Night-shift work increases morbidity of breast cancer and all-cause mortality: a meta-analysis of 16 prospective cohort studies.


:Night-shift work (NSW) has previously been related to incidents of breast cancer and all-cause mortality, but many published studies have reported inconclusive results. The aim of the present study was to quantify a potential dose-effect relationship between NSW and morbidity of breast cancer, and to evaluate the association between NSW and risk of all-cause mortality. The outcomes included NSW, morbidity of breast cancer, cardiovascular mortality, cancer-related mortality, and all-cause mortality. Sixteen investigations were included, involving 2,020,641 participants, 10,004 incident breast cancer cases, 7185 cancer-related deaths, 4820 cardiovascular end points, and 2480 all-cause mortalities. The summary risk ratio (RR) of incident breast cancer for an increase of NSW was 1.057 [95% confidence interval (CI) 1.014-1.102; test for heterogeneity p = 0.358, I(2) = 9.2%]. The combined RR (95% CI) of breast cancer risk for NSW vs daytime work was: 1.029 (0.969-1.093) in the <5-year subgroup, 1.019 (1.001-1.038) for 5-year incremental risk, 1.025 (1.006-1.044) for 5- to 10-year exposure times, 1.074 (1.010-1.142) in the 10- to 20-year subgroup, and 1.088 (1.012-1.169) for >20-year exposure lengths. The overall RR was 1.089 (95% CI 1.016-1.166) in a fixed-effects model (test for heterogeneity p = 0.838, I(2) = 0%) comparing rotating NSW and day work. Night-shift work was associated with an increased risk of cardiovascular death (RR 1.027, 95% CI 1.001-1.053), and all-cause death 1.253 (95% CI 0.786-1.997). In summary, NSW increased the risk of breast cancer morbidity by: 1.9% for 5 years, 2.5% for 5-10 years, 7.4% for 10-20 years, and 8.8% for >20-years of NSW. Additionally, rotating NSW enhanced the morbidity of breast cancer by 8.9%. Moreover, NSW was associated with a 2.7% increase in cardiovascular death.


Sleep Med


Sleep medicine


Lin X,Chen W,Wei F,Ying M,Wei W,Xie X




Has Abstract


2015-11-01 00:00:00














  • Self-reported sleep quality is associated with gut microbiome composition in young, healthy individuals: a pilot study.

    abstract:OBJECTIVES:The microbiota-gut-brain axis is an intricate communication network that is emerging as a key modulator of psychological and physiological wellbeing. Recent pioneering work in the field has suggested a possible link between gut microbiome composition with sleep, an evolutionarily conserved behavior demonstra...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Grosicki GJ,Riemann BL,Flatt AA,Valentino T,Lustgarten MS

    更新日期:2020-09-01 00:00:00

  • Flow cytometry analysis of T-cell subsets in cerebrospinal fluid of narcolepsy type 1 patients with long-lasting disease.

    abstract:BACKGROUND:Type 1 narcolepsy (NT1) is a central hypersomnia linked to the destruction of hypocretin-producing neurons. A great body of genetic and epidemiological data points to likely autoimmune disease aetiology. Recent reports have characterized peripheral blood T-cell subsets in NT1, whereas data regarding the cere...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Moresco M,Lecciso M,Ocadlikova D,Filardi M,Melzi S,Kornum BR,Antelmi E,Pizza F,Mignot E,Curti A,Plazzi G

    更新日期:2018-04-01 00:00:00

  • Decreased concentration of klotho and increased concentration of FGF23 in the cerebrospinal fluid of patients with narcolepsy.

    abstract:OBJECTIVE:to explore the status of concentration of klotho and fibroblast growth factor 23 (FGF23) in cerebrospinal fluid (CSF) of patients with narcolepsy. PATIENTS/METHODS:59 patients with narcolepsy and 17 control individuals were enrolled. We used radioimmunoassay, human klotho enzyme-linked immunosorbent assay (E...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: da Paz Oliveira G,Elias RM,Peres Fernandes GB,Moyses R,Tufik S,Bichuetti DB,Coelho FMS

    更新日期:2020-12-15 00:00:00

  • Selection of response criteria affects the success rate of oral appliance treatment for obstructive sleep apnea.

    abstract:BACKGROUND:In oral appliance therapy for obstructive sleep apnea (OSA), treatment success is arbitrarily defined. We investigated if the selection of response criteria affected the success rate of oral appliance treatment. METHODS:The effects of an oral appliance on apnea-hypopnea index (AHI) and nadir percutaneous ox...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Fukuda T,Tsuiki S,Kobayashi M,Nakayama H,Inoue Y

    更新日期:2014-03-01 00:00:00

  • Improved night shift schedule related to the mortality of critically ill patients with Corona Virus Disease 2019.

