Abstract:
PURPOSE:Dose escalation has been shown beneficial in prostate cancer. Brachytherapy (BT) provides an opportunity for dose escalation beyond what can be safely delivered using only teletherapy methods. The purpose of this study was to determine cancer control and morbidity of external beam radiation therapy (EBRT) plus low-dose-rate (LDR) BT boost in patients with prostate cancer treated at Duke University Health System. METHODS:Between June 1997 and August 2007, 199 patients were consecutively treated at our facility with 46Gy EBRT followed by 100Gy palladium-103 ((103)Pd) or 120Gy iodine-125 ((125)I) LDR prostate implant. Treatment characteristics and followup data were retrospectively analyzed. Intermediate risk was defined as T2b-c, Gleason score 7 (GS 7), or prostate-specific antigen (PSA) of 10.1-19.9ng/mL. High risk was defined as GS 8-10, PSA>20, T3+, or two intermediate risk factors. The Radiation Therapy Oncology Group toxicity scale was used to report morbidity for gastrointestinal (GI) and genitourinary (GU) effects. PSA recurrence was defined as nadir+2ng/mL. RESULTS:Median followup was 4.2 years for all patients, 4.8 years for high-risk patients. Risk categories were as follows: 20% low risk, 47% intermediate risk, and 33% high risk. Forty five percent of patients received adjuvant androgen deprivation therapy (ADT). The median length of time since end of ADT to last followup was 2.7 years in all patients, 2.0 years for high-risk patients. Five-year biochemical relapse-free survival was 87% for all, 81% for high-risk patients. PSA control was similar at 92% for all and 86% for high-risk patients. Five-year actuarial risk of any and Grade 3 late GI morbidity was 38% and 7% respectively, and any and Grade 3 late GU morbidity was 21% and 3%, respectively. There were no significant differences in risk of Grade 2+GI or GU morbidity with choice of isotope. CONCLUSIONS:EBRT plus LDR BT has acceptable morbidity and, with 5-year followup, provides excellent cancer control even in high-risk patients.
journal_name
Brachytherapyjournal_title
Brachytherapyauthors
Koontz BF,Chino J,Lee WR,Hahn CA,Buckley N,Huang S,Kim J,Reagan R,Joyner R,Anscher MSdoi
10.1016/j.brachy.2009.01.002subject
Has Abstractpub_date
2009-04-01 00:00:00pages
191-196issue
2eissn
1538-4721issn
1873-1449pii
S1538-4721(09)00003-8journal_volume
8pub_type
杂志文章相关文献
Brachytherapy文献大全abstract:PURPOSE:To analyze the dosimetric impact and periprocedural outcomes with a bioabsorbable hydrogel rectal spacer injected during low-dose-rate (LDR) prostate brachytherapy implants. METHODS AND MATERIALS:A consecutive series of 80 patients implanted with stranded I-125 LDR brachytherapy seeds were evaluated, of which ...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2019.11.002
更新日期:2020-01-01 00:00:00
abstract:PURPOSE:To improve efficiency, convenience, and cost, a prospective phase II trial was initiated to evaluate accelerated partial breast irradiation delivered with noninvasive image-guided breast brachytherapy (NIBB) via five once-daily fractions. METHODS AND MATERIALS:Women ≥50 years old with early-stage breast cancer...
journal_title:Brachytherapy
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.brachy.2018.05.006
更新日期:2018-01-01 00:00:00
abstract:PURPOSE:Low-dose-rate brachytherapy using iodine-125 seeds is a highly efficacious treatment for low-risk prostate cancer. We propose a bioeffect model may be used to target an ablative dose to the tumor with a lower, therapeutic dose to low-risk regions to maintain high rates of tumor control with reduced toxicity. We...
journal_title:Brachytherapy
pub_type: 杂志文章,多中心研究
doi:10.1016/j.brachy.2013.04.008
更新日期:2013-11-01 00:00:00
abstract:PURPOSE:(1) To demonstrate the feasibility of C-arm cone-beam computed tomography (CBCT)-based postplanning and subsequent adaptation of underdosed critical areas by adding remedial seeds during the transrectal ultrasound (TRUS)-guided implantation of (125)I seeds and (2) to assess the duration of this procedure. METH...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2007.08.005
更新日期:2007-10-01 00:00:00
abstract:PURPOSE:To present a clinical procedure that readjusts catheters to its planned positions based on pretreatment computed tomography (CT) for patients undergoing high-dose-rate (HDR) prostate brachytherapy, and evaluate the magnitude and dosimetric impact of the adjustments. METHODS AND MATERIALS:Patients received a pr...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2012.08.008
更新日期:2013-05-01 00:00:00
abstract:PURPOSE:The available data demonstrating that superiority of LDR brachytherapy (LDR-BT) boost in high-risk prostate cancer patients under represents patients with extracapsular extension (T3a) and/or seminal vesicle invasion (T3b) have been limited. We report long-term clinical outcomes data for patients with cT3a/b di...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2018.07.001
更新日期:2018-01-01 00:00:00
abstract::In 2008, the GEC ESTRO Gyn network launched the first multiinstitutional, observational, and prospective international study on MRI-guided brachytherapy in locally advanced cervical cancer patients (EMBRACE-I). EMBRACE-I was followed by EMBRACE-II from 2016 and ongoing. Among the aims of the EMBRACE studies are to ben...
