当前位置： SCI文献检索 > Nature Communications期刊下所有文献 > The autophagy receptor p62/SQST-1 promotes proteostasis and longevity in C. elegans by inducing autophagy.

The autophagy receptor p62/SQST-1 promotes proteostasis and longevity in C. elegans by inducing autophagy.

Abstract：

:Autophagy can degrade cargos with the help of selective autophagy receptors such as p62/SQSTM1, which facilitates the degradation of ubiquitinated cargo. While the process of autophagy has been linked to aging, the impact of selective autophagy in lifespan regulation remains unclear. We have recently shown in Caenorhabditis elegans that transcript levels of sqst-1/p62 increase upon a hormetic heat shock, suggesting a role of SQST-1/p62 in stress response and aging. Here, we find that sqst-1/p62 is required for hormetic benefits of heat shock, including longevity, improved neuronal proteostasis, and autophagy induction. Furthermore, overexpression of SQST-1/p62 is sufficient to induce autophagy in distinct tissues, extend lifespan, and improve the fitness of mutants with defects in proteostasis in an autophagy-dependent manner. Collectively, these findings illustrate that increased expression of a selective autophagy receptor is sufficient to induce autophagy, enhance proteostasis and extend longevity, and demonstrate an important role for sqst-1/p62 in proteotoxic stress responses.

journal_name

Nat Commun

journal_title

Nature communications

authors

Kumsta C,Chang JT,Lee R,Tan EP,Yang Y,Loureiro R,Choy EH,Lim SHY,Saez I,Springhorn A,Hoppe T,Vilchez D,Hansen M

doi

10.1038/s41467-019-13540-4

subject

Has Abstract

pub_date

2019-12-11 00:00:00

pages

5648

issue

1

issn

2041-1723

pii

10.1038/s41467-019-13540-4

journal_volume

10

pub_type

杂志文章

相关文献

Nature Communications文献大全
  • The MerR-like protein BldC binds DNA direct repeats as cooperative multimers to regulate Streptomyces development.

    abstract：:Streptomycetes are notable for their complex life cycle and production of most clinically important antibiotics. A key factor that controls entry into development and the onset of antibiotic production is the 68-residue protein, BldC. BldC is a putative DNA-binding protein related to MerR regulators, but lacks coiled-...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-03576-3

    authors： Schumacher MA,den Hengst CD,Bush MJ,Le TBK,Tran NT,Chandra G,Zeng W,Travis B,Brennan RG,Buttner MJ

    更新日期：2018-03-19 00:00:00

  • Quantifying exchange forces of a spin spiral on the atomic scale.

    abstract：:The large interest in chiral magnetic structures for realization of nanoscale magnetic storage or logic devices has necessitated methods which can quantify magnetic interactions at the atomic scale. To overcome the limitations of the typically used current-based sensing of atomic-scale exchange interactions, a force-b...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-15024-2

    authors： Hauptmann N,Haldar S,Hung TC,Jolie W,Gutzeit M,Wegner D,Heinze S,Khajetoorians AA

    更新日期：2020-03-05 00:00:00

  • Middle Eocene greenhouse warming facilitated by diminished weathering feedback.

    abstract：:The Middle Eocene Climatic Optimum (MECO) represents a ~500-kyr period of global warming ~40 million years ago and is associated with a rise in atmospheric CO2 concentrations, but the cause of this CO2 rise remains enigmatic. Here we show, based on osmium isotope ratios (187Os/188Os) of marine sediments and published ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-05104-9

    authors： van der Ploeg R,Selby D,Cramwinckel MJ,Li Y,Bohaty SM,Middelburg JJ,Sluijs A

    更新日期：2018-07-23 00:00:00

  • An evaluation of COVID-19 serological assays informs future diagnostics and exposure assessment.

    abstract：:The world is entering a new era of the COVID-19 pandemic in which there is an increasing call for reliable antibody testing. To support decision making on the deployment of serology for either population screening or diagnostics, we present a detailed comparison of serological COVID-19 assays. We show that among the s...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-17317-y

    authors： GeurtsvanKessel CH,Okba NMA,Igloi Z,Bogers S,Embregts CWE,Laksono BM,Leijten L,Rokx C,Rijnders B,Rahamat-Langendoen J,van den Akker JPC,van Kampen JJA,van der Eijk AA,van Binnendijk RS,Haagmans B,Koopmans M