    abstract:PURPOSE:To determine the relationship between the improved night shift schedule and the mortality of critically ill patients with Corona Virus Disease 2019 (COVID-19). METHODS:According to the time of the implementation of the new night shift schedule, we divided all patients into two groups: initial period group and ...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Zhang S,Xu Y,Wu K,Wang T,Su X,Han Q,Xi Y,Zhu S,Gao Y,Wang H,Hu Y,Liu C,Zhong N,Ran P,Zhang N

    更新日期:2020-11-01 00:00:00

  • Aerobic exercise improves self-reported sleep and quality of life in older adults with insomnia.

    abstract:OBJECTIVE:To assess the efficacy of moderate aerobic physical activity with sleep hygiene education to improve sleep, mood and quality of life in older adults with chronic insomnia. METHODS:Seventeen sedentary adults aged >or=55 years with insomnia (mean age 61.6 [SD±4.3] years; 16 female) participated in a randomized...

    journal_title:Sleep medicine

    pub_type: 杂志文章,随机对照试验


    authors: Reid KJ,Baron KG,Lu B,Naylor E,Wolfe L,Zee PC

    更新日期:2010-10-01 00:00:00

  • The influence of different definition criteria on the PLM index.

    abstract:BACKGROUND:Different criteria for the scoring of periodic leg movements (PLM) have been recently proposed. We investigated to what extent changes in PLM criteria for leg movement duration, intermovement interval and combination of bilateral leg movements (LM) influence the PLM index. METHODS:The nocturnal polysomnogra...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Fulda S,Wetter TC

    更新日期:2007-08-01 00:00:00

  • Nocturnal polysomnographic sleep across the menstrual cycle in premenstrual dysphoric disorder.

    abstract:OBJECTIVES:Women with premenstrual dysphoric disorder (PMDD) experience disturbed mood, altered melatonin circadian rhythms, and frequent reports of insomnia during the luteal phase (LP) of their menstrual cycle. In this study we aimed to investigate nocturnal polysomnographic (PSG) sleep across the menstrual cycle in ...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Shechter A,Lespérance P,Ng Ying Kin NM,Boivin DB

    更新日期:2012-09-01 00:00:00

  • Napping and the risk of type 2 diabetes: a population-based prospective study.

    abstract:OBJECTIVE:Some studies indicate an association between napping and increased risk of type 2 diabetes. We studied this prospectively in a sample representative of general population. METHODS:A questionnaire was administered to the Finnish Twin Cohort in 1990 (response rate 77%, age 33-60 years). The study population in...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Hublin C,Lehtovirta M,Partinen M,Koskenvuo M,Kaprio J

    更新日期:2016-01-01 00:00:00

  • Sawtooth wave density analysis during REM sleep in temporal lobe epilepsy patients.

    abstract:BACKGROUND AND PURPOSE:This study analyzes sawtooth waves (STW), a characteristic feature of rapid eye movement (REM) sleep, in temporal lobe epilepsy patients in order to test the hypothesis of STW dysfunction in this population. METHODS:Polysomnographic records from 16 patients with temporal lobe epilepsy and 11 con...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Vega-Bermudez F,Szczepanski S,Malow B,Sato S

    更新日期:2005-07-01 00:00:00

  • Perceived neighborhood safety and sleep quality: a global analysis of six countries.

    abstract:OBJECTIVE:Building on previous North American and European studies of neighborhood context and sleep quality, we tested whether several self-reported sleep outcomes (sleep duration, insomnia symptoms, sleepiness, lethargy, and overall sleep quality) vary according to the level of perceived neighborhood safety in six co...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Hill TD,Trinh HN,Wen M,Hale L

    更新日期:2016-02-01 00:00:00

  • Vitamins and sleep: an exploratory study.

    abstract:STUDY OBJECTIVE:We analyzed archival data from an epidemiology study to test the association between vitamin use and sleep. DESIGN:Random digit dialing was used to recruit 772 people ranging in age from 20 to 98 for a study of people's sleep experience. These individuals completed a set of questionnaires about their s...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Lichstein KL,Payne KL,Soeffing JP,Heith Durrence H,Taylor DJ,Riedel BW,Bush AJ

    更新日期:2007-12-01 00:00:00

  • Prevalence and correlates of delayed sleep phase in high school students.

    abstract:PURPOSE:To investigate prevalence and correlates of delayed sleep phase, characterized by problems falling asleep in the evening and rising at adequate times in the morning, in a large sample of Norwegian high school students. METHODS:A randomized sample of 1285 high school students (aged 16-19 years) participated in ...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Saxvig IW,Pallesen S,Wilhelmsen-Langeland A,Molde H,Bjorvatn B

    更新日期:2012-02-01 00:00:00

  • Light exposure in the natural environment: relevance to mood and sleep disorders.

