Abstract:
OBJECTIVE:Functional connectivity (FC) changes can occur prior to structural changes. This study aimed to evaluate data-driven whole-brain FC associated with isolated rapid eye movement sleep behavior disorder (iRBD) using multivariate pattern analysis (MVPA). METHODS:This was a cross-sectional study of 50 polysomnography-confirmed iRBD patients and 20 age- and sex-matched controls. We used MVPA implemented in the connectome-MVPA CONN toolbox to identify data-driven seed regions for post hoc seed-to-voxel connectivity analysis. The association between FC changes and clinical characteristics, including cognition, depression, autonomic function, and daytime sleepiness, was evaluated. RESULTS:MVPA revealed one significant cluster located in the left posterior insular cortex. Seed-to-voxel FC analysis using the cluster as a seed showed significantly reduced FC with two clusters located in the precuneus in iRBD patients compared to the controls. The degree of FC was associated with the Montreal Cognitive Assessment-Korean version scores (r = 0.317, p = 0.025). CONCLUSION:This study emphasizes the insula as an important neural correlate associated with iRBD that was associated with cognitive function.
journal_name
Sleep Medjournal_title
Sleep medicineauthors
Byun JI,Cha KS,Kim M,Lee WJ,Lee HS,Sunwoo JS,Shin JW,Kim TJ,Moon J,Lee ST,Jung KH,Chu K,Kim MH,Kim HJ,Shin WC,Lee SK,Jung KYdoi
10.1016/j.sleep.2020.12.038subject
Has Abstractpub_date
2021-01-02 00:00:00pages
88-93eissn
1389-9457issn
1878-5506pii
S1389-9457(20)30588-8journal_volume
79pub_type
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