Abstract:
:The standardization of apiceutical products like as propolis extracts has been widely debated worldwide and variations in the propolis chemical composition are still very relevant topics for use-standardized of different propolis-type as medication by much of the world's population. The present manuscript discuss important issues related to the climate effect and variations in propolis metabolite-profiling changes, antioxidant capacity and variations of the antibacterial activity of the Brazilian red propolis metabolites using comprehensive multivariate correlations. It was observed the increasing of guttiferones concentrations during the intense drought period and drastic decreasing in rainy period. The climate variation induced the high concentration of flavonoids in rainy period with pronounced dropped in some rainy months. The Pearson´s analysis demonstrated correlation between IC50 from DPPH and guttiferones and flavonoids concentrations. The PCA-X and Hotelling T2 test showed outliers during the months with lowest concentrations of formononetin and isoliquiritigenin was observed in antibacterial tests. The PLS-DA, OPLS-DA and VIP analysis demonstrate guttiferone E, guttiferone B, liquiritigenin, naringenin are considered important substances responsible by anti-staphylococcal activity in red propolis composition during the rainy season and drought period, but a synergistic effect with other flavonoids and isoflavonoids are not ruled out.
journal_name
Sci Repjournal_title
Scientific reportsauthors
do Nascimento TG,Dos Santos Arruda RE,da Cruz Almeida ET,Dos Santos Oliveira JM,Basílio-Júnior ID,Celerino de Moraes Porto IC,Rodrigues Sabino A,Tonholo J,Gray A,Ebel RE,Clements C,Zhang T,Watson DGdoi
10.1038/s41598-019-54591-3subject
Has Abstractpub_date
2019-12-04 00:00:00pages
18293issue
1issn
2045-2322pii
10.1038/s41598-019-54591-3journal_volume
9pub_type
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