Abstract:
PURPOSE:Although high-dose-rate brachytherapy (HDRBT) offers significant advantages over low dose rate brachytherapy, there are scant data on improved local control (LC) and treatment-related complications in patients with recurrent head and neck (H&N) cancers. We report our preliminary results in patients with recurrent H&N cancers treated with interstitial HDRBT. METHODS AND MATERIALS:Thirty patients with recurrent H&N cancers were treated with HDRBT between September 2003 and October 2005. Seventy-seven percent (23/30) of the patients had either local or regional recurrence in the area of previous external beam radiation therapy. The treatment sites were oral cavity/oropharynx (11/30), neck (10/30), face/nasal cavity (6/30), and parotid bed (3/30). Whereas 18 patients underwent surgical resection followed by HDRBT, 3 patients were treated with combined external beam radiation and HDRBT, and the remaining 9 were treated with HDRBT alone. The dose and fractionation schedules used were 3.4Gy twice per day (b.i.d.) to 34Gy for postoperative cases, 4Gy b.i.d. to 20Gy when combined with 40-50Gy external beam, and 4Gy b.i.d. to 40Gy for definitive treatment. HDRBT was initiated 5 days after catheter placement to allow for tissue healing. RESULTS:With a median followup of 12 months, 6 local recurrences were observed 1-10 months after the procedure. The 2-year LC and overall survival outcomes for the entire group were 71% and 63%, respectively. Patients treated with surgical resection and HDRBT had an improved 2-year LC compared to the patients treated with HDRBT+/-external beam radiation alone (88% vs. 40%, p=0.05). Six Grade II and four Grade III complications were noted in five patients, all observed in the postoperative HDRBT group. CONCLUSION:The preliminary results of HDRBT indicate an acceptable LC and morbidity in recurrent H&N cancers. A planned surgical resection followed by HDRBT is associated with improved tumor control in these high-risk patients. Based on these encouraging results, prospective clinical trials are warranted using HDRBT in recurrent H&N cancers to decrease late toxicity.
journal_name
Brachytherapyjournal_title
Brachytherapyauthors
Narayana A,Cohen GN,Zaider M,Chan K,Lee N,Wong RJ,Boyle J,Shaha A,Kraus D,Shah J,Zelefsky MJdoi
10.1016/j.brachy.2006.12.001subject
Has Abstractpub_date
2007-04-01 00:00:00pages
157-63issue
2eissn
1538-4721issn
1873-1449pii
S1538-4721(07)00005-0journal_volume
6pub_type
杂志文章相关文献
Brachytherapy文献大全abstract:PURPOSE:To analyze the effect of tungsten shields present in a Fletcher-Suit-Delclos ovoid by comparing the dose distribution computed by a treatment planning system (TPS) to the delivered dose distribution measured by radiochromic film dosimetry. METHODS AND MATERIALS:Gafchromic/EBT films were carefully wrapped aroun...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2010.08.008
更新日期:2011-05-01 00:00:00
abstract:PURPOSE:High-dose-rate (HDR) brachytherapy boost is a treatment of intermediate- to high-risk prostate cancer, but long-term clinical outcome data are sparse. We report long-term survival and toxicity data in a cohort of patients treated in a single institution. METHODS:Between 1998 and 2004, 654 patients with localiz...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2019.01.013
更新日期:2019-01-01 00:00:00
abstract:PURPOSE:Stereotactic body radiotherapy (SBRT) is being used with increasing frequency as definitive treatment of early stage prostate cancer. Much of the justification for its adoption was derived from earlier clinical results using high-dose-rate (HDR) brachytherapy. We determine whether HDR's dosimetry can be achieve...
journal_title:Brachytherapy
pub_type: 临床试验,杂志文章
doi:10.1016/j.brachy.2013.03.003
更新日期:2013-09-01 00:00:00
abstract:PURPOSE:For selected early breast cancers, intraoperative radiation therapy (IORT) at the time of lumpectomy can be an efficient alternative to fractionated whole breast radiation therapy (WBRT). However, some patients are later recommended WBRT after IORT due to surgical pathologic findings. To understand risk factor ...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2016.09.012
更新日期:2017-01-01 00:00:00
abstract:PURPOSE:To investigate the feasibility of in vivo dosimetry using microMOSFET dosimeters in patients treated with brachytherapy using two types of gynecological applicators. METHODS AND MATERIALS:In this study, a microMOSFET was placed in an empty needle of an Utrecht Interstitial Fletcher applicator or MUPIT (Martine...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2017.04.240
更新日期:2018-01-01 00:00:00
abstract:PURPOSE:To quantify needle migration and dosimetric impact in high-dose-rate brachytherapy for prostate cancer and propose a threshold for needle migration. METHODS AND MATERIALS:Twenty-four high-risk prostate cancer patients treated with an HDR boost of 2 × 8.5 Gy were included. Patients received an MRI for planning ...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2017.08.005
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVES:To determine the relationship between dosimetric parameters obtained on postimplantation Day 0 and biochemical relapse-free survival (bRFS) in patients treated with (125)I transperineal interstitial permanent prostate brachytherapy (TIPPB). METHODS:Two-hundred twenty men with low-risk (n=155, 70.4%), low-vo...