journal_title:Brachytherapy
pub_type: 杂志文章,评审
doi:10.1016/j.brachy.2020.08.011
更新日期:2020-01-01 00:00:00
abstract:PURPOSE:The purpose of this work was to evaluate whether the delivered dose to the skin surface and at the prescription depth when using a Freiburg flap applicator is in agreement with the one predicted by the treatment planning system (TPS) using the TG-43 dose-calculation formalism. METHODS AND MATERIALS:Monte Carlo...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2011.11.005
更新日期:2012-11-01 00:00:00
abstract:PURPOSE:Patients with cervical and vaginal cancer sometimes have a less straightforward approach for choice of brachytherapy treatment owing to the tumor's location and clinical presentation. The staff at Royal Brisbane & Women's Hospital in Queensland, Australia, is trying to solve this problem by the use of an old te...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2014.10.004
更新日期:2015-03-01 00:00:00
abstract:PURPOSE:In July 2009, American Society of Radiation Oncology (ASTRO) released a consensus statement (CS) to guide patient selection for accelerated partial breast irradiation (APBI). The goal of this study was to examine how practice patterns changed following the guideline's release. METHODS:The Surveillance, Epidemi...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2015.03.003
更新日期:2015-07-01 00:00:00
abstract:PURPOSE:To determine the factors that correlate with cylinder size in vaginal brachytherapy (VB) after hysterectomy for endometrial carcinoma. METHODS AND MATERIALS:Patients treated for endometrial cancer from January 1, 2003 to December 31, 2013 were reviewed from a single institution. Patients included underwent tot...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2016.04.391
更新日期:2016-09-01 00:00:00
abstract:PURPOSE:The aim of this work was to analyze the exposure rates measured in the proximity of patients who underwent prostate low-dose-rate brachytherapy with I-125 implant. Effective doses to relatives and to population were computed to estimate the time to reach radioprotection dose constraints. METHODS AND MATERIALS:...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2020.09.003
更新日期:2021-01-01 00:00:00
abstract:PURPOSE:To report the preliminary results of transabdominal ultrasound (TAUS)-guided brachytherapy (BT) in cervical cancer. METHODS AND MATERIALS:Twenty-nine patients with cervical cancer Stage IB-IVA according to The International Federation of Gynecology and Obstetrics staging were treated by radical radiotherapy fr...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2014.11.001
更新日期:2015-03-01 00:00:00
abstract:PURPOSE:The treatment of locally advanced cervical cancer with definitive chemoradiation (CRT) is associated with vaginal toxicity and altered sexual satisfaction. This prospective study assessed patient-reported sexual adjustment, vaginal dosimetry, and physician-reported vaginal toxicity in patients with cervical can...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2018.09.005
更新日期:2019-01-01 00:00:00
abstract:PURPOSE:The purpose of this study was to evaluate the incidence of late severe (≥Grade 3) urinary toxicity and the long-term efficacy after low-dose-rate brachytherapy (LDR-BT) in patients with localized prostate cancer (PCa). METHODS AND MATERIALS:During the years 1999-2008, 241 patients with PCa who underwent LDR-BT...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2019.05.005
更新日期:2019-01-01 00:00:00
abstract:PURPOSE:To develop a safe and robust workflow for yttrium-90 (Y-90) radioembolization procedures in a multidisciplinary team environment. METHODS AND MATERIALS:A generalized Define-Measure-Analyze-Improve-Control (DMAIC)-based approach to process improvement was applied to a Y-90 radioembolization workflow. In the fir...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2016.08.001
更新日期:2017-01-01 00:00:00
abstract:PURPOSE:To choose the optimal brachytherapeutic modality for uterine cervical cancer, we performed simulation analysis. METHODS AND MATERIALS:For each high-risk clinical target volume (HR CTV), we compared four modalities [classical conventional intracavitary brachytherapy (ConvICBT), Image-guided ICBT (IGICBT), intra...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2015.10.002
更新日期:2016-01-01 00:00:00
abstract:PURPOSE:To assess the feasibility and tumor outcome of re-irradiation with low-dose-rate brachytherapy for macroscopic local recurrences after radical prostatectomy (RP) followed by adjuvant or salvage external beam radiation therapy (EBRT). METHODS AND MATERIALS:Between 2011 and 2018, five men with histologically pro...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2020.07.001
更新日期:2021-01-01 00:00:00
abstract:OBJECTIVE:The aim of the study is to compare the results of the combined external beam radiotherapy (EBRT) with iodine-125 seed brachytherapy vs. brachytherapy alone for prostate cancer treatment in patients with intermediate and high risk of disease recurrence. METHODS AND MATERIALS:Ninety-six patients were treated f...
