Clinical feasibility of interstitial brachytherapy using a "hybrid" applicator combining uterine tandem and interstitial metal needles based on CT for locally advanced cervical cancer.

Abstract:

PURPOSE:To explore the dosimetric advantage of target volume and surrounding normal tissue by using interstitial (IS) brachytherapy (BT) based on three-dimensional CT in locally advanced cervical cancer, as a simple and effective clinical treatment approach. METHODS AND MATERIALS:Fifty-two patients with poor tumor response to external beam radiotherapy and a residual tumor >5 cm at the time of the first BT were included. IS BT was performed using a "hybrid" applicator combining uterine tandem and free metal needles based on three-dimensional CT. The high-risk clinical target volume (HR-CTV), intermediate-risk clinical target volume, and organs at risk were contoured. The total dose, including external beam radiotherapy (45 Gy in 25 fractions) and high-dose-rate BT (30 Gy in 5 fractions), was biologically normalized to conventional 2-Gy fractions. D90 and D100 for HR-CTV and intermediate-risk clinical target volume and D2cc for the bladder, rectum, and sigmoid were analyzed. RESULTS:The mean D90 value for HR-CTV was 88.4 ± 3.5 Gy. Totally, 88.5% of the patients received D90 for HR-CTV ≥87 Gy. The D2cc for the bladder, rectum, and sigmoid were 81.1 ± 5.6, 65.7 ± 5.1, and 63.1 ± 5.4 Gy, respectively. The mean number of needles was 6.9 ± 1.3 for each application. IS BT was associated with minor complications. CONCLUSION:IS BT using the "hybrid" applicator provides a dosimetric advantage for target volume and organs at risk in large-volume (>5 cm) tumors and is, thereby, clinically feasible. However, the long-term curative effect and possible toxicity need further clinical observation.

journal_name

Brachytherapy

journal_title

Brachytherapy

authors

Liu ZS,Guo J,Lin X,Wang HY,Qiu L,Ren XJ,Li YF,Zhang BY,Wang TJ

doi

10.1016/j.brachy.2016.06.004

subject

Has Abstract

pub_date

2016-09-01 00:00:00

pages

562-9

issue

5

eissn

1538-4721

issn

1873-1449

pii

S1538-4721(16)30495-0

journal_volume

15

pub_type

杂志文章
  • Intravaginal 1-week high-dose-rate brachytherapy alone for Stages I-II endometrial cancer.

    abstract:OBJECTIVE:To evaluate the feasibility and intermediate-term results of a short course of high-dose-rate (HDR) intravaginal brachytherapy only after hysterectomy. METHODS AND MATERIALS:From December 1999 to February 2005, 50 patients with International federation of gynecology and obstetrics Stages IA-IIB endometrioid ...

    journal_title:Brachytherapy

    pub_type: 杂志文章

    doi:10.1016/j.brachy.2007.04.001

    authors: Martínez-Monge R,Nagore G,Cambeiro M,Garrán C,Villafranca E,Jurado M

    更新日期:2007-07-01 00:00:00

  • Improving patient-specific dosimetry for intravascular brachytherapy.

    abstract:PURPOSE:Accurate patient-specific dosimetry in intravascular brachytherapy (IVBT) is generally difficult due to the extremely high-dose gradient, complexity of treatment device, and patient-specific geometry (e.g., calcification, stent, curvature, movement of target). The purpose of this study is to analyze quantitativ...

    journal_title:Brachytherapy

    pub_type: 杂志文章

    doi:10.1016/j.brachy.2005.07.004

    authors: Li XA,O'Neill M,Suntharalingam M

    更新日期:2005-01-01 00:00:00

  • Initial analysis of Pro-Qura: a multi-institutional database of prostate brachytherapy dosimetry.

    abstract:PURPOSE:The study aimed to analyze the Pro-Qura database in terms of patient implant sequence number for each institution to determine evidence for a dosimetric learning curve. METHODS AND MATERIALS:In the Pro-Qura database, 2833 of a total of 4614 postplans from 57 brachytherapists were analyzed for evidence of a dos...

