Abstract:
PURPOSE:To compare a standard radio-oncological and a surgical biochemical failure definition after combined-modality radiation therapy (CRT) in men with intermediate- and high-risk prostate cancer. METHODS:425 men were treated with external beam radiotherapy (59.4 Gy, 33 fractions) and 125J seed-brachytherapy (S-BT, 100 Gy). Biochemical recurrence (BR) was defined either as radio-oncologic (rBR), using a +2 ng/mL prostate-specific antigen (PSA) increase above a nadir value, or as surgical (sBR), using a 2-year posttreatment PSA of ≥0.2 ng/mL. Biochemical recurrence-free, metastasis-free, cancer-specific, and overall survival were calculated at 5 and 10 years using the Kaplan-Meier method. Standard validation tests were used to compare both thresholds. RESULTS:After a median of 7 years, overall recurrence rates were 10.4% and 31.5% for rBR and sBR definitions, respectively. Both failure definitions proved sensitive for the prediction of metastases and cancer-specific death, whereas the rBR definition was significantly more specific. The accuracies of a correct prediction of metastases and death of prostate cancer were 73.1% vs. 96.2% and 72.2% vs. 92.9% for sBR vs. rBR, respectively. The inferior validity results of the sBR definition were attributable to a PSA-bounce phenomenon occurring in 56% of patients with sBR. Still, using the less suitable sBR definition, the results of CRT compared favorably to BRFS rates of surgical interventions. CONCLUSION:After CRT, the radio-oncological (aka Phoenix) failure definition is more reliable than a fixed surgical endpoint. Exclusively in high-risk patients, sBR offers a direct comparison across surgical and nonsurgical treatment options at 5 and 10 years.
journal_name
Brachytherapyjournal_title
Brachytherapyauthors
Boehle A,Katic K,König IR,Robrahn-Nitschke I,Brandenburg Bdoi
10.1016/j.brachy.2019.09.001subject
Has Abstractpub_date
2020-01-01 00:00:00pages
24-32issue
1eissn
1538-4721issn
1873-1449pii
S1538-4721(19)30579-3journal_volume
19pub_type
杂志文章相关文献
Brachytherapy文献大全abstract:PURPOSE:Accelerated partial breast irradiation (APBI) continues to increase in popularity. Up to 14% of patients treated with the MammoSite (MS) report some degree of chronic pain, which may be related to chest wall toxicity. Reports from several institutions using the multicatheter (MC) technique have not shown associ...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2008.11.007
更新日期:2009-04-01 00:00:00
abstract:PURPOSE:To explore the dosimetric advantage of target volume and surrounding normal tissue by using interstitial (IS) brachytherapy (BT) based on three-dimensional CT in locally advanced cervical cancer, as a simple and effective clinical treatment approach. METHODS AND MATERIALS:Fifty-two patients with poor tumor res...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2016.06.004
更新日期:2016-09-01 00:00:00
abstract:PURPOSE:To report prostate-specific antigen (PSA) relapse-free survival and treatment-related toxicity outcomes after combining high-dose-rate (HDR) brachytherapy with external beam radiotherapy (EBRT) for patients with clinically localized prostate cancer. METHODS AND MATERIALS:Between 1998 and 2009, 229 patients wer...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2012.05.003
更新日期:2013-01-01 00:00:00
abstract:PURPOSE:To evaluate lumpectomy followed by interstitial brachytherapy as an acceptable salvage therapy for women who have developed localized recurrence of breast cancer after conservation surgery and postoperative external radiotherapy. METHODS AND MATERIALS:Between 1/1998 and 10/2006, 21 patients with T0 or T1 in-br...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2007.12.001
更新日期:2008-01-01 00:00:00
abstract:PURPOSE:Determine feasibility and resultant dosimetry of an intraoperatively placed multichannel intracavitary brachytherapy catheter for accelerated partial breast irradiation (APBI). METHODS:Patients with breast cancer underwent intraoperative brachytherapy catheter placement based on frozen section analysis with im...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2016.08.002
更新日期:2016-01-01 00:00:00
abstract:PURPOSE:With accumulating evidence supporting partial-breast irradiation, we conducted a Phase I/II study to evaluate the role of a second conservative surgery and brachytherapy for patients presenting with a local recurrence/new primary in a breast who has previously undergone a lumpectomy and external radiation thera...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2007.10.006
更新日期:2008-01-01 00:00:00
abstract:PURPOSE:Patients with large prostate glands are underrepresented in clinical trials incorporating brachytherapy due to concerns for excessive toxicity. We sought to compare health-related quality of life (HRQOL) outcomes between small (<60 cc) and large (≥60 cc) prostates treated with high-dose-rate brachytherapy (HDR-...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2018.08.009
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Cervical cancer patients are faced with an enormous amount of medical information in a complex oncology field with sophisticated treatments including brachytherapy. We investigated the use of enhanced vs. standard brachytherapy-specific educational materials on patient-reported satisfaction during the inform...
