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Sleep apnea diagnosis using an ECG Holter device including a nasal pressure (NP) recording: validation of visual and automatic analysis of nasal pressure versus full polysomnography.

Abstract：

BACKGROUND:New simplified techniques for diagnosing sleep apnea should be specially tailored for easy use in cardiologic practice. OBJECTIVES:e dedicated one of the channels of a Holter Electrocardiogram (ECG) device (SpiderView() ELA Medical, France) to nasal pressure (NP) recordings. We also developed an automatic analysis of NP signal providing an apnea-hypopnea index (AHI) for physicians without the know-how in sleep medicine. METHODS:Thirty-four unselected patients referred for symptoms suggesting sleep apnea underwent a polysomnography (PSG) with simultaneous NP and Holter ECG recordings. An expert blinded to PSG results visually scored the Holter plus NP recordings. The results of the AHI obtained in PSG (AHI-PSG) were compared, respectively, to the AHI-NP obtained by visual analysis and automatic analysis (AHI-NP Auto) of Holter ECG nasal pressure. RESULTS:In 10 randomly selected subjects (development set), the best cut-off on Holter ECG for diagnosing sleep apnea patients as defined by AHI>20/h in PSG was determined at 35 events/h by a receiver operator curve (ROC) analysis. Prospective testing of this threshold was then performed in 19 subjects (test set). For visually scored recordings of Holter ECG plus NP, we obtained a negative predictive value (NPV) of 80% and a positive predictive value (PPV) of 100% for sleep apnea. The area under the ROC curve was 0.97. For the automatic analysis, the NPV was 86% and the PPV value 100%. The area under the ROC curve was 0.85. CONCLUSIONS:NP recording using a Holter system is an efficient and easy-to-use tool for screening for sleep-disordered breathing in routine cardiology practice.

journal_name

Sleep Med

journal_title

Sleep medicine

authors

Pépin JL,Defaye P,Vincent E,Christophle-Boulard S,Tamisier R,Lévy P

doi

10.1016/j.sleep.2008.07.002

subject

Has Abstract

pub_date

2009-06-01 00:00:00

pages

651-6

issue

6

eissn

1389-9457

issn

1878-5506

pii

S1389-9457(08)00206-2

journal_volume

10

pub_type

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