    更新日期：2020-07-06 00:00:00

  • Dehydrative π-extension to nanographenes with zig-zag edges.

    abstract：:Zig-zag nanographenes are promising candidates for the applications in organic electronics due to the electronic properties induced by their periphery. However, the synthetic access to these compounds remains virtually unexplored. There is a lack in efficient and mild strategies origins in the reduced stability, incre...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-07095-z

    authors： Lungerich D,Papaianina O,Feofanov M,Liu J,Devarajulu M,Troyanov SI,Maier S,Amsharov K

    更新日期：2018-11-12 00:00:00

  • Patients with basal ganglia damage show preserved learning in an economic game.

    abstract：:Both basal ganglia (BG) and orbitofrontal cortex (OFC) have been widely implicated in social and non-social decision-making. However, unlike OFC damage, BG pathology is not typically associated with disturbances in social functioning. Here we studied the behavior of patients with focal lesions to either BG or OFC in a...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-08766-1

    authors： Zhu L,Jiang Y,Scabini D,Knight RT,Hsu M

    更新日期：2019-02-18 00:00:00

  • Transparent and attachable ionic communicators based on self-cleanable triboelectric nanogenerators.

    abstract：:Human-machine interfaces have benefited from the advent of wireless sensor networks and the internet of things, but rely on wearable/attachable electronics exhibiting stretchability, biocompatibility, and transmittance. Limited by weight and volume, wearable devices should be energy efficient and even self-powered. He...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-03954-x

    authors： Lee Y,Cha SH,Kim YW,Choi D,Sun JY

    更新日期：2018-05-04 00:00:00

  • PNPLA1 has a crucial role in skin barrier function by directing acylceramide biosynthesis.

    abstract：:Mutations in patatin-like phospholipase domain-containing 1 (PNPLA1) cause autosomal recessive congenital ichthyosis, but the mechanism involved remains unclear. Here we show that PNPLA1, an enzyme expressed in differentiated keratinocytes, plays a crucial role in the biosynthesis of ω-O-acylceramide, a lipid componen...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms14609

    authors： Hirabayashi T,Anjo T,Kaneko A,Senoo Y,Shibata A,Takama H,Yokoyama K,Nishito Y,Ono T,Taya C,Muramatsu K,Fukami K,Muñoz-Garcia A,Brash AR,Ikeda K,Arita M,Akiyama M,Murakami M

    更新日期：2017-03-01 00:00:00

  • Supramolecular amplification of amyloid self-assembly by iodination.

    abstract：:Amyloid supramolecular assemblies have found widespread exploitation as ordered nanomaterials in a range of applications from materials science to biotechnology. New strategies are, however, required for understanding and promoting mature fibril formation from simple monomer motifs through easy and scalable processes....

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms8574

    authors： Bertolani A,Pirrie L,Stefan L,Houbenov N,Haataja JS,Catalano L,Terraneo G,Giancane G,Valli L,Milani R,Ikkala O,Resnati G,Metrangolo P

    更新日期：2015-06-30 00:00:00

  • Prothymosin α overexpression contributes to the development of pulmonary emphysema.

    abstract：:Emphysema is one of the disease conditions that comprise chronic obstructive pulmonary disease. Prothymosin α transgenic mice exhibit an emphysema phenotype, but the pathophysiological role of prothymosin α in emphysema remains unclear. Here we show that prothymosin α contributes to the pathogenesis of emphysema by in...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms2906

    authors： Su BH,Tseng YL,Shieh GS,Chen YC,Shiang YC,Wu P,Li KJ,Yen TH,Shiau AL,Wu CL

    更新日期：2013-01-01 00:00:00

  • Super-resolution architecture of mammalian centriole distal appendages reveals distinct blade and matrix functional components.