    journal_title:Brachytherapy

    pub_type: 杂志文章

    doi:10.1016/j.brachy.2006.10.002

    authors: Merrick GS,Grimm PD,Sylvester J,Blasko JC,Butler WM,Allen ZA,Chaudhry UU,Mazza A,Sitter M

    更新日期:2007-01-01 00:00:00

  • Permanent prostate brachytherapy and short-term androgen deprivation for intermediate-risk prostate cancer in Japanese men: outcome and toxicity.

    abstract:OBJECTIVES:To evaluate the interim outcomes of low-dose-rate permanent brachytherapy (PB) combined with short-term androgen deprivation therapy (ADT) in Japanese men with intermediate-risk prostate cancer excluding those with a Gleason score of 4+3. METHODS:The Protocol-intermediate-risk group (Protocol-IRG) was defin...

    journal_title:Brachytherapy

    pub_type: 杂志文章

    doi:10.1016/j.brachy.2014.09.001

    authors: Yamada Y,Masui K,Iwata T,Naitoh Y,Yamada K,Miki T,Okihara K

    更新日期:2015-03-01 00:00:00

  • Prostate-specific antigen bounce after curative brachytherapy for early-stage prostate cancer: A study of 274 African-Caribbean patients.

    abstract:BACKGROUND:Prostate cancer incidence in the African-Caribbean population ranks among the highest worldwide. We aim to evaluate the prostate-specific antigen (PSA) kinetics after brachytherapy, which so far remains unknown in this population. METHODS AND MATERIALS:From 2005 to 2013, 371 patients received (125)I brachyt...

    journal_title:Brachytherapy

    pub_type: 杂志文章

    doi:10.1016/j.brachy.2015.09.005

    authors: Leduc N,Atallah V,Creoff M,Rabia N,Taouil T,Escarmant P,Vinh-Hung V

    更新日期:2015-11-01 00:00:00

  • Postmortem radiation safety and issues pertaining to permanent prostate seed implantation in Japan.

    abstract:PURPOSE:If a prostate cancer patient treated with (125)I brachytherapy dies within 12 months after the treatment, prostate removal before cremation is recommended to avoid problems related to radioactivity in the ashes, such as inhalation of airborne particulate matter by crematorium staff or nearby residents. To provi...

    journal_title:Brachytherapy

    pub_type: 杂志文章,评审

    doi:10.1016/j.brachy.2014.08.043

    authors: Satoh T,Dokiya T,Yamanaka H,Saito S,Ishiyama H,Itami J,Shibuya H,Nakano T,Shigematsu N,Aoki M,Egawa S,Hashimoto M,Nishimura T,Yorozu A

    更新日期:2015-03-01 00:00:00

  • CT-based interstitial brachytherapy in advanced gynecologic malignancies: outcomes from a single institution experience.

    abstract:PURPOSE:To evaluate the clinical outcomes of women receiving a "short" course of high-dose-rate gynecologic interstitial brachytherapy (HDR-ISBT) boost with CT-based 3D planning. METHODS AND MATERIALS:Forty-seven women with no prior radiation received HDR-ISBT from August 2004 to February 2012. The mean external beam ...

    journal_title:Brachytherapy

    pub_type: 杂志文章

    doi:10.1016/j.brachy.2014.02.001

    authors: D'Souza D,Wiebe E,Patil N,Sugimoto A,Prefontaine M,Aulakh S,Whiston F,Stitt L,Surry K

    更新日期:2014-05-01 00:00:00

  • Benefit of adaptive CT-based treatment planning in high-dose-rate endorectal brachytherapy for rectal cancer.

    abstract:PURPOSE:In this planning study, we investigated the dosimetric benefit of repeat CT-based treatment planning at each fraction vs. the use of a single CT-based treatment plan for all fractions for high-dose-rate endorectal brachytherapy (HDREBT) for rectal cancer. METHODS AND MATERIALS:We included 11 patients that rece...

    journal_title:Brachytherapy

    pub_type: 杂志文章

    doi:10.1016/j.brachy.2017.08.011

    authors: van den Ende RPJ,Rijkmans EC,Kerkhof EM,Nout RA,Ketelaars M,Laman MS,Marijnen CAM,van der Heide UA