    abstract::In addition to being necessary for vision, light also plays a primary role in circadian physiology. Humans are diurnal animals and their biological clock synchronizes their physiological functions in such a way that functions associated with activity happen in the daytime while functions associated with rest occur at ...

    journal_title:Sleep medicine

    pub_type: 杂志文章,评审


    authors: Dumont M,Beaulieu C

    更新日期:2007-09-01 00:00:00

  • A review of developmental consequences of poor sleep in childhood.

    abstract::Sleep is a fairly diverse and complex construct to operationalize in a scientific and naturalistic context. We report a systematic review and meta-analysis of reviews published in the last 5 years on poor sleep and developmental outcomes. Following the Preferred Reporting Items for Systematic reviews and Meta-Analyses...

    journal_title:Sleep medicine

    pub_type: 杂志文章,meta分析


    authors: Spruyt K

    更新日期:2019-08-01 00:00:00

  • Headache complaints in relation to nocturnal oxygen saturation among patients with sleep apnea syndrome.

    abstract:BACKGROUND:Morning headaches are often ascribed to patients with sleep apnea syndrome (SAS) but the etiology of headaches in SAS is unclear. Given the relationship between oxygen and other headache syndromes, nocturnal hypoxia might be one factor contributing to headaches in SAS. METHODS:All subjects 18-80 years of ag...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Greenough GP,Nowell PD,Sateia MJ

    更新日期:2002-07-01 00:00:00

  • Dissociable effects of sleep deprivation on functional connectivity in the dorsal and ventral default mode networks.

    abstract:OBJECTIVE:To examine changes in functional connectivity of the default mode network (DMN) that are induced by sleep deprivation, and to identify individual differences that contribute to the vulnerability of the brain's response to sleep deprivation. METHODS:Using functional magnetic resonance imaging, we scanned 51 h...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Chen WH,Chen J,Lin X,Li P,Shi L,Liu JJ,Sun HQ,Lu L,Shi J

    更新日期:2018-10-01 00:00:00

  • Antidepressant action of melatonin in the treatment of Delayed Sleep Phase Syndrome.

    abstract:BACKGROUND:Depression is a common problem in patients with Delayed Sleep Phase Syndrome (DSPS). This study used a randomized, double-blind, crossover, placebo-controlled approach to test the hypothesis that exogenous melatonin (5mg) can attenuate depressive symptomatology in DSPS patients. METHODS:Twenty patients with...

    journal_title:Sleep medicine

    pub_type: 杂志文章,随机对照试验


    authors: Rahman SA,Kayumov L,Shapiro CM

    更新日期:2010-02-01 00:00:00

  • Night-to-night variability of periodic leg movements during sleep in restless legs syndrome and periodic limb movement disorder: comparison between the periodicity index and the PLMS index.

    abstract:BACKGROUND:The number of periodic leg movements during sleep (PLMS index) shows high night-to-night variability, requiring multiple nights for its reliable estimation. It is currently not known if this is also the case for the degree of periodicity of leg movements, quantified by the Periodicity index. OBJECTIVE:To co...

    journal_title:Sleep medicine

    pub_type: 杂志文章,随机对照试验


    authors: Ferri R,Fulda S,Manconi M,Högl B,Ehrmann L,Ferini-Strambi L,Zucconi M

    更新日期:2013-03-01 00:00:00

  • Moving into poverty during childhood is associated with later sleep problems.

    abstract:OBJECTIVE:A social gradient in sleep has been demonstrated across the life span, but previous studies have been cross-sectional and used self-reported socioeconomic status (SES) indicators. Using registry-based data on family income trajectories, the current study examined the association between relative poverty in ch...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Sivertsen B,Bøe T,Skogen JC,Petrie KJ,Hysing M

    更新日期:2017-09-01 00:00:00

  • Unaltered EEG spectral power and functional connectivity in REM microstates in frequent nightmare recallers: are nightmares really a REM parasomnia?

    abstract:BACKGROUND:Frequent nightmares show signs of hyperarousal in NREM sleep. Nevertheless, idiopathic nightmare disorder is considered a REM parasomnia, but the pathophysiology of REM sleep in relation to frequent nightmares is controversial. Cortical oscillatory activity in REM sleep is largely modulated by phasic and ton...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: van der Wijk G,Blaskovich B,Farahzadi Y,Simor P

    更新日期:2020-11-01 00:00:00

  • Floppy eyelid syndrome: clinical features and the association with obstructive sleep apnea.

    abstract::Floppy eyelid syndrome (FES) is a recently recognized entity, originally described in obese men with easily everted upper eyelids and chronic ocular irritation. Although the eyelids are primarily involved, other ocular structures such as the conjunctiva and cornea are frequently affected and cause much of the morbidit...

