Abstract:
PURPOSE:The British Columbia Cancer Agency has been performing iodine-125 prostate brachytherapy since 1998, initially using loose seeds and phasing into the exclusive use of RAPIDStrand (RS) (Oncura Inc., Plymouth Meeting, PA) by November 2000. The aim of this study was to investigate rates of biochemical no evidence of disease (bNED) in patients treated with loose seeds compared with RS from this population-based cohort. METHODS AND MATERIALS:Between July 1998 and February 2006, 1500 implants were performed (327 loose and 1173 RS). Biochemical failure is reported using the Phoenix definition and prostate-specific antigen (PSA) >0.4ng/mL at ≥48 months postimplant. Actuarial estimates were calculated by the Kaplan-Meier method. Analysis was repeated with the first 100 loose and stranded implants excluded to assess the learning curve effect. Log-rank test was used to evaluate differences in bNED. Variables showing association with bNED were included in a multivariate model. RESULTS:There was no difference between loose and stranded seeds. Estimated rate of bNED was 93.5% (95% confidence interval [CI], 90.6-96.4) at 7 years for patients treated with loose seeds and 94.0% (95% CI, 91.8-96.2) for patients treated with RS according to Phoenix definition (p=0.846). Using the PSA >0.4ng/mL definition, estimated rates were 91.3% (95% CI, 88.0-94.6) and 91.9% (95% CI, 89.7-94.1) for loose and stranded seeds, respectively (p=0.871). Exclusion of the first 100 loose and stranded implants also revealed no difference in bNED. CONCLUSION:This study of 1500 patients treated with iodine-125 brachytherapy demonstrates no difference in bNED between loose and stranded seeds, using either Phoenix or PSA >0.4ng/mL definitions of biochemical failure.
journal_name
Brachytherapyjournal_title
Brachytherapyauthors
Herbert C,Morris WJ,Hamm J,Lapointe V,McKenzie M,Pickles T,Spadinger I,Keyes Mdoi
10.1016/j.brachy.2011.01.011subject
Has Abstractpub_date
2011-11-01 00:00:00pages
442-8issue
6eissn
1538-4721issn
1873-1449pii
S1538-4721(11)00022-5journal_volume
10pub_type
杂志文章相关文献
Brachytherapy文献大全abstract:PURPOSE:Determine feasibility and resultant dosimetry of an intraoperatively placed multichannel intracavitary brachytherapy catheter for accelerated partial breast irradiation (APBI). METHODS:Patients with breast cancer underwent intraoperative brachytherapy catheter placement based on frozen section analysis with im...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2016.08.002
更新日期:2016-01-01 00:00:00
abstract:PURPOSE:To investigate the feasibility of in vivo dosimetry using microMOSFET dosimeters in patients treated with brachytherapy using two types of gynecological applicators. METHODS AND MATERIALS:In this study, a microMOSFET was placed in an empty needle of an Utrecht Interstitial Fletcher applicator or MUPIT (Martine...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2017.04.240
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVE:The aim of the study is to compare the results of the combined external beam radiotherapy (EBRT) with iodine-125 seed brachytherapy vs. brachytherapy alone for prostate cancer treatment in patients with intermediate and high risk of disease recurrence. METHODS AND MATERIALS:Ninety-six patients were treated f...
journal_title:Brachytherapy
pub_type: 临床试验,杂志文章
doi:10.1016/j.brachy.2009.07.011
更新日期:2010-10-01 00:00:00
abstract:BACKGROUND:Cervical cancer patients are faced with an enormous amount of medical information in a complex oncology field with sophisticated treatments including brachytherapy. We investigated the use of enhanced vs. standard brachytherapy-specific educational materials on patient-reported satisfaction during the inform...