journal_title:Brachytherapy
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.brachy.2015.09.007
更新日期:2016-01-01 00:00:00
abstract:PURPOSE:The study aimed to evaluate mature outcomes of a Phase I/II high-dose-rate brachytherapy (HDRB) boost protocol. METHODS AND MATERIALS:We analyzed data from 88 patients with T1a-T3a, N0, M0 prostate adenocarcinoma treated on a prospective Phase I/II HDRB boost protocol of 16 (n = 47) or 20 Gy (n = 41) in four f...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2006.08.007
更新日期:2006-10-01 00:00:00
abstract:PURPOSE:Accurate patient-specific dosimetry in intravascular brachytherapy (IVBT) is generally difficult due to the extremely high-dose gradient, complexity of treatment device, and patient-specific geometry (e.g., calcification, stent, curvature, movement of target). The purpose of this study is to analyze quantitativ...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2005.07.004
更新日期:2005-01-01 00:00:00
abstract:PURPOSE:To determine the factors that correlate with cylinder size in vaginal brachytherapy (VB) after hysterectomy for endometrial carcinoma. METHODS AND MATERIALS:Patients treated for endometrial cancer from January 1, 2003 to December 31, 2013 were reviewed from a single institution. Patients included underwent tot...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2016.04.391
更新日期:2016-09-01 00:00:00
abstract:PURPOSE:To develop a dose verification tool for high-dose-rate interstitial brachytherapy treatment planning in accelerated partial breast irradiation. METHODS AND MATERIALS:We have developed a software tool for interstitial brachytherapy treatment planning assessment. The software contains a database of seven (192)Ir...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2012.03.008
更新日期:2012-09-01 00:00:00
abstract:PURPOSE:Symptomatic coronary artery disease is routinely treated with angioplasty and stenting. Unfortunately, treatment failure in the form of in-stent restenosis (ISR) occurs relatively frequently. Intravascular brachytherapy (IVBT) is a safe and effective method proven to markedly reduce the rate of ISR in native co...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2004.05.004
更新日期:2004-01-01 00:00:00
abstract:OBJECTIVES:To determine the relationship between dosimetric parameters obtained on postimplantation Day 0 and biochemical relapse-free survival (bRFS) in patients treated with (125)I transperineal interstitial permanent prostate brachytherapy (TIPPB). METHODS:Two-hundred twenty men with low-risk (n=155, 70.4%), low-vo...
journal_title:Brachytherapy
pub_type: 临床试验,杂志文章
doi:10.1016/j.brachy.2009.04.005
更新日期:2010-01-01 00:00:00
abstract:PURPOSE:To present a clinical procedure that readjusts catheters to its planned positions based on pretreatment computed tomography (CT) for patients undergoing high-dose-rate (HDR) prostate brachytherapy, and evaluate the magnitude and dosimetric impact of the adjustments. METHODS AND MATERIALS:Patients received a pr...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2012.08.008
更新日期:2013-05-01 00:00:00
abstract:PURPOSE:To evaluate the efficacy and side effect profile of adjuvant vaginal vault brachytherapy alone after hysterectomy in Stage I endometrial carcinoma. METHODS AND MATERIALS:Between 23/11/1992 and 16/05/2005, a total of 173 patients with early endometrial carcinoma treated with vaginal vault brachytherapy alone po...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2008.01.001
更新日期:2008-04-01 00:00:00
abstract:PURPOSE:Treatment of locally advanced cervical cancer in patients with a renal graft requires precautions. The graft is usually in a pelvic position, close to the clinical target volume (CTV). Preserving the graft while ensuring local control is a challenge we have faced in two occasions. We report our experience. MET...