    更新日期:2018-01-01 00:00:00

  • Incidence and prognostic factors for seroma development after MammoSite breast brachytherapy.

    abstract:PURPOSE:Describe the incidence and identify risk factors for seroma development after MammoSite breast brachytherapy (MBT). METHODS AND MATERIALS:MBT patient data were prospectively recorded into a quality assurance database. Departmental and electronic records were reviewed to extract patient-, treatment-, and outcom...

    journal_title:Brachytherapy

    pub_type: 杂志文章

    doi:10.1016/j.brachy.2008.07.001

    authors: Watkins JM,Harper JL,Dragun AE,Ashenafi MS,Sinha D,Li J,Cole DJ,Jenrette JM 3rd

    更新日期:2008-10-01 00:00:00

  • Patient-reported sexual adjustment after definitive chemoradiation and MR-guided brachytherapy for cervical cancer.

    abstract:PURPOSE:The treatment of locally advanced cervical cancer with definitive chemoradiation (CRT) is associated with vaginal toxicity and altered sexual satisfaction. This prospective study assessed patient-reported sexual adjustment, vaginal dosimetry, and physician-reported vaginal toxicity in patients with cervical can...

    journal_title:Brachytherapy

    pub_type: 杂志文章

    doi:10.1016/j.brachy.2018.09.005

    authors: Conway JL,Gerber R,Han K,Jiang H,Xie J,Beiki-Ardakani A,Fyles A,Milosevic M,Williamson D,Croke J

    更新日期:2019-01-01 00:00:00

  • Salvage wide resection with intraoperative electron beam therapy or HDR brachytherapy in the management of isolated local recurrences of soft tissue sarcomas of the extremities and the superficial trunk.

    abstract:PURPOSE:To assess the toxicity and efficacy of salvage wide resection (SWR) with intraoperative electron beam radiation therapy (IOERT) or perioperative high-dose-rate brachytherapy (PHDRB) in previously unirradiated patients (PUP) vs. previously irradiated patients (PIP) with isolated local recurrence of soft tissue s...

    journal_title:Brachytherapy

    pub_type: 杂志文章

    doi:10.1016/j.brachy.2014.09.003

    authors: Cambeiro M,Aristu JJ,Moreno Jimenez M,Arbea L,Ramos L,San Julian M,Azinovic I,Calvo FA,Martínez-Monge R

    更新日期:2015-01-01 00:00:00

  • Variations in health-related quality of life in Japanese men who underwent iodine-125 permanent brachytherapy for localized prostate cancer.

    abstract:PURPOSE:The purpose of this study was to prospectively assess the variations in health-related quality of life (HR-QoL) in patients who underwent low-dose rate prostate brachytherapy using iodine-125 seed source during the first year after seed implantation. METHODS AND MATERIALS:Between July 2004 and December 2006, 1...

    journal_title:Brachytherapy

    pub_type: 杂志文章

    doi:10.1016/j.brachy.2009.07.013

    authors: Tanaka N,Fujimoto K,Asakawa I,Hirayama A,Yoneda T,Yoshida K,Hirao Y,Hasegawa M,Konishi N

    更新日期:2010-10-01 00:00:00

  • Evaluating the influence of prostate-specific antigen kinetics on metastasis in men with PSA recurrence after partial gland therapy.

    abstract:PURPOSE:Although current Delphi Consensus guidelines do not recommend a specific definition of biochemical recurrence after partial gland therapy, these guidelines acknowledge that serial prostate-specific antigen (PSA) tests remain the best marker for monitoring disease after treatment. The purpose of this study was t...

    journal_title:Brachytherapy

    pub_type: 杂志文章

    doi:10.1016/j.brachy.2018.12.001

    authors: King MT,Nguyen PL,Boldbaatar N,Yang DD,Muralidhar V,Tempany CM,Cormack RA,Hurwitz MD,Suh WW,Pomerantz MM,D'Amico AV,Orio PF 3rd

    更新日期:2019-01-01 00:00:00

  • A dose verification tool for high-dose-rate interstitial brachytherapy treatment planning in accelerated partial breast irradiation.

