Abstract:
:Many studies now demonstrate high overall response rates with concurrent chemotherapy and radiation (CCR) for locoregionally advanced or inoperable non-small cell lung carcinoma (NSCLC) but often with severe toxicity and only modest improvement in survival beyond 3 years. We report a simple CCR protocol for NSCLC that has resulted in long-term disease-free survival with low toxicity. In this retrospective review, 84 patients with NSCLC were seen between 1985 and 1991. Of these, 10 patients had stage IIIa or IIIb NSCLC without effusion or inoperable NSCLC, with no failed prior treatment at the time of referral for oncology evaluation. Six of these were treated with CCR consisting of three cycles of cisplatin and 5-fluorouracil administered concurrently with radiation treatment followed by maintenance chemotherapy for at least five additional cycles. All six patients treated with this protocol had complete response with minimal side effects. Survival times ranged from 4.5 to more than 10 years. Three patients survived in complete remission; three others were in complete remission at the time of death due to unrelated causes. Stage III NSCLC without effusion and inoperable NSCLC can be treated effectively with concurrent local and systemic treatment without significant toxicity. In patients with complete response, maintenance chemotherapy may overcome residual microscopic systemic disease, leading to long-term survival and possible cure. The CCR strategy that resulted in this favorable outcome is noteworthy and should be pursued in larger numbers of patients.
journal_name
J Natl Med Assocjournal_title
Journal of the National Medical Associationauthors
Anku Vkeywords:
subject
Has Abstractpub_date
2000-03-01 00:00:00pages
105-15issue
3eissn
0027-9684issn
1943-4693journal_volume
92pub_type
杂志文章abstract::The psychosocial adjustment of patients who are experiencing physical disabilities is examined within the context of a family ecological approach. Historical and sociocultural characteristics of African-American families are delineated and explored in terms of their potentially positive impact on the adjustment proces...
journal_title:Journal of the National Medical Association
pub_type: 杂志文章,评审
doi:
更新日期:1994-12-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Cholelithiasis and cholecystitis were thought to be rare in Africans. It is now seen more frequently than previously thought. The essence of this study is to determine the prevalence of cholelithiasis and cholecystitis in a Nigerian population, changing pattern and outcome. DESIGN:Descriptive...
journal_title:Journal of the National Medical Association
pub_type: 杂志文章
doi:
更新日期:2005-11-01 00:00:00
abstract::This study identifies those variables, cognitive and noncognitive, that relate significantly to the successful completion of the combined BA/MD degree program. The study sample included 69 black students who entered at year one, directly from high school, between 1972 and 1981. The Student's t-test identified statisti...
journal_title:Journal of the National Medical Association
pub_type: 杂志文章
doi:
更新日期:1992-03-01 00:00:00
abstract::Peritoneal lavage fluid for cytologic study was obtained in 73 patients undergoing primary surgery for stage I endometrial adenocarcinoma. Preoperative irradiation was not used. Malignant cells consistent with endometrial adenocarcinoma were present in eight (11 percent) cases. There was no significant difference in t...
journal_title:Journal of the National Medical Association
pub_type: 杂志文章
doi:
更新日期:1985-10-01 00:00:00
abstract::Reduction of health disparities in the United States is a high priority. One means of effecting such a reduction is to enroll persons of groups that are subject to health disparities in clinical trials. One barrier to minorities enrolling in clinical research is distrust of the medical establishment based on past abus...
journal_title:Journal of the National Medical Association
pub_type: 杂志文章
doi:
更新日期:2006-05-01 00:00:00
abstract:BACKGROUND:African Americans experience high rates of obesity and other chronic diseases, which may be related, in part, to diet. However, little is known about dietary patterns in this population, particularly from population-based data sources. METHODS:A cross-sectional analysis was conducted of 2,172 African-Americ...
journal_title:Journal of the National Medical Association
pub_type: 杂志文章
doi:
更新日期:2004-12-01 00:00:00
abstract::An eight-year-old black male with severe growth and mental retardation presented with massive myxedema, hyponatremia, and hypothermia. History of hypothyroidism was confirmed by laboratory investigation. The hypothyroidism appeared to be secondary to organic pituitary insufficiency due to diffuse brain damage. Appropr...
journal_title:Journal of the National Medical Association
pub_type: 杂志文章
doi:
更新日期:1980-07-01 00:00:00
abstract::In contrast to their white counterparts, black men in the United States live sicker and die younger. This longstanding phenomenon is sharply reflected in the poor international health status of black males. The NMA president discusses major health issues facing black males and posits a multidimensional strategy for ad...
