Uptake of chylomicron remnants by the liver: further evidence for the modulating role of phospholipids.

abstract：:Using solid phase systems, the kinetics of binding of monoclonal antibody (LRB 45, IgG2b,kappa) to apoC-I and apoC-I on lipoproteins were investigated. At 25 degrees C, the association constant of LRB 45 antibody to apoC-I (3.56 X 10(6) M-1 X sec-1) was almost three times slower than the association constant LRB 45 an...

journal_title：Journal of lipid research

authors： Wong L

更新日期：1985-07-01 00:00:00

abstract：:We studied the effects of the lecithin:cholesterol acyltransferase reaction on the size and composition of the small spherical high density lipoproteins of patients afflicted with familial lecithin:cholesterol acyltransferase deficiency. We isolated these lipoproteins by preparative ultracentrifugation and rate zonal ...

journal_title：Journal of lipid research

authors： Chen C,Applegate K,King WC,Glomset JA,Norum KR,Gjone E

更新日期：1984-03-01 00:00:00

abstract：:Elongation of very long chain fatty acid-like family member 6 (ELOVL6) is a fatty acyl elongase that performs the initial and rate-limiting condensing reaction required for microsomal elongation of long-chain fatty acids. Our previous in vitro studies suggested that ELOVL6 elongated long-chain saturated fatty acids an...

journal_title：Journal of lipid research

authors： Moon YA,Ochoa CR,Mitsche MA,Hammer RE,Horton JD

更新日期：2014-12-01 00:00:00

abstract：:The activity of lipoprotein lipase isolated from rat postheparin plasma has been determined with synthetic lipids, in the presence and absence of apoprotein of the natural substrate very low density lipoprotein, as a function of medium ion-pair concentration of a number of different inorganic salts. The several kineti...

journal_title：Journal of lipid research

authors： Fielding CJ,Fielding PE

更新日期：1976-05-01 00:00:00

abstract：:The central region of apolipoprotein A-I (apoA-I), spanning residues 143--165, has been implicated in lecithin:cholesterol acyltransferase (LCAT) activation and also in high density lipoprotein (HDL) structural rearrangements. To examine the role of individual amino acids in these functions, we constructed, overexpres...

journal_title：Journal of lipid research

authors： Cho KH,Durbin DM,Jonas A

更新日期：2001-03-01 00:00:00

abstract：:We report the molecular basis of familial chylomicronemia and recurrent pancreatitis in five members of a large Dutch family. All patients had normal plasma hepatic lipase and apoC-II levels, but absent lipoprotein lipase (LPL) catalytic activity and low LPL mass in postheparin plasma. The mutation in the LPL gene was...

journal_title：Journal of lipid research

authors： Bruin T,Tuzgöl S,van Diermen DE,Hoogerbrugge-van der Linden N,Brunzell JD,Hayden MR,Kastelein JJ

更新日期：1993-12-01 00:00:00

abstract：:The vitamin D signal transduction system involves a series of cytochrome P450-containing sterol hydroxylases to generate and degrade the active hormone, 1α,25-dihydroxyvitamin D3, which serves as a ligand for the vitamin D receptor-mediated transcriptional gene expression described in companion articles in this review...

journal_title：Journal of lipid research

authors： Jones G,Prosser DE,Kaufmann M

更新日期：2014-01-01 00:00:00

abstract：:Membrane-protein interaction plays key roles in a wide variety of biological processes. Although various methods have been employed to measure membrane binding of soluble proteins, a robust high-throughput assay that is universally applicable to all proteins is lacking at present. Here we report a new fluorescence que...

journal_title：Journal of lipid research

authors： Kim H,Afsari HS,Cho W

更新日期：2013-12-01 00:00:00

abstract：:The demand to study the cellular localization of specific lipids has led to recent advances in lipid probes and microscopy. Alkyne lipids bear a small, noninterfering tag and can be detected upon click reaction with an azide-coupled reporter. Fluorescent alkyne lipid imaging crucially depends on appropriate azide repo...

journal_title：Journal of lipid research

authors： Gaebler A,Penno A,Kuerschner L,Thiele C

更新日期：2016-10-01 00:00:00

abstract：:Genetic polymorphisms of apolipoprotein A-IV (apoA-IV) have been detected by isoelectric focusing of serum proteins. Because genetic variation in apoA-IV has significant effects on lipid risk factors, we used restriction enzyme isoform genotyping (restriction isotyping) to determine apoA-IV isoform genotypes at the DN...

journal_title：Journal of lipid research

authors： Hixson JE,Powers PK

更新日期：1991-09-01 00:00:00

abstract：:The density distribution of electronegative LDL [LDL(-)], a cytotoxic and inflammatory fraction of LDL present in plasma, was studied in 10 normolipemic (NL), 6 FH, and 11 hypertriglyceridemic (HTG) subjects. Six LDL subclasses of increased density (LDL1 to LDL6) were isolated by density-gradient ultracentrifugation (...

