficulty with initiation or maintenance of sleep (DIMS) and excessive daytime sleepiness (EDS) in a general pediatric population, and to evaluate the relationship between these conditions and sleep-disordered breathing (SDB) symptom intensity. METHO...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Kukwa W,Migacz E,Ishman S,Wichniak A

    更新日期:2016-07-01 00:00:00

  • Rem sleep brady-arrhythmias: an indication to pacemaker implantation?

    abstract:OBJECTIVES:Important adjustments in the autonomic nervous system occur during sleep. Bradycardia, due to increased vagal tone, and hypotension, caused by reduction of sympathetic activity, may occur during non rapid eye movement (REM) sleep (NREM). Increased sympathetic activity, causing increased heart rate, is conver...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Serafini A,Dolso P,Gigli GL,Fratticci L,Cancelli I,Facchin D,Gigli M,Valente M

    更新日期:2012-06-01 00:00:00

  • The association of sleep duration and quality with all-cause and cause-specific mortality in the Women's Health Initiative.

    abstract:BACKGROUND/OBJECTIVE:Many studies have shown a U-shaped association of sleep duration with mortality; however, this association is difficult to interpret owing to possible reverse causation, residual confounding, and measurement issues. We used data from the Women's Health Initiative to examine the associations of slee...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Kabat GC,Xue X,Kamensky V,Zaslavsky O,Stone KL,Johnson KC,Wassertheil-Smoller S,Shadyab AH,Luo J,Hale L,Qi L,Cauley JA,Brunner RL,Manson JE,Rohan TE

    更新日期:2018-10-01 00:00:00

  • Aerobic exercise improves self-reported sleep and quality of life in older adults with insomnia.

    abstract:OBJECTIVE:To assess the efficacy of moderate aerobic physical activity with sleep hygiene education to improve sleep, mood and quality of life in older adults with chronic insomnia. METHODS:Seventeen sedentary adults aged >or=55 years with insomnia (mean age 61.6 [SD±4.3] years; 16 female) participated in a randomized...

    journal_title:Sleep medicine

    pub_type: 杂志文章,随机对照试验


    authors: Reid KJ,Baron KG,Lu B,Naylor E,Wolfe L,Zee PC

    更新日期:2010-10-01 00:00:00

  • Pramipexole for Chinese people with primary restless legs syndrome: a 12-week multicenter, randomized, double-blind study.

    abstract:BACKGROUND:Restless legs syndrome (RLS) often responds to agents that enhance dopamine neurotransmission. The present 12-week study aimed to evaluate the efficacy and adverse events of pramipexole (PPX) for the treatment of adult, Chinese people with primary RLS. METHODS:A total of 204 Chinese people with RLS were ran...

    journal_title:Sleep medicine

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Zhang J,Liu B,Zheng Y,Chu T,Yang Z

    更新日期:2015-01-01 00:00:00

  • Hearing loss mediates executive function impairment in sleep-disordered breathing.

    abstract:BACKGROUND:Sleep-disordered breathing (SDB) is often co-morbid with conductive hearing loss in early childhood due to a shared aetiology of adenotonsillar hypertrophy. Hearing loss is independently associated with impairment of executive function and behavioural difficulties. We hypothesised that these impairments in c...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Hill CM,Bucks RS,Kennedy CR,Harrison D,Carroll A,Upton N,Hogan AM

    更新日期:2017-06-01 00:00:00

  • Functional neuroimaging studies in restless legs syndrome.

    abstract::Functional neuroimaging studies may contribute to elucidate pathophysiological mechanisms of the restless legs syndrome (RLS) which still remain unclear. Studies in patients with RLS have been performed using functional magnetic resonance imaging (fMRI), single photon emission computed tomography (SPECT) and, more rec...

    journal_title:Sleep medicine

    pub_type: 杂志文章,评审


    authors: Wetter TC,Eisensehr I,Trenkwalder C

    更新日期:2004-07-01 00:00:00

  • Sleep apnea increased incidence of primary central nervous system cancers: a nationwide cohort study.

    abstract:INTRODUCTION:Obstructive sleep apnea (OSA) was associated with increased incidence of all cancers. We aimed to determine the risk for primary central nervous system (CNS) cancers in patients with sleep apnea syndrome. METHODS:A total of 23,055 incident cases of newly diagnosed sleep apnea syndrome (sleep apnea group) ...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Chen JC,Hwang JH

    更新日期:2014-07-01 00:00:00

  • An assessment of the efficacy and safety of eszopiclone in the treatment of transient insomnia in healthy adults.

    abstract:BACKGROUND AND PURPOSE:This randomized, double-blind, placebo-controlled study assessed the efficacy and safety of eszopiclone, a non-benzodiazepine hypnotic agent, in healthy adults using the first-night effect model of transient insomnia. PATIENTS AND METHODS:A total of 436 healthy, normal sleeping participants were...

    journal_title:Sleep medicine

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Rosenberg R,Caron J,Roth T,Amato D

    更新日期:2005-01-01 00:00:00

  • The clinical features of cataplexy: a questionnaire study in narcolepsy patients with and without hypocretin-1 deficiency.

    abstract:BACKGROUND:Narcolepsy is often not recognized or accurately diagnosed. This may be due to the fact that cataplexy, a core symptom which is virtually 100% specific, can-in practice-only be diagnosed based on the patient's history. However, the current definition of cataplexy is not very precise and the common distinctio...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Overeem S,van Nues SJ,van der Zande WL,Donjacour CE,van Mierlo P,Lammers GJ

    更新日期:2011-01-01 00:00:00

  • Bully victimization is a correlate of sleep loss over worry (SLOW) among adolescents in four South-East Asian countries.