journal_title:Brachytherapy
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.brachy.2015.09.007
更新日期:2016-01-01 00:00:00
abstract:PURPOSE:To evaluate the long-term disease control and toxicity to the organs at risk after dose-escalated image-based adaptive brachytherapy (BT) in cervical cancer. METHODS AND MATERIALS:Sixty patients of cervical cancer were treated with external radiotherapy 46 Gy in 23 fractions with weekly cisplatin and MRI-guide...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2017.09.008
更新日期:2018-01-01 00:00:00
abstract:PURPOSE:Accurate patient-specific dosimetry in intravascular brachytherapy (IVBT) is generally difficult due to the extremely high-dose gradient, complexity of treatment device, and patient-specific geometry (e.g., calcification, stent, curvature, movement of target). The purpose of this study is to analyze quantitativ...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2005.07.004
更新日期:2005-01-01 00:00:00
abstract:PURPOSE:Although surgery remains a treatment option for symptomatic brain metastases, the need for adjuvant radiation after surgery is widely accepted as standard. Despite a multitude of randomized trials aimed at identifying the ideal radiation treatment plan for surgically resected metastases, the development of new ...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2020.11.004
更新日期:2021-01-13 00:00:00
abstract:OBJECTIVES:To evaluate the interim outcomes of low-dose-rate permanent brachytherapy (PB) combined with short-term androgen deprivation therapy (ADT) in Japanese men with intermediate-risk prostate cancer excluding those with a Gleason score of 4+3. METHODS:The Protocol-intermediate-risk group (Protocol-IRG) was defin...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2014.09.001
更新日期:2015-03-01 00:00:00
abstract:PURPOSE:Although current Delphi Consensus guidelines do not recommend a specific definition of biochemical recurrence after partial gland therapy, these guidelines acknowledge that serial prostate-specific antigen (PSA) tests remain the best marker for monitoring disease after treatment. The purpose of this study was t...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2018.12.001
更新日期:2019-01-01 00:00:00
abstract:PURPOSE:To describe in detail British Columbia (BC) Cancer Agency (BCCA) Provincial Prostate Brachytherapy (PB) Quality Assurance (QA) Program. METHODS AND MATERIALS:The BCCA PB Program was established in 1997. It operates as one system, unified and supported by electronic and information systems, making it a single P...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2012.03.006
更新日期:2013-07-01 00:00:00
abstract:PURPOSE:To assess the feasibility and tumor outcome of re-irradiation with low-dose-rate brachytherapy for macroscopic local recurrences after radical prostatectomy (RP) followed by adjuvant or salvage external beam radiation therapy (EBRT). METHODS AND MATERIALS:Between 2011 and 2018, five men with histologically pro...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2020.07.001
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Esophageal neoplasm has a poor prognosis, and palliative care remains an important goal of treatment. The purpose of this study was to assess the ability of high-dose-rate brachytherapy (HDRB) to improve dysphagia in 115 patients treated at our institution. METHODS AND MATERIALS:Patients previou...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2014.09.007
更新日期:2015-01-01 00:00:00
abstract:PURPOSE:Urethral strictures are a rare complication of prostate brachytherapy (BXT), with prior studies showing radiation dose to the bulbomembranous urethra as being associated with stricture formation. This retrospective case-control study explored clinical and dosimetric parameters associated with the development of...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2017.04.242
更新日期:2017-01-01 00:00:00
abstract:PURPOSE:Determine whether fat distribution, body mass index, or clinical and dosimetric factors are associated with prostate specific antigen (PSA) bounce (PSAb) of ≥1.6 ng/mL in patients treated with permanent seed (125)I prostate brachytherapy (PB). METHODS AND MATERIALS:We identified 23 patients with a PSAb of ≥1.6...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2013.05.005
更新日期:2013-11-01 00:00:00
abstract:PURPOSE:To evaluate the effectiveness of the single-energy metal artifact reduction (SEMAR) technique for improving the accuracy of I-125 seed identification in postimplant computed tomography (CT) after prostate brachytherapy. METHODS AND MATERIALS:Postimplant CT images of 40 patients treated with I-125 prostate brac...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2016.07.006
更新日期:2016-01-01 00:00:00
abstract:PURPOSE:We sought to develop an activity nomogram for magnetic resonance (MR)-planned permanent seed prostate brachytherapy to improve quality assurance through a secondary dosimetric check. METHODS AND MATERIALS:Patients undergoing MRI-assisted radiosurgery (MARS), whereby MRI is used for preoperative planning and po...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2019.10.002
更新日期:2020-01-01 00:00:00
abstract:PURPOSE:Permanent LDR brachytherapy and temporary HDR brachytherapy are competitive techniques for clinically localized prostate radiotherapy. Although a randomized trial will likely never be conducted comparing these two forms of brachytherapy, a comparative radiobiological modeling analysis proves useful in understan...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/S1538-4721(02)00101-0
更新日期:2002-01-01 00:00:00
abstract:PURPOSE:Currently, there are high dose rate afterloaders available that can drive two different radioactive sources simultaneously. The source-source and source-cable attenuations are not taken into account by current planning systems. The purpose of this work is to characterize these effects and their overall impact o...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2016.03.007
更新日期:2016-07-01 00:00:00
abstract:PURPOSE:To establish dose-volume effect correlations for late small bowel (SB) toxicities in patients treated for locally advanced cervical cancer with concomitant chemoradiation followed by pulsed-dose rate MRI-guided adaptive brachytherapy. METHODS AND MATERIALS:Patients treated with curative intent and followed pro...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2016.04.004
更新日期:2016-07-01 00:00:00
abstract::While brachytherapy applications are not widely used for cancer diagnoses in the upper GI tract (including the esophagus, liver, stomach, and pancreas), they have a clear role in palliation and symptom management and occasionally definitive locoregional treatment. With the increasing use of image-guided techniques, th...