journal_title:Brachytherapy
pub_type: 临床试验,杂志文章
doi:10.1016/j.brachy.2009.04.005
更新日期:2010-01-01 00:00:00
abstract:PURPOSE:To recognize the practice of radiotherapy for management of cervical cancer in Ontario, Canada, and to use the results of the survey to harmonize and standardize practice across the province. METHODS AND MATERIALS:An electronic survey (SurveyMonkey) was sent to all 14 provincial cancer centers by Cancer Care O...
journal_title:Brachytherapy
pub_type: 杂志文章,多中心研究
doi:10.1016/j.brachy.2018.03.003
更新日期:2018-01-01 00:00:00
abstract:PURPOSE:To provide longitudinal follow-up and assess the intermediate outcomes in breast cancer patients treated with the MammoSite radiation therapy system. METHODS AND MATERIAL:Ninety-two patients with histologically proven stage 0-II breast cancer were treated with MammoSite accelerated partial breast irradiation a...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2008.07.005
更新日期:2009-01-01 00:00:00
abstract:PURPOSE:The aim of this work was to analyze the results of palliative HDR brachytherapy in patients with advanced esophageal cancer. METHODS AND MATERIALS:Ninety-one patients with unresectable, advanced esophageal cancer were treated palliatively by HDR brachytherapy. All patients received a total dose of 22.5 Gy in t...
journal_title:Brachytherapy
pub_type: 临床试验,杂志文章
doi:10.1016/j.brachy.2004.05.003
更新日期:2004-01-01 00:00:00
abstract:PURPOSE:To describe in detail British Columbia (BC) Cancer Agency (BCCA) Provincial Prostate Brachytherapy (PB) Quality Assurance (QA) Program. METHODS AND MATERIALS:The BCCA PB Program was established in 1997. It operates as one system, unified and supported by electronic and information systems, making it a single P...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2012.03.006
更新日期:2013-07-01 00:00:00
abstract:PURPOSE:While the noninvasive breast brachytherapy (NIBB) treatment procedure, known as AccuBoost, for breast cancer patients is well established, the treatment quality can be improved by the efficiency of the workflow delivery. A formalized approach evaluated the current workflow through failure modes and effects anal...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2020.01.007
更新日期:2020-01-01 00:00:00
abstract:PURPOSE:To present a clinical procedure that readjusts catheters to its planned positions based on pretreatment computed tomography (CT) for patients undergoing high-dose-rate (HDR) prostate brachytherapy, and evaluate the magnitude and dosimetric impact of the adjustments. METHODS AND MATERIALS:Patients received a pr...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2012.08.008
更新日期:2013-05-01 00:00:00
abstract:PURPOSE:To choose the optimal brachytherapeutic modality for uterine cervical cancer, we performed simulation analysis. METHODS AND MATERIALS:For each high-risk clinical target volume (HR CTV), we compared four modalities [classical conventional intracavitary brachytherapy (ConvICBT), Image-guided ICBT (IGICBT), intra...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2015.10.002
更新日期:2016-01-01 00:00:00
abstract:PURPOSE:The use of brachytherapy continues to be a vital application of radiation oncology for various cancers. Despite this, there has been a decrease in the utilization of brachytherapy in many cancers. Social media in medicine facilitates engagement and advocacy. We launched a social media campaign to bring awarenes...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2020.07.003
更新日期:2021-01-01 00:00:00
abstract:PURPOSE:To investigate the safety and feasibility of intraluminal brachytherapy using 125I seed strand for locally advanced pancreatic ductal adenocarcinoma with obstructive jaundice. METHODS AND MATERIALS:From January 2010 to February 2015, 18 consecutive patients diagnosed with locally advanced, nonmetastatic, inope...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2016.05.004
更新日期:2016-01-01 00:00:00
abstract:PURPOSE:To evaluate the results of high-dose-rate (HDR)-interstitial brachytherapy (ISBT) in oral tongue carcinomas. METHODS AND MATERIALS:Between September 1999 and August 2007, 50 patients were treated for oral tongue carcinoma with HDR-ISBT. The patient's mean age was 58 years. Forty-two patients were in T1-2 stage...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2009.10.003
更新日期:2010-07-01 00:00:00
abstract:PURPOSE:Brachytherapy (BrT) is a standard treatment for low-risk to favorable-intermediate-risk prostate cancer but is a relative contraindication for patients with obstructive symptoms. We aimed to assess the feasibility and urinary toxicity of a minimal photovaporization (mPVP) before implantation. MATERIALS AND MET...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2020.08.003
更新日期:2021-01-01 00:00:00
abstract::While brachytherapy applications are not widely used for cancer diagnoses in the upper GI tract (including the esophagus, liver, stomach, and pancreas), they have a clear role in palliation and symptom management and occasionally definitive locoregional treatment. With the increasing use of image-guided techniques, th...
