Abstract:
PURPOSE:Treatment options are limited for patients with localized prostate cancer and a prior history of abdominoperineal resection (APR) and pelvic irradiation. We have previously reported on the successful utility of high-dose-rate (HDR) brachytherapy salvage for prostate cancer failing definitive external beam radiation therapy (EBRT). In this report, we describe our technique and early experience with definitive HDR brachytherapy in patients post APR and pelvic EBRT. PATIENTS AND METHODS:Six men with newly diagnosed localized prostate cancer had a prior history of APR and pelvic EBRT. Sixteen to 18 HDR catheters were placed transperineally under transperineal ultrasound-guidance. The critical first two catheters were placed freehand posterior to the inferior rami on both sides of the bulbar urethra under cystoscopic visualization. A template was used for subsequent catheter placement. Using CT-based planning, 5 men received 36Gy in six fractions as monotherapy. One patient initially treated with EBRT to 30Gy, received 24Gy in four fractions. RESULTS:Median age was 67.5 (56-74) years. At a median followup of 26 (14-60) months, all patients are alive and with no evidence of disease per the Phoenix definition of biochemical failure, with a median prostate-specific antigen nadir of 0.19ng/mL. Three men have reported grade 2 late genitourinary toxicity. There has been no report of grade 3-5 toxicity. CONCLUSION:Transperineal ultrasound-guided HDR brachytherapy using the above technique should be considered as definitive therapy for patients with localized prostate cancer and a prior history of APR and pelvic EBRT.
journal_name
Brachytherapyjournal_title
Brachytherapyauthors
Jabbari S,Hsu IC,Kawakami J,Weinberg VK,Speight JL,Gottschalk AR,Roach M 3rd,Shinohara Kdoi
10.1016/j.brachy.2009.02.004subject
Has Abstractpub_date
2009-10-01 00:00:00pages
339-44issue
4eissn
1538-4721issn
1873-1449pii
S1538-4721(09)00200-1journal_volume
8pub_type
杂志文章相关文献
Brachytherapy文献大全abstract:OBJECTIVES:To determine the relationship between dosimetric parameters obtained on postimplantation Day 0 and biochemical relapse-free survival (bRFS) in patients treated with (125)I transperineal interstitial permanent prostate brachytherapy (TIPPB). METHODS:Two-hundred twenty men with low-risk (n=155, 70.4%), low-vo...
journal_title:Brachytherapy
pub_type: 临床试验,杂志文章
doi:10.1016/j.brachy.2009.04.005
更新日期:2010-01-01 00:00:00
abstract:OBJECTIVES:To evaluate the interim outcomes of low-dose-rate permanent brachytherapy (PB) combined with short-term androgen deprivation therapy (ADT) in Japanese men with intermediate-risk prostate cancer excluding those with a Gleason score of 4+3. METHODS:The Protocol-intermediate-risk group (Protocol-IRG) was defin...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2014.09.001
更新日期:2015-03-01 00:00:00
abstract:PURPOSE:Persistent disease after definitive external beam radiation therapy for head and neck (H&N) malignancies negatively impacts survival. In this series, the effectiveness of low-dose-rate brachytherapy in the management of persistent H&N disease is explored. METHODS:All patients who received brachytherapy for per...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2008.12.007
更新日期:2009-07-01 00:00:00
abstract:PURPOSE:In 2012, our institution transitioned from low-dose-rate (LDR) brachytherapy to high dose-rate (HDR) brachytherapy. We report clinical outcomes after brachytherapy for cervical cancer at our institution over a continuous 10-year period. METHODS AND MATERIALS:From 2004 to 2014, 258 women (184 LDR and 74 HDR) we...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2016.12.005
更新日期:2017-01-01 00:00:00
abstract:PURPOSE:To investigate the safety and feasibility of intraluminal brachytherapy using 125I seed strand for locally advanced pancreatic ductal adenocarcinoma with obstructive jaundice. METHODS AND MATERIALS:From January 2010 to February 2015, 18 consecutive patients diagnosed with locally advanced, nonmetastatic, inope...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2016.05.004
更新日期:2016-01-01 00:00:00
abstract:PURPOSE:Permanent LDR brachytherapy and temporary HDR brachytherapy are competitive techniques for clinically localized prostate radiotherapy. Although a randomized trial will likely never be conducted comparing these two forms of brachytherapy, a comparative radiobiological modeling analysis proves useful in understan...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/S1538-4721(02)00101-0
更新日期:2002-01-01 00:00:00
abstract::While brachytherapy applications are not widely used for cancer diagnoses in the upper GI tract (including the esophagus, liver, stomach, and pancreas), they have a clear role in palliation and symptom management and occasionally definitive locoregional treatment. With the increasing use of image-guided techniques, th...