    abstract:PURPOSE:To develop a dose verification tool for high-dose-rate interstitial brachytherapy treatment planning in accelerated partial breast irradiation. METHODS AND MATERIALS:We have developed a software tool for interstitial brachytherapy treatment planning assessment. The software contains a database of seven (192)Ir...

    journal_title:Brachytherapy

    pub_type: 杂志文章

    doi:10.1016/j.brachy.2012.03.008

    authors: Marqa MF,Caudrelier JM,Betrouni N

    更新日期:2012-09-01 00:00:00

  • Is prostate-specific antigen percentage decrease predictive of clinical outcome after permanent iodine-125 interstitial brachytherapy for prostate cancer?

    abstract:OBJECTIVE:To determine the usefulness of prostate-specific antigen (PSA) percentage (vs. pretreatment value assumed as 100%) in prediction of biochemical relapse, after iodine-125 ((125)I) permanent brachytherapy for prostate cancer, to employ a parameter independent by the initial PSA amount and by the individual pros...

    journal_title:Brachytherapy

    pub_type: 杂志文章

    doi:10.1016/j.brachy.2011.08.008

    authors: Paoluzzi M,Mignogna M,Lorenzini E,Valent F,Fontana N,Pinzi N,Repetti F,Ponchietti R

    更新日期:2012-07-01 00:00:00

  • Five fraction accelerated partial breast irradiation using noninvasive image-guided breast brachytherapy: Feasibility and acute toxicity.

    abstract:PURPOSE:To improve efficiency, convenience, and cost, a prospective phase II trial was initiated to evaluate accelerated partial breast irradiation delivered with noninvasive image-guided breast brachytherapy (NIBB) via five once-daily fractions. METHODS AND MATERIALS:Women ≥50 years old with early-stage breast cancer...

    journal_title:Brachytherapy

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1016/j.brachy.2018.05.006

    authors: Hepel JT,Yashar C,Leonard KL,Einck JP,Sha S,DiPetrillo T,Wiggins D,Graves TA,Edmonson D,Brown University Oncology Research Group.,Wazer DE

    更新日期:2018-01-01 00:00:00

  • Vaginal vault brachytherapy as sole postoperative treatment for low-risk endometrial cancer.

    abstract:PURPOSE:To evaluate the efficacy and side effect profile of adjuvant vaginal vault brachytherapy alone after hysterectomy in Stage I endometrial carcinoma. METHODS AND MATERIALS:Between 23/11/1992 and 16/05/2005, a total of 173 patients with early endometrial carcinoma treated with vaginal vault brachytherapy alone po...

    journal_title:Brachytherapy

    pub_type: 杂志文章

    doi:10.1016/j.brachy.2008.01.001

    authors: Chong I,Hoskin PJ

    更新日期:2008-04-01 00:00:00

  • Factors associated with the omission of androgen deprivation therapy in radiation-managed high-risk prostate cancer.

    abstract:PURPOSE:Androgen deprivation therapy (ADT) has been shown to improve survival for men with unfavorable-risk prostate cancer (PCa). We investigated the utilization and factors associated with the omission of ADT in radiation-managed high-risk PCa. METHODS AND MATERIALS:We used the National Cancer Database to identify m...

    journal_title:Brachytherapy

    pub_type: 杂志文章

    doi:10.1016/j.brachy.2016.07.001

    authors: Chen YW,Muralidhar V,Mahal BA,Nezolosky MD,Beard CJ,Choueiri TK,Hoffman KE,Martin NE,Orio PF,Sweeney CJ,Feng FY,Trinh QD,Nguyen PL

    更新日期:2016-01-01 00:00:00

  • Novel and programmatic improvements to the workflow associated with the AccuBoost breast brachytherapy procedure.

    abstract:PURPOSE:While the noninvasive breast brachytherapy (NIBB) treatment procedure, known as AccuBoost, for breast cancer patients is well established, the treatment quality can be improved by the efficiency of the workflow delivery. A formalized approach evaluated the current workflow through failure modes and effects anal...

    journal_title:Brachytherapy

    pub_type: 杂志文章

    doi:10.1016/j.brachy.2020.01.007

    authors: Roles SA,Hepel JT,Leonard KL,Wazer DE,Cardarelli GA,Schwer ML,Saleh ZH,Klein EE,Brindle JM,Rivard MJ