journal_title:Journal of the National Medical Association
pub_type: 杂志文章,评审
doi:
更新日期:2006-04-01 00:00:00
abstract::This survey assessed the reported frequency of breast self-examination (BSE): the knowledge of the technique and attitudes regarding the self-exam of 180 black women. Most respondents indicated having practiced the exam during the previous year, and 50% reported practicing it monthly or more often. Less than half of t...
journal_title:Journal of the National Medical Association
pub_type: 杂志文章
doi:
更新日期:1989-07-01 00:00:00
abstract::This study examines the relationship between sexual behaviors and prevalence of herpes simplex virus-type 2 (HSV-2) among African-American college women. Subjects (n = 138) were recruited randomly from a state university to participate in a study regarding sexual attitudes and behaviors and to have their blood drawn f...
journal_title:Journal of the National Medical Association
pub_type: 杂志文章
doi:
更新日期:1999-04-01 00:00:00
abstract:BACKGROUND:Nigeria is one of the ten countries with the highest tuberculosis (TB) burden globally and is experiencing an increasing incidence of drug resistance. This study aimed to determine the prevalence of mycobacterium tuberculosis and rifampicin resistance (DR-TB) among patients screened at the TB clinic of a ter...
journal_title:Journal of the National Medical Association
pub_type: 杂志文章
doi:10.1016/j.jnma.2017.04.007
更新日期:2018-02-01 00:00:00
abstract:BACKGROUND:Racial inequities in health continue to persist and one major controllable and preventable risk factor is obesity. This study examined whether psychosocial factors such as masculinity ideology and frequency of experiences with racism may be significantly associated with Black men's obesity risk. METHOD:Part...
journal_title:Journal of the National Medical Association
pub_type: 杂志文章
doi:10.1016/j.jnma.2019.08.005
更新日期:2019-12-01 00:00:00
abstract::Enlarged spleen without a clear-cut etiology, and believed to be related to malarial infestations, has been referred to as "tropical splenomegaly" and "cryptogenetic splenomegaly." Splenectomy performed in such cases after a failure of antimalarial therapy shows histopathologically, while some of these meet the criter...
journal_title:Journal of the National Medical Association
pub_type: 杂志文章
doi:
更新日期:1980-04-01 00:00:00
abstract::The Keller resection arthroplasty was first described in 1904. Ninety years later, this operation continues to be useful to orthopaedic surgeons and their patients. This article presents the results of Keller bunionectomies in a private practice setting. Indications, surgical techniques, postoperative management, and ...
journal_title:Journal of the National Medical Association
pub_type: 杂志文章
doi:
更新日期:1996-01-01 00:00:00
abstract::Although mortality from cardiovascular diseases (CVDs) has been declining, it remains the leading cause of death among urban U.S. blacks. McCord and Freeman reported CVD as the major contributor to excess mortality in Central Harlem. However the disease-specific CVD mortality was not assessed. Thus, it was unclear wha...
journal_title:Journal of the National Medical Association
pub_type: 杂志文章
doi:
更新日期:2003-12-01 00:00:00
abstract::Pulmonary edema is a complex subject. Knowledge of the anatomy of the distal air space is essential to the understanding of the pathophysiology of pulmonary edema.Histological evaluation of experimental pulmonary edema in dogs by Staub et al using the quick freeze method indicates that the edema begins in the intersti...
journal_title:Journal of the National Medical Association
pub_type: 杂志文章
doi:
更新日期:1977-03-01 00:00:00
abstract::Patient navigation has been widely implemented by cancer care programs across the United States. While activities of navigators have been described elsewhere, little has been documented regarding specific strategies used or challenges experienced by navigators from their own perspectives. We describe the experience of...
journal_title:Journal of the National Medical Association
pub_type: 杂志文章
doi:10.1016/s0027-9684(15)30412-0
更新日期:2011-08-01 00:00:00
abstract::Among urban low-income and minority patients with compromised access or low adherence to primary care, exacerbations of unrecognized but symptomatic moderate to severe chronic obstructive pulmonary disease (COPD) cause avoidable emergency room visits and hospitalizations. Detection and management of COPD before a firs...
journal_title:Journal of the National Medical Association
pub_type: 杂志文章
doi:10.1016/s0027-9684(15)30623-4
更新日期:2010-07-01 00:00:00
abstract:OBJECTIVE:To examine factors within the patient-provider relationship that influence which role African American men aged 40-70 years prefer when making health care decisions. METHODS:We recruited 40 African American men from barbershops in the Richmond, Virginia, metropolitan area to participate in semistructured int...