journal_title:Brachytherapy
pub_type: 杂志文章,评审
doi:10.1016/j.brachy.2020.11.010
更新日期:2020-12-22 00:00:00
abstract:PURPOSE:For selected early breast cancers, intraoperative radiation therapy (IORT) at the time of lumpectomy can be an efficient alternative to fractionated whole breast radiation therapy (WBRT). However, some patients are later recommended WBRT after IORT due to surgical pathologic findings. To understand risk factor ...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2016.09.012
更新日期:2017-01-01 00:00:00
abstract:PURPOSE:TG43 does not account for a lack of scatter and tissue and applicator heterogeneities. The advanced collapsed-cone engine (ACE) algorithm available for use in the Oncentra Brachy treatment planning system (Elekta AB, Stockholm, Sweden) can model these conditions more accurately and is evaluated for esophageal a...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2020.09.006
更新日期:2020-10-15 00:00:00
abstract:PURPOSE:High-dose-rate (HDR) brachytherapy is a convenient treatment option for selected patients with T1-T2 penile squamous cell carcinoma (SCC), providing high rates of penile preservation and tumor control. We present the results of penile SCC treated with HDR brachytherapy either interstitially or via a surface mol...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2019.12.003
更新日期:2020-01-01 00:00:00
abstract:PURPOSE:To evaluate the clinical outcomes of women receiving a "short" course of high-dose-rate gynecologic interstitial brachytherapy (HDR-ISBT) boost with CT-based 3D planning. METHODS AND MATERIALS:Forty-seven women with no prior radiation received HDR-ISBT from August 2004 to February 2012. The mean external beam ...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2014.02.001
更新日期:2014-05-01 00:00:00
abstract:PURPOSE:To establish dose-volume effect correlations for late small bowel (SB) toxicities in patients treated for locally advanced cervical cancer with concomitant chemoradiation followed by pulsed-dose rate MRI-guided adaptive brachytherapy. METHODS AND MATERIALS:Patients treated with curative intent and followed pro...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2016.04.004
更新日期:2016-07-01 00:00:00
abstract:PURPOSE:With an aim to evaluate and report high dose date interstitial brachytherapy (HDR-ISBT) in vulvar cancers, we undertook this retrospective analysis. METHODS AND MATERIALS:Histologically proven vulvar cancers treated with HDR-ISBT between 2001 and 2016 were analyzed. Radiotherapy details, clinical outcome in te...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2016.10.003
更新日期:2017-01-01 00:00:00
abstract:PURPOSE:To present a clinical procedure that readjusts catheters to its planned positions based on pretreatment computed tomography (CT) for patients undergoing high-dose-rate (HDR) prostate brachytherapy, and evaluate the magnitude and dosimetric impact of the adjustments. METHODS AND MATERIALS:Patients received a pr...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2012.08.008
更新日期:2013-05-01 00:00:00
abstract:PURPOSE:To evaluate outcomes after exclusive salvage high-dose-rate (HDR) intraluminal esophageal brachytherapy given to previously irradiated patients with recurrent esophageal cancer. METHODS AND MATERIALS:We reviewed medical records of 30 patients who were treated by salvage HDR brachytherapy for local esophageal c...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2015.02.392
更新日期:2015-07-01 00:00:00
abstract:PURPOSE:Accurate patient-specific dosimetry in intravascular brachytherapy (IVBT) is generally difficult due to the extremely high-dose gradient, complexity of treatment device, and patient-specific geometry (e.g., calcification, stent, curvature, movement of target). The purpose of this study is to analyze quantitativ...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2005.07.004
更新日期:2005-01-01 00:00:00
abstract:PURPOSE:The study aimed to evaluate mature outcomes of a Phase I/II high-dose-rate brachytherapy (HDRB) boost protocol. METHODS AND MATERIALS:We analyzed data from 88 patients with T1a-T3a, N0, M0 prostate adenocarcinoma treated on a prospective Phase I/II HDRB boost protocol of 16 (n = 47) or 20 Gy (n = 41) in four f...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2006.08.007
更新日期:2006-10-01 00:00:00
abstract:PURPOSE:Low-dose-rate brachytherapy using iodine-125 seeds is a highly efficacious treatment for low-risk prostate cancer. We propose a bioeffect model may be used to target an ablative dose to the tumor with a lower, therapeutic dose to low-risk regions to maintain high rates of tumor control with reduced toxicity. We...