    abstract：:Distal appendages (DAPs) are nanoscale, pinwheel-like structures protruding from the distal end of the centriole that mediate membrane docking during ciliogenesis, marking the cilia base around the ciliary gate. Here we determine a super-resolved multiplex of 16 centriole-distal-end components. Surprisingly, rather th...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-04469-1

    authors： Yang TT,Chong WM,Wang WJ,Mazo G,Tanos B,Chen Z,Tran TMN,Chen YD,Weng RR,Huang CE,Jane WN,Tsou MB,Liao JC

    更新日期：2018-05-22 00:00:00

  • Mutant ASXL1 cooperates with BAP1 to promote myeloid leukaemogenesis.

    abstract：:ASXL1 mutations occur frequently in myeloid neoplasms and are associated with poor prognosis. However, the mechanisms by which mutant ASXL1 induces leukaemogenesis remain unclear. In this study, we report mutually reinforcing effects between a C-terminally truncated form of mutant ASXL1 (ASXL1-MT) and BAP1 in promotin...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-05085-9

    authors： Asada S,Goyama S,Inoue D,Shikata S,Takeda R,Fukushima T,Yonezawa T,Fujino T,Hayashi Y,Kawabata KC,Fukuyama T,Tanaka Y,Yokoyama A,Yamazaki S,Kozuka-Hata H,Oyama M,Kojima S,Kawazu M,Mano H,Kitamura T

    更新日期：2018-07-16 00:00:00

  • Itch/β-arrestin2-dependent non-proteolytic ubiquitylation of SuFu controls Hedgehog signalling and medulloblastoma tumorigenesis.

    abstract：:Suppressor of Fused (SuFu), a tumour suppressor mutated in medulloblastoma, is a central player of Hh signalling, a pathway crucial for development and deregulated in cancer. Although the control of Gli transcription factors by SuFu is critical in Hh signalling, our understanding of the mechanism regulating this key e...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-03339-0

    authors： Infante P,Faedda R,Bernardi F,Bufalieri F,Lospinoso Severini L,Alfonsi R,Mazzà D,Siler M,Coni S,Po A,Petroni M,Ferretti E,Mori M,De Smaele E,Canettieri G,Capalbo C,Maroder M,Screpanti I,Kool M,Pfister SM,Guardavac

    更新日期：2018-03-07 00:00:00

  • Immune-mediated genetic pathways resulting in pulmonary function impairment increase lung cancer susceptibility.

    abstract：:Impaired lung function is often caused by cigarette smoking, making it challenging to disentangle its role in lung cancer susceptibility. Investigation of the shared genetic basis of these phenotypes in the UK Biobank and International Lung Cancer Consortium (29,266 cases, 56,450 controls) shows that lung cancer is ge...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-13855-2

    authors： Kachuri L,Johansson M,Rashkin SR,Graff RE,Bossé Y,Manem V,Caporaso NE,Landi MT,Christiani DC,Vineis P,Liu G,Scelo G,Zaridze D,Shete SS,Albanes D,Aldrich MC,Tardón A,Rennert G,Chen C,Goodman GE,Doherty JA,Bickebö

    更新日期：2020-01-07 00:00:00

  • Nitrogen-doped carbon nanomaterials as non-metal electrocatalysts for water oxidation.

    abstract：:Efficient and low-cost electrocatalysts for the oxygen evolution reaction are essential components of renewable energy technologies, such as solar fuel synthesis and providing a hydrogen source for powering fuel cells. Here we report that the nitrogen-doped carbon materials function as the efficient oxygen evolution e...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms3390

    authors： Zhao Y,Nakamura R,Kamiya K,Nakanishi S,Hashimoto K

    更新日期：2013-01-01 00:00:00

  • Construction and integration of three de novo Japanese human genome assemblies toward a population-specific reference.

    abstract：:The complete human genome sequence is used as a reference for next-generation sequencing analyses. However, some ethnic ancestries are under-represented in the reference genome (e.g., GRCh37) due to its bias toward European and African ancestries. Here, we perform de novo assembly of three Japanese male genomes using ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-20146-8

    authors： Takayama J,Tadaka S,Yano K,Katsuoka F,Gocho C,Funayama T,Makino S,Okamura Y,Kikuchi A,Sugimoto S,Kawashima J,Otsuki A,Sakurai-Yageta M,Yasuda J,Kure S,Kinoshita K,Yamamoto M,Tamiya G

