Abstract:
PURPOSE:The available data demonstrating that superiority of LDR brachytherapy (LDR-BT) boost in high-risk prostate cancer patients under represents patients with extracapsular extension (T3a) and/or seminal vesicle invasion (T3b) have been limited. We report long-term clinical outcomes data for patients with cT3a/b disease receiving LDR-BT. METHODS AND MATERIALS:Ninety-nine men (median age: 69.4 years) with cT3a/bN0M0 high-risk prostate adenocarcinoma received definitive LDR-BT or LDR-BT boost after external beam radiation therapy (EBRT) at a single institution between 1998 and 2007. About 86% of patients received androgen deprivation therapy. Freedom from biochemical failure (FFBF), prostate cancer-specific survival (PCSS), and overall survival (OS) was calculated using the Kaplan-Meier method with the Phoenix definition used as definition of failure. Cox regression analysis was used to compare outcomes between clinical stage, initial PSA, Gleason Score, and percent core positive rate. RESULTS:With a median followup of 7 years, 7-year rate of FFBF, PCSS, and OS for the entire cohort was 65.2% (±5.6%), 90.1% (±3.6%), and 77.9% (±4.7%), respectively. LDR-BT boost patients achieved a 7-year FFBF rate of 73.5 (±6.5%). No significant difference in outcomes was present between T3a or T3b disease, Gleason score, iPSA stratification and percent core positive rates. CONCLUSIONS:LDR-BT, primarily as a boost in conjunction with ADT and EBRT, is not only feasible, but also highly effective in men with cT3a and cT3b high-risk prostate cancer resulting in excellent biochemical control and survival outcomes. LDR-BT boost implantation of patients should be strongly considered for cT3 patients given the merits of trimodality care.
journal_name
Brachytherapyjournal_title
Brachytherapyauthors
Agarwal M,Chhabra AM,Amin N,Braccioforte MH,Molitoris JK,Moran BJdoi
10.1016/j.brachy.2018.07.001subject
Has Abstractpub_date
2018-01-01 00:00:00pages
882-887issue
6eissn
1538-4721issn
1873-1449pii
S1538-4721(18)30457-4journal_volume
17pub_type
杂志文章相关文献
Brachytherapy文献大全abstract:PURPOSE:Brachytherapy re-irradiation may offer an alternative re-treatment of recurrent head-and-neck cancer even after previous full dose radiation therapy. The purposes of this study were to determine the feasibility and accuracy of frameless image-guided interstitial needle implantation. METHODS AND MATERIALS:Betwe...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2005.02.001
更新日期:2005-01-01 00:00:00
abstract:PURPOSE:TG43 does not account for a lack of scatter and tissue and applicator heterogeneities. The advanced collapsed-cone engine (ACE) algorithm available for use in the Oncentra Brachy treatment planning system (Elekta AB, Stockholm, Sweden) can model these conditions more accurately and is evaluated for esophageal a...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2020.09.006
更新日期:2020-10-15 00:00:00
abstract:PURPOSE:To develop a safe and robust workflow for yttrium-90 (Y-90) radioembolization procedures in a multidisciplinary team environment. METHODS AND MATERIALS:A generalized Define-Measure-Analyze-Improve-Control (DMAIC)-based approach to process improvement was applied to a Y-90 radioembolization workflow. In the fir...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2016.08.001
更新日期:2017-01-01 00:00:00
abstract:PURPOSE:In this planning study, we investigated the dosimetric benefit of repeat CT-based treatment planning at each fraction vs. the use of a single CT-based treatment plan for all fractions for high-dose-rate endorectal brachytherapy (HDREBT) for rectal cancer. METHODS AND MATERIALS:We included 11 patients that rece...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2017.08.011
更新日期:2018-01-01 00:00:00
abstract:PURPOSE:Persistent disease after definitive external beam radiation therapy for head and neck (H&N) malignancies negatively impacts survival. In this series, the effectiveness of low-dose-rate brachytherapy in the management of persistent H&N disease is explored. METHODS:All patients who received brachytherapy for per...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2008.12.007
更新日期:2009-07-01 00:00:00
abstract:PURPOSE:To evaluate the impact of general versus spinal anesthesia on postprocedure narcotic use and of extradepartmental planning MRI on treatment time in high-dose-rate brachytherapy for cervical cancer. METHODS AND MATERIALS:Twenty-five patients (10 general anesthesia and 15 spinal anesthesia) who collectively rece...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2018.05.002
更新日期:2018-01-01 00:00:00
abstract:PURPOSE:To quantify needle migration and dosimetric impact in high-dose-rate brachytherapy for prostate cancer and propose a threshold for needle migration. METHODS AND MATERIALS:Twenty-four high-risk prostate cancer patients treated with an HDR boost of 2 × 8.5 Gy were included. Patients received an MRI for planning ...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2017.08.005