journal_title:Brachytherapy
pub_type: 杂志文章,多中心研究
doi:10.1016/j.brachy.2013.04.008
更新日期:2013-11-01 00:00:00
abstract:PURPOSE:To evaluate the feasibility, efficacy, and safety of permanent (125)I seed interstitial brachytherapy reirradiation in patients with retroperitoneal lymph node recurrence under CT guidance. METHODS AND MATERIALS:Seventeen patients with 19 retroperitoneal lymph node recurrence after external beam radiotherapy u...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2015.05.008
更新日期:2015-09-01 00:00:00
abstract:PURPOSE:To evaluate the effectiveness of the single-energy metal artifact reduction (SEMAR) technique for improving the accuracy of I-125 seed identification in postimplant computed tomography (CT) after prostate brachytherapy. METHODS AND MATERIALS:Postimplant CT images of 40 patients treated with I-125 prostate brac...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2016.07.006
更新日期:2016-01-01 00:00:00
abstract:PURPOSE:The radioactive gold grain applicator and seeds offer the flexibility necessary for effective use in the treatment of difficult sites of head-and-neck cancers. This study reviews our experience with gold grain (198Au) implants in locally advanced head-and-neck cancer to demonstrate their efficacy and feasibilit...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/s1538-4721(02)00054-5
更新日期:2002-01-01 00:00:00
abstract:PURPOSE:To evaluate lumpectomy followed by interstitial brachytherapy as an acceptable salvage therapy for women who have developed localized recurrence of breast cancer after conservation surgery and postoperative external radiotherapy. METHODS AND MATERIALS:Between 1/1998 and 10/2006, 21 patients with T0 or T1 in-br...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2007.12.001
更新日期:2008-01-01 00:00:00
abstract:PURPOSE:The aim of the study was to evaluate the results of high-dose-rate interstitial brachytherapy (HDR-ISBT) for patients with advanced cervical carcinoma in which intracavitary radiation therapy may result in a suboptimal dose distribution. METHODS AND MATERIALS:Between 1995 and 2005, 25 patients of median age 64...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2008.12.002
更新日期:2009-04-01 00:00:00
abstract:PURPOSE:If a prostate cancer patient treated with (125)I brachytherapy dies within 12 months after the treatment, prostate removal before cremation is recommended to avoid problems related to radioactivity in the ashes, such as inhalation of airborne particulate matter by crematorium staff or nearby residents. To provi...
journal_title:Brachytherapy
pub_type: 杂志文章,评审
doi:10.1016/j.brachy.2014.08.043
更新日期:2015-03-01 00:00:00
abstract:OBJECTIVE:To compare dosimetrically the stereotactic CyberKnife (CK) therapy and multicatheter high-dose-rate (HDR) brachytherapy (BT) for accelerated partial breast irradiation (APBI). METHODS:Treatment plans of 25 patients treated with CK were selected, and additional plans using multicatheter HDR BT were created on...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2020.10.003
更新日期:2020-11-18 00:00:00
abstract:PURPOSE:To explore the dosimetric advantage of target volume and surrounding normal tissue by using interstitial (IS) brachytherapy (BT) based on three-dimensional CT in locally advanced cervical cancer, as a simple and effective clinical treatment approach. METHODS AND MATERIALS:Fifty-two patients with poor tumor res...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2016.06.004
更新日期:2016-09-01 00:00:00
abstract:PURPOSE:Although current Delphi Consensus guidelines do not recommend a specific definition of biochemical recurrence after partial gland therapy, these guidelines acknowledge that serial prostate-specific antigen (PSA) tests remain the best marker for monitoring disease after treatment. The purpose of this study was t...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2018.12.001
更新日期:2019-01-01 00:00:00
abstract:PURPOSE:To quantify needle migration and dosimetric impact in high-dose-rate brachytherapy for prostate cancer and propose a threshold for needle migration. METHODS AND MATERIALS:Twenty-four high-risk prostate cancer patients treated with an HDR boost of 2 × 8.5 Gy were included. Patients received an MRI for planning ...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2017.08.005
更新日期:2018-01-01 00:00:00
abstract:PURPOSE:To determine the factors that correlate with cylinder size in vaginal brachytherapy (VB) after hysterectomy for endometrial carcinoma. METHODS AND MATERIALS:Patients treated for endometrial cancer from January 1, 2003 to December 31, 2013 were reviewed from a single institution. Patients included underwent tot...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2016.04.391
更新日期:2016-09-01 00:00:00
abstract:PURPOSE:The treatment of locally advanced cervical cancer with definitive chemoradiation (CRT) is associated with vaginal toxicity and altered sexual satisfaction. This prospective study assessed patient-reported sexual adjustment, vaginal dosimetry, and physician-reported vaginal toxicity in patients with cervical can...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2018.09.005
更新日期:2019-01-01 00:00:00