Abstract：
:Opioid use disorder (OUD) constitutes a significant public health burden as opioid overdose deaths have continued to rise in the United States. Although treatment modalities are available to manage OUD, some patients experience challenges achieving their OUD management goals. Some of these challenges may be attributable to inherited genetic variations, or polymorphisms, on the genes that code for proteins impacting the pharmacokinetics or pharmacodynamics of medications used in OUD management. Clinical pharmacogenomics testing can elucidate these polymorphisms; however, a lack of real-world evidence for the use of pharmacogenomics in OUD management complicates the implementation process. We conducted a retrospective cohort study of 113 patients undergoing buprenorphine-based OUD management in Northeast Washington D.C. to determine if clinical pharmacogenomics testing for CYP3A4 and CYP3A5 would impact treatment outcomes. Data were collected from the electronic medical record (EMR) from December 30, 2015 to December 31, 2016. Study outcomes were based on presence of withdrawal symptoms, instances of unauthorized substances in urine drug tests (UDTs), and sublingual buprenorphine/naloxone (SBN) dose with standard-of-care (SOC) dosing versus pharmacogenomics (PGx)-based dosing. Pearson correlation tests, Wilcoxon signed rank tests, Wilcoxon rank sum tests, and one-way ANOVA tests were used. Linear and logistic regression analyses were used to assess predictors of withdrawal symptomatology. Kaplan-Meier survival analyses were used to assess time to first withdrawal. Our research suggests that patients with at least one copy of the CYP3A4*1B allele exhibit an accelerated rate of metabolism compared to the wild-type allele CYP3A4*1.
journal_name
J Natl Med Assocjournal_title
Journal of the National Medical Associationauthors
Ettienne EB,Ofoegbu A,Maneno MK,Briggs J,Ezeude G,Williams S,Walker C,Chapman Edoi
10.1016/j.jnma.2019.09.006subject
Has Abstractpub_date
2019-12-01 00:00:00pages
674-681issue
6eissn
0027-9684issn
1943-4693pii
S0027-9684(19)30215-9journal_volume
111pub_type
杂志文章abstract：:Nosocomial sinusitis is occasionally overlooked as a source of sepsis in critically ill patients. Physical examination is usually unreliable and purulent nasal discharge is absent up to 73% of the time. Computed tomography scans of the sinuses and aspiration and culture of sinus fluid are the hallmark of diagnosis. Th...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章,评审
doi：
更新日期：1992-12-01 00:00:00
abstract：:A Nigerian school boy with the syndrome of multiple jaw cysts, skeletal anomalies, and basal cell nevi is described and discussed. To the authors' knowledge, this is the first report of this syndrome in a black African. ...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：1980-03-01 00:00:00
abstract：:Many studies now demonstrate high overall response rates with concurrent chemotherapy and radiation (CCR) for locoregionally advanced or inoperable non-small cell lung carcinoma (NSCLC) but often with severe toxicity and only modest improvement in survival beyond 3 years. We report a simple CCR protocol for NSCLC that...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：2000-03-01 00:00:00
abstract：:Trichinosis is world-wide in distribution, occurring in tropical, temperate, and polar regions. Although incidence of the disease appears to be declining in most regions, it is still widely distributed in Europe and is increasing in many parts of Africa. In recent years, the incidence of trichinosis in the United Stat...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章,评审
doi：
更新日期：1983-06-01 00:00:00
abstract：:Lung cancer is the leading cause of cancer-related mortality. Nonsmall-cell lung cancer (NSCLC) constitutes approximately 80% of all the lung cancers observed. Despite the aggressive nature of this disease, totally adequate and fully comprehensive treatment yielding outstanding outcomes and survival has yet to be disc...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章,评审
doi：10.1016/s0027-9684(15)31342-0
更新日期：2008-06-01 00:00:00
abstract：:A 64-year-old man got trismus and trigeminal neuralgia under the diagnosis of colon cancer with mandibular metastasis after emergency appendectomy and elective hemicolectomy. The patient chose to forgo further surgery and was given only palliative chemotherapy and radiotherapy. He died six months after diagnosis. Meta...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：10.1016/s0027-9684(15)31353-5
更新日期：2008-06-01 00:00:00
abstract：:In 1977, the National Institute of Mental Health funded the National Survey of Black Americans (NSBA). The NSBA was an omnibus, nationally representative sample (N = 2,107) of adult black Americans that explored numerous issues relevant to black quality of life. One topic that has received much attention is where blac...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：1988-09-01 00:00:00
abstract：:Stroke in black Americans is an important health problem that has been understudied. A brief review of the pertinent literature and strategies for evaluating and managing patients with cerebrovascular disease are presented. ...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：1987-01-01 00:00:00