    更新日期:2020-01-01 00:00:00

  • Rectal spacing, prostate coverage, and periprocedural outcomes after hydrogel spacer injection during low-dose-rate brachytherapy implantation.

    abstract:PURPOSE:To analyze the dosimetric impact and periprocedural outcomes with a bioabsorbable hydrogel rectal spacer injected during low-dose-rate (LDR) prostate brachytherapy implants. METHODS AND MATERIALS:A consecutive series of 80 patients implanted with stranded I-125 LDR brachytherapy seeds were evaluated, of which ...

    journal_title:Brachytherapy

    pub_type: 杂志文章

    doi:10.1016/j.brachy.2019.11.002

    authors: Kahn J,Dahman B,McLaughlin C,Kapoor P,Kapoor R,Harris E,Sharma M,Schutzer M,Moghanaki D

    更新日期:2020-01-01 00:00:00

  • Efficacy of high-dose-rate interstitial brachytherapy in patients with oral tongue carcinoma.

    abstract:PURPOSE:To evaluate the results of high-dose-rate (HDR)-interstitial brachytherapy (ISBT) in oral tongue carcinomas. METHODS AND MATERIALS:Between September 1999 and August 2007, 50 patients were treated for oral tongue carcinoma with HDR-ISBT. The patient's mean age was 58 years. Forty-two patients were in T1-2 stage...

    journal_title:Brachytherapy

    pub_type: 杂志文章

    doi:10.1016/j.brachy.2009.10.003

    authors: Guinot JL,Santos M,Tortajada MI,Carrascosa M,Estellés E,Vendrell JB,Muelas R,Chust ML,Mengual JL,Arribas L

    更新日期:2010-07-01 00:00:00

  • The feasibility of a second lumpectomy and breast brachytherapy for localized cancer in a breast previously treated with lumpectomy and radiation therapy for breast cancer.

    abstract:PURPOSE:With accumulating evidence supporting partial-breast irradiation, we conducted a Phase I/II study to evaluate the role of a second conservative surgery and brachytherapy for patients presenting with a local recurrence/new primary in a breast who has previously undergone a lumpectomy and external radiation thera...

    journal_title:Brachytherapy

    pub_type: 杂志文章

    doi:10.1016/j.brachy.2007.10.006

    authors: Chadha M,Feldman S,Boolbol S,Wang L,Harrison LB

    更新日期:2008-01-01 00:00:00

  • Intravascular brachytherapy using 90Sr for saphenous vein grafts having diameters ranging from 2.0-5.0 mm.

    abstract:PURPOSE:Symptomatic coronary artery disease is routinely treated with angioplasty and stenting. Unfortunately, treatment failure in the form of in-stent restenosis (ISR) occurs relatively frequently. Intravascular brachytherapy (IVBT) is a safe and effective method proven to markedly reduce the rate of ISR in native co...

    journal_title:Brachytherapy

    pub_type: 杂志文章

    doi:10.1016/j.brachy.2004.05.004

    authors: Mignano JE,Rivard MJ

    更新日期:2004-01-01 00:00:00

  • Process improvement for the safe delivery of multidisciplinary-executed treatments-A case in Y-90 microspheres therapy.

    abstract:PURPOSE:To develop a safe and robust workflow for yttrium-90 (Y-90) radioembolization procedures in a multidisciplinary team environment. METHODS AND MATERIALS:A generalized Define-Measure-Analyze-Improve-Control (DMAIC)-based approach to process improvement was applied to a Y-90 radioembolization workflow. In the fir...

    journal_title:Brachytherapy

    pub_type: 杂志文章

    doi:10.1016/j.brachy.2016.08.001

    authors: Cai B,Altman MB,Garcia-Ramirez J,LaBrash J,Goddu SM,Mutic S,Parikh PJ,Olsen JR,Saad N,Zoberi JE

    更新日期:2017-01-01 00:00:00

  • CT-guided permanent 125I seed interstitial brachytherapy for recurrent retroperitoneal lymph node metastases after external beam radiotherapy.