    abstract:OBJECTIVE:To examine the unique contribution of bully victimization to sleep loss over worry (SLOW) among adolescents in four Southeast Asian countries, while controlling for loneliness and selected lifestyle factors. METHODS:Data was derived from the Global School-Based Student Health Survey (2014-2015). Responses fr...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Wang Q,Liu Y,Mati K

    更新日期:2020-05-01 00:00:00

  • Associations between poor sleep quality and different measures of obesity.

    abstract:OBJECTIVE:Poor sleep may be a risk factor for obesity. Previous studies have mainly investigated the effects of sleep duration on body mass index, but research considering overall sleep quality and other anthropometric measures is scarce. The aim of this study was to examine the association between sleep quality and di...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Rahe C,Czira ME,Teismann H,Berger K

    更新日期:2015-10-01 00:00:00

  • Obstructive sleep apnea and diet-controlled gestational diabetes.

    abstract:BACKGROUND:Obstructive sleep apnea (OSA) was shown to be associated with gestational diabetes mellitus (GDM). However, prevalence of OSA in GDM women, its relationship to metabolic control, and predictive factors have not been studied. MATERIAL AND METHODS:Eighty-two obese pregnant women with diet-controlled GDM betwe...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Wanitcharoenkul E,Chirakalwasan N,Amnakkittikul S,Charoensri S,Saetung S,Chanprasertyothin S,Chailurkit LO,Panburana P,Bumrungphuet S,Ongphiphadhanakul B,Reutrakul S

    更新日期:2017-11-01 00:00:00

  • Psychosocial adjustment following relief of chronic narcolepsy.

    abstract:BACKGROUND AND PURPOSE:No previous research has examined the psychosocial adjustment of chronic narcolepsy patients following efficacious pharmacotherapy. In contrast, considerable research has examined the process of psychosocial adjustment following surgical relief of chronic epilepsy. This process can manifest as a ...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Wilson SJ,Frazer DW,Lawrence JA,Bladin PF

    更新日期:2007-04-01 00:00:00

  • Treatment of elderly primary insomnia patients with EVT 201 improves sleep initiation, sleep maintenance, and daytime sleepiness.

    abstract:OBJECTIVE:Two doses of EVT 201, a partial positive allosteric modulator of the GABA(A) system, were evaluated in elderly primary insomnia patients with daytime sleepiness. PATIENTS AND METHODS:Participants were 149 elderly patients with DSM-IV primary insomnia including evidence of daytime sleepiness (53 males, 96 fem...

    journal_title:Sleep medicine

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Walsh JK,Salkeld L,Knowles LJ,Tasker T,Hunneyball IM

    更新日期:2010-01-01 00:00:00

  • Timing of light exposure and activity in adults with delayed sleep-wake phase disorder.

    abstract:OBJECTIVE:To characterize the patterns of light exposure and physical activity level and assess their relationship with sleep quality and depressive symptoms in adults with delayed sleep-wake phase disorder (DSWPD). METHODS:42 DSWPD (22 female, mean age 34.5 y) and 26 (±4 years) age-and-sex-matched controls (12 female...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Joo EY,Abbott SM,Reid KJ,Wu D,Kang J,Wilson J,Zee PC

    更新日期:2017-04-01 00:00:00

  • Selection of response criteria affects the success rate of oral appliance treatment for obstructive sleep apnea.

    abstract:BACKGROUND:In oral appliance therapy for obstructive sleep apnea (OSA), treatment success is arbitrarily defined. We investigated if the selection of response criteria affected the success rate of oral appliance treatment. METHODS:The effects of an oral appliance on apnea-hypopnea index (AHI) and nadir percutaneous ox...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Fukuda T,Tsuiki S,Kobayashi M,Nakayama H,Inoue Y

    更新日期:2014-03-01 00:00:00

  • The fate of patients with REM sleep behavior disorder and mild cognitive impairment.

    abstract:OBJECTIVE:To investigate clinical and dopaminergic pre-synaptic brain imaging characteristics of subjects with idiopathic rapid eye movement (REM) behavior disorder (iRBD) and mild cognitive impairment (MCI), and to evaluate the combined predictive value of risk factors for short-term conversion to synucleinopathy. ME...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Arnaldi D,Chincarini A,De Carli F,Famà F,Girtler N,Brugnolo A,Pardini M,Massa F,Meli R,Schenone C,Bauckneht M,Morbelli S,Nobili F

    更新日期:2020-02-29 00:00:00

  • Correlates of nocturnal sleep duration, nocturnal sleep variability, and nocturnal sleep problems in toddlers: results from the GET UP! Study.

    abstract:OBJECTIVE:To explore the correlates of nocturnal sleep duration, nocturnal sleep variability, and nocturnal sleep problems in a sample of Australian toddlers. METHODS:Participants were 173 toddlers (average age 19.7 ± 4.1 months) from the GET UP! STUDY:Nocturnal sleep duration, nocturnal sleep variability, nap(s) and...

    journal_title:Sleep medicine

    pub_type: 杂志文章,随机对照试验


    authors: Zhang Z,Sousa-Sá E,Pereira J,Chaput JP,Okely A,Feng X,Santos R

    更新日期:2019-01-01 00:00:00

  • Test-to-test variability in motor activity during the suggested immobilization test in restless legs patients.

    abstract:BACKGROUND AND PURPOSE:To evaluate the test-to-test variability of the suggested immobilization test (SIT) in patients with restless legs syndrome (RLS). PATIENTS AND METHODS:Twenty patients with primary RLS (12 men and eight women; age: 53.3+/-11.3 years) were selected for the study. We compared the results of two SI...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Haba-Rubio J,Sforza E

    更新日期:2006-10-01 00:00:00