journal_title:Brachytherapy
pub_type: 社论
doi:10.1016/j.brachy.2013.11.003
更新日期:2014-01-01 00:00:00
abstract:PURPOSE:The treatment of locally advanced cervical cancer with definitive chemoradiation (CRT) is associated with vaginal toxicity and altered sexual satisfaction. This prospective study assessed patient-reported sexual adjustment, vaginal dosimetry, and physician-reported vaginal toxicity in patients with cervical can...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2018.09.005
更新日期:2019-01-01 00:00:00
abstract:PURPOSE:To describe in detail British Columbia (BC) Cancer Agency (BCCA) Provincial Prostate Brachytherapy (PB) Quality Assurance (QA) Program. METHODS AND MATERIALS:The BCCA PB Program was established in 1997. It operates as one system, unified and supported by electronic and information systems, making it a single P...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2012.03.006
更新日期:2013-07-01 00:00:00
abstract:PURPOSE:We sought to develop an activity nomogram for magnetic resonance (MR)-planned permanent seed prostate brachytherapy to improve quality assurance through a secondary dosimetric check. METHODS AND MATERIALS:Patients undergoing MRI-assisted radiosurgery (MARS), whereby MRI is used for preoperative planning and po...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2019.10.002
更新日期:2020-01-01 00:00:00
abstract:PURPOSE:Permanent LDR brachytherapy and temporary HDR brachytherapy are competitive techniques for clinically localized prostate radiotherapy. Although a randomized trial will likely never be conducted comparing these two forms of brachytherapy, a comparative radiobiological modeling analysis proves useful in understan...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/S1538-4721(02)00101-0
更新日期:2002-01-01 00:00:00
abstract:PURPOSE:To quantify needle migration and dosimetric impact in high-dose-rate brachytherapy for prostate cancer and propose a threshold for needle migration. METHODS AND MATERIALS:Twenty-four high-risk prostate cancer patients treated with an HDR boost of 2 × 8.5 Gy were included. Patients received an MRI for planning ...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2017.08.005
更新日期:2018-01-01 00:00:00
abstract:PURPOSE:To evaluate clinical outcome and feasibility of a four-dimensional image-guided adaptive brachytherapy concept in patients with locally recurrent endometrial cancer. METHODS AND MATERIALS:Forty-three patients with locally recurrent endometrial cancer were included. Treatment consisted of conformal external bea...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2014.06.004
更新日期:2014-11-01 00:00:00
abstract:PURPOSE:High-dose-rate (HDR) brachytherapy is a convenient treatment option for selected patients with T1-T2 penile squamous cell carcinoma (SCC), providing high rates of penile preservation and tumor control. We present the results of penile SCC treated with HDR brachytherapy either interstitially or via a surface mol...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2019.12.003
更新日期:2020-01-01 00:00:00
abstract:PURPOSE:The available data demonstrating that superiority of LDR brachytherapy (LDR-BT) boost in high-risk prostate cancer patients under represents patients with extracapsular extension (T3a) and/or seminal vesicle invasion (T3b) have been limited. We report long-term clinical outcomes data for patients with cT3a/b di...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2018.07.001
更新日期:2018-01-01 00:00:00
abstract:PURPOSE:The British Columbia Cancer Agency has been performing iodine-125 prostate brachytherapy since 1998, initially using loose seeds and phasing into the exclusive use of RAPIDStrand (RS) (Oncura Inc., Plymouth Meeting, PA) by November 2000. The aim of this study was to investigate rates of biochemical no evidence ...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2011.01.011
更新日期:2011-11-01 00:00:00
abstract:PURPOSE:Although high-dose-rate brachytherapy (HDRBT) offers significant advantages over low dose rate brachytherapy, there are scant data on improved local control (LC) and treatment-related complications in patients with recurrent head and neck (H&N) cancers. We report our preliminary results in patients with recurre...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2006.12.001
更新日期:2007-04-01 00:00:00
abstract:PURPOSE:To assess the safety, feasibility, and efficacy of free-hand intraoperative multicatheter breast implant (FHIOMBI) and perioperative high-dose-rate brachytherapy (PHDRBT) in early breast cancer. METHODS AND MATERIALS:Patients with early breast cancer candidates for breast conservative surgery (BCS) were prospe...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2016.03.001
更新日期:2016-07-01 00:00:00
abstract:BACKGROUND:To determine the feasibility of combined perioperative high-dose-rate brachytherapy (PHDRB) and intermediate-dose external beam radiation therapy (EBRT) as an alternative to full-dose adjuvant EBRT in patients with unirradiated squamous cell cancer (SCC) of the oral cavity and oropharynx. METHODS AND MATERI...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2008.10.002
更新日期:2009-01-01 00:00:00
abstract:PURPOSE:Currently, there are high dose rate afterloaders available that can drive two different radioactive sources simultaneously. The source-source and source-cable attenuations are not taken into account by current planning systems. The purpose of this work is to characterize these effects and their overall impact o...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2016.03.007
更新日期:2016-07-01 00:00:00