Pediatric multiple sclerosis: from clinical basis to imaging spectrum and differential diagnosis.

Abstract:

:Pediatric multiple sclerosis (MS) deserves special attention because of its impact on cognitive function and development. Although knowledge regarding pediatric MS has rapidly increased, understanding the peculiarities of this population remains crucial for disease management. There is limited expertise about the efficacy and safety of current disease-modifying agents. Although pathophysiology is not entirely understood, some risk factors and immunological features have been described and are discussed herein. While the revised International Pediatric MS Study Group diagnostic criteria have improved the accuracy of diagnosis, the recently revised McDonald criteria also offer some new insights into the pediatric population. It is fundamental that radiologists have strong knowledge about the vast spectrum of demyelinating disorders that can occur in childhood to ensure appropriate diagnosis and provide early treatment.

journal_name

Pediatr Radiol

journal_title

Pediatric radiology

authors

Padilha IG,Fonseca APA,Pettengill ALM,Fragoso DC,Pacheco FT,Nunes RH,Maia ACM Jr,da Rocha AJ

doi

10.1007/s00247-019-04582-3

subject

Has Abstract

pub_date

2020-05-01 00:00:00

pages

776-792

issue

6

eissn

0301-0449

issn

1432-1998

pii

10.1007/s00247-019-04582-3

journal_volume

50

pub_type

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