Abstract：
PURPOSE:The aim of the study was to evaluate the results of high-dose-rate interstitial brachytherapy (HDR-ISBT) for patients with advanced cervical carcinoma in which intracavitary radiation therapy may result in a suboptimal dose distribution. METHODS AND MATERIALS:Between 1995 and 2005, 25 patients of median age 64 years were treated with external beam radiation therapy and HDR-ISBT. The International Federation of Gynecology and Obstetrics stages of the patients were I (4%), II (16%), III (68%), and IVA (12%). Whole pelvic irradiation of 30Gy/15 fractions was followed by HDR-ISBT of 30Gy/5 fractions/3 days. Subsequently, additional pelvic external beam radiation therapy of 20Gy/10 fractions was delivered with a midline block. The median followup period was 55 months. RESULTS:The actuarial 5-year progression-free survival and overall survival rates for all cases were 42% and 54%, respectively. For the 17 patients with a Stage III tumor, the 5-year local control and overall survival rates were 73% and 51%, respectively. Two patients (8%) developed late toxicities of Grade 3. CONCLUSIONS:A high rate of pelvic control and survival with acceptable level of late toxicities were obtained for patients with advanced cervical carcinoma treated with HDR-ISBT.
journal_name
Brachytherapyjournal_title
Brachytherapyauthors
Isohashi F,Yoshioka Y,Koizumi M,Konishi K,Sumida I,Takahashi Y,Ogata T,Morishige KI,Enomoto T,Kawaguchi Y,Kotsuma T,Adachi K,Fukuda S,Akino Y,Inoue Tdoi
10.1016/j.brachy.2008.12.002subject
Has Abstractpub_date
2009-04-01 00:00:00pages
234-239issue
2eissn
1538-4721issn
1873-1449pii
S1538-4721(08)00701-0journal_volume
8pub_type
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