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Clinical outcome of high-dose-rate interstitial brachytherapy in vulvar cancer: A single institutional experience.

Abstract：

PURPOSE:With an aim to evaluate and report high dose date interstitial brachytherapy (HDR-ISBT) in vulvar cancers, we undertook this retrospective analysis. METHODS AND MATERIALS:Histologically proven vulvar cancers treated with HDR-ISBT between 2001 and 2016 were analyzed. Radiotherapy details, clinical outcome in terms of local control rates, survivals, and toxicities were evaluated. RESULTS:A total of 38 patients received HDR-ISBT, with definitive radiation in 29 (76.3%), adjuvant postoperative in six (15.8%) and salvage radiation in three (7.9%) patients. Of them, 29 patients received brachytherapy boost and nine patients ISBT alone. BT procedure included freehand plastic tube technique in 23 (single [n = 5] or multiple plane [n = 18]), 13 patients with template based and two patients combined approach. Patients with brachytherapy alone received median EQD2 of 38.4 Gy10 (35.5-46.7 Gy10), as boost received median 23.3 Gy10 (13-37.3 Gy10). At 3-month post-treatment response evaluation, 30 patients achieved clinically complete response, two patients partial response and six maintained postoperative status. With a median follow-up of 30 months, 29 (76.3%) were disease free, and 9 (23.7%) patients had relapsed disease with four patients expired due to disease and two died of other causes. The 5-year overall survival, disease free survival, and local control rates were 82%, 51%, and 77%, respectively. CONCLUSIONS:HDR-ISBT in vulvar cancer is a feasible and a viable option with acceptable and comparable outcomes.

journal_name

Brachytherapy

journal_title

Brachytherapy

authors

Mahantshetty U,Naga P,Engineer R,Sastri S,Ghadi Y,Upreti U,Somesan V,Kadam S,Kohle S,Deshpande D,Shrivastava SK

doi

10.1016/j.brachy.2016.10.003

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

153-160

issue

1

eissn

1538-4721

issn

1873-1449

pii

S1538-4721(16)30567-0

journal_volume

16

pub_type

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