更新日期:2018-01-01 00:00:00
abstract:PURPOSE:To evaluate the long-term disease control and toxicity to the organs at risk after dose-escalated image-based adaptive brachytherapy (BT) in cervical cancer. METHODS AND MATERIALS:Sixty patients of cervical cancer were treated with external radiotherapy 46 Gy in 23 fractions with weekly cisplatin and MRI-guide...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2017.09.008
更新日期:2018-01-01 00:00:00
abstract:PURPOSE:Limited information is available comparing target volume and normal tissue dosimetry with the different techniques of partial breast irradiation (PBI). We present results of a dosimetric comparison of single catheter, balloon-based brachytherapy using the MammoSite catheter (BRT), 3D conformal radiation therapy...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2006.06.001
更新日期:2006-07-01 00:00:00
abstract:PURPOSE:Treatment options are limited for patients with localized prostate cancer and a prior history of abdominoperineal resection (APR) and pelvic irradiation. We have previously reported on the successful utility of high-dose-rate (HDR) brachytherapy salvage for prostate cancer failing definitive external beam radia...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2009.02.004
更新日期:2009-10-01 00:00:00
abstract:PURPOSE:HDRILBT is one of the best methods of palliation for advanced esophageal cancer (AEC) by improving dysphagia-free survival (DFS) and overall survival (OS). This study examines if the addition of EBRT would further improve the outcome by improving DFS in AEC. METHODS AND MATERIALS:Patients with inoperable AEC w...
journal_title:Brachytherapy
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.brachy.2004.09.004
更新日期:2004-01-01 00:00:00
abstract:PURPOSE:Certain subsets of patients have an increased risk of all-cause mortality when androgen deprivation therapy (ADT) is used with definitive radiotherapy. We evaluated the relationship between pretreatment serum testosterone, age, and comorbidities on survival after prostate brachytherapy in men treated with and w...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2009.06.008
更新日期:2010-01-01 00:00:00
abstract:PURPOSE:Accurate patient-specific dosimetry in intravascular brachytherapy (IVBT) is generally difficult due to the extremely high-dose gradient, complexity of treatment device, and patient-specific geometry (e.g., calcification, stent, curvature, movement of target). The purpose of this study is to analyze quantitativ...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2005.07.004
更新日期:2005-01-01 00:00:00
abstract:PURPOSE:To develop an improved Xoft electronic skin brachytherapy process and identify areas of further improvement. METHODS AND MATERIALS:A multidisciplinary team conducted a failure modes and effects analysis (FMEA) by developing a process map and a corresponding list of failure modes. The failure modes were scored ...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2018.04.002
更新日期:2018-01-01 00:00:00
abstract:PURPOSE:Symptomatic coronary artery disease is routinely treated with angioplasty and stenting. Unfortunately, treatment failure in the form of in-stent restenosis (ISR) occurs relatively frequently. Intravascular brachytherapy (IVBT) is a safe and effective method proven to markedly reduce the rate of ISR in native co...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2004.05.004
更新日期:2004-01-01 00:00:00
abstract:PURPOSE:To evaluate lumpectomy followed by interstitial brachytherapy as an acceptable salvage therapy for women who have developed localized recurrence of breast cancer after conservation surgery and postoperative external radiotherapy. METHODS AND MATERIALS:Between 1/1998 and 10/2006, 21 patients with T0 or T1 in-br...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2007.12.001
更新日期:2008-01-01 00:00:00
abstract:PURPOSE:To evaluate the effect of hormonal manipulation on catheter dependency, the resolution of urinary symptomatology, and the need for postbrachytherapy transurethral/transincisional resection (TURP/TUIP). METHODS AND MATERIALS:Seven hundred sixteen consecutive patients (median follow-up, 29 months) underwent brac...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2003.12.001
更新日期:2004-01-01 00:00:00
abstract:PURPOSE:The British Columbia Cancer Agency has been performing iodine-125 prostate brachytherapy since 1998, initially using loose seeds and phasing into the exclusive use of RAPIDStrand (RS) (Oncura Inc., Plymouth Meeting, PA) by November 2000. The aim of this study was to investigate rates of biochemical no evidence ...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2011.01.011
更新日期:2011-11-01 00:00:00