journal_title:Journal of the National Medical Association
pub_type: 杂志文章
doi:10.1016/s0027-9684(15)30176-0
更新日期:2012-07-01 00:00:00
abstract::A retrospective review was conducted to determine if there were identifiable racial markers in patients who were explored and misdiagnosed as having appendicitis. Between May 1983 and May 1987, 100 patients were explored for appendicitis. There were 65 whites and 35 blacks with a male predominance in each group. The a...
journal_title:Journal of the National Medical Association
pub_type: 杂志文章
doi:
更新日期:1989-03-01 00:00:00
abstract:BACKGROUND:Black women in Minnesota and beyond have a greater burden of death due to some cancers than their White counterparts. Delayed screening and treatment may explain these disparate statistics. The purpose of this study was to work in collaboration with a local Black faith-based organization to gain an updated u...
journal_title:Journal of the National Medical Association
pub_type: 杂志文章
doi:10.1016/j.jnma.2019.02.006
更新日期:2020-10-01 00:00:00
abstract::The study aimed at finding out the clinicopathologic, ophthalmic and visual profiles, management and outcome of mucoceles of the paranasal sinuses in Nigerians. The study was a retrospective review of 20 cases of mucoceles who presented to the ENT clinic and referred to the eye clinic of the University College Hospita...
journal_title:Journal of the National Medical Association
pub_type: 杂志文章
doi:
更新日期:2006-01-01 00:00:00
abstract::Two women over the age of 50 years presented with ketoacidosis as the first manifestation of diabetes mellitus. The first patient failed to respond to a regimen of hourly intramuscular injections of regular insulin. She only improved when a continuous intravenous infusion of regular insulin was utilized. The second pa...
journal_title:Journal of the National Medical Association
pub_type: 杂志文章
doi:
更新日期:1986-02-01 00:00:00
abstract::Little is known about the adverse consequences of anemia during infancy or maternal anemia during pregnancy on the behavioral development of the infant. The present research investigates one aspect of these relationships. ...
journal_title:Journal of the National Medical Association
pub_type: 杂志文章
doi:
更新日期:1986-10-01 00:00:00
abstract:INTRODUCTION:To determine the efficacy and safety of Kahook Dual Blade (KDB) goniotomy alone or combined with phacoemulsification cataract surgery to lower intraocular pressure and medication burden in Black and Afro-Latinx patients with open angle glaucoma (OAG). MATERIALS AND METHOD:A retrospective, single center ca...
journal_title:Journal of the National Medical Association
pub_type: 杂志文章
doi:10.1016/j.jnma.2020.09.147
更新日期:2020-11-03 00:00:00
abstract::In addition to well known parameters used for measuring in vitro cellular radiosensitivity (mean lethal dose, extrapolation number, quasithreshold dose), there are other, less well known measures that may be more important. The authors recently surveyed the literature and found that mean activation dose (D) has been n...
journal_title:Journal of the National Medical Association
pub_type: 杂志文章,评审
doi:
更新日期:1989-07-01 00:00:00
abstract:BACKGROUND:Compared to whites, African Americans have almost a 2-fold increased risk of first-ever stroke. Our study sought to determine awareness of stroke risk factors and management, symptoms, and risk reduction strategies in African Americans in Mississippi, which is part of the "stroke belt. METHODS:We conducted ...
journal_title:Journal of the National Medical Association
pub_type: 杂志文章
doi:10.1016/s0027-9684(15)30495-8
更新日期:2010-02-01 00:00:00
abstract::Anorexia nervosa has been considered rare or nonexistent among blacks. A report of the presentation and clinical course of this disorder in two black female adolescents illustrates a serious medical psychiatric problem that may be increasingly detected among predisposed teenagers of the black middle and professional c...
journal_title:Journal of the National Medical Association
pub_type: 杂志文章,评审
doi:
更新日期:1984-01-01 00:00:00
abstract::Stenosing tenosynovitis of the first dorsal compartment of the wrist (de Quervain's disease) is a common cause of radial wrist and hand pain and disability. Nonoperative management of the disease has been thought to provide only temporary relief of pain and swelling, while surgical intervention has been viewed as a mo...
journal_title:Journal of the National Medical Association
pub_type: 杂志文章
doi:
更新日期:1998-08-01 00:00:00
abstract::Bellevue Hospital, the oldest public hospital in the United States and a lineal descendant of an infirmary for slaves, accepted its first African-American resident, Dr. Ubert Conrad Vincent, in 1918. This occurred at a time when many medical centers were not accepting African-American residents. At the end of WWII, on...
journal_title:Journal of the National Medical Association
pub_type: 历史文章,杂志文章
doi:
更新日期:2004-03-01 00:00:00