abstract：:Baclofen is widely used in the treatment of spasticity of spinal origin. It is relatively free of side effects or toxic actions on the nervous system or other organs. Agitation, personality change, and auditory and visual hallucinations have been described following its abrupt withdrawal. One patient with generalized ...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：1984-05-01 00:00:00
abstract：BACKGROUND AND STUDY AIMS:Barrett's Esophagus (BE) is a well-recognized pre-malignant condition. Previous data indicate histologically confirmed BE frequency varies by ethnicity in the United States. However, clinical factor assessment to explain this has only occurred in a veteran population to date. The study aim was...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：10.1016/j.jnma.2018.09.008
更新日期：2019-04-01 00:00:00
abstract：:The author traces the history of theories of food digestion from the prescientific era to the chemical techniques of 19th century investigators. ...
journal_title：Journal of the National Medical Association
pub_type： 历史文章,杂志文章
doi：
更新日期：1987-11-01 00:00:00
abstract：:Sixteen trauma victims with adult respiratory distress syndrome were retrospectively examined. High injury severity score (mean: 44), massive transfusion requirements, and prolonged ventilator days characterize this group. Persistent intra-abdominal infection accounted for two of three deaths in this series. Most of t...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：1991-06-01 00:00:00
abstract：:Strongyloides stercoralis affects 30 to 100 million people worldwide and is a common cause of abdominal pain and diarrhea. Strongyloidiasis is a chronic and limited disease; however, in immunocompromised patients, hyperinfection syndrome can occur. Diagnosing strongyloidiasis early is important, as almost all deaths d...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章,评审
doi：10.1016/s0027-9684(15)30246-7
更新日期：2011-01-01 00:00:00
abstract：:Relatively high serum albumin levels compared to low levels have been associated with reduced cardiovascular mortality and coronary heart disease and stroke incidence. The nature of these associations remains undefined. Therefore, widely accepted criteria of Bradford Hill were used to assess the likelihood that the as...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章,评审
doi：
更新日期：2000-01-01 00:00:00
abstract：OBJECTIVE:To determine if a patient's degree of access to healthcare predicts his or her fund of knowledge about cardiovascular diseases. METHODS:Trained research associates at a public, urban emergency department in New York City administered cross-sectional surveys to selected patients from June 2005 to January 2007...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：2007-12-01 00:00:00
abstract：:Strangulated right Richter's inguinal hernia of the cecum is relatively rare. A case of this unusual hernia was successfully managed with a wedge resection and closure of the infarcted bowel wall in conjunction with complementary tube cecostomy. The procedure is easy to perform and relatively safe and is therefore rec...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：1982-07-01 00:00:00
abstract：:Endomyocardial fibrosis (EMF), an idiopathic cardiac disorder, occurs predominantly in the tropical and subtropical regions of the world. We present herein a report of EMF in a young man from the savannah belt of Nigeria. He was a 19-year-old young man who presented with recent onset of palpitation and dyspnea and was...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：10.1016/s0027-9684(15)30756-2
更新日期：2010-12-01 00:00:00
abstract：:Upper gastrointestinal bleeding occurs above the ligament of Treitz as a result of duodenal or gastric ulcers, gastric or esophageal varices caused by cirrhosis of the liver, or Mallory-Weiss syndrome. Bleeding that requires more than three units of blood in 24 hours usually demands operative measures. ...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：1985-11-01 00:00:00
abstract：:Early detection of pregnancy offers many advantages for the fetus and the mother. Many medical benefits depend on early detection, including social and emotional well-being and the aviodance of medicationss, irradiation, and other teratogencis. In the past, women became aware of their pregnancies only when organogen...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：1984-03-01 00:00:00
abstract：:Although pulmonary tuberculosis has decreased, extra pulmonary tuberculosis has shown a relative increase in frequency during the past decade. This paper discusses three cases of extrapulmonary tuberculosis which presented with abdominal signs. The patients were completely evaluated and surgery was done, followed by a...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：1978-02-01 00:00:00
abstract：:Vitamin D deficiency has been linked to fracture risk and chronic musculoskeletal pain. Adults with sickle cell disease have a high prevalence of low bone density and chronic pain with poorly defined etiologies. We recognized that vitamin D deficiency may represent a treatable etiology and sought to determine the prev...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章,多中心研究
doi：10.1016/s0027-9684(15)30605-2
更新日期：2010-04-01 00:00:00
abstract：:A convenience sample of all medical journals found in a medical clinic was reviewed for pharmaceutical advertisements. Ads were present in 25 (96%) of the 26 journals. Ad space varied from 0-34% (mean 12) in research, and 9-48% (mean: 36) in nonresearch journals. In 23 (88%) journals, individual ads consisted of more ...