abstract:PURPOSE:With accumulating evidence supporting partial-breast irradiation, we conducted a Phase I/II study to evaluate the role of a second conservative surgery and brachytherapy for patients presenting with a local recurrence/new primary in a breast who has previously undergone a lumpectomy and external radiation thera...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2007.10.006
更新日期:2008-01-01 00:00:00
abstract:PURPOSE:Given the limited data using an interstitial approach with 3D-based planning for definitive cervical cancer utilizing the GEC-ESTRO defined high-risk clinical target volume (HR-CTV), we reviewed our institutional experience of cervical cancer patients with HR-CTVs ≥ 30 cc to determine whether our clinical and t...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2017.10.004
更新日期:2018-01-01 00:00:00
abstract:PURPOSE:Although high-dose-rate brachytherapy (HDRBT) offers significant advantages over low dose rate brachytherapy, there are scant data on improved local control (LC) and treatment-related complications in patients with recurrent head and neck (H&N) cancers. We report our preliminary results in patients with recurre...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2006.12.001
更新日期:2007-04-01 00:00:00
abstract:PURPOSE:To analyze the dosimetric impact and periprocedural outcomes with a bioabsorbable hydrogel rectal spacer injected during low-dose-rate (LDR) prostate brachytherapy implants. METHODS AND MATERIALS:A consecutive series of 80 patients implanted with stranded I-125 LDR brachytherapy seeds were evaluated, of which ...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2019.11.002
更新日期:2020-01-01 00:00:00
abstract:PURPOSE:To describe in detail British Columbia (BC) Cancer Agency (BCCA) Provincial Prostate Brachytherapy (PB) Quality Assurance (QA) Program. METHODS AND MATERIALS:The BCCA PB Program was established in 1997. It operates as one system, unified and supported by electronic and information systems, making it a single P...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2012.03.006
更新日期:2013-07-01 00:00:00
abstract:PURPOSE:To evaluate the clinical outcomes of women receiving a "short" course of high-dose-rate gynecologic interstitial brachytherapy (HDR-ISBT) boost with CT-based 3D planning. METHODS AND MATERIALS:Forty-seven women with no prior radiation received HDR-ISBT from August 2004 to February 2012. The mean external beam ...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2014.02.001
更新日期:2014-05-01 00:00:00
abstract:PURPOSE:To evaluate outcomes after exclusive salvage high-dose-rate (HDR) intraluminal esophageal brachytherapy given to previously irradiated patients with recurrent esophageal cancer. METHODS AND MATERIALS:We reviewed medical records of 30 patients who were treated by salvage HDR brachytherapy for local esophageal c...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2015.02.392
更新日期:2015-07-01 00:00:00
abstract:PURPOSE:To present recommendations for the use of interstitial brachytherapy in patients with vaginal cancer or recurrent endometrial cancer in the vagina. METHODS:A panel of members of the American Brachytherapy Society reviewed the literature, supplemented that with their clinical experience, and formulated recommen...
journal_title:Brachytherapy
pub_type: 杂志文章,实务指引
doi:10.1016/j.brachy.2011.06.008
更新日期:2012-01-01 00:00:00
abstract:PURPOSE:The aim of this work was to analyze the exposure rates measured in the proximity of patients who underwent prostate low-dose-rate brachytherapy with I-125 implant. Effective doses to relatives and to population were computed to estimate the time to reach radioprotection dose constraints. METHODS AND MATERIALS:...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2020.09.003
更新日期:2021-01-01 00:00:00
abstract:PURPOSE:To analyze the feasibility, reproducibility, and impact on functional status of postoperative accelerated and partial breast irradiation (APBI) using interstitial high-dose rate-brachytherapy in women older than 70 years. METHODS AND MATERIALS:From July 2004 to April 2008, 46 patients were screened for enrollm...
journal_title:Brachytherapy
pub_type: 杂志文章,多中心研究
doi:10.1016/j.brachy.2012.06.004
更新日期:2013-07-01 00:00:00
abstract:INTRODUCTION:Substantial as opposed to focal or no lymphovascular space invasion (LVSI) is proposed as an independent adverse prognostic factor in patients with early-stage endometrioid endometrial cancer (EEC). We reviewed outcomes of patients treated with adjuvant vaginal brachytherapy (VB) alone in a single institut...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2020.12.006
更新日期:2021-01-20 00:00:00
abstract:PURPOSE:This work quantifies the influence of intrafraction DNA damage repair and cellular repopulation on biologically effective dose (BED) in Ir-192 high-dose-rate brachytherapy for prostate cancer. In addition, it examines the effect of source-decay-induced BED variation for patients treated at different time points...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2019.04.005
更新日期:2019-01-01 00:00:00