journal_title：Journal of lipid research

authors： Sánchez-Quesada JL,Benítez S,Otal C,Franco M,Blanco-Vaca F,Ordóñez-Llanos J

更新日期：2002-05-01 00:00:00

abstract：:Sphingolipids comprise a highly diverse and complex class of molecules that serve not only as structural components of membranes but also as signaling molecules. To understand the differential role of sphingolipids in a regulatory network, it is important to use specific and quantitative methods. We developed a novel ...

journal_title：Journal of lipid research

authors： Scherer M,Leuthäuser-Jaschinski K,Ecker J,Schmitz G,Liebisch G

更新日期：2010-07-01 00:00:00

abstract：:The activity of rat liver microsomal squalene epoxidase is inhibited effectively by digitonin. Concentrations of 0.8 to 1.2 mg/ml of digitonin cause total inhibition of microsomal (0.75 mg protein/ml) squalene epoxidase either in microsomes that were pretreated with digitonin and subsequently washed and subjected to e...

journal_title：Journal of lipid research

authors： Eilenberg H,Klinger E,Przedecki F,Shechter I

更新日期：1989-08-01 00:00:00

abstract：:Ceramides (Cers) with ultralong (∼32-carbon) chains and ω-esterified linoleic acid, composing a subclass called omega-O-acylceramides (acylCers), are indispensable components of the skin barrier. Normal barriers typically contain acylCer concentrations of ∼10 mol%; diminished concentrations, along with altered or miss...

journal_title：Journal of lipid research

authors： Opálka L,Kováčik A,Pullmannová P,Maixner J,Vávrová K

更新日期：2020-02-01 00:00:00

abstract：:Since the discovery of proprotein convertase subtilisin/kexin type 9 (PCSK9) as an attractive target in the treatment of hypercholesterolemia, multiple anti-PCSK9 therapeutic modalities have been pursued in drug development. The objective of this research is to set the stage for the quantitative benchmarking of two an...

journal_title：Journal of lipid research

authors： Sokolov V,Helmlinger G,Nilsson C,Zhudenkov K,Skrtic S,Hamrén B,Peskov K,Hurt-Camejo E,Jansson-Löfmark R

更新日期：2019-09-01 00:00:00

abstract：:LDL receptor-null (LDLR(-/-)) mice on a Western diet (WD) develop endothelial dysfunction and atherosclerosis, which are improved by the apolipoprotein A-I (apoA-I) mimetic peptide D-4F. Focusing on the kidney, LDLR(-/-)mice were fed a WD with D-4F or the inactive control peptide scrambled D-4F (ScD-4F) added to their...

journal_title：Journal of lipid research

authors： Buga GM,Frank JS,Mottino GA,Hakhamian A,Narasimha A,Watson AD,Yekta B,Navab M,Reddy ST,Anantharamaiah GM,Fogelman AM

更新日期：2008-01-01 00:00:00

abstract：:Thyroid hormone lowers serum cholesterol and alters sterol metabolic processes. This laboratory has previously reported increased biliary lipid secretion as an early effect of triiodothyronine (T3) in the rat. To evaluate whether the bile lipid action of T3 is a primary or secondary effect, the isolated-perfused rat l...

journal_title：Journal of lipid research

authors： Gebhard RL,Stone BG,Andreini JP,Duane WC,Evans CD,Prigge W

更新日期：1992-10-01 00:00:00

abstract：:Retinoic acid (RA), the active metabolite of vitamin A, is required for spermatogenesis and many other biological processes. RA formation requires irreversible oxidation of retinal to RA by aldehyde dehydrogenase enzymes of the 1A family (ALDH1A). While ALDH1A1, ALDH1A2, and ALDH1A3 all form RA, the expression pattern...

journal_title：Journal of lipid research

authors： Arnold SL,Kent T,Hogarth CA,Schlatt S,Prasad B,Haenisch M,Walsh T,Muller CH,Griswold MD,Amory JK,Isoherranen N

更新日期：2015-02-01 00:00:00

abstract：:The early premalignant liver provides a model in which to study metabolic alterations that may be permissive for the development of full malignancy. Although there are biochemical changes in this model, there are no detectable morphological ones when compared with a normal, fully differentiated liver. The maintenance ...

journal_title：Journal of lipid research

authors： Erickson SK,Lear SR,Barker ME,Musliner TA

更新日期：1990-05-01 00:00:00

abstract：:In mammals, white adipose tissue (WAT) stores and releases lipids, whereas brown adipose tissue (BAT) oxidizes lipids to fuel thermogenesis. In obese individuals, WAT undergoes profound changes; it expands, becomes dysfunctional, and develops a low-grade inflammatory state. Importantly, BAT content and activity declin...

journal_title：Journal of lipid research

authors： Kotzbeck P,Giordano A,Mondini E,Murano I,Severi I,Venema W,Cecchini MP,Kershaw EE,Barbatelli G,Haemmerle G,Zechner R,Cinti S