    更新日期：2021-01-11 00:00:00

  • Engineering and optimising deaminase fusions for genome editing.

    abstract：:Precise editing is essential for biomedical research and gene therapy. Yet, homology-directed genome modification is limited by the requirements for genomic lesions, homology donors and the endogenous DNA repair machinery. Here we engineered programmable cytidine deaminases and test if we could introduce site-specific...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms13330

    authors： Yang L,Briggs AW,Chew WL,Mali P,Guell M,Aach J,Goodman DB,Cox D,Kan Y,Lesha E,Soundararajan V,Zhang F,Church G

    更新日期：2016-11-02 00:00:00

  • Two pathways regulate cortical granule translocation to prevent polyspermy in mouse oocytes.

    abstract：:An egg must be fertilized by a single sperm only. To prevent polyspermy, the zona pellucida, a structure that surrounds mammalian eggs, becomes impermeable upon fertilization, preventing the entry of further sperm. The structural changes in the zona upon fertilization are driven by the exocytosis of cortical granules....

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms13726

    authors： Cheeseman LP,Boulanger J,Bond LM,Schuh M

    更新日期：2016-12-19 00:00:00

  • Molecular preservation of 1.88 Ga Gunflint organic microfossils as a function of temperature and mineralogy.

    abstract：:The significant degradation that fossilized biomolecules may experience during burial makes it challenging to assess the biogenicity of organic microstructures in ancient rocks. Here we investigate the molecular signatures of 1.88 Ga Gunflint organic microfossils as a function of their diagenetic history. Synchrotron-...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms11977

    authors： Alleon J,Bernard S,Le Guillou C,Marin-Carbonne J,Pont S,Beyssac O,McKeegan KD,Robert F

    更新日期：2016-06-17 00:00:00

  • Genome-wide CRISPR screen identifies ELP5 as a determinant of gemcitabine sensitivity in gallbladder cancer.

    abstract：:Gemcitabine is the first-line treatment for locally advanced and metastatic gallbladder cancer (GBC), but poor gemcitabine response is universal. Here, we utilize a genome-wide CRISPR screen to identify that loss of ELP5 reduces the gemcitabine-induced apoptosis in GBC cells in a P53-dependent manner through the Elong...

    journal_title：Nature communications

    pub_type： 临床试验,杂志文章

    doi：10.1038/s41467-019-13420-x

    authors： Xu S,Zhan M,Jiang C,He M,Yang L,Shen H,Huang S,Huang X,Lin R,Shi Y,Liu Q,Chen W,Mohan M,Wang J

    更新日期：2019-12-02 00:00:00

  • Electronic spin separation induced by nuclear motion near conical intersections.

    abstract：:Though the concept of Berry force was proposed thirty years ago, little is known about the practical consequences of this force as far as chemical dynamics are concerned. Here, we report that when molecular dynamics pass near a conical intersection, a massive Berry force can appear as a result of even a small amount o...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-20831-8

    authors： Wu Y,Subotnik JE

    更新日期：2021-01-29 00:00:00

  • Electrophysiological mechanisms of human memory consolidation.

    abstract：:Consolidation stabilizes memory traces after initial encoding. Rodent studies suggest that memory consolidation depends on replay of stimulus-specific activity patterns during fast hippocampal "ripple" oscillations. Here, we measured replay in intracranial electroencephalography recordings in human epilepsy patients, ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-06553-y

    authors： Zhang H,Fell J,Axmacher N

    更新日期：2018-10-05 00:00:00

  • Germination and infectivity of microconidia in the rice blast fungus Magnaporthe oryzae.