journal_title:Brachytherapy
pub_type: 临床试验,杂志文章
doi:10.1016/j.brachy.2009.07.011
更新日期:2010-10-01 00:00:00
abstract:PURPOSE:The American Brachytherapy Society (ABS) consensus guidelines for high-dose-rate (HDR) prostate brachytherapy suggest 11 different dose constraints for the urethra. The purpose of this study is to evaluate whether a single urethral constraint of D0.1 cm3 < 110% could meet all the proposed ABS urethral constrain...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2019.12.001
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:To determine the usefulness of prostate-specific antigen (PSA) percentage (vs. pretreatment value assumed as 100%) in prediction of biochemical relapse, after iodine-125 ((125)I) permanent brachytherapy for prostate cancer, to employ a parameter independent by the initial PSA amount and by the individual pros...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2011.08.008
更新日期:2012-07-01 00:00:00
abstract:PURPOSE:To establish dose-volume effect correlations for late small bowel (SB) toxicities in patients treated for locally advanced cervical cancer with concomitant chemoradiation followed by pulsed-dose rate MRI-guided adaptive brachytherapy. METHODS AND MATERIALS:Patients treated with curative intent and followed pro...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2016.04.004
更新日期:2016-07-01 00:00:00
abstract:PURPOSE:To identify patients at extremely low risk of biochemical recurrence (BCR) of prostate cancer after low-dose-rate brachytherapy (LDR-BT) to determine when prostate-specific antigen (PSA) monitoring can be stopped. METHODS AND MATERIALS:We retrospectively reviewed clinicopathologic data of patients with prostat...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2018.08.018
更新日期:2018-01-01 00:00:00
abstract:PURPOSE:To investigate the safety and feasibility of intraluminal brachytherapy using 125I seed strand for locally advanced pancreatic ductal adenocarcinoma with obstructive jaundice. METHODS AND MATERIALS:From January 2010 to February 2015, 18 consecutive patients diagnosed with locally advanced, nonmetastatic, inope...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2016.05.004
更新日期:2016-01-01 00:00:00
abstract:PURPOSE:In this study, computer modeling was used to compare the relative doses with the bladder, rectum, and bowel when two different brachytherapy modalities were used to treat cervical cancer with a tandem and ovoid applicator. A standard high-dose rate (HDR) (192)Ir treatment plan was compared with a "mixed-source"...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2010.08.009
更新日期:2011-03-01 00:00:00
abstract:PURPOSE:Determine feasibility and resultant dosimetry of an intraoperatively placed multichannel intracavitary brachytherapy catheter for accelerated partial breast irradiation (APBI). METHODS:Patients with breast cancer underwent intraoperative brachytherapy catheter placement based on frozen section analysis with im...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2016.08.002
更新日期:2016-01-01 00:00:00
abstract:PURPOSE:If a prostate cancer patient treated with (125)I brachytherapy dies within 12 months after the treatment, prostate removal before cremation is recommended to avoid problems related to radioactivity in the ashes, such as inhalation of airborne particulate matter by crematorium staff or nearby residents. To provi...
journal_title:Brachytherapy
pub_type: 杂志文章,评审
doi:10.1016/j.brachy.2014.08.043
更新日期:2015-03-01 00:00:00
abstract:PURPOSE:To compare a standard radio-oncological and a surgical biochemical failure definition after combined-modality radiation therapy (CRT) in men with intermediate- and high-risk prostate cancer. METHODS:425 men were treated with external beam radiotherapy (59.4 Gy, 33 fractions) and 125J seed-brachytherapy (S-BT, ...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2019.09.001
更新日期:2020-01-01 00:00:00
abstract:PURPOSE:High-dose-rate (HDR) brachytherapy is a convenient treatment option for selected patients with T1-T2 penile squamous cell carcinoma (SCC), providing high rates of penile preservation and tumor control. We present the results of penile SCC treated with HDR brachytherapy either interstitially or via a surface mol...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2019.12.003
更新日期:2020-01-01 00:00:00
abstract:PURPOSE:The purpose of this study was to report our experience regarding the development of a low-cost multichannel vaginal cylinder applicator for superficial and recurrent vaginal tumors. METHODS AND MATERIALS:The applicator mold was created by applying heated wax sheets in layers around a plastic tube. Interstitial...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2020.05.001
更新日期:2020-01-01 00:00:00