更新日期：2018-05-01 00:00:00

abstract：:Human striated muscle samples, from male control and Duchenne muscular dystrophy-affected children, were subjected to cluster-time-of-flight secondary ion mass spectrometry (cluster-ToF-SIMS) imaging using a 25 keV Bi(3)(+) liquid metal ion gun under static SIMS conditions. Spectra and ion density maps, or secondary i...

journal_title：Journal of lipid research

authors： Tahallah N,Brunelle A,De La Porte S,Laprévote O

更新日期：2008-02-01 00:00:00

abstract：:The essential fatty acid DHA (22:6, omega-3 or n-3) is enriched in and required for the membrane biogenesis and function of photoreceptor cells (PRC), synapses, mitochondria, etc. of the CNS. PRC DHA becomes an acyl chain at the sn-2 of phosphatidylcholine (PC), amounting to more than 50% of the PRC outer segment phos...

journal_title：Journal of lipid research

authors： Bazan NG

更新日期：2020-10-26 00:00:00

abstract：:Lysophospholipid (LP) research has experienced a period of renaissance with the discovery of the lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) receptors in the late 1990s. Vertebrate LP receptors regulate embryogenesis, vascular development, neurogenesis, uterine development, oocyte survival, immune ce...

journal_title：Journal of lipid research

authors： Skoura A,Hla T

更新日期：2009-04-01 00:00:00

abstract：:We have previously observed that the Ya subunit-containing glutathione (GSH) S-transferases from rat liver exhibit a common high affinity binding site for lithocholic acid, bilirubin, and sulfobromophthalein (BSP) (1984. J. Lipid Res. 25: 1177-1183). Subsequently we found that cholic acid and its amidates bound to a s...

journal_title：Journal of lipid research

authors： Takikawa H,Kaplowitz N

更新日期：1988-03-01 00:00:00

abstract：:Atherogenic mixed dyslipidemia associates with oxidative stress and defective HDL antioxidative function in metabolic syndrome (MetS). The impact of statin treatment on the capacity of HDL to inactivate LDL-derived, redox-active phospholipid hydroperoxides (PCOOHs) in MetS is indeterminate. Insulin-resistant, hypertri...

journal_title：Journal of lipid research

authors： Orsoni A,Thérond P,Tan R,Giral P,Robillard P,Kontush A,Meikle PJ,Chapman MJ

更新日期：2016-11-01 00:00:00

abstract：:Guinea pig gallbladder bile contains chenodeoxycholic acid (62 +/- 5%), ursodeoxycholic acid (8 +/- 5%), and 7-ketolithocholic acid (30 +/- 5%). All three bile acids became labeled to the same specific activity within 30 min after [3H]cholesterol was injected into bile fistula guinea pigs. When a mixture of [3H]ursode...

journal_title：Journal of lipid research

authors： Tint GS,Xu GR,Batta AK,Shefer S,Niemann W,Salen G

更新日期：1990-07-01 00:00:00

abstract：:Consumption of industrially produced trans fatty acids (IP-TFA) has been positively associated with systemic markers of low-grade inflammation and endothelial dysfunction in cross-sectional studies, but results from intervention studies are inconclusive. Therefore, we conducted a 16 week double-blind parallel interven...

journal_title：Journal of lipid research

authors： Bendsen NT,Stender S,Szecsi PB,Pedersen SB,Basu S,Hellgren LI,Newman JW,Larsen TM,Haugaard SB,Astrup A

更新日期：2011-10-01 00:00:00

abstract：:Prostaglandin (PG)E(2) is relevant in tumor biology, and interactions between tumor and stroma cells dramatically influence tumor progression. We tested the hypothesis that cross-talk between head and neck squamous cell carcinoma (HNSCC) cells and fibroblasts could substantially enhance PGE(2) biosynthesis. We observe...

journal_title：Journal of lipid research

authors： Alcolea S,Antón R,Camacho M,Soler M,Alfranca A,Avilés-Jurado FX,Redondo JM,Quer M,León X,Vila L

更新日期：2012-04-01 00:00:00

abstract：:Small angle X-ray diffraction was used to examine arterial smooth muscle cell (SMC) plasma membranes isolated from control and cholesterol-fed (2%) atherosclerotic rabbits. A microsomal membrane enriched with plasma membrane obtained from animals fed cholesterol for up to 13 weeks showed a progressive elevation in the...

journal_title：Journal of lipid research

authors： Tulenko TN,Chen M,Mason PE,Mason RP

更新日期：1998-05-01 00:00:00

abstract：:It has been suggested that phytosterol and phytostanol esters possess similar cholesterol-lowering properties, however, whether mechanisms responsible are identical has not been addressed. To address this question, cholesterol plasma levels, absorption, biosynthesis, and turnover were measured in 15 hypercholesterolem...

journal_title：Journal of lipid research

authors： Jones PJ,Raeini-Sarjaz M,Ntanios FY,Vanstone CA,Feng JY,Parsons WE

更新日期：2000-05-01 00:00:00