    abstract：:The rice blast fungus Magnaporthe oryzae is a model for studying fungal-plant interactions. Although it produces two types of spores (microconidia and macroconidia), previous infection studies have exclusively dealt with macroconidia. Germination of microconidia has not been reported, and their role in plant infection...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms5518

    authors： Zhang H,Wu Z,Wang C,Li Y,Xu JR

    更新日期：2014-08-01 00:00:00

  • Observation of an evolving magnetic flux rope before and during a solar eruption.

    abstract：:Explosive energy release is a common phenomenon occurring in magnetized plasma systems ranging from laboratories, Earth's magnetosphere, the solar corona and astrophysical environments. Its physical explanation is usually attributed to magnetic reconnection in a thin current sheet. Here we report the important role of...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms1753

    authors： Zhang J,Cheng X,Ding MD

    更新日期：2012-03-20 00:00:00

  • Blackbody radiation shift assessment for a lutetium ion clock.

    abstract：:The accuracy of state-of-the-art atomic clocks is derived from the insensitivity of narrow optical atomic resonances to environmental perturbations. Two such resonances in singly ionized lutetium have been identified with potentially lower sensitivities compared to other clock candidates. Here we report measurement of...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-04079-x

    authors： Arnold KJ,Kaewuam R,Roy A,Tan TR,Barrett MD

    更新日期：2018-04-25 00:00:00

  • Nitric oxide-dependent anaerobic ammonium oxidation.

    abstract：:Nitric oxide (NO) has important functions in biology and atmospheric chemistry as a toxin, signaling molecule, ozone depleting agent and the precursor of the greenhouse gas nitrous oxide (N2O). Although NO is a potent oxidant, and was available on Earth earlier than oxygen, it is unclear whether NO can be used by micr...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-09268-w

    authors： Hu Z,Wessels HJCT,van Alen T,Jetten MSM,Kartal B

    更新日期：2019-03-20 00:00:00

  • Ontogenetic asymmetry modulates population biomass production and response to harvest.

    abstract：:Patterns in biomass production are determined by resource input (productivity) and trophic transfer efficiency. At fixed resource input, variation in consumer biomass production has been related to food quality, metabolic type and diversity among species. In contrast, intraspecific variation in individual body size be...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms7441

    authors： Reichstein B,Persson L,De Roos AM

    更新日期：2015-03-04 00:00:00

  • Wave-induced loss of ultra-relativistic electrons in the Van Allen radiation belts.

    abstract：:The dipole configuration of the Earth's magnetic field allows for the trapping of highly energetic particles, which form the radiation belts. Although significant advances have been made in understanding the acceleration mechanisms in the radiation belts, the loss processes remain poorly understood. Unique observation...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms12883

    authors： Shprits YY,Drozdov AY,Spasojevic M,Kellerman AC,Usanova ME,Engebretson MJ,Agapitov OV,Zhelavskaya IS,Raita TJ,Spence HE,Baker DN,Zhu H,Aseev NA

    更新日期：2016-09-28 00:00:00

  • Fossil black smoker yields oxygen isotopic composition of Neoproterozoic seawater.

    abstract：:The evolution of the seawater oxygen isotopic composition (δ18O) through geological time remains controversial. Yet, the past δ18Oseawater is key to assess past seawater temperatures, providing insights into past climate change and life evolution. Here we provide a new and unprecedentedly precise δ18O value of -1.33 ±...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-03890-w

    authors： Hodel F,Macouin M,Trindade RIF,Triantafyllou A,Ganne J,Chavagnac V,Berger J,Rospabé M,Destrigneville C,Carlut J,Ennih N,Agrinier P

    更新日期：2018-04-13 00:00:00

  • Functional profiling of single CRISPR/Cas9-edited human long-term hematopoietic stem cells.

    abstract：:In the human hematopoietic system, rare self-renewing multipotent long-term hematopoietic stem cells (LT-HSCs) are responsible for the lifelong production of mature blood cells and are the rational target for clinical regenerative therapies. However, the heterogeneity in the hematopoietic stem cell compartment and var...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-12726-0

    authors： Wagenblast E,Azkanaz M,Smith SA,Shakib L,McLeod JL,Krivdova G,Araújo J,Shultz LD,Gan OI,Dick JE,Lechman ER

    更新日期：2019-10-18 00:00:00