journal_title:Brachytherapy
pub_type: 杂志文章,评审
doi:10.1016/j.brachy.2020.11.010
更新日期:2020-12-22 00:00:00
abstract:PURPOSE:To explore the dosimetric advantage of target volume and surrounding normal tissue by using interstitial (IS) brachytherapy (BT) based on three-dimensional CT in locally advanced cervical cancer, as a simple and effective clinical treatment approach. METHODS AND MATERIALS:Fifty-two patients with poor tumor res...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2016.06.004
更新日期:2016-09-01 00:00:00
abstract:PURPOSE:Patients with large prostate glands are underrepresented in clinical trials incorporating brachytherapy due to concerns for excessive toxicity. We sought to compare health-related quality of life (HRQOL) outcomes between small (<60 cc) and large (≥60 cc) prostates treated with high-dose-rate brachytherapy (HDR-...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2018.08.009
更新日期:2019-01-01 00:00:00
abstract:INTRODUCTION:Substantial as opposed to focal or no lymphovascular space invasion (LVSI) is proposed as an independent adverse prognostic factor in patients with early-stage endometrioid endometrial cancer (EEC). We reviewed outcomes of patients treated with adjuvant vaginal brachytherapy (VB) alone in a single institut...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2020.12.006
更新日期:2021-01-20 00:00:00
abstract:PURPOSE:The aim of this work was to analyze the exposure rates measured in the proximity of patients who underwent prostate low-dose-rate brachytherapy with I-125 implant. Effective doses to relatives and to population were computed to estimate the time to reach radioprotection dose constraints. METHODS AND MATERIALS:...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2020.09.003
更新日期:2021-01-01 00:00:00
abstract:PURPOSE:To evaluate the long-term disease control and toxicity to the organs at risk after dose-escalated image-based adaptive brachytherapy (BT) in cervical cancer. METHODS AND MATERIALS:Sixty patients of cervical cancer were treated with external radiotherapy 46 Gy in 23 fractions with weekly cisplatin and MRI-guide...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2017.09.008
更新日期:2018-01-01 00:00:00
abstract:PURPOSE:Brachytherapy re-irradiation may offer an alternative re-treatment of recurrent head-and-neck cancer even after previous full dose radiation therapy. The purposes of this study were to determine the feasibility and accuracy of frameless image-guided interstitial needle implantation. METHODS AND MATERIALS:Betwe...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2005.02.001
更新日期:2005-01-01 00:00:00
abstract:PURPOSE:Persistent disease after definitive external beam radiation therapy for head and neck (H&N) malignancies negatively impacts survival. In this series, the effectiveness of low-dose-rate brachytherapy in the management of persistent H&N disease is explored. METHODS:All patients who received brachytherapy for per...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2008.12.007
更新日期:2009-07-01 00:00:00
abstract:PURPOSE:There is strong evidence relating postimplant dosimetry for low-dose-rate prostate seed brachytherapy to local control rates. The delineation of the prostate on CT images, however, represents a challenge due to the lack of soft-tissue contrast to identify the prostate borders. This study aims at quantifying the...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2016.08.013
更新日期:2016-01-01 00:00:00
abstract:PURPOSE:Accurate patient-specific dosimetry in intravascular brachytherapy (IVBT) is generally difficult due to the extremely high-dose gradient, complexity of treatment device, and patient-specific geometry (e.g., calcification, stent, curvature, movement of target). The purpose of this study is to analyze quantitativ...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2005.07.004
更新日期:2005-01-01 00:00:00
abstract:PURPOSE:To evaluate clinical outcome and feasibility of a four-dimensional image-guided adaptive brachytherapy concept in patients with locally recurrent endometrial cancer. METHODS AND MATERIALS:Forty-three patients with locally recurrent endometrial cancer were included. Treatment consisted of conformal external bea...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2014.06.004
更新日期:2014-11-01 00:00:00
abstract:PURPOSE:To evaluate dosimetry and source location relative to CT-based dosimetry when performing real-time dynamic permanent prostate brachytherapy (PPB) with inverse treatment planning. METHODS AND MATERIALS:A treatment algorithm for dynamic PPB was developed using inverse treatment planning. The technique utilizes r...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/S1538-4721(03)00134-X
更新日期:2003-01-01 00:00:00