    journal_title:Sleep medicine

    pub_type: 杂志文章,评审


    authors: Leibovitch I,Selva D

    更新日期:2006-03-01 00:00:00

  • The fate of patients with REM sleep behavior disorder and mild cognitive impairment.

    abstract:OBJECTIVE:To investigate clinical and dopaminergic pre-synaptic brain imaging characteristics of subjects with idiopathic rapid eye movement (REM) behavior disorder (iRBD) and mild cognitive impairment (MCI), and to evaluate the combined predictive value of risk factors for short-term conversion to synucleinopathy. ME...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Arnaldi D,Chincarini A,De Carli F,Famà F,Girtler N,Brugnolo A,Pardini M,Massa F,Meli R,Schenone C,Bauckneht M,Morbelli S,Nobili F

    更新日期:2020-02-29 00:00:00

  • Comparison between home and hospital set-up for unattended home-based polysomnography: a prospective randomized study.

    abstract:BACKGROUND:Unattended home-based polysomnography (H-PSG) is a reliable tool for the diagnosis of obstructive sleep apnoea (OSA). The quality of the recording can be influenced by several factors including the set-up location - at home versus in the sleep laboratory. Previous studies have suggested that the failure rate...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Bruyneel M,Libert W,Ameye L,Ninane V

    更新日期:2015-11-01 00:00:00

  • The lullaby of the sun: the role of vitamin D in sleep disturbance.

    abstract::Vitamin D is a pro-hormone belonging to the category of the fat-soluble group of vitamins; it is obtained more from solar exposure and in smaller quantities through feeding. Although vitamin D has traditionally been shown to be involved in calcium homeostasis and bone health, recent studies have found a positive assoc...

    journal_title:Sleep medicine

    pub_type: 杂志文章,评审


    authors: Muscogiuri G,Barrea L,Scannapieco M,Di Somma C,Scacchi M,Aimaretti G,Savastano S,Colao A,Marzullo P

    更新日期:2019-02-01 00:00:00

  • Pramipexole for Chinese people with primary restless legs syndrome: a 12-week multicenter, randomized, double-blind study.

    abstract:BACKGROUND:Restless legs syndrome (RLS) often responds to agents that enhance dopamine neurotransmission. The present 12-week study aimed to evaluate the efficacy and adverse events of pramipexole (PPX) for the treatment of adult, Chinese people with primary RLS. METHODS:A total of 204 Chinese people with RLS were ran...

    journal_title:Sleep medicine

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Zhang J,Liu B,Zheng Y,Chu T,Yang Z

    更新日期:2015-01-01 00:00:00

  • Examining social capital in relation to sleep duration, insomnia, and daytime sleepiness.

    abstract:OBJECTIVE:Sleep, which plays an important role in health and well-being, is socially patterned such that certain demographic groups have worse sleep health than others. One possible mechanism driving sleep disparities is social capital. The current study examines the association between social capital and self-reported...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Robbins R,Jean-Louis G,Gallagher RA,Hale L,Branas CC,Gooneratne N,Alfonso-Miller P,Perlis M,Grandner MA

    更新日期:2019-08-01 00:00:00

  • Daytime sleep state misperception in a tertiary sleep centre population.

    abstract:STUDY OBJECTIVES:Sleep state misperception is common in various sleep disorders, especially in chronic insomnia with a prevalence ranging between 9-50%. Most prior studies used nocturnal polysomnography (PSG) for the identification of sleep state misperception during nighttime. Our objective was to assess sleep state m...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Schinkelshoek MS,de Wit K,Bruggink V,Fronczek R,Lammers GJ

    更新日期:2020-05-01 00:00:00

  • The Great Leap Forward: the anatomic basis for the acquisition of speech and obstructive sleep apnea.

    abstract::Obstructive sleep apnea is an anatomic illness caused by evolutionary changes in the human upper respiratory tract. These changes include shortening of the maxillary, ethmoid, palatal and mandibular bones, acute oral cavity-skull base angulation, pharyngeal collapse with anterior migration of the foramen magnum, poste...

    journal_title:Sleep medicine

    pub_type: 杂志文章,评审


    authors: Davidson TM

    更新日期:2003-05-01 00:00:00

  • Associations between sleep duration and physical activity and dietary behaviors in Chinese adolescents: results from the Youth Behavioral Risk Factor Surveys of 2015.

    abstract:OBJECTIVE:To assess the association between sleep duration and physical activity and dietary behaviors among adolescents in a representative sample. METHODS:The analysis was performed using data from the 2015 Ningbo Youth Risk Behavior Survey. Associations between physical activity and dietary behaviors and sleep dura...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Gong QH,Li H,Zhang XH,Zhang T,Cui J,Xu GZ

    更新日期:2017-09-01 00:00:00