journal_title：Journal of the National Medical Association
pub_type： 社论
doi：
更新日期：2005-05-01 00:00:00
abstract：:This survey assessed the reported frequency of breast self-examination (BSE): the knowledge of the technique and attitudes regarding the self-exam of 180 black women. Most respondents indicated having practiced the exam during the previous year, and 50% reported practicing it monthly or more often. Less than half of t...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：1989-07-01 00:00:00
abstract：BACKGROUND/PURPOSE:With the urgency to create more equitable health care, increased research and early exposure to health interventions and clinical medicine are imperative. Health disparities continue to persist nationwide, particularly in underserved areas and among traditionally disadvantaged populations. In additio...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：10.1016/j.jnma.2019.12.003
更新日期：2020-02-01 00:00:00
abstract：:Painful palmar and plantar erythema is an uncommon systemic complication of chemotherapy and has been reported in association with methotrexate, cystosine arabinoside, doxorubicin, and 5-fluorouracil. The authors report a case in which the syndrome was precipitated by hepatic artery infusion of 5-FUdR. The previous re...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：1987-06-01 00:00:00
abstract：:Four hundred ninety-nine nosocomial infections (with 657 isolates) in 288 Surgical Service patients were monitored from February 1986 to June 1987 (17 months) to determine the influence that pathogen or site of infection had on the length of hospital stay. Patients with upper respiratory and skin infections were more ...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：1990-04-01 00:00:00
abstract：BACKGROUND:The prevalence of skipped hemodialysis or no-show is higher among African Americans, younger Sages, smokers and illicit drug users. The effect of the weekly hemodialysis treatment schedules (Mondays, Wednesdays, Fridays (MWF); or Tuesdays, Thursdays, Saturdays (TTS)] on adherence is unknown. METHODS:Our hem...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：10.1016/s0027-9684(15)31274-8
更新日期：2008-04-01 00:00:00
abstract：BACKGROUND:Physician diversity is linked to improved quality of care of diverse patient populations. The transition from medical school to residency is an opportunity to improve and increase workforce diversity in all specialties. However, there is limited published literature on the factors contributing to the ranking...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：10.1016/j.jnma.2019.09.002
更新日期：2019-12-01 00:00:00
abstract：:The surgical approach to liver injury depends on a clear and concise characterization of the wound. Blunt trauma can produce devastating wounds that disrupt hepatic venous drainage. Atrial caval shunting remains a useful technique for Grade V liver wounds. Liver packing may be necessary if diffuse lobar injury, acidos...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：1994-01-01 00:00:00
abstract：:Ten children with acute increased intracranial pressure, documented by the Cheek screw technique, were treated for Reye's syndrome, other toxic/metabolic encephalopathies, encephalitis, and traumatic encephalopathies. The rationale for the use of hyperventilation, head position, maintenance of adequate cerebral perfus...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：1983-12-01 00:00:00
