Abstract:
PURPOSE:Limited information is available comparing target volume and normal tissue dosimetry with the different techniques of partial breast irradiation (PBI). We present results of a dosimetric comparison of single catheter, balloon-based brachytherapy using the MammoSite catheter (BRT), 3D conformal radiation therapy (3DCRT), and intensity-modulated radiation therapy (IMRT). METHODS AND MATERIALS:Fifteen patients were treated using the BRT device. With the use of CT scans with balloons in inflated and deflated states, plans were developed for each patient using each of the methods of PBI, for a total of 45 plans. The plans were then compared using the below dosimetric parameters. RESULTS:The mean V100 was 95%, 92%, and 94% for the BRT, 3DCRT, and IMRT techniques, respectively. The mean ipsilateral breast V50 was 29%, 56%, and 46% (p < 0.0001) and the mean ipsilateral lung V30 was 5%, 7%, and 2% (p < 0.001 for IMRT vs. others) for the BRT, 3DCRT, and IMRT methods, respectively. For the 10 patients with left-sided breast tumors, the mean heart V5 was 12%, 4%, and 1% for the BRT, 3DCRT, and IMRT methods, respectively (p < 0.01). CONCLUSIONS:With increasing interest in PBI, our data may help clinicians individualize patient treatment decisions.
journal_name
Brachytherapyjournal_title
Brachytherapyauthors
Khan AJ,Kirk MC,Mehta PS,Seif NS,Griem KL,Bernard DA,Chu JC,Dickler Adoi
10.1016/j.brachy.2006.06.001subject
Has Abstractpub_date
2006-07-01 00:00:00pages
183-8issue
3eissn
1538-4721issn
1873-1449pii
S1538-4721(06)00201-7journal_volume
5pub_type
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