Abstract:
:beta-Thalassaemia major is a hereditary haemolytic anaemia that is treated with multiple blood transfusions. A major complication of this treatment is iron overload, which leads to cell death and organ dysfunction. Chelation therapy, used for iron elimination, requires effective monitoring of the body burden of iron, for which serum ferritin levels and liver iron content measured in liver biopsies are used as markers, but are not reliable. MRI based on iron-induced T2 relaxation enhancement can be used for the evaluation of tissue siderosis. Various MR protocols using signal intensity ratio and mainstream relaxometry methods have been used, sometimes with discrepant results. Relaxometry methods using multiple echoes achieve better sampling of the time domain in which relaxation mechanisms take place and lead to more precise results. In several studies the MRI parameters of liver siderosis have failed to correlate with those of other affected organs, underlining the necessity for MRI iron evaluation in individual organs. Most studies have included children in the evaluated population, but MRI data on very young children are lacking. Wider application of relaxometry methods is indicated, with the establishment of universally accepted MRI protocols, and further studies, including young children, are needed.
journal_name
Pediatr Radioljournal_title
Pediatric radiologyauthors
Argyropoulou MI,Astrakas Ldoi
10.1007/s00247-007-0567-1subject
Has Abstractpub_date
2007-12-01 00:00:00pages
1191-200; quiz 1308-9issue
12eissn
0301-0449issn
1432-1998journal_volume
37pub_type
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journal_title:Pediatric radiology
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更新日期:2012-02-01 00:00:00
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