journal_title:Brachytherapy
pub_type: 杂志文章,评审
doi:10.1016/j.brachy.2020.11.010
更新日期:2020-12-22 00:00:00
abstract:PURPOSE:To present a clinical procedure that readjusts catheters to its planned positions based on pretreatment computed tomography (CT) for patients undergoing high-dose-rate (HDR) prostate brachytherapy, and evaluate the magnitude and dosimetric impact of the adjustments. METHODS AND MATERIALS:Patients received a pr...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2012.08.008
更新日期:2013-05-01 00:00:00
abstract:PURPOSE:Accelerated partial breast irradiation (APBI) continues to increase in popularity. Up to 14% of patients treated with the MammoSite (MS) report some degree of chronic pain, which may be related to chest wall toxicity. Reports from several institutions using the multicatheter (MC) technique have not shown associ...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2008.11.007
更新日期:2009-04-01 00:00:00
abstract:PURPOSE:To develop an improved Xoft electronic skin brachytherapy process and identify areas of further improvement. METHODS AND MATERIALS:A multidisciplinary team conducted a failure modes and effects analysis (FMEA) by developing a process map and a corresponding list of failure modes. The failure modes were scored ...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2018.04.002
更新日期:2018-01-01 00:00:00
abstract:PURPOSE:To evaluate the results of high-dose-rate (HDR)-interstitial brachytherapy (ISBT) in oral tongue carcinomas. METHODS AND MATERIALS:Between September 1999 and August 2007, 50 patients were treated for oral tongue carcinoma with HDR-ISBT. The patient's mean age was 58 years. Forty-two patients were in T1-2 stage...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2009.10.003
更新日期:2010-07-01 00:00:00
abstract:PURPOSE:The treatment of locally advanced cervical cancer with definitive chemoradiation (CRT) is associated with vaginal toxicity and altered sexual satisfaction. This prospective study assessed patient-reported sexual adjustment, vaginal dosimetry, and physician-reported vaginal toxicity in patients with cervical can...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2018.09.005
更新日期:2019-01-01 00:00:00
abstract:PURPOSE:Given the limited data using an interstitial approach with 3D-based planning for definitive cervical cancer utilizing the GEC-ESTRO defined high-risk clinical target volume (HR-CTV), we reviewed our institutional experience of cervical cancer patients with HR-CTVs ≥ 30 cc to determine whether our clinical and t...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2017.10.004
更新日期:2018-01-01 00:00:00
abstract:PURPOSE:Treatment of locally advanced cervical cancer in patients with a renal graft requires precautions. The graft is usually in a pelvic position, close to the clinical target volume (CTV). Preserving the graft while ensuring local control is a challenge we have faced in two occasions. We report our experience. MET...
journal_title:Brachytherapy
pub_type: 社论
doi:10.1016/j.brachy.2013.11.003
更新日期:2014-01-01 00:00:00
abstract:PURPOSE:The aim of this work was to analyze the exposure rates measured in the proximity of patients who underwent prostate low-dose-rate brachytherapy with I-125 implant. Effective doses to relatives and to population were computed to estimate the time to reach radioprotection dose constraints. METHODS AND MATERIALS:...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2020.09.003
更新日期:2021-01-01 00:00:00
abstract:PURPOSE:The available data demonstrating that superiority of LDR brachytherapy (LDR-BT) boost in high-risk prostate cancer patients under represents patients with extracapsular extension (T3a) and/or seminal vesicle invasion (T3b) have been limited. We report long-term clinical outcomes data for patients with cT3a/b di...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2018.07.001
更新日期:2018-01-01 00:00:00
abstract:PURPOSE:This work quantifies the influence of intrafraction DNA damage repair and cellular repopulation on biologically effective dose (BED) in Ir-192 high-dose-rate brachytherapy for prostate cancer. In addition, it examines the effect of source-decay-induced BED variation for patients treated at different time points...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2019.04.005
更新日期:2019-01-01 00:00:00