    abstract:PURPOSE:To evaluate the feasibility, efficacy, and safety of permanent (125)I seed interstitial brachytherapy reirradiation in patients with retroperitoneal lymph node recurrence under CT guidance. METHODS AND MATERIALS:Seventeen patients with 19 retroperitoneal lymph node recurrence after external beam radiotherapy u...

    journal_title:Brachytherapy

    pub_type: 杂志文章

    doi:10.1016/j.brachy.2015.05.008

    authors: Yao L,Jiang Y,Jiang P,Wang H,Meng N,Qu A,Tian S,Sun H,Liu C,Wang J,Zhang K

    更新日期:2015-09-01 00:00:00

  • Measuring relief of dysphagia in locally advanced esophageal carcinoma patients submitted to high-dose-rate brachytherapy.

    abstract:BACKGROUND AND PURPOSE:Esophageal neoplasm has a poor prognosis, and palliative care remains an important goal of treatment. The purpose of this study was to assess the ability of high-dose-rate brachytherapy (HDRB) to improve dysphagia in 115 patients treated at our institution. METHODS AND MATERIALS:Patients previou...

    journal_title:Brachytherapy

    pub_type: 杂志文章

    doi:10.1016/j.brachy.2014.09.007

    authors: Grazziotin Reisner R,Reisner ML,Ferreira MA,Rosa AA,Veras IM,Carneiro TM,Wolff B,Viégas CM,Mendonça de Araújo CM,Marchiori E

    更新日期:2015-01-01 00:00:00

  • High-dose-rate interstitial brachytherapy in oral cancer-Its impact on quality of life.

    abstract:PURPOSE:The aim of the study was to assess the impact of high-dose-rate (HDR) interstitial brachytherapy on quality of life (QOL) in oral cancer. METHODS AND MATERIALS:Thirty-two patients of oral cancer treated at our institute from January 2010 to December 2014 with radical radiotherapy (external beam radiotherapy + ...

    journal_title:Brachytherapy

    pub_type: 杂志文章

    doi:10.1016/j.brachy.2016.02.002

    authors: Bajwa HK,Singareddy R,Alluri KR

    更新日期:2016-05-01 00:00:00

  • Evaluation of impact of an external breast shield (FlexiShield) in electronic brachytherapy for breast IORT: A phantom study.

    abstract:PURPOSE:To investigate Axxent (iCAD, Inc., San Jose, CA) electronic brachytherapy balloon deformation and its dosimetric impact because of an external flexible shield (FlexiShield [FS]; iCAD, Inc.). METHODS AND MATERIALS:Prostheses breast tissue phantom overlaid three spherical balloon applicators to simulate three cl...

    journal_title:Brachytherapy

    pub_type: 杂志文章

    doi:10.1016/j.brachy.2017.01.009

    authors: Kim Y,Huynh JW,Gonzalez VJ

    更新日期:2017-01-01 00:00:00

  • The effect of pelvic radiotherapy on vaginal brachytherapy cylinder diameter: Implications for optimal treatment order.

    abstract:PURPOSE:To determine the factors that correlate with cylinder size in vaginal brachytherapy (VB) after hysterectomy for endometrial carcinoma. METHODS AND MATERIALS:Patients treated for endometrial cancer from January 1, 2003 to December 31, 2013 were reviewed from a single institution. Patients included underwent tot...

    journal_title:Brachytherapy

    pub_type: 杂志文章

    doi:10.1016/j.brachy.2016.04.391

    authors: Rakhra SS,Weaver C,Donnelly ED,Helenowski I,Prescott AE,Strauss JB

    更新日期:2016-09-01 00:00:00

  • A detailed examination of the difference between planned and treated margins in 125I permanent prostate brachytherapy.

    abstract:PURPOSE:To determine whether potential extraprostatic extension (EPE) of prostate adenocarcinoma is covered by the prescribed dose when permanent 125I implants are planned with a 5-mm treatment margin. METHODS AND MATERIALS:The postimplant dosimetry of 60 consecutive 125I prostate implants was analyzed to determine wh...

    journal_title:Brachytherapy

    pub_type: 杂志文章

    doi:10.1016/j.brachy.2003.09.002

    authors: Patel AB,Waterman FM,Dicker AP

    更新日期:2003-01-01 00:00:00